현대생물학의 방향

이민재 韓國生物敎育學會 1970 생물교육 Vol.4 No.-

Exosomes as the source of biomarkers of metabolic diseases

이민재,박동호,강주희 대한소아내분비학회 2016 Annals of Pediatirc Endocrinology & Metabolism Vol.21 No.3

Exosomes are extracellular vesicles that contain molecules that regulate the metabolic functions of adjacent or remote cells. Recent in vitro, in vivo and clinical studies support the hypothesis that exosomes released from various cell types play roles in the progression of metabolic disorders including type 2 diabetes. Based on this concept and advances in other diseases, the proteins, mRNA, microRNA and lipids in exosomes isolated from biological fluids have been proposed as biomarkers in metabolic disorders. However, several problems with the development of clinically applicable biomarkers have not been resolved. In this review, the biologic functions of exosomes are briefly introduced, and we discuss the technical and practical pros and cons of different methods of exosome isolation for the identification of exosomal biomarkers of metabolic disorders. Standardization of preanalytical variables and isolation of high-purity exosomes from fully characterized biological fluids will be necessary for the identification of useful exosomal biomarkers that can provide insights into the pathogenic mechanisms of complications of metabolic syndrome and of whole-body metabolism.

뇌졸중 환자에 대한 기능적 전기자극 치료를 병행한 거울치료의 효과

이민재,구현모 대한통합의학회 2018 대한통합의학회지 Vol.6 No.3

Purpose : The purpose of this study was to investigate the effects of mirror therapy with functional electrical stimulation to improve upper extremity motor function and activities of daily living (ADL) in stroke patients. Method : Thirty patients were randomly assigned to the experimental and control groups 15 patients in each. All subjects received the general occupational therapy consisting of five 30 min sessions per week for 8 weeks, in addition to 30 min of mirror therapy with functional electrical stimulation for the experimental group and 30 min of functional electrical stimulation for the control group for each session. To measure the functions of the upper limb and performance capacities in ADL, the Fugl-Meyer Assessment (FMA), and Manual Function Test (MFT), Modified Barthel Index (MBI) were used before and after the interventions. Results : Both the experimental and control groups showed a statistically significant increase in post-treatment FMA, MFT and MBI scores compared to their pre-treatment scores (p<.05). In addition, intergroup comparisons revealed a statistically significant increase in the scores of all assessments for the experimental group compared to those for the control group (p<.05). Conclusion : Based on these results, it is reasonable to conclude that mirror therapy with functional electrical stimulation is an effective intervention for improving upper limb motor function and ADL performance in stroke patients. Purpose : The purpose of this study was to investigate the effects of mirror therapy with functional electrical stimulation to improve upper extremity motor function and activities of daily living(ADL) for stroke patients. Method : Thirty patients were randomly allocated to the experimental and control groups with 15 patients in each group. All subjects were given the general occupational therapy consisting of five 30 min sessions per week for 8 weeks, in addition to 30 min of mirror therapy with functional electrical stimulation for the experimental group and 30 min of functional electrical stimulation for the control group for each session. To measure the functions of the upper limb and performance capacities in the ADL, the Fugl-Meyer assessment (FMA), Manual Function Test (MFT), Modified Barthel Index (MBI) were used before and after the intervention. Results : Both the experimental and control groups showed a statistically significant increase in post-treatment FMA, MFT and MBI scores as compared to the pre-treatment scores (p<.05). Intergroup comparisons found that the experimental group showed a statistically significant increase in scores of all assessments compared to the control group (p<.05). Conclusion : Based on these results, it is reasonable to conclude that mirror therapy with functional electrical stimulation is an effective intervention method to improve upper limb motor function and the ability to perform ADL in patients with stroke patients.

농촌지역 노인 하지불안증후군 역학연구; 운수면 인터뷰 연구

이민재,권오대,김지언 대한수면연구학회 2012 Journal of sleep medicine Vol.9 No.2

Restless legs syndrome (RLS) is a common neurological condition characterized by uncomfortable and unpleasant sensations in the legs that are relieved by movement. While RLS is a common disorder, many patients are still remained undiagnosed. Objectives: The aim of this study was to determine the prevalence, sociodemographic characteristics of RLS in rural elderly. Various comorbidity, depression and sleep disturbance were also assessed. Methods: This study was designed as a descriptive, cross-sectional, face-to-face interview research by well trained neuropsychologist and neurologist. A total of 328 people aged 65 years old and over participated. The criteria suggested by Korean version of the international restless legs syndrome study group were used in the assessment of RLS. We performed face-to-face interview and various clinical examinations. Geriatric Depression Scale (GDepS), Pittsburgh sleep quality index (PSQI), and insomnia severity index (ISI) were carried out. Results: The prevalence of RLS in rural elderly was 9.67% (male, 5.1%; female, 11.7%). No significant differences were found in comorbidities between the subjects with and without RLS. Estimated GDepS, PSQI, and ISI showed no statistical significance, too. Conclusions: The prevalence of RLS was relatively high in this study, compared to previous studies.

소형 전기차 디자인의 기술 동향

이민재 한국자동차공학회 2011 한국자동차공학회 Workshop Vol.2011 No.9

수종 유황환원균주의 분리, 동정 및 그의 생리적 특성에 대하여

이민재,오명수 한국미생물학회 1972 미생물학회지 Vol.10 No.4

This work was designed to illustrate physiological effects on the elimination of sulfur and its compounds in petroleum using sulfur-reducing bacteria. Deulfurizing bacteria were collected from sewage and soil at several areas in Soul and Ulsan, Korea. Seven supecies of sulfur-reducing microbes isolated were identified as : Pseudomonas marginata, Ps.effusa, Ps. putrefaciens, Ps.pseudcmcnelli, Ps. xanthochlora, Ps.bowlesiae, and Ps.aeruginosa. And some experiments were performed to define the growing characteristics of the Pseudomonads and the results obtained are as follows : 1) Shaking culture method was more effective for the growth of the cells than stagnant culture. 2) Beef peptone medium was better for the growth than other media. 3) Cuprous chloride of 50 ppm and cupper sulfate of 300 ppm treated, respectively, in the medium were effective for the growth. 4) Benzene of toluene of 5,000 ppm and petroleum ether of 50,000 ppm did not show remarkable inhibitory effects on the growth.

위의 위치 및 산도에 관한 X선학적 연구

이민재 대한영상의학회 1970 대한영상의학회지 Vol.6 No.1

The position and form of the stomach vary depending upon the position and habit of the bodym, spatial conditions of the abdominal cavity, phase of respiration, level of the liver and diaphragm. There has been much speculation about the criteria and significance of gastroptosis. Some regardgastroptosis as a manifestation of asthenic habit, while others claim that this entity is a generalized symptom complex. However, it appears that many clinicians in this country prefer to ascribe the gastric symptoms subtly to gastroptosis in the patients in whom no organic lesions can be detectable on x-ray study and physical examination of the gastrointestinal tract. Furthermore, they say that level of the stomach is considerably lower in position and the incidence fo gastroptosis is much gigher in Koreans than in western peoples or in Japanes. Employing a roentgenological study the author made observations on the level and form of the stomach in 100 healthy Korean adults and onthe interrelationships of the stomach, level of the other abdominal viscera and gastric emptying time in 46 symptomatic patients with no demonstrable organic lesions. The interrelationship between the acidity of gastric secretion and the mucosal pattern of the stomach and duodenum was also evaluated in 92 patients in whom no demonsrable organic lesion was found.

글로벌 가치사슬(GVC) 재편에 따른 충청북도의 공공외교 추진전략

이민재,정진섭 대한산업경영학회 2021 산업융합연구 Vol.19 No.6

본 연구는 글로벌 공급망 변화로 인해 국내외 기업의 투자유치를 통한 지역경제 활성화가 긴요한 시점에서 충청북도를 중심으로 공공외교를 활용한 지방정부의 경쟁력 강화 방안을 모색했다. 최근 글로벌 비즈니스 환경에서 나타나고 있는 주요 이슈를 정리하면, 글로벌 가치사슬의 지역화 강화, 리쇼어링 현상과 공급망 다변화, 디지털 전환을 통한 효율적인 글로벌 가치사슬 창출 등이다. 따라서 본 연구는 이러한 변화를 바탕으로 공공외교 전략의 필요성을 강조하고 SWOT 분석을 통해 충북의 대응 여건 및 세부 전략을 도출했다. 또한, 이를 종합하여 ABCD 모델을 기반으 로 충북형 공공외교 전략을 수립하고, 충북의 경쟁력을 한 단계 업그레이드하기 위한 전략적 시사점을 제시했다. This study sought ways to strengthen the competitiveness of local governments using public diplomacy, especially in Chungcheongbuk-do, at a time when it is urgent to revitalize the local economy by attracting investment from domestic and foreign companies due to changes in the global supply chain. The main issues that have recently emerged in the global business environment include strengthening the localization of the global value chain, diversifying reshoring and supply chains, and creating an efficient global value chain through digital transformation. Therefore, this study emphasized the necessity of a strategy for public diplomacy based on these changes, and derived the response conditions and detailed strategies of Chungcheongbuk-do through SWOT analysis. In addition, based on the ABCD model, we set up a Chungbuk-type public diplomacy strategy and suggested strategic implications for upgrading Chungbuk’s competitiveness.

교회교육 파노라마 제주영락교회 토요체험학교

이민재 장로회신학대학교 기독교교육연구원 2013 교육교회 Vol.429 No.-

외식기업의 CSR에 따른 지속가능경영이 조직성과에 미치는 영향

이민재,김주호 관광경영학회 2019 관광경영연구 Vol.89 No.-

The purpose of this study is to investigate the effect of CSR activities on food service industry job satisfaction and turnover intention by using food service industry CSR activities with 350 out of 400 (effective sample rate: 87.5%) As a result of the analysis, it was found that factor reduction of ISO 26000 was executed from the same factor of human rights and labor practices, and it was derived as six factors, and the relationship between CSR activities and sustainability management was partially influenced. Among the CSR activities, three factors of labor / human rights practices, fair operating practices, and participation in community development were found to have a significant effect on sustainability management. All of the hypotheses were adopted. The implication of this study is that ISO 26000 is identified as a social responsibility activity.