교권과 교원

채수연 한국박문학회 1995 박문논집 Vol.2 No.1

심한 통증을 동반한 성인 수족구병을 갈근해기탕으로 치료한 증례

채수연,박성식 사상체질의학회 2022 사상체질의학회지 Vol.34 No.4

Objectives The purpose of this case study is to report the improvement of hand foot and mouth disease after using Galgeunhaegi-tang Methods A Taeumin patient suffering from painful hand foot and mouth disease was treated with herb medicine Galgeunhaegi-tang, acupuncture and cupping therapy. Rhei radix et rhizoma was added or removed from herb medicine according to patient’s stool condition. Severity of pain and general symptom was measured using Numerical Rating Scale(NRS), and the picture of patient’s hand and foot was taken. Results & Conclusions After taking Galgeunhaegi-tang, symptoms including pain, rash, blisters, and general conditions improved as patient’s stool condition improved from constipation to normal. In conclusion, this case report shows that Galgeunhaegi-tang can be effective to Taeumin hand foot and mouth disease patients.

The Effectiveness and Safety of Dokwhalkisaeng-tang Combined with the Medication on Rheumatoid Arthritis: A Study Protocol for Systematic Review and Meta-analysis

채수연,정찬영,김주희,김은정,서병관,황민섭,박성식,김경호,윤종화,성원석 대한한의학방제학회 2022 大韓韓醫學方劑學會誌 Vol.30 No.2

Objectives : Recent studies reported that Dokwhalkisaeng-tang (DHJST) could relieve the clinical rheumatoid arthritis (RA) symptoms and the level of RA-related blood test. However, evidence-based review on effectiveness and safety of DHJST with medication on RA was not yet provided. Methods : Searching randomized controlled trials on the use of DHJST for RA will be performed using multiple electronic databases, manual search, and contact to author. Studies will be selected according to the pre-defined criteria and collected data on study participants, interventions, control groups, outcome measurements, the results, adverse events, and risk of bias will be summarized. Primary outcome will be the disease activity score (including effective rate, swollen joint count, tender joint count, and morning stiffness), and the secondary outcomes will be RA-related blood test and adverse events. We will use Review Manager software to perform a meta-analysis, Cochrane Collaboration “risk of bias” tool for assessing the risk of bias, and Grades of Recommendation, Assessment, Development and Evaluation for the determination of quality of evidence. Results : We are going to investigate the effectiveness and safety of DHJST with medication for RA. Conclusion : This study will provide reliable evidence on whether DHJST combined with medicine is more effective on RA than medicine monotherapy.

별불가사리 추출물의 면역세포 활성화 효과

채수연,김미정,김도순,박정은,조성기,이성태,Chae, Su-Yeon,Kim, Mi-Jung,Kim, Do-Soon,Park, Jung-Eun,Jo, Sung-Kee,Yee, Sung-Tae 한국식품영양과학회 2007 한국식품영양과학회지 Vol.36 No.3

In this experiment, the effects of Asterina pectinifera extracts on the activation of immune cells were studied. An immune cell activating factor was partially purified from starfish, Asterina pectinifera, by means of physiological saline extraction, acetone precipitation and heating inactivation. Starfish extracts increased the proliferation of spleen cells and induced the production of IL-6 and $IFN-{\gamma}$ by spleen cells. Also, it increased the proliferation of purified B cells and production of IgM and IgG in the presence of Asterina pectinifera extracts. Starfish extract self-induced NO synthesis in mouse macrophage cell line (RAW264.7). When cell lines was treated with extracts, the mRNA expression of inducible NO synthetase (iNOS), $TNF-{\alpha}$, IL-6, and GM-CSF were markedly increased in RT-PCR analysis. Therefore starfish extract can self-activate spleen cells, B cells and macrophages. These results might be useful in further studies into a possible immune activating agent from the starfish, Asterina pectinifera, for the development of functional foods and drugs. 불가사리 추출물을 이용하여 생쥐 비장에 있는 면역세포 활성화 효과에 대해 실험한 결과, 다음과 같은 결과를 얻었다. 첫째, 별불가사리 추출물 중에서 B세포와 대식세포를 활성화시키는 성분은 아세톤처리로 추출할 수 있었다. 둘째, 이 성분은 농도 의존적으로 생쥐 비장세포의 증식반응을 유도하였으며, IL-6와 $IFN-{\gamma}$의 생산을 유도하였다. 셋째, 이 성분은 B세포의 증식을 유도하였으며, 이 때 면역글로불린 IgM과 IgG의 생산도 유도하였다. 넷째, 이 성분은 대식세포주의 일산화질소 생산을 유도하였으며, 또 $TNF-{\alpha}$, GM- CSF와 IL-6의 분비를 유도하였다. 이상의 실험 결과, 본 실험에서 사용한 별불가사리 추출물에는 B세포와 대식세포 같은 면역세포의 증식과 각종 사이토카인을 생산을 유도하여, 면역반응을 조절하는 성분이 포함되어 있는 것으로 생각된다.

종일 지속되는 소양인 원발성 전신 다한증의 치험 1례

채수연,박성식 사상체질의학회 2023 사상체질의학회지 Vol.35 No.4

Objectives This case study aimed to report the improvement of stress-induced generalized primary hyperhidrosis of Soyangin patient. Methods Soyangin patient suffering from daylong generalized primary hyperhidrosis was treated with acupuncture, psychological counseling, and herbal medicine. The severity of hyperhidrosis was measured using Visual Analog Scale (VAS). Results & Conclusions After treatment with Tae-Geuk acupuncture, Dojeokganggi-tang, and psychological counseling, the VAS score of hyperhidrosis was reduced from 10 to 2 during three days of admission. Herbal medicine was prescribed for 30 more days after discharge. The relieved state was maintained when monitored after two months. This case report proposes the potential of Sasang constitutional medicine for stress-induced generalized primary hyperhidrosis.

지하철 주행에 의한 건물내 고체음

채수연 한국기술사회 1986 技術士 Vol.19 No.2

Structure-borne noise due to forced vibration which is originated from subway operation and transmitted to buildings in order of rail-wood tie-concrete bed-structure-soil-building foundations-members of building results in social problem of environmental pollution. Moreover this becomes a serious problem because of the increment of surface traffic and subway operation made by meeting traffic system in crowded cities. Since subway is constructed along the principal road or through the residential area and as the worst case may be, building foundations is contact with top part of subway structure, it is possible that vibration resonance results in fatal damage of buildings. And, structure-borne vibration noise due to subway operation at late and early hours have the residents suffer from insonmia, restlessness and so on. Therefore, to satisfy the future need concerning the environmental protection, this report deals with the influence of structure-borne vibration noise on the basis of the characteristics of Seoul Subway System.

Arabinoxylane과 PSP의 면역세포 활성화 효과

채수연(Su-Yeon Chae),신성해(Sung-Hae Shin),배만종(Man-Jong Bae),박미현(Mi-Hyun Park),송미경(Mi-Kyung Song),황성주(Sung-Ju Hwang),이성태(Sung-Tae Yee) 한국식품영양과학회 2004 한국식품영양과학회지 Vol.33 No.2

Arabinoxylane과 PSP는 농도 의존적으로 비장세포의 증식과 IFN-γ 생산을 유도하였으며 특히, PSP는 IL-2, IL-4, IL-10의 생산도 유도하였다. 그리고, 항체생산 세포수를 나타내는 PFC은 11~14%, 활성화된 T세포수를 나타내는 RFC은 9~30% 증가하였다. Arabinoxylane은 T세포의 증식을 유도하지 못하였지만, PSP는 높은 농도에서 T세포의 증식 반응을 유도하였다. Arabinoxylane과 PSP는 비장세포에서 분리한 B세포의 증식을 유도하였고, 대식세포의 탐식능은 약 20~22%정도 증가하였다. 그리고, 농도 의존적으로 대식세포의 일산화질소 생산을 유도하였으며, TNF-α와 IL-6의 생산을 현저하게 유도하였다. 특히, PSP는 IL-1β의 생산도 유도하였다. 또한, 대식세포 표면의 주조직적합 복합체 Ⅱ(MHC Class Ⅱ)의 발현을 유도하였다. 이상의 결과로 arabinoxylane과 PSP는 면역반응에 관여하는 T세포, B세포 그리고 대식세포의 다양한 활성을 유도하는 효과가 있는 것으로 생각되어 면역기능을 강화하는 소재와, 노약자나 회복기 환자 등을 위한 특수 식이용 소재로서 사용이 가능한 것으로 생각된다. The objective of the current study was to determine the effects of arabinoxylane and PSP on mouse splenocytes, T cells, B cells and macrophages in vitro. Arabinoxylane and PSP directly induced the proliferation of spleen cells in a dose-dependent manner and increased IFN-γ synthesis. Especially, PSP induced IL-2, IL-4 and IL-10 production. Both arabinoxylane and PSP increased PFC (plaque forming cell) and RFC (rosette forming cell) formation. Arabinoxylane was not induced the proliferation of T cells, but PSP directly induced the proliferation of T cells in a high dose. Arabinoxylane and PSP increased the proliferation of B cells and the phagocytic effects of macrophage. When arabinoxylane and PSP were used in macrophage cell line stimulation, there was a marked induction of NO synthesis in a dose-dependent and an increased TNF-α and IL-6 synthesis. Especially, PSP also induced IL-1β production. When arabinoxylane and PSP treated in macrophage cell line, there was induction of MHC class Ⅱ expression. These results suggest that the capacity of arabinoxylane and PSP seem to act as a potent immunomodulator causing augmentation of immune cell activity, and with the absence of notable side-effects, arabinoxylane and PSP could be used as a biological response modifier having possible therapeutic effects against immunological disorders.

프라이버시 계산모형 관점에서 스마트 웨어러블 기기 사용의도에 관한 연구

채수연(Sooyeon Chae),이윤구(Yoonku Lee),정윤혁(Yoonhyuk Jung),최세정(Sejung Marina Choi) 한국정보사회학회 2016 정보사회와 미디어 Vol.17 No.2

사물인터넷 기술이 제공하는 광범위한 유용성에도 불구하고, 그 기술에 의한 사생활 침해에 대해 사회적 관심이 점점 높아지고 있다. 개인정보 수집과 활용이 어느 기술보다 용이한 사물인터넷 서비스에 대해 사용자의 개인정보 유출에 대한 취약성은 더욱 커진다고 할 수 있다. 사용자의 사생활 침해에 대한 염려가 정보기술 사용에 심각한 부정적 영향을 미친다는 기존의 연구결과를 고려했을 때, 이러한 염려는 사물인터넷의 확산에 큰 장애물이 될 수 있다. 최근 사물인터넷 기술의 한 종류인 웨어러블 디바이스에 대한 사용과 관심이 증가하고 있다는 측면에서, 사용자의 사생활 침해 염려가 정보기술의 수용에 미치는 영향에 대한 연구가 수행될 필요가 있다. 따라서 본 연구는 프라이버시 계산모형(Privacy Calculus Model)에 기초하여 웨어러블 디바이스의 사용자 수용을 탐색하였다. 본 연구는 다양한 사생활 침해 관련 위험발생 요인들과 기술이 제공하는 가치 요소들을 연구모형에 포함하고, 그것들의 사용의도에 대한 영향력을 검증함으로써, 기존의 프라이버시 계산모형을 확장하였다. 기존 모형을 보완하기 위해, 본 연구의 연구모형은 다양한 위험발생 요인, 즉 외부환경적 위험발생 요인(정보기술, 서비스제공자, 법제도적 요인)과 사용자 내적 위험발생 요인(위험성향, 사생활 침해 경험) 등을 포함하였다. 또한, 정보기술이 제공하는 가치의 다면성(multi-dimensionality)에 기초하여 유희적, 효용적, 사회적 가치가 웨어러블 디바이스 사용의도에 대한 영향을 검증하였다. 565명의 사용자가 온라인설문에 참여하였다. 본 연구의 결과는 사생활 침해의 특징을 가진 사물인터넷 서비스의 사용자 수용을 이해하는 데에 유용한 지식을 제공하고 있다. 또한, 본 연구는 다양한 위험발생 요소들과 다면적 가치측면을 포함하는 연구모형을 제시하여 기존 프라이버시 계산모형을 확장했다는 점에 그 가치가 있다. Despite tremendous potentials of Internet of Things (IoT) services, the technology causes concern of wide collection and disclosure of personal information. Considering that prior findings that the user’s privacy concern has a significant impact on intention to use information technology services, IoT privacy issue can be a substantial barrier to diffusion of the technology. In spite of the recent high interest in wearable devices that is a subset of IoT technology, there is little research on users’ response to the ubiquitous risk of privacy. Therefore, this study attempts to examine factors, which can affect users’ intention to use wearables, from the perspective of a privacy calculus model. This study improved the model by encompassing various risk and value factors. The research model broadly consisted of risk and value factors, as does a privacy calculous model. To elaborate the privacy calculus model, risk factors in our research model encompass extrinsic risk components (risk on the technology, service providers, and regulation) and intrinsic risk ones (risk propensity and past privacy hazard experience). We also use a multi-dimensional value concept, consisting of utilitarian, hedonic, and social value. Five hundred sixty-five Korean participated in online survey. Findings of the study are valuable in understanding user adoption of IoT services, which make users feel vulnerability to privacy leaks. The study also makes contribution by extending a privacy calculus model with diverse risk and value factors.

국군간호사관학교 생도의 신종감염병에 대한 인식, 신종감염병 상황에서의 윤리인식, 윤리적 의사결정

채수연 ( Chae Sooyeon ),류하은 ( Ryu Haeun ),오효진 ( Oh Hyojin ),이나경 ( Lee Nakyung ),이다현 ( Lee Dahyun ),백서영 ( Baek Seoyoung ) 국군간호사관학교 군건강정책연구소 2021 군진간호연구 Vol.39 No.2

Purpose: The purpose of this study was to investigate the level of awareness about emerging infectious diseases (EID), ethical awareness, and decision-making in responding to EID among Korea Armed Forces Nursing Academy (KAFNA) cadets, and to identify their relationship. Methods: KAFNA cadets participated in this cross-sectional survey. The structured questionnaire consisted of 41 questions about awareness about EID, ethical awareness, decision-making, and general characteristics of participants. Results: The average score of awareness, and ethical awareness were 3.67±0.33, and 4.17±0.38 out of 5. The average rate of answering questions about ethical decision-making was 92.0%. Ethical decision-making was positively correlated with both awareness about EID (r=.14, p=.016), and ethical awareness (r=.22, p<.001). In addition, there was significantly positive correlation between awareness and the ethical awareness (r=.38, p<.001). Conclusion: Based on the study results, an education program for KAFNA cadets to improve the awareness about EID and ethical awareness is needed to enhance the ethical decision-making in response to future pandemic outbreaks of EID.

보중익기탕(補中益氣湯)의 T세포 증식 유도 효과

채수연(Su-Yeon Chae),신성해(Sung-Hae Shin),하미혜(Mee-Hye Ha),조성기(Sung-Kee Jo),김성호(Sung-Ho Kim),변명우(Myung-Woo Byun),이성태(Sung-Tae Yee) 한국식품영양과학회 2004 한국식품영양과학회지 Vol.33 No.7

먼저 OVA항원에 대해 특이적으로 증식반응을 나타내는 T세포주를 수립하였고, 수립된 세포주는 세포 표면 단백질이 CD4^+ CD8-이며 IL-2와 IFN-γ를 분비하는 Type I에 속하는 보조 T세포(Th1)인 것을 확인하였다. 보중익기탕의 total분획은 OVA항원에 대해 특이적으로 반응하는 Th1세포의 증식반응을 증가시키는 효과를 나타내지 않았으며 고농도에서 오히려 증식반응을 억제하였다. 그러나, 보중익기탕의 polysaccharide 분획은 전반적인 농도에서 T세포의 증식반응을 유의하게 증가시키는 효과가 있는 것으로 나타났다. 보중익기탕의 polysaccharide 분획을 첨가하였을 때 T세포의 IL-2 분비량은 대조군보다 약간 적었지만, IFN-γ 분비량은 대조군보다 증가하였다. 그리고, 분비된 IL-2와 결합하는 T세포의 IL-2 수용체 발현양도 증가하는 것으로 나타났다. 또한, 항원제시세포의 MHC class II의 발현양도 증가시켰다. 이상의 결과로 보중익기탕의 polysaccharide 분획은 T세포의 IL-2 수용체 발현양을 증가시키고, 항원제시세포의 MHC classs II의 발현양을 증가시켜서 T세포의 증식반응을 증가시키는 것으로 생각된다. 그리고 보중익기탕이 생체 면역반응에 미치는 보다 정확한 효과를 평가하기 위해서는 직접 살아있는 실험동물에 투여하는 in vivo 실험이 필요하다. Bu-Zhong-Yi-Qi-Tang extracts is a traditional oriental medicine in a mixture type exhibiting strong anti-bacterial, analgesic, and chemopreventive activities. In this study, we have evaluated effects of the total and polysaccharide fraction of Bu-Zhong-Yi-Qi-Tang extracts on the T cell proliferation, cytokine production, and induction of IL-2 receptor and MHC class Ⅱ. For this experiment, we established CD4^+ CD8^- T cell line producing IL-2 and IFN-γ when stimulated with ovalbumin antigen in the presence of antigen presenting cells. The significant effect of Bu-Zhong-Yi-Qi-Tang on antigen-induced T cell proliferation in the presence of antigen presenting cells was observed. The proliferation and IFN-γ production of T cells was increased in a dose dependent manner, and expression of IL-2 receptor on T cells and MHC class II molecule on antigen presenting cells was also induced in the presence of Bu-Zhong-Yi-Qi-Tang polysaccharide fraction. It was demonstrated that polysaccharide fraction of Bu-Zhong-Yi-Qi-Tang stimulates the antigen-induced T cell proliferation and the production of IFN-γ possibly through the increase of IL-2 receptor and MHC class Ⅱ expression. Therefore Bu-Zhong-Yi-Qi-Tang can be regarded as a natural and useful immunomodulator having a relatively nonotoxic property. Further studies are needed to better characterize the nature of Bu-Zhong-Yi-Qi-Tang extract.