http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
허민희 ( Min Hee Hur ) 대한임상종양학회 2009 Korean Journal of Clinical Oncology Vol.5 No.2
Cancer Stem Cells Recent results have supported the cancer stem cells hypothesis in which tumors originate from tissue stem cells or their early progenitors and, as a result, produce tumors that retain stem cell properties. These properties drive tumorigenesis and differentiation that contributes to cellular heterogeneity. In breast cancers, a cell population of surface marker CD44(+)CD24(-or low) is highly tumorigenic. Aldehyde dehydronase(ALDH) positive cells are also powerfully tumorigenic and this marker can be poor prognostic factor in breast cancer patients. The number of cancer stem cells is very small, and is tightly controlled by the self-renewal pathway and the signals of their environment (niche). Epithelial-mesenchymal transition(EMT) is a key development program that is often activated during cancer invasion and metastasis. Although our understanding of the biology of these cancer stem cells remains rudimentary, the existence of these cells has implications for current conceptualization of malignant transformation and the treatment of cancer.
임라주,이숙현,윤찬석,고승상,허민희,강성수,이해경,Ra Joo Lim,Sook Hyun Lee,Chan Seok Yoon,Ph.D.,Seung Sang Ko,Ph.D.,Min Hee Hur,Ph.D.,Sung Soo Kang,Ph.D. and Hae Kyung Lee,Ph.D. 대한갑상선-내분비외과학회 2009 The Koreran journal of Endocrine Surgery Vol.9 No.2
Purpose: There has been a rapid rise in the incidence of thyroid cancer, particularly papillary thyroid microcarcinoma (PTMC). However, there is a lack of consensus of treatment guidelines or follow-up strategies. Methods: A retrospective analysis of 606 patients who underwent operation due to thyroid cancer from March 2000 to December 2008 was conducted. Of these patients, 587 with pure papillary carcinomas were studied, of whom 392 (67%) presented with PTMC. Results: Only 23% of patients were symptomatic, but 75% of patients were positive using the imaging techniques ultrasonography or positron emission tomography. When the microcarcinoma patient group (G1) was compared with the group of remaining patients (G2), less aggressive operations were chosen for G1. A lobectomy was performed in 63.8% of G1 versus in 14% of G2, and the central compartment neck dissection was omitted in 30% of G1 versus 16% of G2. During the follow-up period (mean 37.9±25.2 months), there were 11 recurrences. Two patients developed contralateral cancers 42 and 49 months after lobectomy. One patient had recurrences on central compartment lymph nodes 34 months post-operatively. Eight patients had lateral neck lymph nodes metastases 13∼52 months post- operatively. Three of these eight patients had concomitant central neck lymph node metastases. Conclusion: Less aggressive treatments can be chosen for PTMC patients compared to non-PTMC patients. To clarify these results, longer follow up and larger and multi-institutional data are needed. (Korean J Endocrine Surg 2009; 9:74-78)
측경부 최소침습절개술을 이용한 갑상선 일엽절제술의 효용성
강선미,이해경,강성수,허민희,고승상,윤찬석,강태호,김세원,Sun Mi Kang,Hae Kyung Lee,Seong Soo Kang,Min Hee Hur,Seung Sang Ko,Chan Seok Yoon,Tae Ho Kang and Se Won Kim 대한갑상선-내분비외과학회 2012 The Koreran journal of Endocrine Surgery Vol.12 No.4
Purpose: Minimal invasive open thyroidectomy is one option for minimal invasive surgery. The population of planned unilateral lobectomy is on the rise in parallel to the increased incidence of confined papillary thyroid microcarcinomas in Korea. In contrast to other minimal invasive modalities, few studies have examined the surgical outcome of minimal invasive open thyroidectomy. This study compared the lateral minimal invasive open thyroid lobectomy with conventional surgery and endoscopic surgery in terms of the feasibility and safety. Methods: A retrospective study was performed on 197 patients undergoing a thyroid lobectomy between January 2001 and December 2010. One hundred and three patients underwent a lateral minimal invasive open thyroid lobectomy, 42 patients underwent conventional surgery, and 44 patients underwent endoscopic surgery. Results: The hospitalization period with endoscopic surgery was 6.2 days, which was longer than the 5.3 days with a lateral minimal invasive open thyroid lobectomy (P=0.000). The surgical time was lower in those who underwent a lateral minimal invasive open thyroid lobectomy (88.2 minutes) than in those who underwent conventional surgery (107 minutes, P=0.000) or endoscopic surgery (124.1 minutes, P=0.000). In the patients with a diagnosis of malignancy, the mean number of retrieved LNs was similar in the three groups. Conclusion: A lateral minimal invasive open thyroid lobectomy offers advantages, such as a shorter surgical time and hospitalization period than others. This procedure can be a feasible alternative to the conventional or endoscopic approach in selected patients undergoing thyroid lobectomy.
갑상선 결절에 대한 세침흡입 세포검사에서 반복적인 비진단적 검체의 원인에 대한 분석
최영근<SUP>1<.SUP>,윤찬석,고승상,허민희,강성수,이지현,전이경<SUP>2<.SUP>,박지영<SUP>2<.SUP>,이해경,Young Gun Choi,<SUP>1<.SUP>,Chan Seok Yoon,Seung Sang Ko,Min Hee Hur,Sung Soo Kang,Jee Hyun Lee,Yi Kyeong Chun,<SUP>2<.SUP>,Ji Y 대한갑상선-내분비외과학회 2006 The Koreran journal of Endocrine Surgery Vol.6 No.1