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성인에서 호산구성 점액에 의해 발생한 중간엽증후군 2예
황하원 ( Ha Won Hwang ),김주희 ( Joo Hee Kim ),김숙연 ( Suk Yeon Kim ),이선호 ( Sun Ho Lee ),이수행 ( Soo Haeng Lee ),박성훈 ( Sunghoon Park ),황용일 ( Yong Il Hwang ),장승훈 ( Seung Hun Jang ),정기석 ( Ki Suck Jung ),이인재 ( In 대한천식알레르기학회(구 대한알레르기학회) 2016 Allergy Asthma & Respiratory Disease Vol.4 No.2
Right middle lobe syndrome (RMLS) is defined as a transient or recurrent, chronic collapse of the middle lobe of the right lung by certain pathologic conditions. RMLS is a relatively uncommon condition having multiple etiologies and various clinical presentations. Two patients were referred to Hallym University Sacred Heart Hospital, one for the treatment of coughing and the other for the treatment of pneumonia. A diagnosis of RMLS was identified through X-ray and computed tomography image evaluation for each condition. Bronchoscopy revealed mucus obstruction in the right middle lobe bronchus. Biopsy of the aspirated mucus showed mucus containing many eosinophils and Charcot-Leyden crystals. After removal of impacted mucus, clinical and radiological improvements were observed in both patients. Therefore, eosinophilic mucus impaction can be considered a potential cause of RMLS, irrespective of any underlying asthmatic symptoms. (Allergy Asthma Respir Dis 2016;4:149-153)
Mouse Single Oral Dose Toxicity Test of Chongmyung-tang Aqueous Extracts
황하연,장우석,백경민,Hwang, Ha-Yeon,Jang, Woo-Seok,Baek, Kyung-Min The Society of Internal Korean Medicine 2014 大韓韓方內科學會誌 Vol.35 No.1
목적 및 방법 : 본 연구에서는 한의학에서 전통적으로 신경보호 약물로 사용되어온 총명탕 물 추출물의 급성 독성증상을 관찰하기 위하여 한국식품의약품안전청 고시 제 2009-116호에 따라 암수 ICR마우스 단회 경구투여 독성 실험을 실시하였다. 반수치사량, 개략적치사량, 표적장기 등을 관찰하기 위하여, 수율 9.70% 총명탕 물 추출물 2,000, 1,000 및 500 mg/kg을 암수 마우스에 단회 경구 투여하고, 투여 후 14일 동안의 임상증상, 사망례, 체중 및 증체량의 변화 및 부검소견을 관찰하였으며, 투여 14일 후 14개 주요 실질 장기에 대한 중량 및 조직병리학적 관찰을 실시하였다. 또한 별도의 암수 매체 대조군을 두어 그 결과를 비교하였다. 결 과 : 본 실험의 결과, 설치류 최대 한계투여 용량인 2,000 mg/kg까지 총명탕 물 추출물 투여와 관련된 사망례가 인정되지 않았으며, 암수 매체 대조군을 포함하여, 모든 실험군에 걸쳐 산발적으로 관찰된 일부 우발적인 육안부검 및 조직병리학적 소견을 제외하고, 총명탕 물 추출물 투여와 관련된 임상증상, 체중 및 장기 중량의 변화, 14개 주요장기에 대한 육안부검 및 조직병리학적 소견이 인정되지 않았다. 결 론 : 따라서 마우스 단회 경구투여 독성실험에서 총명탕 물 추출물의 반수치사량 및 개략적 치사량은 각각 설치류 투여 한계용량인 2,000 mg/kg 이상으로 관찰되어, 매우 안전한 약물로 판단되며, 임상사용에는 별 다른 문제를 일으키지는 않을 것으로 판단된다. Objectives & Methods : The objective of this study was to evaluate the single oral dose toxicity of Chongmyung-tang (CMT) in ICR mice. Korean traditional herbal prescription CMT has traditionally been used as a neuroprotective for treatment of learning disability and memory improvement. CMT, lyophilized aqueous extracts (yield=9.7%) were administered to female and male mice with oral dose of 2,000, 1,000 and 500 mg/kg (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) Guidelines. Animals were monitored for mortality, changes in body weight, clinical signs and gross observation during 14 days after administration upon necropsy; organ weight and histopathology of 14 principle organs were examined. Results : We could not find any CMT extracts treatment related mortalities, clinical signs, changes in body and organ weight, or gross and histopathological observations against 14 principle organs up to 2,000 mg/kg in both female and male mice, except for some accidental sporadic findings which did not show any obvious dose-relations and most of which also demonstrated in both the female and male vehicle control mice in this experiments. Conclusions : Based on the results of this experiment, the 50% lethal dose ($LD_{50}$) and approximate lethal dose (ALD) of CMT extracts after single oral treatment in female and male mice can be considered to be over 2,000 mg/kg, and is likely to be safe in humans.
김숙연 ( Suk Yeon Kim ),김주희 ( Joo Hee Kim ),황하원 ( Ha Won Hwang ),김광윤 ( Kwang Youn Kim ),박성훈 ( Sung Hoon Park ),황용일 ( Young Il Hwang ),장승훈 ( Seung Hun Jang ),정기석 ( Ki Suck Jung ) 대한천식알레르기학회(구 대한알레르기학회) 2015 Allergy Asthma & Respiratory Disease Vol.3 No.5
Good’s syndrome is an acquired immunodeficiency state associated with thymoma. It is characterized by recurrent infection, autoimmune disease, and immunologic abnormality. The insufficient immunity can be managed by intravenous immunoglobulin (IVIG) replacement therapy. We describe 2 patients who presented with Pneumocystis jiroveci pneumonia and Cytomegalovirus pneumonia after thymectomy for a thymoma. Immunologic study revealed hypogammaglobulinemia with very low B-cell count, consistent with Good’s syndrome. They were successfully treated with trimethoprim/sulfamethoxazole and gancyclovir respectively, and they are all well without additional infections, receiving regular IVIG replacement. (Allergy Asthma Respir Dis 2015;3:365-369)
이재섭,황하연,주정현,장우석,백경민,Lee, Jae-Seob,Hwang, Ha-Yeon,Joo, Jeong-Hyun,Jang, Woo-Seok,Baek, Kyung-Min 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.3
Objectives: This study is a report of the clinical application of traditional Korean medicine on ataxia with cerebellar atrophy. Methods: The ataxia in this case occurred 5 years ago. The symptoms had been getting worse until the patient came to hospital. The MRI of this patient showed atrophy of the cerebellum. We measured the state of this case with the Korean version of the Berg Balance Scale (K-BBS), before and after treatment and Numeric Rating Scale-11 (NRS-11) of the symptoms, every week. We treated the case with traditional Korean medicine such as acupuncture and Gamiyukmijihwang-tang. Results: After treatment, the score of K-BBS increased, while the score of NRS-11 decreased. Conclusions: According to this study, traditional Korean medicine is effective for controlling ataxia caused by cerebellar atrophy.
이재섭,황하연,백경민,장우석,Lee, Jae-Seob,Hwang, Ha-Yeon,Baek, Kyung-min,Jang, Woo-Seok 대한중풍순환신경학회 2012 대한중풍.순환신경학회지 Vol.13 No.1
Object : The Purpose of this study is to report the clinical application of Korean traditional medicine on gait disturbance with arteriosclerosis of lower limbs. Methods : The patient in this case had been already treated by anticoagulation and varicose vein operation for subsiding and improving intermittent claduication and rest pain, but these methods didn't work on the patient. Although the patient was classified as TASC-II D, bypass operation couldn't be treated because of heart disease of the patient. We treated Korean traditional medicine such as acupuncture, moxibustion, Danggwisaeyeoktang. Results : After treatment, peak walking time was increased, rest pain occurrence was decreased and going up and down the stairs was improved. Conclusions : According to this study, Korean traditional medicine such as acupuncture, moxibustion, Danggwisaeyeoktang is effective for the cure of intermittent claudication and rest pain caused by arteriosclerosis of lower limbs.
뇌졸중 후 우울증 : 한방 치료에 대한 국내외 최신 문헌 고찰
이제원,이보매나,장우석,황하연,백경민,Lee, Je-Won,Lee, Bo-Mae-Na,Jang, Woo-Seok,Hwang, Ha-Yeon,Baek, Kyung-Min 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.4
Objectives : This study reviews the latest articles in Korea and other countries that studied oriental medicine treatment on poststroke depression. Methods : Korean articles were retrieved from the 9 major Korean web article search engines. Foreign articles were retrieved from PubMed. Article published date was from 2000 up to September 2012. There were no restrictions on the types of publication, but articles not available in full text were excluded. The methodological quality was assessed according to Cochrane's assessment of risk of bias and Newcastle-Ottawa quality assessment scale. Results : Twenty-two articles were included in this study. Eleven articles were published in Korea, the rest were published in China. Nine articles were randomized controlled trials (RCT), one article was a non-randomized study (NRS), four articles were case reports, three articles were cross-sectional studies, two articles were comparative studies. In RCT articles, risk of selection bias and performance bias were generally high, risk of detection bias was unclear. The NRS article took four stars in Newcastle-Ottawa quality assessment. Comparison Hamilton rating scale for depression score between oriental medicine treated group and western medicine treated group revealed that there was no remarkable difference in mean score changes after treatment on PSD. Conclusions : The results of this study suggest that oriental medicine treatment is as effective as western medicine treatment for PSD. In the future, more rigorous oriental medicine treatment studies should be conducted.
김세원 ( Sae Won Kim ),이재섭 ( Jae Seob Lee ),황하연 ( Ha Yeon Hwang ),장우석 ( Woo Seok Jang ),백경민 ( Kyung Min Baek ) 대구한의대학교 제한동의학술원 2014 東西醫學 Vol.39 No.1
Objectives : The study was designed to evaluate articles on Korean medicine therapy of insomnia, especially herbal medicine. Methods : We searched articles in several search engines with keyword ‘insomnia’, ‘insomnia and herb’. Among them. We selected the clinical trial studies related with herbal medicine therapy. Results : 14 articles were selected. They were all case reports. Conclusions : Most studies had simple evaluation and inclusion tools. Further studies of insomnia need to be processed as Randomized controlled trial or Meta-analysis. Insomnia can be devided three types, and more specified studies about insomnia are needed. To prove the effect of Korean medicine therapy, more studies are needed comparing the effect between herbal medicine and western medicine.