차세대 셀룰러 이동망에서 셀 경계 성능 향상을 위한 핸드오버 게이트웨이 시스템

정의창(Eui Chang Jung),류현석(Hyun Seok Ryu),강충구(Chung G. Kang) 한국통신학회 2009 한국통신학회 학술대회논문집 Vol.2009 No.11

궤양성 악성 모낭종 1 예

주현중(Hyun Joong Joo),정의창(Eui Chang Chung),김완섭(Wan Sub Kim) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.10

We report a case of trichilemmal carcimoma in a 82-year-old man who resented an ulcerative tumor. Initially, a crusted mass was observed on the scalp and with subsequent removal of the crust, purulent and ulcerative lesion was seen. After treatment with sensitive antibiotics for 8 days, purulent discharge was markedly decreased in the lesion. Histopathologic findings showed clear cells tumor with trichilemmal keratinization. The tumor cells stained positive to PAS, sensitive to diastase and showed negative findings to CEA, EMA and S-100.

단발성 선천성 부정형 세포 조직구종

장경애 ( Kyoung Ae Jang ),정의창 ( Eui Chang Chung ),최지호 ( Jee Ho Choi ),성경제 ( Kyung Jeh Sung ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.3

Indeterminate cell proliferations are rarely described in dermatology literature. Indeterminate cells are characterized by positivity for S-100 protein and CD-la, but are distinguished from Langerhans cells by the absence of Birbeck granules. We present a case of congenital indeterminate cell histiocytoma in a 6-day-old male infant. A Skin examination revealed a solitary, erythematous, 6*6cm, superficially crusted, dome shaped papule on his forehead. A Histopathologic examination showed a dense cellular infiltrate in the dermis, below the atrophic epidermis. Frequently, the nucleus demonstrated a single cleft or crease like the shape of a kidney. These cells showed positivity for S-100 protein. Birbeck granules were not found on electron microscopic examination. (Korean J Dermatol 1998;36(3): 498-501)

당뇨환자에서 Itraconazole 의 효용성과 안정성

최원영(Won Young Chey),김영걸(Young Gull Kim),이애영(Ai Young Lee),정의창(Eui Chang Chung) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.8

N/A Introduction : As the number of diabetics increase with younger onset and longer duration, patients are confronted with higher incidence of diabetes related complications such as distal extremity vasculopathy, neuropathy and various infectious diseases. Such diabetics are more prone to a much higher rate of onychomycosis compared to normal subjects and because this could trigger irreversible consequences, confirmation of fungal involvement should be promptly taken care of. Itraconazole is a widely used drug nowadays and compared to drugs such as griseofulvin and ketoconazole, has many advantages in efficacy, cost, duration of therapy which eventually results in better patient compliance. Objective : Our study was designed to better dictate the usage of itraconazole in diabetics so these patient can receive quality treatment when it is needed. Method : The study consisted of 101 patients with both onychomycosis and diabetes who were receiving treatment in Eulji hospital. They all received 3 pulses of itraconazole and were evaluated for efficacy and safety of their treatment. The patients were observed on routine examinations for 36 weeks and at their visits they were interviewed and received microscopic examinations. Result : Eighty four percent of the patients showed clinical and mycological improvement with 33% of them showing total clearance. There were no hypo-or hyperglycemic events and 17 patients complained of mostly mild side effects such as indigestion. Two patients dropped out of the study due to epigastric pain and peripheral extremity swelling. Conclusion : The use of itraconazole in the treatment of onychomycosis seemed to be effective and relatively safe for diabetics.

편평상피세포암 세포주 AMC-HN-6의 Retinoids 대사에 all-Trans-rectionic Acid Structural Analog인 Sorbic Acid가 미치는 영향

한인석 ( In Seok Han ),김상윤 ( Sang Yoon Kim ),문기찬 ( Kee Chan Moon ),성경재 ( Kyung Jeh Sung ),최지호 ( Jee Ho Choi ),고재경 ( Jai Kyoung Koh ),정의창 ( Eui Chang Chung ) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.8

Retinoids는 피부과 질환인 건선, 여드름, 피부노화, 주름살제거 등의 치료에 사용되는 이외에도 급성 전골수구성 백혈병(acute promyelocytic leukemia)의 치료제, 두경부암의 치료 후 발생하는 이차 원발암의 방지 및 암의 전구질환인 백판증(leukoplakia)이 암으로 진행되는 것을 억제하는 등 악성종양의 치료제로도 이용되고 있다. Retinoids의 치료 효과를 얻기 위해서는 retinoids를 세포내에서 일정한 농도 이상으로 장기간 유지하는 것이 필요한데 retinoids를 투여하면 이를 대사시키는 효소가 유도되고 그 결과로 retinoic acid가 매우 빨리 대사되어 비활성화되는 문제점이 있다. 세포내 all-trans retinoic acid(ATRA) 농도를 결정하는 기전은 세포에 의한 all-trans retinoic acid(CRABP)의 발현정도, cytochrome P450을 포함한 all-trans retinoic acid 대사에 관여하는 효소들의 활성도 등 여러 가지 요소들이 관여하고 있다. All-trans retinoic acid에 의해서 발현이 유도되는 all-trans retinoic acid specific cytochrome P450은 all-trans retinoic acid의 대사에 관여하는 가장 중요한 효소중의 하나로 all-trans retinoic acid를 all-trans-4-hydroxy-retinoic acid(4-OH-RA), all-trans -18-hydroxy-retinoic acid(18-OH-RA) 및 all-trans-4-oxo-retinoic acid(4-OXO-RA) 등 극성대사산물(polar metabolites)로 대사시킴으로써 all-trans retinoic acid의 세포내 농도를 저하시키고 그 결과로 all-trans retinoic acid의 생물학적 효과를 감소시켜서 임상적 사용에 장애요인으로 작용한다. 따라서 all-trans retinoic acid specific cytochrome P450을 선택적으로 억제하는 약제의 개발은 all-trans retinoic acid의 임상적 효과를 유지하거나 강화하는데 필요하며 세포내 내인성 all-trans retinoic acid의 농도를 증가시켜줌으로써 all-trans retinoic acid의 투여에서 오는 부작용들도 감소시켜줄 수 있으므로 최근에 많은 연구가 이루어지고 있다. 최근에 liarozole과 ketoconazole이 세포내 all-trans retinoic acid 대사에 관여하는 cytochrome P450을 억제한다는 것이 밝혀졌으며 두 약제를 실험동물에 투여하면 all-trans retinoic acid 투여 없이도 혈중 all-trans retinoic acid 농도를 증가시킨다는 보고도 있다. 저자들은 이전의 연구결과를 통해서 all-trans retinoic acid 분자의 꼬리부분(carboxyl-terminus)은 정전기적힘(electrostatic force)에 의해 all-trans retinoic acid specific cytochrome P450의 특정 부위에 결합하며 all-trans retinoic acid 분자의 머리부분(β-cyclogeramylidene ring)은 소수성 결합력(hydrophobic force)에 의해서 cytochrome P450의 활성 부위에 결합할 가능성을 이미 보고한 바 있다. 이에 따라 두경부 편평상피세포암 환자들에서 만든 8개의 AMC-HN 편평상피세포암 세포주들 중에서 all-trans retinoic acid에 의해서 P450이 현저하게 유도되는 AMC-HN-6 편평상피세포암 세포주를 이용해서 all-trans retinoic acid 분자의 꼬리부분과 구조적으로 유사한 sorbic acid(Fig. 1)가 all-trans retinoic acid specific cytochrome P450에 결합되어 all-trans retinoic acid의 대사에 어떠한 영향을 미치는가를 알아보기 위해서 본 연구를 시행하였다. Background:All-trans-retinoic acid metabolism by cytochrome P450 is one of the major mechanisms that can regulate the level of retinoids in cells. Therefore, enhanced metabolism of all-trans retinoic acid by all-trans retinoic acid induced cytochrome P450 would probably decrease the therapeutic effects of active retinoids. We previously reported that the tail of all-trans retinoic acid(the carboxyl-terminus) may bind to a binding site of cytochrome P450 in part by electrostatic forces, and the head of RA(the β-cyclogeranylidene ring) may bind to an active site of cytochrome P450 in part by hydrophobic forces. It is very interesting to study the interactions between the RA binding site of cytochrome P50 induced by all-trans retinoic acid and the structural analogs of all-trans retinoic acid and its effects of RA metabolism. Objective:The purpose of this study is to examine the effects of sorbic acid, that has a similar structure with the tail of all-trans retinoic acid, on RA metabolism in head-neck squamous cell carcinoma cell line AMC-HN-6 which showed a much increased induction of cytochrome P450 by all-trans retinoic acid. Methods:We examined the effects of sorbic acid on RA metabolism in all-trans retinoic acid specific cytochrome P450-inducible AMC-HN-6 cell line using cytochrome P450 enzyme assay with acid were separated by thin layer chromatography and the radioactivity was measured by β-counter. Metabolic activity was expressed as the percentage of total radioactivity of polar metabolites. Results:The results are summurized as follows: 1. RA metabolism of AMC-HN-6 cell line was inhibited by actinomycin D and cyclohexamide and was also inhibited by ketoconazole, the cytochrome P450 inhibitor, in a concentration-dependent manner. 2. Cytochrome P450-mediated oxidation was induced by all-trans retinoic acid, 13-cis-RA, 9-cis-RA, and retinal, but not by retinol in AMC-HN-6 cell line. 3. Sorbic acid inhibited RA metabolism of AMC-HN-6 cell line in a concentration-dependent manner when the enzyme assay was performed on microsomal protein but could not inhibit RA metabolism in total cell lysate enzyme assay. Conclusion:The conversion of all-trans retinoic acid to polar metabolites is inhibited by sorbic acid in microsomal enzyme assay of AMC-HN-6 cell line, but not in total cell assay. These results suggest that sorbic acid can bind to the active binding site of cytochrome P450 but binding affinity of sorbic acid to RA binding molecules such as CRABP-Ⅰ,-Ⅱ, RARs, RXRs may be stronger than that of sorbic acid to cytochrome P450.(Korean J Dermatol 1999;37(8):992∼1000)

에크린 혈관종성 과오종 1예

최준,정의창 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.7

Eccrine angiomatous hamartoma is a rare condition characterized histologically by increased numbers of eccrine structures and numerous capillary channels. It may be congenital or appear later in childhood. It rarely arises during puberty or adulthood. We report a case of eccrine angiomatous hamartoma on the left shoulder in a 34-year-old man. The patient presented with asymptomatic, dome-shaped, about 3 × 2.5 cm, reddish telangiectatic nodule on the left shoulder. Histological examination showed an increased numbers of eccrine sweat glands and vascular structures. (Korean J Dermatol 2003;41(7) : ?951~953)

극세포해리성 이각화성 표피모반 1예

주현중,정의창,이애영 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.8

Acantholytic dyskeratosis is seen in Darier's disease, transient acantholytic dermatosis and warty dyskeratoma. It is also occasionally observed incidental histological finding in pityriasis rosea, pityriasis rubra pilaris and is occasionally found in linear epidermal nevus. A 10-month-old boy presented linear hyperkeratotic plaques on the right sole and the left hand along with erythematous scaly papules on the posterior neck, the left axilla and the face. Histological findings showed acantholytic dyskeratosis with common histopathological findings of epidermal nevus. Acantholytic dyskeratosis is an occasional finding in linear epidermal nevus, but has been rarely reported in an infant(5 cases reported in 20 years). We report a case of linear epidermal nevus with acantholytic dyskeratosis in an infant.

과각화성 혈관반 1예

주현중,김영걸,정의창,이애영 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.9

The tens, hyperkemtotic vascular stains is a peculiar form of capillary malformations commonly called as giokeratoma or verrucous hemangioma. Hyperkeratotic vascular stains present at birth and consist of vascular dilatation and epidermal proliferation manifested as hyperkeratosis. acanthosis, and papillomatosis. Some authors insisted that angiokeratoma and verrucous hemangioma are not proper terms because they are not true tumors but malformations due to their lack of endothelial proliferation. Wide and deep excisions have been preferred as curative therapy. The patient was a 9-year-old girl with multiple. linear, bluish black colored, hyperkeratotic plaques on her let lower leg. The red patches at birth had slowly enlarged and had become verrucous. Some satellite lesions had also developed. Histopathologic examination showed dilated capillaries filled with red blood cells in the papillary dermis and subcutaneous fat layer. The carbon dioxide laser was used to remove hyperkeratotic plaques. The flash-lamp pumped-pulsed dye laser and intense noncoherent pulsed light were used to remove satellite lesions and vascular lesions for a year. One of the lesions resistant to laser therapy was completely excised. Because multiple hyperkeramtic vascular stains are often impossible to be excised completely, laser therapy may be tried as the first choice.

혈전정맥염이 동반된 재발성 다발성 연골염 1예

문기찬,성경제,최지호,정의창,고재경 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.1

Relapsing polychondritis is a rare systemic disorder characterized by recurrent inflammation of cartilaginous structures, the eye, the audiovestibular and cardiovascular systems. Skin lesions, found in 17% to 38% of cases, include leukocytoclastic vasculitis, livedo reticularis, erythema nodosum, erythema multiforme, keratoderma blenorrhagicum, psoriasis, polyarteritis nodosa, thrombophlebitis and other various conditions. We report a 65-year old man with relapsing polychondritis and associated thrombophlebitis. The patient was treated with oral dapsone and systemic steroid with complete resolution of symptoms. However, the patient died of severe intractable pneumonia.

광선각화증양 및 지루각화증양 태선화 각화증 2예

장경애,문기찬,성경제,최지호,고재경,정의창 대한피부과학회 1998 大韓皮膚科學會誌 Vol.36 No.6

Lichenoid keratosis (LK), a lichen planus-like keratosis, is a rather frequent skin disorder that has some histological features similar to lichen planus. However, the classification system for LK has not been settled. We report two cases of LK and propose a new classification for LK correlating with clinicohistopathological findings.