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      • KCI등재

        Loganin Inhibits α-MSH and IBMX-induced Melanogenesis by Suppressing the Expression of Tyrosinase in B16F10 Melanoma Cells

        정희진,방은진,김병무,정성호,이길한,정해영,Jung, Hee Jin,Bang, EunJin,Kim, Byeong Moo,Jeong, Seong Ho,Lee, Gil Han,Chung, Hae Young Korean Society of Life Science 2019 생명과학회지 Vol.29 No.11

        Ultraviolet radiation exposure is a major cause of extrinsic skin aging, which leads to skin hyperpigmentation. Loganin, a major iridoid glycoside obtained from Corni fructus, has anti-inflammatory, anti-diabetic, and neuroprotective effects. In this study, we investigated the mechanisms underlying the anti-melanogenic effects of loganin in B16F10 melanocytes treated with ${\alpha}$-melanocyte stimulating hormone (${\alpha}-MSH$) and 3-isobutyl-1-methylxanthine (IBMX). Anti-melanogenic activity was measured by treating cells with loganin at concentrations between 1 and $20{\mu}m$. Cell viability assays confirmed that doses of loganin up to $20{\mu}m$ were not cytotoxic. Loganin significantly and dose-dependently decreased intracellular melanin production. We also investigated potential molecular signaling pathways for the anti-melanogenesis effects of loganin. Western blotting showed that treatment with ${\alpha}-MSH$ and IBMX increased the phosphorylation of cAMP response element-binding protein (CREB) and the gene expressions of microphthalmia-associated transcription factor (MITF) and tyrosinase. Addition of loganin suppressed these increases, while promoting the phosphorylation of extracellular signal regulated kinase (ERK) and the anti-melanogenesis response. Our data therefore indicated that loganin could attenuate the increased melanin synthesis induced by ${\alpha}-MSH$ and IBMX treatment of B16F10 melanocytes. This attenuation appears to occur by downregulation of CREB phosphorylation and MITF and tyrosinase gene expression and upregulation of ERK phosphorylation. These finding suggests that loganin could be a valuable candidate for treatment of skin diseases related to hyperpigmentation. Loganin은 Corni fructus의 주요 iridoid glycoside이며 항염증, 항당뇨 그리고 뇌신경보호 효과 등이 보고되었다. 본 연구에서는 ${\alpha}-MSH$와 IBMX처리된 B16F10세포에서 loganin의 melanogenesis억제효과의 신호전달 경로를 조사하였다. Loganin의 미백 활성을 확인하기 위해 B16F10세포에서 $1{\mu}m$에서 $20{\mu}m$사이의 농도를 처리하여 세포독성 실험을 수행한 결과 최대 $20{\mu}m$농도에서 독성을 나타내지 않았다. 또한 loganin은 ${\alpha}-MSH$와 IBMX처리된 B16F10세포에서 농도-의존적으로 멜라닌 생성을 감소시키는 것을 확인하였다. 또한 loganin의 멜라닌 생성을 억제하는 신호전달 경로를 Western blotting을 실시하여 조사하였다. Western blot결과에 따르면 loganin은 ${\alpha}-MSH$와 IBMX 처리된 B16F10세포에서 증가된 CREB인산화(Ser133)와 MITF 발현 및 tyrosinase의 유전자 발현을 감소시켰고 ERK의 인산화를 증가시켜 melanin 생성을 억제하였다. 결론적으로 loganin은 ${\alpha}-MSH$와 IBMX에 의해 유도된 과도한 멜라닌 합성을 CREB인산화와 MITF 및 tyrosinase의 유전자 발현을 억제하고 ERK의 활성화를 통해 멜라닌 합성을 감소됨을 확인하였다. 따라서 loganin은 과색소 침착과 관련된 피부질환의 보호제로서 활용될 가능성을 가지는 것으로 사료된다.

      • KCI등재

        신한류에 대한 Psychographics에 따른 시장세분화

        정희진(Jung, Hee-Jin),백용창(Back, Yong-Chang),이계희(Lee, Gye-Hee) 한국산학기술학회 2011 한국산학기술학회논문지 Vol.12 No.7

        국가의 브랜드 파워와 국가 이미지를 강화시킬 수 있는 문화원천으로 판단되는 신한류는 꾸준한 경제적 파 급효과를 가져올 것으로 예상됨에 따라 본 연구에서는 신한류의 주요 소비자인 일본 및 중국인 관광객을 대상으로 신 한류에 관한 관여 요인, 신념, 태도 요인을 근거하여 이들 집단들을 세분화하고, 한국관광에 대한 만족도, 충성도 및 여행경비 등의 관광행동에 있어서의 차이와, 각 집단별로 다양한 장르의 신한류 참여활동을 비교하였다. 연구 결과 신 한류에 관한 적극적인 관여와 신념, 태도를 보이는 집단이 한국을 재방문하고자 하는 계획과 의도 및 주변인들에게 한국 방문에 대한 추천의사가 매우 높았으며 이러한 집단이 다른 집단에 비해 방문 시 지출하는 금액이 많다는 결과 를 토대로 신한류가 갖고 있는 경제적 파급효과를 입증하였다. Psychological involvement, belief, and attitude as important variables in explaining tourism behavior have been widely examined in the tourism context for its usefulness in differentiating markets. This study investigated foreign tourists' Neo-Han Ryu related trip behaviors based on their psychological involvement, belief, and attitude toward Neo-Han Ryu. A self-administered on-site survey was conducted in January 2010. Three distinctive clusters were identified from cluster analysis. These three segment show sharp contrast in terms of their psychological involvement, attitude and belief about Neo-Han Ryu and thus differ from each other with respect to their behaviors, including satisfaction, intention to revisit, recommendation, and trip expenditure. The results clearly indicate that the segment with a high Neo-Han Ryu involvement reported stronger intention to revisit and recommendation to others compared to the less involved segments. The findings provides important implications to the marketers regarding how to utilize Neo-Han Ryu to expand Korean inbound market and how to select target markets.

      • KCI등재

        사회적 강화와 촉진의 용암에 의한 발달지체 유아의 착석행동 및 지시 따르기의 변화: 개별대상연구

        정희진 ( Jung Hee Jin ),양명희 ( Yang Myoung Hee ) 대구대학교 특수교육재활과학연구소 2014 특수교육재활과학연구 Vol.53 No.1

        본 연구는 G시 어린이집의 발달지체 만 5세 남아 1명에게 대집단 이야기나누기 상황에서 사회적 강화와 촉진의 용암을 통해 착석행동과 지시 따르기 행동이 변화하는지 알아보고자했다. 사회적 강화는 표적행동이 발생할 때마다 제공했고 촉진의 용암은 네 단계로 이루어졌다. 중재를 적용하자 표적행동은 즉각적 변화를 보이며 증가했다. 촉진이 모두 제거 된 뒤사회적 강화만 남아있는 구간에서는 착석행동과 지시 따르기 행동이 약간 감소추세를 보였지만 평균값이 기초선에 비해 뚜렷하게 높아 유지 효과를 보였다. 본 연구 결과는 사회적 강화와 촉진의 용암이 발달지체유아의 수업 및 활동의 참여행동을 향상시키기 위해 교사가 적용할 수 있는 효과적인 중재 방법임을 시사해준다. The purpose of this study was to examine the effects of social reinforcement and faded prompts on the behavior of taking a seat and following directions of a 5 year old boy with developmental disabilities at day care center. The target behaviors were examined by duration recording and controlled presentations recording respectively. The modified design of changing criterion design and multitreatment design was applied. Whenever the subject’s target behavior was occurred, social reinforcement was consistently provided. Prompts fading consisted of four stages. The criterion of fading of each prompt is a more than 40% of taking a seat and following direction behavior for consecutive three days. The research data were analyzed visually. Upon the intervention, the target behaviors increased immediately. After all prompts were eliminated, the phase of social reinforcement showed slightly reduced trend. However, the average is distinctly higher than the base line data. This research indicates that social reinforcement and faded prompts are effective for the behavior of taking a seat and following direction of young children with disabilities.

      • KCI등재

        전자ㆍ통신업체의 경영효율성 평가에 관한 연구

        정희진(Hee Jin Jung) 한국컴퓨터정보학회 2000 韓國컴퓨터情報學會論文誌 Vol.5 No.2

        본 연구에서는 자료포괄분석(DEA : Data Envelopment Analysis)을 이용하여 전자ㆍ통신업체들의 경영효율성 평가를 하였다. 자료포괄분석은 다수 생산자의 효율성을 평가하기 위해 Charnes 등에 의해 개발된 기법으로서 다차원의 투입변수와 다차원의 산출변수를 동시에 고려한 수 있는 기법이라 할 수 있다. 본 연구에서 투입변수로는 원재료비, 종업원수, 생산능력이, 산출변수로는 생산실적, 총매출액 및 당기순이익이 선정되었다. 효율성 평가 결과 대부분의 기업이 대상기간동안 경영효율성이 증가하거나 계속 효율적인 것으로 평가되었으며, 투입 및 산출변수는 높은 상관관계를 가지는 것으로 나타났다. The purpose of this study is concerned with evaluating management performance in electronics and communication companies using DEA(Data Envelopment Analysis). DEA is a linear programming based technique for measuring the relative performance of organizational units where the presence of multiple inputs and outputs makes comparisons difficult. In this research, input variables are raw-material costs, number of employees, and production capacity. Real production, sales revenue and net earning are suggested as output variables. Management performance of most companies are increased or equal during 97 and 98 fiscal year and input & output variables show high correlation.

      • KCI등재

        강원도 동해안 3개 하천 하구역 일대의 식물상

        정희진 ( Hee Jin Jung ),천경식 ( Kyeong Sik Cheon ),옥길환 ( Gil Hwan Ok ),유기억 ( Ki Oug Yoo ) 한국환경복원기술학회(구 한국환경복원녹화기술학회) 2012 한국환경복원기술학회지 Vol.15 No.2

        This study was carried out to investigate the flora of estuary regions, Namdaecheon, Jusucheon, and Maeupcheon, placed in the east coast of Gangwon-do. The vascular plants were summarized as 441taxa, including 90 families, 277 genera, 388 species, 2 subspecies, 35 varieties, and 6 forms. Number of species in each investigated region was 271taxa of Namdaecheon, 247taxa of Jusucheon, and 285taxa of Maeupcheon, respectively. Among the investigated 441taxa, 7 Korean endemic, 5 rare plants and 37 specially designated plants by Ministry of Environment were also included. Aquatic and hydrophyte plants were collected 41taxa, and the thinophyte and halophyte plants were investigated 22taxa. The naturalized plants were 59taxa, and the percent of naturalized plant species was estimated as 13.3%. Based on the floristic composition, Maeupcheon was estimated as well conserved estuary region among the investigated 3 rivers.

      • KCI등재
      • KCI우수등재

        학술대회(學術大會) 우수론문(優秀論文) : 확장 Triandis 모델을 적용한 국내관광 소비자의 소셜 미디어 커뮤니티 몰입의 영향요인

        정희진 ( Hee Jin Jung ),김태구 ( Tae Goo Kim ),이계희 ( Gye Hee Lee ) 한국관광학회 2011 관광학연구 Vol.35 No.7

        Social media have come into playing indispensible roles in travel planning, social networking, and actual bookings and purchasing of tourism and tourism related products. This study was designed to identify the determinants of the users` commitment to the social media community based on the theoretical framework of Triandis model(1980), which helps researchers understand the structure of information usage behavior in various contexts. The data for this study were derived from an national panel online survey, which was conducted among Bloggers who had taken leisure travels for the last one year prior to the survey. A total of 236 Bloggers, were included in the model test of path analysis. Results showed that affect, social factors and near-term consequences were positively related to commitment. Also, commitment positively affected the intention to continue to use social media for travel information search. However, contrary to our expectation, long-term consequences and facilitating conditions were found to be an insignificant predictor for commitment and intention to continue to use social media. Practical implications and future research direction were also presented.

      • KCI등재
      • 고강도 콘크리트의 폭렬발생 및 폭렬저감 메커니즘에 관한 문헌적 고찰

        정희진(Jung, Hee-Jin),이재영(Lee, Jae-Young),김재환(Kim, Jae-Hwan),한병찬(Han, Byung-Chan),권영진(Kwon, Young-Jin) 한국화재소방학회 2008 한국화재소방학회 학술대회 논문집 Vol.2008 No.춘계

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        Nowadays, the use of high strength concrete has become increasingly popular. Thus, the theory of this study gives a definition of HSC mechanism through study factors of spalling occurrence of HSC and solutions of failure mechanism. During the fire goes on, building structure using HSC causes explosive spalling and finally it gets to the breaking of the structure down. As a result of this failure mechanism, it remains to be investigated to prevent from explosive spalling of HSC and needs to provide basic problems of HSC at high temperature.

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