http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
사상인 체질병증 험위증(險危證) 중 악성 종양으로 유발될 수 있는 증(證)에 대한 고찰
이수민,박소라,이수경,Lee, Soo-Min,Park, So-Ra,Lee, Soo-Kyung 사상체질의학회 2015 사상체질의학회지 Vol.27 No.3
Objectives The purpose of study was to identify cancer related symptoms of Sasang Constitution based on the classic of Sasang Constitutional Medicine (SCM). Methods The bibliographical study was performed with "Dongyisoosebowon-Shinchukbon(東醫壽世保元 辛丑本)", Dongyisoosebowon-Sasangchobongwon(東醫壽世保元 四象草本券), "Cancer", and several review articles. The perspective on severe illness in SCM was investigated. And 'the critical state' of constitutional symptoms based on "Dongyisoosebowon" was identified as cancer related symptoms. Results and Conclusions The perspective on severe illness of SCM was focused on the human being itself, compared with symptom based traditional Chinese medicine. The preservation of requisite energy (保命之主) was a vital factor of longevity to maintain healthy status and the classification of severity of disease. And critical state was an important indicator to control severe illness. Regarding cancer related symptoms in SCM, Janggwol(臟厥), Eumsung-gyeokyang(陰盛隔陽證), Janggyeol(藏結證) of Soeumin symptoms, Hwangdal(黃疸), Haso(下消), Eumheo-oyel(陰虛午熱證), Gochang, Tohyul(吐血) of Soyangin's symptoms, Joyeol(燥熱證), Bokchang-bujong(腹脹浮腫) of Taeeumin's symptoms, and Eolgyek of Taeyangin's symptoms could be shown the association with cancer. According to the prognosis on disease severity, regimens of daily life, behavior modifications as well as medications were also emphasized with great importance to control severe illness in SCM. These holistic approach for controlling severe illness in SCM could lead to the improvement of treatment outcome.
목질바이오매스의 초임계수 처리에 의한 리그닌의 화학적 변환
이수민(Lee, Soo-Min),이오규(Lee, Oh-Kyu),최석환(Choi, Seok-Hwan),최준원(Choi, Joon-Weon),최돈하(Choi, Don-Ha) 한국신재생에너지학회 2008 한국신재생에너지학회 학술대회논문집 Vol.2008 No.05
The modified supercritical water treatment method is adopted for hydrolysis of wood powder, Populus albatimesglandulosa. This modified method is containing 0.05% HCl or HNO₃ as acid catalyst. The supercritical water treatment(SCW) was performed for 1 min. with 350?C, 380?C, 400?C and 425?C, respectively, under 230 pm 10 atm using continuous flow system. When acid was added to powder prepared for SCW treatment, the yields of monomeric sugars were significantly increased. The lignin remained after supercritical treatment was applied to gel permeation chromatography(GPC) for molecular weight distribution analysis. Compared to the lignin produced from SCW treatment without acid catalyst, the average molecular weight of lignin compounds treated with acid was clearly decreased. Particularly, Mn/Mw ratio is decreased. This result shows supercritical water treatment of wood powder can change the molecular weight of lignin to small size. However, it is necessary to be further studied for exactly characterizing the lignin produced from supercritical water treatment.
전이된 담도암 환자의 패혈증을 한다열소탕 및 우담과 항생제를 병행하여 치료한 환자 1례
이수민,최성헌,송안나,이지영,채진,정의홍,이수경,Lee, Soo-Min,Choi, Seong-Heon,Song, An-Na,Lee, Ji-Young,Chae, Jin,Jung, Eu-Hong,Lee, Soo-Kyung 사상체질의학회 2013 사상체질의학회지 Vol.25 No.4
Objectives Despite the treatment with antibiotics, patients with sepsis has a high mortality (80%) in the underlying disease group. The aim of this study was to report the improvement of septic condition of the cholangiocarcinoma patient after the treatment with Handayeolso-tang, Fel Tauri, and antibiotics. Methods We retrospectively reviewed the medical records. The patient's subjective symptoms such as chilling and abdominal pain were evaluated by NRS and the performance status was evaluated by ECOG. This case was literally compared with relevant published studies on prognosis of sepsis. Results Despite poor prognostic factor(MEDS score 18), the patient's symptoms such as fever, chilling, abdominal pain, and diarrhea and ECOG(Eastern Cooperative Oncology Group) improved. The patient was hemodynamically stabilized on 3rd day from the treatment, and her laboratory test results were normalized on 7th day. Conclusions A female patient of metastatic cholangiocarcinoma came to the hospital for cholangitis, later causing septic shock. Both her symptoms and laboratory tests showed significant improvement after the treatment of antibiotics, Handayeolso-tang and Fel Tauri. To our knowledge, this is the first case reporting the synergistic combination of Korean oriental medicine and Western medicine approaching to sepsis.
단신 : 고에너지밀도 펠릿제조를 위한 목재칩 반탄화 특성
이재원 ( Jae Won Lee ),김영훈 ( Young Hun Kim ),이수민 ( Soo Min Lee ),이형우 ( Hyoung Woo Lee ) 한국화학공학회 2012 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.50 No.2
본 연구에서는 소나무 혼합수종을 이용하여 에너지 밀도 증가, 균일한 품질의 바이오매스 제공을 위해 무산소 조건에서 반탄화를 실시하였다. 반응온도는 240, 260, 280˚C로 하여 30분 동안 반응시킨 후반탄화 바이오매스 특성을 조사하였다. 침엽수혼합수종의 반탄화는 무처리 바이오매스와 비교하여 발열량이 향상되었음을 확인하였다. 반탄화 온도가 증가할수록 반탄화된 바이오매스의 탄소함량은 최대 46.55%에서 55.73%로 증가하였다. 반면 수소와 산소의 함 량은 각각 6.00%에서 5.87%, 30.55%에서 27.21%로 감소하였다. 반탄화 과정에서 주로 헤미셀룰로오스와 휘발성 물 질이 제거되었다. 280˚C에서 30분 동안 반응하였을 때 최대 발열량 5,132 kcal/kg을 나타냈다. 이것은 처리전 바이오 매스의 발열량 보다 약 13% 증가하였음을 나타내고 있다. 중량감소율과 에너지수율을 고려하여 비교한 결과 240˚C 에서 30분 동안 처리하였을 때 효과적인 반탄화가 이루어졌다. In this study, torrefaction of mixed softwood chips under anoxic condition was performed to improve energy density and maintain consistent quality of biomass. Characteristics of torrefied biomass depending on reaction time (30 min) and temperature (240, 260, 280˚C) were investigated. Torrefaction of mixed softwood chips significantly improved the heating value compared to that of untreated biomass. As the torrefaction temperature was increased, the carbon content of torrefied biomass increased from 46.55 to 55.73%, while its hydrogen and oxygen contents decreased from 6.00 to 5.87% and from 30.55 to 27.21%, respectively. Most of hemicelluloses and volatile compounds were removed during torrefaction. The highest heating value was 5132 kcal/kg when torrefaction was performed at 280˚C for 30 min. It implied that the heating value increased by 13% compared to that of original biomass. However, the condition of effective torrefaction was at 240˚C for 30 min when weight loss and energy yield was considered.
무정형 고체분산체를 이용한 엔잘루타마이드 고함량 정제의 개발
이수민(Su Min Lee),이정균(Jeong Gyun Lee),김경수(Kyeong Soo Kim) 한국산학기술학회 2023 한국산학기술학회논문지 Vol.24 No.8
이 연구의 목적은 난용성 약물인 엔잘루타마이드의 용해도 및 용출률을 개선시킨 고함량 엔잘루타마이드 정제를 개발하여 시판 제품보다 우수한 약물 복용 순응도를 가진 정제 제형을 개발하는 것이다. 결정형 엔잘루타마이드를 용매 증발법을 이용하여 무정형의 엔잘루타마이드로 제조한 분말과, Kollidon VA64를 추가하여 고체분산체를 제조한 분말 및 결정형 약물과 비교하여 각각의 용해도 및 분말 특성을 비교하였다. 최종 선정된 고체분산체를 이용하여 최적의 정제처방을 선정하기 위하여 다양한 첨가제를 비율별로 추가하여 정제를 제조하였다. 유당일수화물 및 미결정셀룰로오스를 수용성 및 수불용성 충전제로 사용하였으며, 크로스포비돈 및 크로스카멜로오스 소듐을 붕해제로 사용하여 다양한 질량비로 정제를 제조하였다. 최종 선정된 정제 조성은 엔잘루타마이드 80 mg 해당량의 엔잘루타마이드 고체분산체, 유당일수화물, 미세결정셀룰로오스, 크로스카멜로스나트륨, 크로스포비돈, 마그네슘 스테아레이트의 질량비 200/100/100/20/10/4 (w/w/w/w/w/w)로 제조되었다. 최종 선정된 고함량 엔잘루타마이드 정제를 시판품 (엑스탄디<SUP>®</SUP> 연질캡슐)과 비교 용출시험을 진행하였다. 선정된 조성물은 pH 1.0, 4.0, 6.8 용액에서 엑스탄디<SUP>®</SUP> 연질캡슐과 유사한 용출 속도를 나타내었다. 따라서 이렇게 제조된 고함량의 엔잘루타마이드 함유 정제 제형은 시판 제품보다 작은 정제 크기로 복용 환자의 약물 복용 순응성을 향상시킬 수 있을 것으로 사료되었다. 이 연구의 결과로 얻어진 조성물은 첨가제의 영향을 고려하여 선정된 최적의 고함량 엔잘루타마이드 정제로서 우수한 엔잘루타마이드의 용출 양상을 나타내기 때문에 엑스탄디® 연질캡슐의 대체 제품으로 사용가능성이 높을 것으로 사료되었다. This study was undertaken to develop a high-content loaded enzalutamide tablet formulation to improve medication compliance for commercial enzalutamide products. Kollidon VA64 was added to enzalutamide, which was prepared as a solid dispersion by solvent evaporation. Crystalline, amorphous enzalutamide, as well as the selected enzalutamide solid dispersion, were characterized by scanning electron microscopy and in vitro solubility tests. Lactose and microcrystalline cellulose were chosen as water-soluble and insoluble diluents, respectively. Croscarmellose sodium and crospovidone were selected as disintegrants, and magnesium stearate was added as a lubricant. The final selected tablet formulation, comprising enzalutamide solid dispersion (as enzalutamide 80 mg), lactose, microcrystalline cellulose, croscarmellose sodium, crospovidone, and magnesium stearate at a weight ratio of 200/100/100/20/10/4 (w/w/w/w/w/w), exhibited a dissolution rate similar to the commercial product. The final selected enzalutamide tablets were evaluated and compared to a commercial 40 mg enzalutamide product (Xtandi<SUP>®</SUP> soft capsule). The selected tablet formulation showed a similar dissolution rate to Xtandi<SUP>®</SUP> soft capsule in solutions with pH 1.0, 4.0, and 6.8 at the final dissolution time point. Thus, we determined that the selected enzalutamide tablet formulation potentially reduces the size of the enzalutamide product and improves patient medication compliance. This research indicates that based on the influence of excipients, the selected optimal enzalutamide tablet is suitable as an oral solid dosage form that could be a suitable candidate for a high-content loaded enzalutamide formulation, enhancing the dissolution rate of enzalutamide and preventing recrystallization.
임신 28주에 자기공명영상으로 진단한 파열되지 않은 흔적 자궁각임신
이수민 ( Soo Min Lee ),박인양 ( In Yang Park ),신종철 ( Jong Chul Shin ),권지영 ( Ji Young Kwon ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.10
Pregnancy in rudimentary horn is rare. Rupture tends to occur in the second trimester. Only a few cases of the diagnosis of unruptured third-trimester rudimentary horn pregnancy have been reported. We experienced a case of unruptured rudimentary horn pregnancy at 28+3 weeks gestation confirmed by MRI. Successful delivery of a live male fetus weighing 955 g by cesarean section and excision of the rudimentary horn with ipsilateral salpinx were carried.