PTBD 관을 통한 담낭암의 피부 착상 전이 1 예

고재경 ( Jai Kyoung Koh ),문기찬 ( Kee Chan Moon ),최지호 ( Jee Ho Choi ),김경진 ( Kyoung Jin Kim ),김은성 ( Eun Sung Kim ),성경제 ( Kyung Jeh Sung ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.5

The occurrence of metastatic center from the gallbladder to the skin is uncommon and only less than ten cases of distant cutaneous metastases of gallbladder cancer have been reported in literatures. However. cutaneous implantation metastases of gallbladder cancer following laparoscopic cholecystectomy or percutaneous biliary catheter have been described more commonly than distant metastasis. We present herein a case of cutaneous implantation metastasis of gallbladder adenocarcinoma at the sites of percutaneous transhepatic biliary drainage(PTBK).

제57차 추계학술대회 및 총회 : 학술대회장 인사

고재경 ( Jai Kyoung Koh ) 대한피부과학회 2005 초록집 Vol.43 No.20

제57차 추계학술대회 및 총회 : 학술대회장 인사

고재경 ( Jai Kyoung Koh ) 대한피부과학회 2005 대한피부과학회 학술발표대회집 Vol.57 No.2

Micropapular Sarcoidosis 1 예

고재경 ( Jai Kyoung Koh ),문기찬 ( Kee Chan Moon ),최지호 ( Jee Ho Choi ),김경진 ( Kyoung Jin Kim ),배지영 ( Gee Young Bae ),서호석 ( Ho Seok Suh ),성경제 ( Kyung Jeh Sung ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.5

Cutaneous sarcoidosis occurs in 20-25% of systemic sarcoidosis and be presented without other organ involvement. Most frequent clicical are maculopapule, nodule, plaque, subcutaneous mokule, infiltrative scar and lupus pernio, but uncommon forms including ulcer, alopecia, hypopiminted and micropapular type have been described. Micropapular type is a rare from of cutaneous sarcoidosis with good prognosis. We present a case of generalized micropapular sarcoidosis without other organ involvement

Short Report / 모낭성 피지선 아포크린 분화를 보인 연골양 한관종 1예

고재경 ( Jai Kyoung Koh ),노기영 ( Kee Young Roh ),양정은 ( Jeong Eun Yang ),김형옥 ( Hyung Ok Kim ),강석진 ( Suk Jin Kang ) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.12

Chondroid syringoma is referred as mixed tumor because it has epithelial structure and mesenchymal elements. Mixed tumors could be divided into two distinct types, eccrine and apocrine. Mixed tumor with follicular, sebaceous and apocrine differentiation is considered as an expression of the common embryologic origin of elements of the folliculosebaceous-apocrine unit. A 32-year old man presented with an asymptomatic firm erythematous nodule on the left cheek. Histologically, it showed typical features of chondroid syringoma with tubules exhibiting branching and cystic dilatation in the myxoid and chondroid stroma. Our case is unique in that the tumor arose from follicular infundibulum with follicular, sebacesous and apocrine differentiation. (Korean J Dermatol 2000;38(12): 1673~1676)

한국에서의 호산구성 농포성 모낭염의 임상 및 병리조직학적 연구

장경애 ( Kyoung Ae Jang ),고광진 ( Gwang Jin Koh ),김성범 ( Sung Bum Kim ),최지호 ( Jee Ho Choi ),성경제 ( Kyung Jeh Sung ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.10

Background:Eosinophilic pustular folliculitis (EPF) is a rare chronic disease of unknown cause with pruritic papulopustular lesions and a prominent eosinophilic infiltrate. Objective:The purpose of this study was aimed at evaluating the clinical and histopathological features of EPF.Methods:The hospital charts and histopathologic slides of 8 patients with EPF diagnosed at Asan Medical Center from 1989 to 1998 were reviewed. We also reviewed the previously published reports of 10 patients with EPF in Korea. Results:Nine male and nine female patients were enrolled in this study. The mean age at diagnosis of EPF was 26 years in men and 27 years in women. All the patients complained of mild to severe pruritus. EPF was presented with follicular papules or pustules, except 2 patients, who presented with erythematous plaques free of papules or pustules. All the patients showed the typical histopathological findings of EPF. Laboratory investigation showed hypereosinophilia in 73% of patients (11/15). The levels of blood eosinophils tended to decrease as cutaneous lesions resolved. EPF was improved with dapsone in 12 patients and the rest were treated with topical or systemic steroid or antihistamines.Conclusion:EPF may be more common in Korea than can be suspected. Because EPF showed characteristic histopathological findings and EPF responds well to dapsone, the knowledge with this disease may be important to diagnose and treat it. (Korean J Dermatol 2000;38(10):1287~1293)

홍피증 환자 39명에 대한 임상 소견 및 원인 규명에 관한 연구

장경애 ( Kyoung Ae Jang ),안세진 ( Se Jin Ahn ),최지호 ( Jee Ho Choi ),성경제 ( Kyung Jeh Sung ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.5

Background: Erythroderma may result from different causes. Almost all the published original clinical series of erythroderma originated from western countries. Objectives: The objective was to evaluate various causes of erythroderma in our environment, frequency, clinical and laboratory findings, and patient evolution. Method: We reviewed the clinical and laboratory findings including biopsy materials of 39 patients diagnosed as erythroderma and treated during the last 9 years (from 1989 to 1998). (continue...) (Korean J Derrnatol 1999;37(5): 598-602)

건선에서의 피부 림프구 관련 항원 ( Cutaneous Lymphocyte-Associated Antigen ) 의 발현

장경애 ( Kyoung Ae Jang ),최지호 ( Jee Ho Choi ),성경제 ( Kyung Jeh Sung ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.10

Background:Arbutin is a glycosylated hydroquinone found at high concentration in certain plants capable of surviving extreme and sustained dehydration. It has been suggested as an inhibitory compound of melanogenesis. Objective:The purpose of this study was to investigate the effect of arbutin on melanogenesis in cultured human melanocytes and to evaluate the effectiveness of arbutin in patients with melasma. Methods:I. In vitro study:we examine the cell number, SRB assay, tyrosinase activity, and melanin contents of cultured human melanocytes in control(absence of arbutin) and experimental groups (presence of 10-5 M, 10-4 M, and 10-3 M arbutin). II. In vivo study:6 patients with melasma applied a 3 % arbutin solution twice daily for 8 weeks. Clinical response to treatment was evaluated by patients' subjective assessment and MASI(Melasma Area and Severity Index) score after 8 weeks of treatment. Results:I. In vitro study 1. The number of melanocytes was decreased in groups treated with 10-5 M, 10-4 M, 10-3 M arbutin for 2 days and 10-4 M, 10-3 M arbutin for 7 days. 2. On SRB assay, the proliferation of melanocytes was decreased in groups treated with 10-5 M, 10-4 M, 10-3 M arbutin for 2 days and for 7 days. 3. Tyrosinase activity was decreased in groups treated with 10-4 M, 10-3 M arbutin for 2 days and 10-5 M, 10-4 M, 10-3 M arbutin for 7 days. 4. The melanin contents were decreased in group treated with 10-3 M arbutin for 7 days. II. In vivo study 1. On patients'subjective assessment, one showed moderate improvement, one showed mild improvement, and the other four showed no change. 2. On MASI score, there was less than 10% improvement in all 6 patients. 3. Side effects were not found in all 6 patients.Conclusion:Although arbutin showed an inhibitory effect on cell proliferation, tyrosinase activity, and melanin synthesis in cultured human melanocytes, there was no significant effect of depigmentation in the patients with melasma. (Korean J Dermatol 2000;38(10):1303~1308)

Multiple Painful Subcutaneous Nodules on the Face and Extremities

장경애 ( Kyoung Ae Jang ),최지호 ( Jee Ho Choi ),성경제 ( Kyung Jeh Sung ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ),권영미 ( Young Mi Kwon ),지현숙 ( Hyun Sook Chi ) 대한피부과학회 1998 대한피부과학회 학술발표대회집 Vol.50 No.2

기저세포암의 임상 및 병리조직학적 연구

장경애 ( Kyoung Ae Jang ),최지호 ( Jee Ho Choi ),문기찬 ( Kee Chan Moon ),고재경 ( Jai Kyoung Koh ),성경제 ( Kyung Jeh Sung ) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.12

Background:Basal cell carcinomas(BCC) are seen almost on hair-bearing skin, especially on the face. There have been a few reports about BCC in Korea. Objective:The purpose of this study was to investigate the clinico-pathological characteristics of BCC. Methods:A total of 95 patients with BCC were enrolled in this study. The medical records and histopathological slides of BCC diagnosed at Asan Medical Center from 1989 to 1999 were reviewed. We classified our cases based on the predominant histopathological findings as follows; solid, adenoid, pigmented, superficial multicentric, clear cell, keratotic, morpheic, basosquamous, trichoblastoma-like, fibroepithelioma of Pinkus-like. Results: 1. The male- female ratio was 1.1:1. The mean age at diagnosis was 64.8 years in male patients and 66.9 years in female patients. 2. The clinical diagnoses were BCC(76.8%), melanoma, actinic keratoses, seborrheic keratosis, and so on. 3. The face was the most preferred site, especially nose(41.2%). Solid, adenoid, keratotic, morpheic, and basosquamous types developed exclusively on the face, while superficial multicentric types did not show on the favored sites. 4. Pruritus of the lesion, easy bleeding, and rapid increment of the size were the main complaints. 5. Solid type was the most frequent type(30%). Three cases of BCC arising from organoid nevus were included. In two cases of organoid nevus-origin, fibrofolliculoma of Pinkus-like histopathological findings were noted. 3 cases were recurrent after laser therapy or simple curettage. 6. Ninety two cases were successfully treated with wide excision. One case was treated with radiation therapy, but the lesion persisted. The lesion was widely excised without recurrence. Systemic metastases were absent in our study. (Korean J Dermatol 2000;38(12):1575~1582)