운동선수의 혈청 총 호모시스테인 농도와 생화학적 대사변인 및 심장구조의 관련성

정인근(In-Geun Jung),강형숙(Hyung-Sook Kang) 대한체질인류학회 2008 해부·생물인류학 (Anat Biol Anthropol) Vol.21 No.4

이 연구는 운동선수(육상, 축구, 농구)의 혈청 총 호모시스테인 농도가 생화학적 대사변인과 심장구조 및 기능에 미치는 영향을 비교하기 위하여 운동선수군 31명, 대조군 31명을 대상으로 심장초음파검사(3D echocardiography)와 혈장 생화학적인 변인을 분석하였다. 운동선수군은 대조군에 비해서 보다 높은 확장기말 왼심실 내경, 수축기말 왼심실 내경, 1회 박출량, 크레아틴키나아제 및 유산탈수소효소 값을 보인 반면 내경단축율, 안정시 심박수, 심박출량 값 및 혈청 크레아티닌 농도는 대조군보다 낮게 나타났으며(p<.05), 혈청 총 호모시스테인 농도의 분포는 운동선수군과 대조군 모두 정규분포를 보였으며, 심혈관계 질환의 위험 요인으로서 10 μ㏖/ℓ의 농도에 해당하는 비율은(운동선수군 74.2%, 대조군 87.1%) 두 군 모두 비교적 높게 나타나 통계적으로 유의한 차이가 없었다. 혈청 총 호모시스테인 농도는 운동선수군의 경우 혈청 크레아티닌 및 요산 농도와 유의한 관련성 (p<.05)을 나타내었고, 혈청 총 호모시스테인 농도는 대조군에서 내경단축율(FS (%))과 유의한 양의 상관관계를 나타내었지만(p>.05), 운동선수군에서는 상관관계를 나타내지 않았다. 이러한 결과로 종합해 볼 때 혈청 총 호모시스테인 농도는 운동선수와 대조군 모두 상이한 방식으로 심장구조 및 기능에 영향을 미친다는 것을 알 수 있었다. The objective of this study was to compare the difference in serum total homocysteine (tHcy) concentration between controls and athletes, and examine its influence on biochemical parameters or cardiac structure and function of our study participants. Biochemical assay including serum tHcy and folic acid concentration were performed by automatic analyzer, and analyses on cardiac structure and function of study participants carried out by 3D echocardiography, respectively. There were significant positive correlation between serum tHcy and biochemical parameters such as serum creatinine and uric acid concentration in athletes, while there were significant positive correlation between serum tHcy and echocardiographic parameter such as FS(%) value in controls(p<.05). In conclusion, our data suggest that the interaction between serum tHcy concentration and clinical parameters in athletes might be at least in part controlled by the difference way with controls. Further studies using larger sample size will be necessary to clarify the precise mechanism behind these interactions.

운동선수의 베타3-아드레날린성 수용체 유전자의 Trp64Arg 다형성이 혈압, 신체조성 및 골밀도에 미치는 영향

정인근,오상덕,김태욱,강병용,하남주,하남주,Jung In Geun,Oh Sang Duk,Kim Tae Wook,Kang Byung Yong,Ha Nam Joo,Ha Nam Joo 대한약학회 2005 약학회지 Vol.49 No.1

The purpose of this study was to investigate the relationship between Trp64Arg polymorphism in the ${\beta}_3$-adrenergic receptor gene and complex phenotypes such as blood pressure, body compositions and bone parameters in young men about 20 years, and to collect the fundamental data in designing the exercise program. Eighty healthy young men including 41 controls and 39 athletes were recruited, Trp64Arg polymorphism in the ${\beta}_3$-adrenergic receptor gene was genotyped by PCR-RFLP method. By association study, there were no significance in genotype and allele frequencies of Trp64Arg polymorphism in the ${\beta}_3$-adrenergic receptor gene between controls and athletes, respectively (p>0.05). When the relationship between physiological parameters and Trp64Arg polymorphism in the ${\beta}_3$-adrenergic receptor gene was tested, this polymorphism was significantly associated with 3th lumber and left femoral neck Z-score values in controls (p<0.05), but these associations were not detected in athletic groups (p>0.05). It is likely that Trp64Arg polymorphism in the ${\beta}_3$-adrenergic receptor gene is a genetic marker for the bone mineral density index in young men, but environmental factors such as exercise modify the significant effect of this polymorphism. Thus, our results suggest that Trp64Arg polymorphism in the ${\beta}_3$-adrenergic receptor gene may be applicable as a predictive marker for osteoporosis in Korean young men, and regular exercise may prevent the disadventageous effect of this polymorphism for bone mineral density in male athletic group.

기계체조 안마 트래블 동작의 운동학적 분석

정인근(Jung In-Geun),우병훈(Woo Byung-Hoon) 한국체육과학회 2011 한국체육과학회지 Vol.20 No.2

The purpose of this study was to analyze kinematic parameters on difficulty degree during travels motion in gymnastics the pommel horse. Ten elite H-university gymnastics players were participated in this study for the comparison. The 3D kinematic data were collected for each group during circle motion. Conclusion is as following. In motion time, saddle group was faster than pommel group. In lateral-medial and anterior-posterior displacement of COG, pommel group was larger than saddle group at event 3. In displacement of left hip joint, saddle group was more extended at event 1, 2. In displacement of right hip joint, pommel group was more extended at event 5. In displacement of left knee joint, saddle group was more extended at event 2. In displacement of right knee joint, saddle group was more extended at event 3. In displacement of left shoulder joint, pommel group was more extended at event 2, saddle group was more extended at event 3. In displacement of right shoulder joint, saddle group was more extended at event 1. In displacement of right elbow joint, saddle group was more extended at event 3.

한국인 남성 운동선수군에서 Osteocalcin 유전자의 C298T 다형성의 분포와 골밀도와의 관계

정인근(In Geun Jung),강병용(Byung Ypng Kang),김지영(Ji Young Kim),오상덕(Sang Duk Oh),하남주(Nam Joo Ha) 대한약학회 2006 약학회지 Vol.50 No.1

Osteocalcin is a vitamin K dependent and bone specific protein which plays an important role in the regulation of bone and calcium metabolism. In this study, we evaluated the relationship between the C298T polymorphism in the osteocalcin gene and bone mineral density (BMD) in Korean young men and their interaction with physical activity. BMDs of the femoral neck and lumbar spine were measured using dual energy X-ray absorptiometry, and the C298T polymorphism in the osteocalcin gene determined using polymerase chain reaction (PCR)-HindⅢ restriction fragment length polymorphism (RFLP) method. We did not observe any significant differences in the femoral neck and lumbar spine BMDs across genotypes of this polymorphism in controls, athletes or combined groups, respectively (P>0.05). Therefore, our data suggest that the C298T polymorphism in the osteocalcin gene is not a suitable genetic marker for the susceptibility to BMD.

운동선수군의 혈청 TGF-β₁ 농도 및 유전자 다형성이 심혈관계 기능에 미치는 영향

정인근(In Geun Jung) 한국사회체육학회 2009 한국사회체육학회지 Vol.0 No.38

The objective of this study was to test whether TGF-β1 gene polymorphism and its serum leve are related to cardiovascular function in our subjects including 34 athletes and 35 controls, respectively. Serum biochemical parameters including TGF-β1 level were assayed by automatic analyzer, and data on cardiac structure and function were measured by M-mode echocardiography, respectively. Genotyping of TGF-β1 gene polymorphism was also performed by SNaPshot method. Pearson correlation revealed the significant positive correlation between serum TGF-β1 level and HR(rest) value in controls, while there were significant negative correlation between TGF-β1 level and LV(mass), SV and CO values in athletes, respectively(p<.05). Also, TGF-β1 gene polymorphism was significantly associated with weight in controls, but with serum HDL-cholesterol level in athletes, respectively(p<.05). Further studies using larger sample size and other polymorphisms in TGF-β1 gene will be needed in order to clarify the influence of TGF-β1 gene on cardiovascular function.

TOYOTA 국제 체조대회 남자 체조선수 마루운동 기술 동향 연구

정인근(Jung In-Geun) 한국체육과학회 2008 한국체육과학회지 Vol.17 No.3

The purpose of this study was to investigate the technical trend through the analysis of item difficulties on eight floor exercise players participating in 2008 Toyota International gymnastics competitions, and following conclusion is drawn as follows. 1. The mean value of item difficulties performed by eight players is 10.63 ± 0.74. The element C was tried most frequently, and the element A was tried by three players of Germany and Columbia. 2. According to the analysis of item difficulties, only three players performed most lowest element A. In the case of element C, eight players performed totally 37 times, and this element is most popular among players. Among element D, eight players performed Any salto backwords with 5/2t technique, while five players performed Any salto fwd. with 2/1t technique. With respect to element E, total three kinds of techniques were performed by players. 3. Elements by connection were performed by six kinds of techniques. The three kinds of connections by C+C, D+B or B+D difficulties or two kinds of connections by C+C+C or B+D+B difficulties were performed. In conclusion, to obtain high scores in International competition, the abilities of players will be improved to be able to high quality of performance above C element.

남자 기계체조 종별선수권대회 철봉 연기내용분석

정인근(Jung, In-Geun) 한국체육과학회 2011 한국체육과학회지 Vol.20 No.5

The aim of this study was to classify and analyze the performance contents of horizontal bar item by each element on a total of fifty five gymnast above top 15, who participated in the 65th National Gymnastics Championship held in the gymnasium of Jecheon-si in Chungcheongbuk-do. They were classified by 3 groups including 15 high school, 15 universiy, and 15 adult gymnastics, and the following results were obtained. 1. Mean start values of study participants were 15.0 ± 0.7 in high school gymnasts, 15.4 ± 0.3 in university gymnasts and 15.9 ± 0.8 in adult gymnasts, respectively, obtaining most values in adult gymnasts. 2. With respect to the analysis of item difficulties, element A was performed 15 times by high school gymnasts, 10 times by university gymnasts, and 9 times by adult gymnasts, respectively. Elemet B was performed 43 times by high school gymnasts, 28 times by university gymnasts, and 29 times by adult gymnasts, respectively. Elemet C was performed 45 times by high school gymnasts, 53 times by university gymnasts, and 49 times by adult gymnasts, respectively. Element D was performed 29 times by high school gymnasts, 40 times by university gymnasts, and 64 times by adult gymnasts, respectively. Element E was performed one time by high school gymnasts, 5 times by university gymnasts, and 10 times (6.l%) by adult gymnasts, respectively. Element F was only performed 2 times by university gymnasts and adult gymnasts, while this element was not performed by high school gymnasts. Element G were not performed by any study participants. 3. With respect to the analysis by each group, "Flying giang swing bwd. with 1/1t (group Ⅰ)", "Endo with 1/1t. thr hdst. in el-grip (group Ⅲ)" and "Watanabe (group Ⅴ)" techniques were performed most frequently by adult gymnasts, "Tkatchev (group Ⅱ)" and "Double salto bwd. str. with 1/1t (group Ⅴ)" techniques were performed most frequently by high school gymnasts, and "E1-grip giant swing" technique was performed most frequently by university gymnasts, respectively.

The Distribution of Haptoglobin Protein Phenotype in University Gymnastic Players

Jung In-Geun(정인근),Kim Dong-Hwa(김동화) 한국체육교육학회 2016 한국체육교육학회지 Vol.21 No.1

합토글로빈은(Hp)은 간에서 합성된 후 순환계로 방출되는 철분대사의 항상성을 조절하는 혈장 단백질의 일종으로 알려져 있다. 따라서 본 연구에서는 대학 남성 대조군과 기계체조 선수군을 대상으로 합토글로빈 단백질 다형성의 분포를 조사함과 함께 철분대사와 관련된 변인들과의 관련성 여부를 조사하고자 하였다. 합토글로빈 단백질 다형성의 표현형 분포는, 폴리아크릴 아미드 겔 전기 영동법과 퍼옥시디아제 염색방법에 의해 분석하였으며, 철분대사와 관련된 변인들은 자동분석법을 이용하여 측정하였다. 합토글로빈 단백질 다형성의 분포는 Hp11, Hp21 및 Hp22가 각각 14.0%, 42.0% 및 44.0%인 것으로 나타났으며, 관찰된 표현형의 빈도는 Hardy-Weinberg 평형으로부터 벗어나지 않았다. 또한, 합토글로빈 단백질 다형성은 대조군과 기계체조 선수군 모두 혈청 합토글로빈 농도와 유의한 관련성을 나타내었으며(P < 0.05) 특히, Hp11 표현형(118.4± 33.4 mg/dL)을 갖는 대상자들은 Hp21(79.5 ± 29.5 mg/dL) 및 Hp22 표현형(62.9 ± 23.3 mg/dL)을 갖는 대상자들에 비해 유의하게 높은 혈청 합토글로빈 농도를 나타내었다. 이러한 결과는 합토글로빈 단백질 다형성이 대조군과 기계체조 선수군을 막론하고 혈철 합토글로빈 농도의 개인차에 유의한 영향을 미친다는 사실을 시사한다. Purpose: Haptoglobin (Hp) is a plasma protein that is synthesized by the liver and released into circulation and which plays an important role in iron metabolism. Methods: In this study, we investigated the distribution of Hp protein polymorphism in a university male control group and gymnast group as well as its correlation with iron metabolism. The phenotype distribution of Hp protein polymorphism was measured by polyacrylamide gel electrophoresis and peroxidase staining methods, and serum iron metabolism-associated parameters were analyzed automatically. Results: The distribution of Hp protein polymorphism was 14.0%, 42.0% and 44.0% for Hp11, Hp21 and Hp22 phenotypes, respectively. The observed phenotype distribution did not deviate from the Hardy-Weinberg equilibrium. There were no statistically significant differences in phenotype and allele frequencies between the normal control group and the gymnasts. There were significant differences in serum Hp level among each phenotype of Hp gene polymorphism (P < 0.05). In particular, the subjects with the Hp11 phenotype (118.4 ± 33.4 mg/dL) had significantly higher serum Hp concentrations than those with the Hp21 phenotype (79.5 ± 29.5 mg/dL) or the Hp22 phenotype (62.9 ± 23.3 mg/dL). This significance was maintained when the subjects were divided into the control group and the gymnast group. Conclusion: Thus, our data suggest that Hp protein polymorphism significantly affects serum Hp level in the both groups

대학운동선수 및 체육학과 학생들의 에스트로젠 수용체-α 유전자 다형성 분포와 생리학적 변인들의 특성차이

강병용(Byung Yong Kang),정인근(In Geun Jung),최승현(Seung Hyun Choi),이강오(Kang Oh Lee),이재구(Jae Koo Lee) 한국발육발달학회 2006 한국발육발달학회지 Vol.14 No.4

Blood pressure, obesity and bone mineral density are multifactorial traits influenced by genetic and environmental factors. The purpose of this study was to clarify the associations among three genetic polymorphisms in the ER-α gene and several clinical phenotypes in college athletes and major students in physical education. Seventy two healthy young men including 34 athletes and 38 controls were recruited in the sudy. Pheripheral blood samples were collected from each individuals and total genomic DNA were isolated from buffy coat Experiments were performed by anthropometric and genetic nalyses. Statistical analysis were carried out using unpaired t-test or one-way ANOVA test for quantitative data such as anthropometrical and biochemical parameters, and x2-test for categorical data such as genotype and allele distributions. The results were produced as follows. Firstly, for PouII RFLP in 5-UTR of ER-α gene, this site was monomorphic in our subjects, and further analysis could not performed. Secondly, in the case of PoaII RFLP in the intron 1 of this gene, this polymorphism was significantly associated with SBP and DBP values in controls (p<.05). Therefore, this polymorphism might be useful as a genetic marker for inter-individual susceptibility in blood pressure regulation. Lastly, XbaI RFLP in the intron 1 of this gene was significantly associated with SBP, DBP, height, weight, BMR and spinal BMC values in young men (p<.05). Therefore, it is likely that this polymorphism is useful as a predictive marker for inter-individual susceptibility to several clinical phenotypes such as blood pressure, obesity and bone mineral density in korean college athletes and major students in physical education.

유도선수의 미토콘드리아 DNA 3316G/A 다형성이 철분대사 변인에 미치는 영향

신혜정(Sin Hye-Jung),강병용(Kang Byung-Yong),정인근(Jung In-Geun),이재구(Lee Jae-Koo) 한국체육과학회 2009 한국체육과학회지 Vol.18 No.1

Mitochondria includes the circular DNA molecules, and the genes in the mitochondrial DNA(mtDNA) are those of the candidates associated with iron metabolism . In this study, we examined the distribution of the 3316G/A polymorphism in the mtDNA between normal controls and judo players, respectively, and compared the influence of this polymorphism on iron metabolism in the both groups. Blood iron parameters were assayed by automatic analyzer, and the 3316G/A polymorphism in the mtDNA analyzed by polymerase chain reaction(PCR) and HaeIII restriction fragment length polymorphism(RFLP) methods. With respect to iron parameters, there were significant differences in several iron parameters between two groups(p<.05). Especially, judo players indicated significantly lower red blood cell(RBC) count, hematocrit, serum iron and transferrin levels compared with normal controls, respectively. Also the A allele of the 3316G/A polymorphism in the mtDNA was only observed in judo players , and this allele significantly associated with serum haptoglobin level in this group(p<.05). Reasonable mechanism for the this association will be identified through further studies.