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알레르기 병력이 없는 일반인에 있어서의 피부단자시험 및 RAST 성적
최귀애,허영구,강영모,김항재,김능수 대한천식알레르기학회 1989 천식 및 알레르기 Vol.9 No.3
To evaluate the incidence of positive skin prick test and the agreement between results of skin test and RAST in nonallergic subjects, 777 nonallergic subjects were studied on the skin prick test using Bencard allergen extracts, I.e,, D. farinae, D. pteronyssinus and Cockroach. The RAST was performed in 79 skin test positive subjects by using 3M diagnostic systems, IgE FAST-Plus test. The criteria for including a given subject in this study were no history of allergic disease and the absence of recent medication of steroids, bronchodilators, or antihistamines as a part of the treatment of other current diseases. Positive skin test reactivity of 3mm or greater of wheal diameter(3+ or greater) was 38.2Foin D. farinae, 23.8% in D. pteronyssinus, and 9.4i in Cockroach. The agreement rate between positive skin test and positive RAST of the above three allergens was 32.4%, 48.7% and 36.4% of participants, respectively. Theae findings in nonallergic subject allergic skin test, even with RAST, has some limitations in determining causative allergens in allergic patients.
알레르기 병력이 없는 한국인에 있어서의 피부단자시험 성적
강영모,허영구,최귀애,김항재,김능수 대한천식알레르기학회 1989 천식 및 알레르기 Vol.9 No.3
A study of the incidence of positive skin prick tests was performed in 607 nonallergic subjects using five common aeroallergens. The criteria for including a given subject in this study were no history of allergic diseases, the absence of recent medication of steroids, bronchodilators, or antihistamines as a part of the teatment of other current diseases. Positive reactions of 3mm or greater of wheal diameter(3+) to one or more allergens occurred in 47.9% of the participants. Reactions of 5mm or greater(4+) and those greater than histamine control occurred in 23.1% and 10.9%, respectively. D. farinae showed the highest incidence(37.7%) of positive reactivity(3+ or greater) among the five tested allergens. And the positivity to D. fa- rinae was higher in subjects of the fifth decades, while the positivity to other four allergens showed no predilection in age group. Male subjects have higher incidence of positive reactions to one or more allergens than females. The findings of high incidence of positive reactions in nonallergic subjects may suggest that one should be careful in assessment of positive 8klll reactions and in defining the causative allergens by allergic skin tests in allergic patients.
기관지천식 환자에서의 혈액 및 타액의 Theophylline 농도 비교
이정림,최광진,이성구,이중기,허영구,최귀애,강영모,김항재,김능수 대한천식알레르기학회 1989 천식 및 알레르기 Vol.9 No.3
To evaluate the reliability of salivary theophylline levels as a predictor of serum theophylline levels, we investigated 32 chronic perennial asthmatics, free of other disease, who were receiving oral sustained-release theophylline. The blood and saliva theophylline levels from 20 patients(group I ) were uaed to develop a formula for predicting serum theophylline levels from saliva levels, and a correlation coefficient was obtained between the serum and salivary theophylline levels. The blood and saliva theophylline levels from 12 patients(group II ) were used to test the formula obtained. A strong correlation between the serum and salivary theophylline levels, r=0.82 was found in group I and there was no statistically significant difference in the serum-saliva ratio in each patient, and also there was a good correlation between the predicted and actual serum theophylline concentrations, r=0.79, These suggest that the determination of salivary theophylline concentration may be a convenient, noninvasive method for routine monitoring of serum theophylline concentration.
알레르기 환자에서 면역료법 전후의 말초혈액 Fcε 수용체 보유 림프구의 변화
강영모(Young Mo Kang),허영구(Young Gu Hoe),최귀애(Gui Ae Choi),김항재(Hang Jae Kim),김능수(Nung Soo Kim) 대한내과학회 1989 대한내과학회지 Vol.37 No.6
N/A We studied the effect of immunotherapy on the pro- portion of Fcε receptor bearing cells [Fcε R(+) cells] in PB lymphocytes, serum IgE and PB T cells with their subsets in 18 allergic patients with asthma or rhinitis who were treated with effective immunotherapy (6 months to 12 months) and 16 untreated allergic patients. The proportion of Fcε R(+) cells in PB lymphocytes in immunotherapy-treated patients was significantly lower than that in untreated patients, even though both of those showed higher levels than the normal ranges. However, there were no significant differences in serum IgE levels and the proportions of T cells with their subsets in PB lymphocytes between the groups of immunotherapy-treated patients and untreated patients. These findings may suggest that the proportion of Fcε R(+) cells in PB lymphocytes could be one of the parameters to monitor the early immunological changes in effective immunotherapy.