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김현만,홍욱균,한지영 대한내분비학회 1991 Endocrinology and metabolism Vol.6 No.4
Although it has been well recognized that the neurofibromatosis frequently associates with endocrine anomalies such as pheochromocytoma, thyroid tumor and hyperparathyroidism, there are very few instances of neurofibromatosis associated with acromegaly. The etiological basis of this association is not clear. We report one case of neurofibromatosis concurrently occurenored with acromegaly in a 17-year-old man. A diagnosis of neurofibromatosis had been made by typical skin manifestation on physical examination followed by pathological findings of biopsied tissue from the lesion. A diagnosis of acromegaly had been made by elevated serum growth hormone level followed by detection of mass lesion on brain CT scan. His growth hormone level became lower after bromocriptine therapy. The tumor will be regularly checked up by brain CT scan for growing or changing in nature. (J Kor Soc Endocrinol 6:371~376, 1991)
한국 성인에서 뇌하수체 기능부전증의 원인 및 내분비학적 특성
김현만,허갑범,이현철,이은직,홍욱균,오미희 대한내분비학회 1993 Endocrinology and metabolism Vol.8 No.4
Pituitary insufficiency can be caused by various diseases. The present study was perfomed on Korean patients with pituitary insufficiency, who were examined from January 1982 to June 1991. Cases under hormone treatment or cases with hypopituitarism developed after surgery or radiotherapy on the pituitary gland were excluded in this study. Two hundred fory senen cases with pituitary insufficiency, which was confirmed by high resolution sella CT scan and combined pituitary stimulation test, were classified basing on their primary causes. The results were as follows: 1) Anomg 247 cases with pituitary insufficiency, 169 cases (68.4%) were pituitary adenoma, 64 cases (25.9%) ischemic necrosis of pituitary gland, 3 cases (1.2%) head trauma, and 11 cases (4.5%) idiopathic 2) Seventy two out of 93 male patients with pituitary insufficiency (77.4%) were pituitary adenoma, with the most prevalent age being the 4 th 5 th decade. 3) Dighty one out of 154 female patients with pituitary insufficiency (51.6%) were pituitary adnoma and 57 cases(37.0%) were Sheehan's syndrome. Most pituitary tumors were found in the 3 rd decade but Sheehan's syndrome were found in the 6 th decade. 4) There was no significant change in nmber of the annual cases with Sheehan's syndrome. 5) Pan-or near total hypopituitarism were observed in 86.1% of cases with Sheehan's syndrome and in 40.4% of cases with pituitary insufficiency caused by tumors. It can be concluded that the most common cause of pituitary insufficiency in Korea is pituitary tumor. However, Sheehan's syndrome is the main cause of pituitary insufficiency in female patients after age of 40. And the degree of pituitary insufficiency in cases with Sheehan's syndrome is more serious than that in pituitary tumor. (J Kor Soc Endocrinol 8:390~397, 1993)