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- 저자 : 조정제 ( Jung Je Cho ) (검색결과 4 건)
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조정제 ( Jung Je Cho ),나승원 ( Seung Won Ra ),이광하 ( Kwang Ha Lee ),이정아 ( Jung A Lee ),강채훈 ( Chae Hoon Kang ),권동일 ( Dong Il Gwon ),오연목 ( Yeon Mok Oh ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.1
Pregnancy induces many physiologic changes, and it can cause hemoptysis in relation to the underlying or potential pulmonary diseases. Although hemoptysis is not a frequent event during pregnancy, a thorough search for its etiology and then immediate management should be initiated for a case of massive hemoptysis to avoid serious adverse effects on both the fetus and the mother. Most hemoptysis events during pregnancy are related to well known etiologies, but there are a few reported cases of hemoptysis in pregnant women who are without any underlying lung lesion. We report here on a case of a pregnant woman with total lung collapse due to hemoptysis, and a thorough search for the etiology after delivery could not reveal any etiology.
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Th2 세포에서 IL-12에 의한 IL-18R ${\alpha}$의 발현유지 및 IL-18 자극에 의한 GATA-3의 유도
주인숙,선민정,김동영,이수진,하윤문,조정제,박증석,안현종,Joo, In-Sook,Sun, Min-Jung,Kim, Dong-Young,Lee, Su-Jin,Ha, Youn-Mun,Cho, Jeong-Je,Park, Cheung-Seog,Ahn, Hyun-Jong 대한면역학회 2005 Immune Network Vol.5 No.1
Background: IL-18 was originally cloned as a IFN-${\gamma}$ inducing factor in primed T cells. In synergy with IL-12, IL-18 has been shown to induce strikingly high levels of IFN-${\gamma}$ production by T cells and to enhance Th1 development. Also this cytokine exerts induction of Th2 development through IL-4 induction. Methods: Resting $CD4^+$ T cells were sorted by negative selection and activated by anti-CD3 plus anti-CD28 Ab. Expression of IL-12 binding sites, IL-18 binding sites, IL-18R ${\alpha}$, and GATA-3 mRNA were analysed by FACS and RT-PCR, respectively. Results: Resting $CD4^+$ T cells expressed IL-18R ${\alpha}$ chain but not IL-18 binding sites, suggesting a lack of IL-18R ${\beta}$ expression. IL-18R ${\alpha}$ was maintained on the Th1 and Th2 committed cells. IL-18 binding sites were induced on the Th1 but not Th2 cells. Exposure of these cells to IL-18 led to up-regulation of GATA-3 mRNA expression only in Th2 committed cells. To elucidate the relationship between IL-18R ${\alpha}$ expression and GATA-3 induction by IL-18, Th1 and Th2 committed cells were further cultured in medium with or without IL-12 for 2 days. IL-12 binding sites were maintained on the Th1 and Th2 cells regardless of IL-12 treatment, but IL-18R a expression was rapidly down-regulated on the IL12-untreated Th2 cells which did not induce GATA-3 mRNA expression followed by IL-18 stimulation. Conclusion: IL-12 supports expression of IL-18R ${\alpha}$ and GATA-3 mRNA expression was induced by IL-18 through IL-18R ${\alpha}$ without expression of IL-18 binding site in Th2 cells.
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증례 : 내분비-대사 ; 50대에 진단된 MELAS 증후군 1예
황윤우 ( Yoo Noo Hwang ),정재호 ( Jae Ho Jeong ),김유석 ( Yu Seok Kim ),조정제 ( Jung Je Cho ),이우제 ( Woo Je Lee ),박중열 ( Joong Yeol Park ),이기업 ( Ki Up Lee ) 대한내과학회 2011 대한내과학회지 Vol.80 No.2
저자들은 10년 이상 당뇨병으로 치료받던 52세 여자가 고혈당과 의식저하로 내원하여 치료하던 중 MELAS 증후군으로 진단받은 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. MELAS 증후군은 매우 드문 질환이며 대부분이 40세 이전에 진단된다. 하지만 당뇨병을 가진 환자가 혈관 질환으로 설명할 수 없는 뇌졸중 유사증상과 원인 모를 젖산혈증이 있으며 감각신경성 난청의 병력, 모계 유전 당뇨병의 가족력 등이 있을 경우 비록 나이가 많더라도 MELAS 증후군의 가능성을 고려해 봐야 할 것이다. Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes, abbreviated to MELAS, syndrome is a common mitochondrial disease that can present with a wide range of clinical symptoms, including seizures, stroke-like episodes, neuropathy, myopathy, sensorineural hearing loss, and encephalopathy. Although more than 90% of patients present with stroke-like episodes before the age of 40 years, some reports have described patients presenting later in life. Here, we report MELAS syndrome diagnosed in a 52-year-old Korean woman admitted because of altered mentality. She had a history of diabetes, sensorineural hearing loss, and cardiomyopathy. The patient`s mentality fluctuated and her lactic acid level was elevated in the hospital. Although she was in her 50s, her medical history, encephalopathy, and lactic acidosis made us strongly suspect MELAS syndrome. The diagnosis was confirmed when a test showed the A3243G mitochondrial DNA mutation. (Korean J Med 2011;80:225-230)
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유훈 ( Hoon Yu ),이승범 ( Seung Bum Lee ),정경원 ( Kyoung Won Jung ),박현정 ( Hyun Jung Park ),조정제 ( Jung Je Cho ),박영훈 ( Young Hoon Park ),김성한 ( Sung Han Kim ) 대한내과학회 2011 대한내과학회지 Vol.80 No.6
감염성 동맥류는 대부분의 경우 무증상이거나 비 특이적인 증상을 보여 진단이 어려운 질환이다. 그러므로 진단이되지 못하거나 늦어짐으로써 생명을 잃는 수도 있다. 본 증례는 결핵성 복막염으로 치료받던 환자에게서 간동맥에 발생한 감염성 동맥류를 진단하였으며, 성공적 치료를 시행한경우이다. 감염성 동맥류는 드물지만 환자의 생명과 직결되는 상황을 초래할 수 있는 질환으로 감염성 질환의 진단과 치료를 하는 데 있어 이러한 합병증의 가능성을 항상 염두에 두어야겠다. A 28-year-old man was admitted due to abdominal pain and nausea. The patient had been diagnosed with peritoneal tuberculosis and was being treated with anti-tuberculous drugs. After 7 months of therapy, he developed abdominal pain, nausea, and melena. Gastrofiberscopy showed a duodenal ulcer and fistular opening. Abdominal CT revealed an aneurysm of the replaced hepatic artery due to abdominal tuberculous lymphadenopathy. After embolization of the aneurysm, his symptoms improved. Although mycotic aneurysm occurs rarely as a complication of tuberculous lymphadenopathy, it should be diagnosed as early as possible because of the high rate of rupture and associated high mortality. (Korean J Med 2011;80:734-738)
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