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정재훈(Jae Hoon Chung),박중열(Joong Yeol Park),박용수(Yong Soo Park),이문규(Moon Kyu Lee),이병두(Byoung Doo Rhee),이홍규(Hong Kyu Lee),고창순(Chang Soon Koh),민헌기(Hun Ki Min),조수헌(Soo Hun Cho),강문호(Moon Ho Kang) 대한내과학회 1989 대한내과학회지 Vol.36 No.3
N/A In order to evaluate the effectiveness of systemic hyperbaric oxygen (HBO) therapy on diabetic gangrene, we treated 11 patients with diabetic gangrene with HBO therapy and 7 without HBO therapy in 1988. Seventeen patients with diabetic gangrene were treated without HBO therapy in 1987. HBO was administered in 60-min sessions twice a day or in daily 75-min sessions (20±4 times) within a monoplace oxygen chamber pressurized at 2.5 atm. Clinical characteristics such as sex, age, diabetes duration, fasting blood glucose, HbA1c, severity of diabetic microangiopathy and macroangiopathy were comparable in the patients of 1987 and 1988. In 1988, 13 patients (72.2%) recovered or showed improvement, 2 patients (11.1%) showed no improvement, and 3 patients (16.7%) were amputated. By contraries, in 1987, 8 patients (47.0%) recovered or showed improvement, 8 patients (47.0%) were amputated, and the remaining patient (6.0%) expired. There was a significant difference in hospitalization period (days) between the groups (33.8±3.7 vs 60.1±7.1, p<0.05 by Wilcoxon rank sum test). However, the values of nerve conduction velocity, amplitude, and latency of electrophysiologic test performed before and after HBO therapy were not altered. We conclude that HBO therapy may be an effective modality for the treatment of diabetic gangrene.
인슐린 투여가 당뇨병 환자의 삶의 질, 우울 요소에 미치는 영향
이상아 ( Sang Ah Lee ),박중열 ( Joong Yeol Park ) 대한내과학회 2009 대한내과학회지 Vol.77 No.1
Insulin is the most effective drug for reducing blood glucose in patients with diabetes commonly. But it has negative aspect for diabetic patients to change from oral hypoglycemic drug to insulin injection. Insulin injection makes patients feel reducing self-esteem and QOL (quality of life). So they complain depressive moods. Multiple insulin injection has an effect on patient`s emotion more negatively than one or two injection of insulin. It is suggested that physicians much more concern about self-esteem and emotional aspect of patients when they prescript insulin. (Korean J Med 77:57-59, 2009)
벽 근처에서 자유 낙하하는 입자의 마이크로 유체 관점 수치해석
김정목(Joeng Mok Kim),백성열(Seong Yeol Bak),박중열(Joong Yull Park) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.11
Cell-size particle in microfluidics seems to move slower near wall, even in static fluid. The cell has very small volume compared to channel or well. Usually, the cell itself does not affect the flow of channel, due to its size and density. But in this paper, we have regarded the cell as sphere that has volume, momentum and torque, by using Macroscopic Particle Model (MPM) to consider the wall-effect of free-falling particle. To validate the result, 200~300 μm glass bead was used for both simulation and experiment. Simulation shows that the cell dropped near wall was slowed down to 23.5% comparing to free-fall without wall-effect. While experiment data does not match well with simulation, the same tendency of slower falling velocity near wall was observed. Also, the particles dropped near wall tends to move to center of channel, which would help forming the spheroid or inspecting the collision activities of cells.
벽 근처에서 자유 낙하하는 입자의 마이크로 유체 관점 수치해석
김정목(Joeng Mok Kim),백성열(Seong Yeol Bak),박중열(Joong Yull Park) 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.11
Cell-size particle in microfluidics seems to move slower near wall, even in static fluid. The cell has very small volume compared to channel or well. Usually, the cell itself does not affect the flow of channel, due to its size and density. But in this paper, we have regarded the cell as sphere that has volume, momentum and torque, by using Macroscopic Particle Model (MPM) to consider the wall-effect of free-falling particle. To validate the result, 200~300 μm glass bead was used for both simulation and experiment. Simulation shows that the cell dropped near wall was slowed down to 23.5% comparing to free-fall without wall-effect. While experiment data does not match well with simulation, the same tendency of slower falling velocity near wall was observed. Also, the particles dropped near wall tends to move to center of channel, which would help forming the spheroid or inspecting the collision activities of cells.
인슐린 비의존형 당뇨병환자에서 혈관합병증과 Lipoprotein ( a ) 의 관계
김선희(Seon Hee Kim),채희복(Hee Book Chai),박중열(Joong Yeol Park),민원기(Won Ki Min),김우건(Woo Kun Kim),김기수(Ghi Su Kim),이기업(Ki Up Lee) 대한내과학회 1997 대한내과학회지 Vol.52 No.3
N/A Objectives: High serum Lp(a) concentration is associated with a high risk of coronary artery disease(CAD). This study was initiated to determine whether increased Lp(a) levels are associated with diabetic vascular complications in Korean patients with NIDDM. Methods: A total of 183 NDDM patients were studied cross-sectionally for the presence of various vascular complications. Lp(a) levels were measured by 1-step sandwich ELISA method. Results: The patients with overt proteinuria had higher Lp(a) levels than the patients with mormo- albuminuria or microalbuminuria(26.8mg/dl vs 13.8 mg/dl and 17.3mg/dl, p<0.05), The patients with proliferative retinopathy and/or those treated by photocoagulation had higher Lp(a) levels than those without retinopathy or those with background retinopathy(34.1mg/dl vs 13.3mg/dl and 16,9mg/dl, p<0.05), The Lp(a) levels were also higher in the patients with CAD than those without CAD(30.9mg/ dl vs 16.3mg/dl, p<0.05). Multiple logistic regression analysis revealed that high Lp(a) levels were independantly associated with CAD and severe diabetic retinopath3. Conclusion: High Lp(a) levels are associated with CAD and proliferative retinopathy in Korean patients with NIDDM.
인슐린 비의존형 당뇨병환자에서 중식성 망막증 발생에 관한 종적연구
조구영(Goo Yeong Cho),김상욱(Sang Wook Kim),이미화(Mee Wha Lee),박중열(Joong Yeol Park),제수정(Soo Jung Je),이기업(Ki Up Lee),김기수(Ghi Su Kim) 대한내과학회 1994 대한내과학회지 Vol.47 No.4
N/A Background: Proliferative diabetic retinopathy (PDR), a late stage of diabetic retinopathy, is the com- monest cause of acquired blindness in adults. Despite many previous studies, the risk factors for the development of PDR in Korean NIDDM patients have not been precisely defined yet. The aims of the present study were to evaluate the incidence and the risk factors of PDR. Method: From April to June 1993, we retrospectively studied 243 NIDDM outpatients (duration of diabetes 7.9±7.1, age 54.5±10.8, male 110 and fema1e 133) who had undertaken fundoscopic examination for diabetic retinopathy before April 1991. At the time of the examination, 70 patients had nonproliferative diabetic retinopathy (NPDR). Of those, 12 patients progressed to PDR and 58 patients did not. Clinical characteristics and laboratory findings of progressed group were compared with non-progressed group. Results: Of the 162 patients who were free of diabetic retinopathy at the initial examination, 18 patients progressed to diabetic retinopathy; the incidence rate of diabetic retinopathy was 34.9/1,000 person-yr. Of these, 1 patients had PDR (1.9/1,000 person-yr). After 2.6 years of mean follow-up, 12 out of 70 patients with initial NPDR progressed to PDR. The incidence rate of PDR in the patients with NPDR was 63.2/1,000 person-yr. Microalbuminuria, more severe weight loss, lower level of C-peptide and insulin therapy were associated with an increased 2.6-year risk of developing PDR. However, sex, smoking, use of antihypertensive drugs or aspirin, age, duration of diabetes and the mean fasting serum glucose, hemoglobin Al, cholesterol, systolic or diastolic blood pressure levels during the follow-up period were not associated with the progression to PDR. Forward stepwise multiple logistic regression analysis revealed that initial microalbuminuria and delta BMI are significant independent predictor for the progression to PDR. Conclusion: Microalbuminuria can be used as a predictor for progression to PDR. Lower level of C-peptide, more severe weight loss and current insulin use may be also the risk factors for progression to PDR in Korean NIDDM patients with nonproliferative retinopathy. However, long-term prospective study is warranted to answer the question more properly.
미세단백뇨를 동반한 인슐린비의존형 당뇨병 환자에서 신장 병리 소견의 다양성
정윤이(Yun Ey Chung),이기업(Ki Up Lee),박중열(Joong Yeol Park),홍성관(Sung Kwan Hong),강재영(Jae Young Kang),이종수(Jong Soo Lee),오영하(Young Ha Oh),정재걸(Jae Gul Chung),유은실(Eun Sil Yu),박정식(Jung Sik Park) 대한내과학회 1998 대한내과학회지 Vol.55 No.5
N/A Objective: It was suggested that the cause of microalbuminuria is heterogeneous in NIDDM. However, only a few studies are available that investigated the renal pathology in NIDDM patients with microalbuminuria. This study was undertaken to evaluate renal pathology in Korean NIDDM patients with microalbuminuria. Methods: Fifty NIDDM patients with microalbuminuria and without retinopathy were undertaken renal biopsy. Renal pathologic findings were classified as follows' group A, near normal finding; group B, typical diabetic nephropathology; group C, atypical patterns of renal injury (mild glomerular change with disproportionally severe tubulointerstitial lesion, arteriolar hyalinosis or global glomerular sclerosis); group D, non-diabetic renal lesion. Results: Seventeen patients were classified into group A, 19 into group B and 8 into group C. Six patients had non-diabetic renal lesions and they were all confirmed to be IgA nephropathy, Fasting blood sugar and GFR were significantly higher in group B than in group A and group C respectively, and systolic blood pressure was higher in group C than in group A. Conclusion: Renal pathology in microalbuminuric NIDDM patients without retinopathy was heterogeneous. This may explain heterogeneous clinical meaning of microalbuminuria in NIDDM.