산부인과 영역에서의 수술후 Prostaglandin F2a 의 효과

고성민(SM Ko),최상준(SJ Choi),임광호(KH Lim),조정식(JS CHO),김치문(CM Kim),백원민(WM Baek),오세량(SR Oh) 대한산부인과학회 1988 Obstetrics & Gynecology Science Vol.31 No.6

산부인과적 개복수술예에서 수술후 장관운동 회복을 촉진하기 위하여 Prostaglandin F2a를 투여한 결과 다음과 같은 성적을 얻었다. 1. 복명까지의 소요시간과 배변까지의 소요시간이 모두 현저하게 단축되었다. 2. 수술후의 동통정도와 발열 등의 합병증에서 유의한 차가 없었다. 3. 배기까지의 소요기간과 연령사이에는 유의한 상관이 없었다. To assess the recovery of the interstinal movement after surgery Prostaglandin F2a was administered to the patients at 6 and 18 hours after completion of abdominal surgery. The result wer as follow ; the times from the completion of operation to recovery of intestinal peristalsis gas-out , and defection were markedly shortened compared with control. No complications due to administration of Prostaglandin F2a were observed

Krukenberg 종양 1 예

최상준,이만종,홍성기,손대언,문경란,김윤신 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.10

저자 등은 위가 원발병소로서 양측난소와 자궁근층, 자궁경부 및 골수로 전이된 Krukenberg 종양 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Krukenberg Tumor of ovary is relatively rare, We experienced a case of Krukenberg Tumor on Uterus, uterine cervix, both ovaires, and bone marrow involvement originated from stomach carcinoma and presented with brief review of literature.

자궁경부종양의 진행과 T세포의 변화

최상준,임성철 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.1

The host immune response is commonly cited as a determining factor in the development or clearance of various neoplasia, but the immunobiology of neoplastic progression is poorly understood. The cervix has the largest concentration of lymphocytes found in the female genital tract as a component of the common mucosal immune system, but cervical immunocytes have not been well characterized in the neoplasia itself. The objective of this study was to characterize the subpopulations of lymphocytes that infiltrate various grades of cervical neoplasia. To establish the characteristics we examined 60 cases of uterine cervix which were divided 4 categories according to the Bethesda classification system: normal cervix(15), low grade squamous intraepithelial lesions(LSILs)(15), high grade squamous intraepithelial lesions(HSILs)(15), and invasive squamous cell carcinomas(15 cases). The degrees and subpopulations of infiltrating lymphocytes were assessed quantitativ-ely and qualitatively by immunohistochemical stain and electron microscopy. There were significant increasing the numbers and the proportions of T-cells in the invasive cancers compared with those in the preinvasive lesions. The ratios of CD4(+)/CD8(+) cells between the preinvasive groups and the invasive group were reversed by profound increment of CD8(+) cells and relative decrement of CD4(+) cells in the invasive group. On ultrastructural observations, there were many of apoptosis of the tumor infiltrating lymphocytes and cancer cells in the invasive cancer group, and there were a few of apoptosis of the only neoplastic cells in the preinvasive groups. In conclusion, the UCHL1-positive T cells infiltrate far exceeded in the invasive, but not in the preinvasive lesions, a finding that suggests that T cells, especially CD8(+) cells are recruited preferentially to cervical lesions with progression to invasion. It is suggested that the T cell recruitment is related to inactivation, autosuppression or apoptosis of the T cells, especially CD8(+) cells, and the profound decrement of helper T cells have the essen-tial role in tumor invasion.

산전초음파로 발견된 일측성 완전 선천성 횡격막 이완증 1 예

최상준,안태규,여인동 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.1

A complete congenital eventration of the diaphragm is relatively rare congenital anomaly. We experienced a case of the anomaly in a infant who died ten hoursafter operation. This anomaly was detected by ultrasonograpy performed at 22 weeks gestational age suggested diaphragmatic hernia. After operation, this anomaly was defined a complete congenital eventration combined with a ipsilateral pulmonary hypoplasia.

쌍태아 임신경과중 자연소실된 비면역 태아수종 1 례

정혁,최상준,송창훈,김영호 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.9

Nonimmune hydrops fetals is defined as generalized edema of the fetal soft tissue in utero and may be associated with effusion in the serous cavities without hematologic evidence of isoimmunization. The most common demonstrable causes are cardiac anomalies, followed by chromosomal disorders, congenital malformations, α-thalassemia, and the twin-twin transfu-sion syndrome. We have experienced a case of nonimmune hydrops fetalis in identical twin which caused by congenital mitral valve insufficiency and disappeared spontaneously at 35 wks. Now we report a case of nonimmune hydrops fetalis that slowly and spontaneously imp-roved without interventions with a brief review of related literatures.

난소의 양성기형종에서 발생한 소세포암의 좌측 견갑상부임파선 원격전이 1 례

한세준,최상준,류경철 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.2

The development of cancer in a pre-existing benign cystic teratoma of the ovary with distant metastasis to the supraclavicular lymph nodes has not been previously reported. We experienced a case of a 28-year-old woman with distant metastasis from small cell cacinoma arising in benign mature cystic teratoma of the ovary to the supraclavicular lymph nodes. The staging laparotomy and total abdominal hysterectomy with both salpingooophorectomy were peformed. There was no metastatic site except the supraclavicular lymph nodes, thereafter adjuvant chemotherapies with bleomycin, etoposide, cisplatin have been doing. We report a case of benign cystic teratoma with malignant change and metastasis with the literature.

자궁의 지방평활근종 - 1 증례보고 -

이미숙,최상준,장하종,임성철,정유경,정순봉 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.7

Lipoleiomyoma of the uterus is extremely rare and consists of mixed smooth muscle and adipose cells. The histogenesis of this tumor is not clear. It usually occur in the corpus uteri as intramural growth. We report a unique case of a uterine lipoleiomyoma occuring in the isthmus as a subserosal polypoid mass, measuring 3.5x3.0x3.0cm. Histologically, it was mostly composed of mature fatty tissue intermingled with small amount of fibrous and smooth muscle components in an irregularly reticular pattern. Immunohistochemical study revealed a positive reaction of α-smooth muscle actin in smooth muscle fibers. Its histogenesis and a brief review of the literatures also have been discussed.

산전에 진단된 Thanatophoric Dwarfism 1 례

정혁,한세준,최상준,장하종,송창훈,고명윤 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.12

저자들은 30세 경산부의 산전진찰시 양수과소증과 동반된 Thanatophoric dysplasia이라고 사료되는 1례를 경험하였기에 간단한 문헌고찰과 함께 보고하는 바이다. Thanatophoric dysplasia is a disease which is charaterized by extreme rhizomelia, bowed long bone, narrow thorax, and relatively large cranium. The incidence rate is 0.69 per 10,000 births, the most common from of fatal neonatal skeletal dysplasia. We experienced a case of fetal dwarfism on antenatal ultrasound examination and then the baby was delivered by cesarean section. The diagnosis was confirmed to thanatophoric dwarfism by clinical features, radiological findings. We reported a case of thanatophoric dwarfism with review of literature.

상피성 난소암에서 면역화학적 염색에 의한 bc1-2와 p53 유전자발현에 관한 연구

정혁,한세준,최상준,송창훈,임성철,김영호,류경철 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.11

Bcl-2 and p53, two proteins, have implicated in apoptosis and among them p53 is known as adverse prognostic factor in a number of tumors. But it is variable in different tissues whe-ther bcl-2 expression and its role are related in the prognosis. The present study was aimed to find the role of bcl-2 and p53 in prognosis of epithelial ovarian cancer. We examined 32 epithelial ovarian cancer specimens of different histologic types and stages by immunohistochemical staining. Bcl-2 protein expression was found in 11/32 epithelial ovarian cancers and it was related in survival(p=0.0038) and p53 accumulation was found in 17/32 epithelial ovarian cancers but it was not rrelated in survival(p=0.0717). But bcl-2 expression and p53 accumulation were not related to the FIGO stages(p>0.05). The analysis of the postoperative course of 32 patients showed that survival depended on the FIGO stages(p=0.001 2) and the histologic type(p=0.009). However, bcl-2 immunohistochemistry identified a subgroup of patients with p53 and bcl-2 positive carcinomas who had not a statistically better outcome(p=0.082) than patients with p53 positive and bcl-2 negative carcinomas. Thus our observations point to different molecular alterations possibly underlying phenotypic diversity of ovarian carcinomas and provide clues for a better understanding of tumor progression in these neoplasms.

난소의 악성 중배엽성 혼재성 종양 1 예

정혁,한세준,최상준,송창훈,임성철,김영호,류경철,여인동 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.4

저자 등은 경우 난소의 악성 중배엽성 혼재성 종양을 경험하였으며, 환자는 수술 후 병기 Ⅲc로 한차례 복합 화학요법 시행 후 6 개월째 생존중이다. Malignant mixed m llerian tumor (MMMT) of the ovary is a rare tumor with dismal prognosis. MMMT by definition contain epithelial and mensenchymal elements, both of which are histologically malignant. They are classified as endometrial lesions because the glands often appear endometrial-like and the stroma resemble that of the endometrium. The disease is usually advanced (Stage Ⅲ) when diagnosed and thus provides a difficult challenge to any postoperative therapy. We experienced a case of MMMT of ovary with neuroectodermal differentiation in 69 years-old multiparous women and report our experience with a brief review of literature.