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      • KCI등재
      • SCIESCOPUSKCI등재

        백서 두개골 결손부에서 항생제를 함유한 키토산 차단막의 골재생 유도 효과

        채경준,김태균,정의원,이수복,정용식,이용근,김창성,채중규,조규성,김종관,최성호,Chae, Gyung-Joon,Kim, Tae-Gyun,Jung, Ui-Won,Lee, Soo-Bok,Jung, Yong-Sik,Lee, Yong-Keun,Kim, Chang-Sung,Chae, Jung-Kiu,Cho, Kyoo-Sung,Kim, Chong-Kwan,Choi, S 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.4

        The major goals of periodontal therapy are the functional regeneration of periodontal supporting structures already destructed by periodontal disease as well as the reduction of signs and symptoms of progressive periodontal disease. There have been many efforts to develop materials and therapeutic methods to promote periodontal wound healing. There have been increasing interest on the chitosan made by chtin. Chitosan is a derivative of chitin made by deacetylation of side chains. Chitosan has been widely studied as bone substitution and membrane material in periodontology. Many experiments using chitosan in various animal models have proven its beneficial effects. Tetracycline has been considered for use in the treatment of chronic periodontal disease and gingivitis. The aim of this study is to evlauate the osteogenesis of tetracycline blended chitosan membranes on the calvarial critical size defect in Sprague Dawley rats. An 8mm surgical defect was produced with a trephine bur in the area of the midsagittal suture. The rats were divided into five groups: Untreated control group versus four experimental group. Four types of membranes were made and comparative study was been done. Two types of non-woven membranes were made by immersing non-woven chitosan into either the tetracycline solution or chitosan-tetracycline solution. Other two types of sponge membranes were fabricated by immersing chitosan sponge into the tetracycline solution, and subsequent freeze-drying. The animals were sacrificed at 2 and 8 weeks after surgical procedure. The specimens were examined by histologic analyses. The results are as follows: 1. Clinically the use of tetracycline blended chitosan membrane showed great healing capacity. 2. The new bone formations of all the experimental group, non-woven and sponge type membranes were greater than those of control group. But, there was no significant difference between the experimental groups. 3. Resorption of chitosan membranes were not shown in any groups at 2 weeks and 8 weeks. These results suggest that the use of tetracycline blended chitosan membrane on the calvarial defects in rats has significant effect on the regeneration of bone tissue in itself. And it implicate that tetracycline blended chitosan membrane might be useful for guided tissue regeneration.

      • KCI등재

        상악에 식립된 Frialit-2 임플란트의 성공률에 대한 후향적 연구

        채경준,정의원,김창성,심준성,조규성,김종관,최성호,Chae, Gyung-Joon,Jung, Ui-Won,Kim, Chang-Sung,Shim, June-Sung,Cho, Kyoo-Sung,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.2

        Objectives Aim of this study was to evaluate the clinical use and the efficacy of Frialit-2 implant system. Experimental Methods Fifty nine patients received placement of Frilalit-2 implants(137 implants) in their maxillary anterior and posterior sites(40 and 97 implants). Intraoral & clinical examination, chart review and radiographs were taken from each patient. Results 1. The total implant survival rate was 92.7% after a mean follow-up period of 19.9 months. 2. The implant survival rate placed in anterior region was 97.5%. 3. The implant survival rate placed in posterior region was 90.7%. 4. The implant survival rate placed in atrophic posterior maxilla with advanced technique (GBR, Sinus elevation) was 87.2%. 5. The implant survival rate placed in type N(D4) bone was 82%, while 95.7% in type III (D3), and 100% in type II(D2) bone. 6. Most of the failed implants(7 of 10) were removed during the maintenance stage after prosthodontic treatment. Conclusion It was concluded that Frialit-2 implant could be used satisfactorily in the esthetic anterior region, but the use in the posterior region, especially with poor bone quality and quantity, further studies are needed.

      • SCIESCOPUSKCI등재

        ($Implantium^{(R)}$) implant의 단기 생존율 및 치유 양상에 대한 연구

        채경준,정성민,정의원,조규성,채중규,김종관,최성호,김창성,Chae, Gyung-Joon,Chung, Sung-Min,Jung, Ui-Won,Cho, Kyoo-Sung,Chai, Jung-Kyu,Kim, Chong-Kwan,Choi, Seong-Ho,Kim, Chang-Sung 대한치주과학회 2006 Journal of Periodontal & Implant Science Vol.36 No.3

        This study is an analysis of distribution of patients who installed Implantium implant in Yonsei University Dental Hospital and types of implant site for about 1 years recall check and success rate. 164 implants were installed to 52 patients in this study. It shows the conclusion below. 1. Patients at the age of 40s and 50s were 65% of all implant cases and average number of implant was 4 (man), and 2.7 (woman). 75 implants were operated on maxilla and 89 were mandible. 19 implants on anterior region and 145 implants on posterior region. 2. Most distribution of bone qaulity for implant site was type III(37.2%) and bone quantity was type C(61. 7%) 3. The majority of implants were those of 10, 12mm in length (85%) and regular diameter in width (48.8%). 4. 30 implants were installed with the advanced technique-GER, window opemng, osteotome technique. 5. Two implants were removed before prosthodontic treatment due to the osseointegraton failure. The success rate was 98.8% in 15.2 months follow up period and the marginal bone loss was 0.28mm. The results provided us with basic data on patient type, implant distribution, bone condition, and survival rate. Within the limit of present study, It was concluded that Implantium implant could be used satisfactorily in various clinical situations.

      • KCI등재

        The effects of Hydroxyapatite nano-coating implants on healing of surgically created circumferential gap in dogs

        채경준,임현창,최정유,정성민,이인섭,조규성,김종관,최성호 대한치주과학회 2008 Journal of Periodontal & Implant Science Vol.38 No.2

        Purpose: The aim of this study is to compare the healing response of various Hydroxyapatite(HA) coated dental implants by Ion-Beam Assisted Deposition(IBAD) placed in the surgically created circumferential gap in dogs. Materials and methods: In four mongrel dogs, all mandibular premolars and the first molar were extracted. After an 8weeks healing period, six submerged type implants were placed and the circumferential cylindrical 2mm coronal defects around the implants were made surgically with customized step drills. Groups were divided into six groups : anodized surface, anodized surface with 150nm HA and heat treatment, anodized surface with 300nm HA and heat treatment, anodized surface with 150nm HA and no heat treatment, and anodized surface with 150nm HA, heat treatment and bone graft, anodized surface with bone graft. The dogs were sacrificed following 12 weeks healing period. Specimens were analyzed histologically and histomorphometrically. Results: During the healing period, healing was uneventful and implants were well maintained. Anodized surface with HA coating and 430゜C heat treatment showed an improved regenerative characteristics. Most of the gaps were filled with newly regenerated bone. The implant surface was covered with bone layer as base for intensive bone formation and remodeling. In case that graft the alloplastic material to the gaps, most of the coronal gaps were filled with newly formed bone and remaining graft particles. The bone-implant contact and bone density parameters showed similar results with the histological findings. The bone graft group presented the best bone-implant contact value which had statistical significance. Conclusion: Within the scope of this study, nano-scale HA coated dental implants appeared to have significant effect on the development of new bone formation. And additional bone graft is an effective method in overcoming the gaps around the implants. (J Korean Acad Periodontol 2008;38:373-384) Purpose: The aim of this study is to compare the healing response of various Hydroxyapatite(HA) coated dental implants by Ion-Beam Assisted Deposition(IBAD) placed in the surgically created circumferential gap in dogs. Materials and methods: In four mongrel dogs, all mandibular premolars and the first molar were extracted. After an 8weeks healing period, six submerged type implants were placed and the circumferential cylindrical 2mm coronal defects around the implants were made surgically with customized step drills. Groups were divided into six groups : anodized surface, anodized surface with 150nm HA and heat treatment, anodized surface with 300nm HA and heat treatment, anodized surface with 150nm HA and no heat treatment, and anodized surface with 150nm HA, heat treatment and bone graft, anodized surface with bone graft. The dogs were sacrificed following 12 weeks healing period. Specimens were analyzed histologically and histomorphometrically. Results: During the healing period, healing was uneventful and implants were well maintained. Anodized surface with HA coating and 430゜C heat treatment showed an improved regenerative characteristics. Most of the gaps were filled with newly regenerated bone. The implant surface was covered with bone layer as base for intensive bone formation and remodeling. In case that graft the alloplastic material to the gaps, most of the coronal gaps were filled with newly formed bone and remaining graft particles. The bone-implant contact and bone density parameters showed similar results with the histological findings. The bone graft group presented the best bone-implant contact value which had statistical significance. Conclusion: Within the scope of this study, nano-scale HA coated dental implants appeared to have significant effect on the development of new bone formation. And additional bone graft is an effective method in overcoming the gaps around the implants. (J Korean Acad Periodontol 2008;38:373-384)

      • KCI등재후보

        Evaluation of Sonic Toothbrush on the Reduction of Clinical Parameters, Interleukin-1, MMP-8 and Periodontal Pathogens in Incipient to Moderate Periodontitis

        유호선,채경준,홍지연,최성호,김종관 대한치과의사협회 2008 대한치과의사협회지 Vol.46 No.12

        Daily plaque removal with toothbrush is an important component of oral hygiene program to prevent and treat periodontal diseases.1-4) Although it has been reported that both manual and electric toothbrushes are effective in removing supragingival plaque and reducing clinical signs of gingival inflammation, several recent studies reported that electric toothbrushes show superiority to manual brushes.5-11) The Sonicare® toothbrush utilizes solid-state electronics to create sonic-frequency bristle movement with 520 brush strokes per second. This rapid bristle movement creates dynamic activities in surrounding fluids in addition to its scrubbing plaque-removing activity. It has been suggested that these fluid forces lift and disperse plaque bacteria from tooth surfaces about 2-3 mm beyond the physical reach of the bristles.12-15) Furthermore, in vitro experiments have shown that low-amplitude acoustic energy such as that generated by the Sonicare® brush has structural and metabolic effects on oral bacteria, which may retard their ability to form plaque by disrupting bacterial adherence properties.16) Increased levels of bacterial pathogens common in periodontal pockets are known to be associated with an elevated biochemical inflammatory response that promotes bone resorption. Understanding the process of periodontal pathogenesis in terms of the biochemical pathway prompted by greater than normal levels of bacteria and mitigating the subsequent effects is a primary component of periodontal therapy.17-20) The most potent pro-inflammatory cytokine stimulating bone resorption is interleukin-1 (IL-1).21,22) IL-1 is a pleiotropic cytokine having multiple biological activities including stimulation of osteoclast recruitment and activation. IL-1 also stimulates fibroblast to produce matrix metalloproteinases (MMPs) important for the degradation of non-mineralized extracellular tissue. Several studies have reported increased levels of inflammatory mediators, such as IL-1 and prostaglandin E2 (PGE2), in gingival crevicular fluids (GCFs) from diseased sites exhibiting periodontal bone loss when compared with healthy sites. Furthermore, GCF from diseased sites has been shown to stimulate bone resorption in vitro to a higher degree than GCF from healthy sites. One important factor responsible for this bone resorbing activity seems to be IL-1.21-24) Matrix metalloproteinases (MMPs) are enzymes activated by IL-1 and are involved in tissue destruction and regeneration.15) A complex cascade involving both host and microbial derived proteinases mediates extracellular matrix degradation during periodontal disease. In this regard, the host-derived MMPs are thought to play a key role. Enhanced activity of these enzymes is a consequence of microbial induced inflammation in the periodontal tissues. Polymorphonuclear leukocyte (PMN)-derived MMPs (MMP-8, MMP-9) are the main proteinases related to tissue destruction and remodeling events in periodontal diseases.23) Traditional clinical measurements such as assessments of probing pocket depth, attachment level, gingival inflammation and microbial plaque yield only historic information about periodontal status. By directly analyzing the changes in the levels of MMPs and IL-1 in GCF, we can associate parameters of inflammation with clinical parameters of tissue destruction. Among several methods that have been applied to detect periodontopathogenic microorganisms, nucleic acid-based methods using DNA probes can give insight on changes in bacterial counts in the periodontal pocket.24) Objectives of this study were to assess the effects of the Sonicare® toothbrush on clinical parameters [Probing Pocket Depth (PPD), Plaque index (PI), Gingival index (GI), Bleeding on probing (BOP), Clinical attachment level (CAL)] and to evaluate the changes in MMP-8, IL-1 and the reduction of 4 bacterial species (PG, TF, SS, AV) testing 16S rRNA at 3 sites of selected teeth with moderate chronic periodont... Daily plaque removal with toothbrush is an important component of oral hygiene program to prevent and treat periodontal diseases.1-4) Although it has been reported that both manual and electric toothbrushes are effective in removing supragingival plaque and reducing clinical signs of gingival inflammation, several recent studies reported that electric toothbrushes show superiority to manual brushes.5-11) The Sonicare® toothbrush utilizes solid-state electronics to create sonic-frequency bristle movement with 520 brush strokes per second. This rapid bristle movement creates dynamic activities in surrounding fluids in addition to its scrubbing plaque-removing activity. It has been suggested that these fluid forces lift and disperse plaque bacteria from tooth surfaces about 2-3 mm beyond the physical reach of the bristles.12-15) Furthermore, in vitro experiments have shown that low-amplitude acoustic energy such as that generated by the Sonicare® brush has structural and metabolic effects on oral bacteria, which may retard their ability to form plaque by disrupting bacterial adherence properties.16) Increased levels of bacterial pathogens common in periodontal pockets are known to be associated with an elevated biochemical inflammatory response that promotes bone resorption. Understanding the process of periodontal pathogenesis in terms of the biochemical pathway prompted by greater than normal levels of bacteria and mitigating the subsequent effects is a primary component of periodontal therapy.17-20) The most potent pro-inflammatory cytokine stimulating bone resorption is interleukin-1 (IL-1).21,22) IL-1 is a pleiotropic cytokine having multiple biological activities including stimulation of osteoclast recruitment and activation. IL-1 also stimulates fibroblast to produce matrix metalloproteinases (MMPs) important for the degradation of non-mineralized extracellular tissue. Several studies have reported increased levels of inflammatory mediators, such as IL-1 and prostaglandin E2 (PGE2), in gingival crevicular fluids (GCFs) from diseased sites exhibiting periodontal bone loss when compared with healthy sites. Furthermore, GCF from diseased sites has been shown to stimulate bone resorption in vitro to a higher degree than GCF from healthy sites. One important factor responsible for this bone resorbing activity seems to be IL-1.21-24) Matrix metalloproteinases (MMPs) are enzymes activated by IL-1 and are involved in tissue destruction and regeneration.15) A complex cascade involving both host and microbial derived proteinases mediates extracellular matrix degradation during periodontal disease. In this regard, the host-derived MMPs are thought to play a key role. Enhanced activity of these enzymes is a consequence of microbial induced inflammation in the periodontal tissues. Polymorphonuclear leukocyte (PMN)-derived MMPs (MMP-8, MMP-9) are the main proteinases related to tissue destruction and remodeling events in periodontal diseases.23) Traditional clinical measurements such as assessments of probing pocket depth, attachment level, gingival inflammation and microbial plaque yield only historic information about periodontal status. By directly analyzing the changes in the levels of MMPs and IL-1 in GCF, we can associate parameters of inflammation with clinical parameters of tissue destruction. Among several methods that have been applied to detect periodontopathogenic microorganisms, nucleic acid-based methods using DNA probes can give insight on changes in bacterial counts in the periodontal pocket.24) Objectives of this study were to assess the effects of the Sonicare® toothbrush on clinical parameters [Probing Pocket Depth (PPD), Plaque index (PI), Gingival index (GI), Bleeding on probing (BOP), Clinical attachment level (CAL)] and to evaluate the changes in MMP-8, IL-1 and the reduction of 4 bacterial species (PG, TF, SS, AV) testing 16S rRNA at 3 sites of selected teeth with moderate chronic periodontitis follo...

      • KCI등재

        새롭게 개발된 비정질의 Calcium Phosphate가 백서두개골의 골재생에 미치는 영향

        최정유,채경준,김창성,이용근,조규성,채중규,김종관,최성호,Choi, Jung-Yoo,Chae, Gyung-Joon,Kim, Chang-Sung,Lee, Yong-Keun,Cho, Kyoo-Sung,Chai, Joong-Kyu,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.4

        Purpose: The purpose of this study was to evaluate the bone regeneration of novel biodegradable amorphous calcium phosphate. Materials and Method: An 8-mm, calvarial, critical-size osteotomy defect was created in each of 20 male Sprague-Dawley rats(weight $250{\sim}300g$). The animals were divided into two groups of 10 animals each and allowed to heal for 2 weeks(10 rats). The first group was the control group and the other group was the experimental group which received the novel biodegradable calcium phosphate. Results: The healing of the calvarium in the control group was uneventful. The histologic results showed little bone formation in the control group. The experimental group which received the novel biodegradable calcium phosphate showed a normal wound healing. There were a lot of new bone formation around the biomaterial in 2 weeks. The bone formation increased in 8 weeks when compared to 2 weeks and there was a significant bone increase as well(P<0.01). The nobel biodegradable calcium phosphate showed statistical significance when compared to the control group (P<0.05). The novel biodegradable calcium phosphate in 8 weeks showed a significant increase in bone formation when compared to 2 weeks $(40.4{\pm}1.6)$(%). The biodegradable calcium phosphate which is made from mixing calcium phosphate glass(CPG), NaCO and NaOH solution, is biocompatible, osteoconductive and has a high potency of bone formation. Conclusion: We can conclude that the novel biodegradable calcium phosphate can be used as an efficient bone graft material for its biodegradability and osteoconductivity.

      • KCI등재

        치조골 결손부 치료시 calcium carbonate와 calcium sulfate 혼합물의 임상적 효과

        이승범,채경준,정의원,김창성,최성호,조규성,김종관,채중규,Lee, Seung-Bum,Chae, Gyung-Jun,Jung, Ui-Won,Kim, Chang-Sung,Choi, Seong-Ho,Cho, Kyoo-Sung,Kim, Chong-Kwan,Chai, Jung-Kyu 대한치주과학회 2008 Journal of Periodontal & Implant Science Vol.38 No.2

        Purpose: If bone grafts and guided tissue regeneration are effective individually in treating osseous defects, then the questionis, what would happen when they are combined. Bone grafts using Calcium Carbonate(Biocoral) and Guided Tissue Regeneration using Calcium Sulfate(CALMATRIX) will maximize their advantages and show the best clinical results in intrabony defects. This study was to compare the effects of a combination of CS and CC with control treated only with modified widman flap in a periodontal repair of intrabony defects. Materials and Methods: 30 patients with chronic periodontitis were used in this study. 10 patients were treated with a combination of CS and CC as the experimental group II and another 10 patients were treated with CC as the experimental group I, and the remaining 10 patients, the control group were treated only with modified widman flap. Clinical parameters including probing depth, gingival recession, bone probing depth and loss of attachment were recorded 6 months later. Results: The probing depth changes were $3.30{\pm}1.34\;mm$ in the control group, $4.2{\pm}1.55\;mm$ in the experimental group I(CC) and $5.00{\pm}1.33\;mm$ in the experimental group II(CS+CC). They all showed a significant decrease 6 months after surgery(p<0.01). There was a significant difference(p<0.05) between the control and experimental group. However there were no significant difference(p<0.05) between the experimental group I and II. The gingival recession changes w $-1.30{\pm}1.25\;mm$ in the control group, This is a significant difference(p<0.01). However, there was a $-0.50{\pm}0.53\;mm$ change in the experimental group I(CC) and $-0.60{\pm}0.97\;mm$ in the experimental group II(CS+CC). In addition, in terms of gingival recession, there was a no significance difference(p<0.05) among the groups. The clinical attachment level changes were $2.00{\pm}1.33\;mm$ in the control group, $3.60{\pm}1.58\;mm$ in the experimental group I(CC) and $4.40{\pm}1.17\;mm$ in the experimental group II(CS+CC). They all showed a significant decrease 6 months after surgery(p<0.01). There was a significant difference(p<0.05) between the control and experimental group. However there was a no significance difference(p<0.05) between the experimental group I and II. The bone probing depth changes were $0.60{\pm}0.52\;mm$ in the control group, $3.20{\pm}1.48\;mm$ in the experimental group I(CC) and $4.60{\pm}1.43\;mm$ in the experimental group II(CS+CC). All of them showed a significant decrease 6 months after surgery(p<0.01), there was a significance difference(p<0.05) among the groups. Conclusion: Treatment using a combination of CS and CC have a potential to improve periodontal parameters in intrabony defects and More efficient clinical results can be expected in intrabony defects less than 2 walls grafted with CS and CC.

      • KCI등재

        백서 피하층에서 흡수성 차단막의 초기 조직 반응

        임현창,채경준,정의원,김창성,이용근,조규성,김종관,최성호,Lim, Hyun-Chang,Chae, Gyung-Joon,Jung, Ui-Won,Kim, Chang-Sung,Lee, Yong-Keun,Cho, Kyoo-Sung,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.4

        Purpose: Various kinds of biodegradable membranes are currently used in dental clinics. And the frequency and the necessity of their usage are increasing due to their numerous advantages. Therefore it is important to understand the difference of various membranes and histological reaction against implanted membranes. Materials and Methods: Biodegradable membranes of $Biogide^{(R)}$, $Resolute^{(R)}$, and $Tutodent^{(R)}$ were cut into small pieces by $1.0{\times}0.5cm$. The membranes were implanted 1.5cm apart from each other under the epithelium on the skull of 18 Sprague Dawley rats. The animals were sacrificed at 3, 7, and 14 days after surgical procedure. The specimens were examined by histological analysis. Results: 1. Early period after implantation of the membranes showed connective tissues surrounding membranes and there were a few inflammatory cells present. 2. In $Biogide^{(R)}$ and $Tutodent^{(R)}$ specimens, inflammatory cells and surrounding tissues were shown to infiltrate from outside with slight density difference inside. In $Resolute^{(R)}$ specimens, membranes were fragmented. Inflammatory cells and connective tissues were also observed inside. 3. In $Resolute^{(R)}$ specimen, giant cells were present which implicates that foreign body reaction has occurred. 4. $Biogide^{(R)}$ had lower integrity than other membranes and is not enough to be used alone in defect area. However, $Resolute^{(R)}$ had superior firmness than others. $Tutodent^{(R)}$ had middle level of integrity. Conclusion: This experimental model enabled to observe early inflammatory reactions and morphological changes of materials and can be used to develop and evaluate the efficacy of biodegradable membranes. Duplication of standardized human oral environment will be required in future experiments.

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