도시 초등학교 4학년의 굴절 이상과 안 계측치 변화

한은령,강지은,전루민,최규룡 대한안과학회 2007 대한안과학회지 Vol.48 No.8

Purpose: To evaluate changes in refractive errors and quantify optometric values in 4th graders at an urban elementary school in Korea. Methods: A total of 188 school children (376 eyes) were assessed in a population-based, cross-sectional and longitudinal follow-up study between March and December 2003. Uncorrected visual acuity, best corrected visual acuity, corneal refractive power measured with auto keratometer (KR-8100, Topcon? Inc., Japan), axial length measured with A-scan ultrasound biometry (A/B-scan system 835, Humphrey? Inc., Dublin, CA), and cycloplegic refraction were evaluated on March and December, respectively. Results: Mean visual acuity decreased from -0.15±0.29 LogMAR to -0.20±0.35 LogMAR and mean spherical equivalent (SE) showed myopic progression from -0.65±1.57 diopter (D) to -0.88±1.75D. The prevalence rate of myopia (≤-0.50D SE) was increased from 44.1% to 50.3%, while that of hyperopia (≥+1.00D SE) was decreased from 8.0% to 5.8%. Mean corneal refractive power changed from 43.21±1.29D to 43.35±1.31D, and mean axial length changed from 23.38±0.88 mm to 23.60±0.92 mm, respectively. Conclusions: We assessed the changes of refractive errors and quantified the optometric values in a population-based, longitudinal follow-up study. The results showed that the prevalence of myopia and the mean axial length increased during our study in urban elementary 4th graders in Korea.

실험적 포도막염에서 종양괴사인자 단일세포군항체의 치료 효과

한은령,오민진,조민선,이지수,이정희,Eun-Ryung Han,Min-Jin Oh,Min-Seon Cho,Ji Soo Lee,Jeong-Hee Lee 대한안과학회 2007 대한안과학회지 Vol.48 No.8

Purpose: We investigated the therapeutic effects of monoclonal anti-TNF antibody (infliximab) on experimental uveitis. Methods: Twenty New Zealand White rabbits were immunized with Mycobacterium tuberculosis H37Ra antigen and then challenged with intravitreal injection of tuberculin antigen to introduce a uveitis. Then infliximab was injected into rabbit eyes at an intravenous concentration of 5 mg/kg and intravitreal concentrations of 1 mg/0.1mL and 100 microg/0.1mL. As a control, the vehicle was injected intravenously or intravitreally. To evaluate the therapeutic effects, inflammation was assessed by slit lamp biomicroscopy and scored according to the severity of inflammation. The animals were also evaluated by electroretinography and histopathology. Results: Regardless of the administration route, inflammatory activities of anterior chamber and engorgement of vascular structures were reduced in the infliximab treated group compared to control. Different administration routes and different concentrations of infliximab did not affect the therapeutic outcome of the clinical scoring. Intravenous (5 mg/kg) and intravitreal diluted (100 microg/0.1mL) infliximab injection groups showed significant improvement in electroretinographic findings and significant reduction of inflammatory cells with preservation of retinal tissue architecture on histopathologic examination. However, focal loss of the photoreceptor outer segment is observed in intravitreal undiluted (1 mg/0.1 mL) infliximab injected eyes. Conclusions: Infliximab may be a useful treatment modality to suppress ocular inflammation in experimental uveitis models in rabbits.

녹내장의 초기 진행에 따른 시신경유두 형태 변화

한은령,서울,이수영,최규룡.Eun-Ryung Han. M.D.. Wool Suh. M.D.. Soo Young Lee. M.D.. Kyu Ryong Choi. M.D. 대한안과학회 2007 대한안과학회지 Vol.48 No.9

Purpose: To investigate the clinical manifestation and the structural optic disc changes according to the development of reproducible visual field defects in a group of preperimetric patients converting to early glaucoma. Methods: Standard automated perimetry (Humphrey Field Analyzer) was performed every six months in 294 preperimetric patients. Each subject was classified as either converter or non-converter according to glaucomatous visual field changes, and the clinical manifestations were analyzed retrospectively. Sequential optic disc images were obtained using the TopSS scanning laser ophthalmoscope (TopSSTM) and optic disc parameters were measured to determine if any change had occurred. Results: A total of 44 eyes from 44 subjects (14.9%) in 294 patients subsequently developed early glaucomatous field loss (converters). The progression rate of visual field defect is 0.43dB/year. In respect to age, sex, refractive error, and diabetes mellitus, no significant differences were observed. Elevated IOP, hypertension, and family history of glaucoma were detected more frequently in the converter group than in the non-converter group. Among TopSS parameters, cup-to-disc ratio, effective area, volume above, maximum slope, and neuroretinal rim area showed statistically significant change. Changes of the neuroretinal rim were prominent in superior and inferior sectors. Conclusions: Among TopSS parameters, cup-to-disc ratio, effective area, volume above, and neuroretinal rim are useful in detecting the progression of glaucoma. Furthermore, neuroretinal rim changes in each sector may provide clinically relevant information in detecting and monitoring the progression of glaucoma.

제 6 뇌신경 마비의 임상적 고찰

한은령,임기환.Eun Ryung Han. M.D.. Key Hwan Lim. M.D.. Ph.D. 대한안과학회 2008 대한안과학회지 Vol.49 No.8

Purpose: To evaluate the clinical features and natural course of sixth cranial nerve palsy. Methods: We reviewed the medical records of 50 patients who were diagnosed with sixth nerve palsy from January 2000 to December 2006 to analyze the age of onset, etiology, recovery, and natural course of this disease. Results: The mean age at onset was 43.2 years old. Vascular disease (n=17, 34.0%) was the most common cause of sixth cranial nerve palsy, followed by undetermined causes (n=14, 28.0%), trauma (n=10, 20.0%), and neoplasm (n=3, 6.0%). According to age group, vascular disease (n=7, 46.7%) was the most common cause in patients in their fifties and sixties, and trauma and undetermined causes (n=10, 76.9%) were the most common causes of this disease in patients in their twenties and thirties. Of the 40 patients who were followed up for more than 6 months, 28 (70.0%) showed improvement of paresis and 26 (65.0%) achieved complete recovery. The mean period to recovery was 3.7 months. No significant differences were observed in sex, age, laterality, and etiology between non-recovered and completely-recovered patients, but completely-recovered patients showed a significantly smaller initial angle of deviation than non-recovered patients. Conclusions: Vascular disease was the most common etiology of sixth nerve palsy. Sixty-five percent of patients showed spontaneous complete recovery, and completely-recovered patients showed a significantly smaller initial angle of deviation compared to that of non-recovered patients. J Korean Ophthalmol Soc 49(8):1323-1329, 2008

Silica Complexed with Fe^3+ Does not Influence Pulmonary Inflammation and Injury

Lee, Jihee,Suh, Woul,Han, Eunleung 梨花女子大學校 醫科大學 醫科學硏究所 2000 EMJ (Ewha medical journal) Vol.23 No.3

배경 : 유리규산(silica)에 결합되어있는 표면 철이 Fenton reaction에 의하여 유리규산으로 인한 폐 반응을 증폭시킬 수 있다는 가설을 입증하고자 연구하였다. 방법 : 생리식염수, silica-H^+, 또는 silica-Fe^3+를 기관내 투여한 4시간 후에 폐손상 정도와 호중구의 폐포내 유입을 기관지폐포세척액에서 단백질양과 호중구수를 측정하여 평가하였고, 폐포대식세포 배양액에서 nitric oxide 생성을 nitrate assay로 측정하였다. 또한 silica-H^+, 또는 silica-Fe^3+를 폐포대식세포에 생체외로 투여한 후 활성산소종 생성을 chemiluminescence assay로 측정하였다. 결과 : Silica-H^+, 또는 silica-Fe^3+ 생체내 투여 군은 생리식염수 투여군에 비하여 폐손상과 호중구의 폐포내 유입, 폐포대식세포에 의한 NO 생성이 의미있게 증가되었으나, silica-H^+, 또는 silica-Fe^3+ 투여군간의 유의한 차이는 없었다. 또한 silica-H^+, 또는 silica-Fe^3+를 폐포대식세포에 생체외로 투여한 경우 활성산소종의 생성은 의미있게 증가되었으나, 이들 silica투여군간의 유의한 차이는 없었다. 결론 : Fe^3+가 결합된 유리규산은 생체내 또는 외 투여로 인한 폐 손상 및 염증 반응에 영향을 끼치지 않는다.