백서 두개골 결손부에서 키토산의 골조직 재생 유도 효과

정의원,서종진,최성호,조규성,채중규,김종관,Jung, Ui-Won,Suh, Jong-Jin,Choi, Seong-Ho,Choi, Kyoo-Sung,Chai, Jung-Kiu,Kim, Chong-Kwan 대한치주과학회 2000 Journal of Periodontal & Implant Science Vol.30 No.4

The major goals of periodontal therapy is the functional regeneration of periodontal supporting structures already destructed by periodontal disease as well as the reduction of signs and symptoms of progressive periodontal disease. There have been many efforts to develop materials and therapeutic methods to promote periodontal wound healing. There have been increasing interest on the chitosan made by chitin. Chitin is second only to cellulose as the most abundant natural biopolymer. It is a structural component of the exoskeleton of invertebrates(e.g., shrimp, crabs, lobsters), of the cell wall of fungi, and of the cuticle of insects. Chitosan is a derivative of chitin made by deacetylation of side chains. Many experiments using chitosan in various animal models have proven its beneficial effects. The aim of this study is to evaluate the osteogenesis of chitosan on the calvarial critical size defect in Sprague Dawley rats. An 8 mm surgical defect was produced with a trephine bur in the area of the midsagittal suture. The rats were divided into two groups: Untreated control group versus experimental group with 50mg of soluble chitosan gel. The animals were sacrificed at 2, 4 and 8 weeks after surgical procedure. The specimens were examined by histologic, histomorphometric and radiodensitometric analyses. The results are as follows: 1. The length of newly formed bone in the defects was $102.91{\pm}25.46{\mu}m$, $219.46{\pm}97.81{\mu}m$ at the 2 weeks, $130.95{\pm}39.24{\mu}m$, $212.39{\pm}89.22{\mu}m$ at the 4 weeks, $181.53{\pm}76.35{\mu}m$ and $257.12{\pm}51.22{\mu}m$ at the 8 weeks in the control group and experimental group respectively. At all periods, the means of experimental group was greater than those of control group. But, there was no statistically significant difference between the two groups. 2. The area of newly formed bone in the defects was $2962.06{\pm}1284.48{\mu}m^2$, $5194.88{\pm}1247.88{\mu}m^2$ at the 2 weeks, $5103.25{\pm}1375.88{\mu}m^2$, $7751.43{\pm}2228.20{\mu}m^2$ at the 4 weeks and $8046.20{\pm}818.99{\mu}m^2$, $15578.57{\pm}5606.55{\mu}m^2$ at the 8 weeks in the control group and experimental group respectively. At all periods, the means of experimental group was greater than those of control group. The experimental group showed statistically significant difference to the control group at the 2 and 8 weeks. 3. The density of newly formed bone in the defects was $14.26{\pm}6.33%$, $27.91{\pm}6.65%$ at the 2 weeks, $20.06{\pm}9.07%$, $27.86{\pm}8.20%$ at the 4 weeks and $22.99{\pm}3.76%$, $32.17{\pm}6.38%$ at the 8 weeks in the control group and experimental group respectively. At all periods, the means of experimental group was greater than those of control group. The experimental group showed statistically significant difference to the control group at the 2 and 8 weeks. These results suggest that the use of chitosan on the calvarial defects in rats has significant effect on the regeneration of bone tissue in itself

Bisphosphonates induced osteonecrosis of the jaw의 기전, 예방, 위험 평가 및 치료 방법

박정철,정의원,김창성,조규성,채중규,김종관,최성호,Park, Jung-Chul,Jung, Ui-Won,Kim, Chang-Sung,Cho, Kyoo-Sung,Chai, Jung-Kiu,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 2009 Journal of Periodontal & Implant Science Vol.39 No.1

Purpose: Bisphosphonates are drugs used to suppress osteoclastic activity and to treat osteoporosis, Paget's disease of bone and bone metastasis. The purpose of this report is to review the literatures on bisphosphonates use that could affect bone healing and cause osteonecrosis of the jaws. Materials and methods: Medline research was carried out to find relevant articles on bisphosphonates and osteonecrosis of the jaw. Results: Oral administration of bisphosphonates is reported to decrease the risk of adverse bone outcomes. On the contrary, IV bisphosphonates is known to significantly increase the risk. Prevention of the osteonecrosis of the jaw is primary concern before usage. If the adverse bone reaction takes place, proper management and treatments are required to alleviate pain of patients and prevent further progression of necrosis. Conclusion: Case reports of bisphosphonates induced osteonecrosis of the jaw are increasing. Dentists and physicians should be aware of the higher frequency of osteonecrosis of the jaw in patients receiving IV bisphosphonates and be prepared to prevent and cope with adverse bone reaction.

하악에 식립된 Xive implant 환자의 분포 및 식립부 유형과 생존율

장인권,정의원,김창성,심준성,조규성,채중규,김종관,최성호,Jang, In-Kwon,Jung, Ui-Won,Kim, Chang-Sung,Shim, Joon-Sung,Cho, Kyoo-Sung,Chai, Jung-Kiu,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.2

This study is an analysis of distribution of patients who installed Xive implant in Yonsei University Hospital and types of implant site for about 2 years recall check and cumulative survival rate. 41 implant were used in this study. It shows the conclusion below. 1. Patients at the age of 40s and 50s were 60% of all implant cases and average number of implant was 2.4(man), and 1.9(woman). All cases were operated on mandible, 3 implants on anterior region and 38 implants on posterior region. 2. The major cause of tooth loss is dental caries(48.8%), followed by periodontal disease. 3. Most distribution of bone qaulity for mandibular implant site was type II(65.8%) and bone quantity was type B(75.6%). 4. The majority of implants were those of 11, 13mm in length(95%) and regular diameter in width (64%). 5. The 41(19 persons) Xive implants that were placed in the mandibular anterior and posterior region were all survival and showed a 100% 2 year cumulative survival rate. The results provided us with basic data on patient type, implant distribution, bone condition, and survival rate. We wish that our results coupled with other research data helps assist in the further study for better implant success rates, etc.

흡연 환자에서의 치주치료와 임플란트 수술

박정철(Jung-Chul Park),정의원(Ui-Won Jung),조규성(Kyoo-Sung Cho),황지완(Ji-Wan Hwang),최성호(Seong-Ho Choi),김창성(Chang-Sung Kim) 대한치과의사협회 2011 대한치과의사협회지 Vol.49 No.10

Cigarette smoking is a significant risk factor for periodontaldiseases and implant treatments. Smoking control is regarded as a key to the success of dental treatments as well as the well-being of the patients. The aim of this study was to reviewthe effects of smoking on periodontal health, and the results of periodontal therapy and implant treatments. Also, in vitro, microbiological, immunological and epidemiological relationships were studied. In vitro studies show that smoking interferes with normal healing process and increased tissue destruction. There is still controversy on the population of microbes of smokers. Smokers showed significantly less gingival inflammation and bleeding on probing compared with non-smokers. After periodontal treatments, a compromised clinical outcome was noted for smokers in terms of pocket depth reduction and gain in attachment levels. In conclusion, data from in vitro, epidemiological, cross-sectional and case?control studiesstrongly suggest that quitting smoking is beneficial to patients before periodontal and implant treatments.

Original Article 1 - 합성골 이식재인 Osteon$^{(R)}$을 이용한 상악동 거상술-임상적, 방사선 계측학적 연구

차재국,정의원,김민수,엄유정,김창성,조규성,최성호,정성민,Cha, Jae-Kook,Jung, Ui-Won,Kim, Min-Soo,Um, Yoo-Jung,Kim, Chang-Sung,Cho, Kyoo-Sung,Choi, Seong-Ho,Chung, Sung-Min 대한치과의사협회 2010 대한치과의사협회지 Vol.48 No.1

Purpose: The aim of this study was to evaluate 1 year cumulative survival rate of implants placed on augmented sinus using Osteon$^{(R)}$, bone graft material and to assess height of the grafted material radiographically. Material and Methods: 10 maxillary sinuses were augmented in 10 patients and 25 implant fixtures were installed simultaneously or after 6 months healing period. The height of the sinus graft material was measured using panoramic images immediately after augmentation and up to 19 months subsequently. Changes in the height of the sinus graft material were calculated with respect to implant length and original sinus wall height. Results: The cumulative survival rate was 100% in all 25 implants. Additionally, normal healing process without any complication was observed in all patients. The mean crown/Implant ratio was 1.25. The mean marginal bone loss was 0.95mm and the mean resorption rate of Osteon$^{(R)}$ was 0.05mm/month. The fastest resorption site of Osteon$^{(R)}$ is the first molar area. The grafted material was well maintained in sinus and decreased slightly over 1 year. Conclusion: In conclusion, It can be suggested that Osteon$^{(R)}$ may have predictable result when it was used as a grafting material for sinus floor augmentation.

접촉 유한요소모델을 이용한 미니 임플란트의 초기 응력분포 연구

윤현주,정의원,이종석,김창성,김정문,조규성,김종관,최성호,Yoon, Hyun-Joo,Jung, Ui-Won,Lee, Jong-Suk,Kim, Chang-Sung,Kim, Jung-Moon,Cho, Kyoo-Sung,Kim, Chong-Kwan,Choi, Sung-Ho 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.4

Mini implants had been used provisionally for the healing period of implants in the beginning. But it becomes used for the on-going purpose, because it is simple to use, economic and especially suitable for the overdenture. But there is few studies about the stability of mini implants, that is most important factor for the on-going purpose, and particularly the implant parameters affecting the initial stability. The purpose of this study was to evaluate the stress and the strain distribution pattern of immediate-loaded screw type orthodontic mini-implant and the parameters affecting the initial stability of immediate-loaded mini-implant. Two dimensional finite element models were made and contact non-linear finite element analysis was performed. The magnitude and distribution of Von Mises stresses were evaluated. The obtained results were as follows: 1. The stress was concentrated on the thread tip of an implant in the cortical bone. 2. The direction of load is the most important factor for the stress distribution in cortical bone. 3. The diameter of an implant is the most important factor for the stress distribution in the trabecular bone. In conclusion, if the horizontal load vector is successfully controlled, mini-implants, which diameter is under 3mm, can be used for the on-going purpose.

Human immunodeficiency virus 감염과 치주 질환의 상관관계, 진단 및 처치에 관한 문헌 고찰

박정철(Jung-Chul Park),엄유정(Yoo-Jung Um),정의원(Ui-Won Jung),김창성(Chang-Sung Kim),조규성(Kyoo-Sung Cho),채중규(Jung-Kiu Chai),김종관(Chong-Kwan Kim),최성호(Seong-Ho Choi) 대한치과의사협회 2009 대한치과의사협회지 Vol.47 No.8

Purpose: Infection with HIV-1 virus has become a critical worldwide public health problem. The oral complications of HIV infection with its progression of Impairment of the host response to combat infection present unique challenges to the periodontists. Material and Methods : Medline research was carried out to find relationship of the progression of HIV infection to the occurrence of oral lesions including the HIV-related periodontal diseases. Results; The linear gingival erythema, necrotizing ulcerative periodontitis, necrotizing ulcerative gingivitis and oral candidiasis are common lesions in HIV-infected individuals. The linear gingival erythema and necrotizing ulcerative periodontitis lesions in HIV-infected subjects were found to have a similar microbiological profile. There are several general considerations in the periodontal management of the HIV-infected patient with or without periodontal disease. The altered immunity and host response in patients with HIV infection may also affect the incidence and severity of other common forms of periodontal disease not associated with HIV infection. Conclusion: Periodontal diseases in HIV-infected individuals present unique challenges in diagnosis, monitoring, treatment and maintenance. Therefore exact HIV staging, geographic location, antiviral and antimicrobial therapies and oral habits should be taken into consideration when treating HIV-infected patients.

Full mouth disinfection therapy의 단기간 임상 효과 연구

조익현,정의원,차정헌,김중수,이대실,김창성,김종관,최성호,Cho, Ik-Hyun,Jung, Ui-Won,Cha, Jeong-Heon,Kim, Joong-Su,Lee, Dae-Sil,Kim, Chang-Seong,Kim, Chong-Kwan,Choi, Seong-Ho 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.3

The aim of this study is to determine whether full-mouth disinfection therapy(FMT) in our clinical setting would show better improvement of clinical parameters than partial mouth disinfection therapy(PMT) in chronic periodontitis and aggressive periodontitis patients. Among 12 patients, 6 were treated FMT and other 6 were treated PMT. Clinical parameters were calculated 3 months and 6 months after initial therapy. 1. There were no statistically significant differences between FMT and PMT in the reduction rate of bleeding on probing after 3 months, 6 months 2. Initial probing depth was 4-6mm, the mean probing depth after 3 months was 2.2mm vs 2.5mm(FMT vs PMT), after 6 months was 2.4mm vs 2.8mm. This was significantly lower in the FMT groups. 3. Initial probing depth was ${\geqq}$ 7mm, the reduction rate of mean probing depth during first 3 months was 4.8mm vs 4.1mm(FMT vs PMT), and 3 to 6 months was 0.5mm vs 0.3mm. This was significantly larger in the FMT groups. 4. Initial probing depth was 4-6mm, the mean clinical attachment level after 3 months was 2.3mm vs 2.7mm(FMT vs PMT), after 6 months was 2.7mm vs 3.0mm. This was significantly lower in the FMT groups. 5. Initial probing depth was ${\geqq}$ 7mm, the reduction rate of mean probing depth during first 3 months was 4.0mm vs 3.0mm(FMT vs PMT), and 3 to 6 months was 0mm vs -0.1mm. This was significantly larger in the FMT groups. Although the results provided us with succeccful clinical improvement in aggressive periodontitis, further research is needed to prove its additional benefit in the treatment of chronic periodontitis

치과 진료실에서의 신속 구강 점막 도말 HIV 항체 검사에 대한 태도 및 지식에 관한 연구

박정철(Jung-Chul Park),김용태(Yong-Tae Kim),정임희(Im-Hee Jung),엄유정(Yoo-Jung Um),정의원(Ui-Won Jung),김창성(Chang-Sung Kim),조규성(Kyoo-Sung Cho),채중규(Jung-Kiu Chai),김종관(Chong-Kwan Kim),최성호(Seong-Ho Choi) 대한치과의사협회 2009 대한치과의사협회지 Vol.47 No.5

Purpose: The aim of this study was to evaluate the patient’s and dentist’s perspective and knowledge on rapid human immunodeficiency virus screening test in dental setting. Material and Methods: In March 2009, 100 patients and 100 dentists at College of Dentistry, Yonsei University were provided an attitude assessment survey. Results: Results were analyzed for acceptance of testing and potential barriers. 94% of patients agreed to take a rapid HIV screening test and 77% of dentists were willing to provide the test to their patients. Also the current knowledge state of patients and dentists on HIV infection was not accurate as expected. Conclusion: Overall, dental clinic patients widely accepted the offer of rapid oral HIV screening. Rapid HIV screening test in the dental setting can be an important option to increase the number of individuals who know their HIV status.

Bone Added Osteotome Sinus Floor Elevation with Simultaneous Placement of Branemark Ti-Unite and ITI SLA implants

강남원,정의원,최성호,조규성,채중규,김종관,김창성,Kang, Nam-Won,Jung, Ui-Won,Choi, Seong-Ho,Cho, Kyoo-Sung,Chai, Jung-Kiu,Kim, Chong-Kwan,Kim, Chang-Sung The Korean Academy of Periodontoloy 2005 Journal of Periodontal & Implant Science Vol.35 No.3

1. 목적 Osteotome 상악동거상술(Bone Added Odteotome Sinus Floor Elevation ; 이하 BAOSFE) 과 동시에 식립한 임프란트($Br{\aa}nemark$, ITI)의 예상 생존율에 대해 현재까지 정확히 알려진 바는 없었으며, $Br{\aa}nemark$ Ti-Unite 과 ITI SLA 임프란트의 표면에 대한 비교 연구 또한없었다. 이번 연구는 BAOSFE 술식과 동시에 식립한 $Br{\aa}nemark$ Ti-Unite 과 ITI SLA 임프란트의 임상 결과를 비교, 평가하고 초기 치유기간 동안의 이식골 높이의 변화를 방사선학적으로 관찰하여 두 가지 임프란트 시스템을 비교해 보고자 한다. 2. 방법 위축된 상악 구치부를 갖는 22명의 환자를 대상으로, BAOSFE술식과동시에 $Br{\aa}nemark$ Ti-Unite(11명, 13 임프란트)임프란트와 ITI SLA(11명, 18 임프란트)임프란트를 식립하였다. 수술 전, 임프란트 식립 직후, 술후 6개월의 파노라마 방사선 사진을 촬영하여 비교 및 평가에 사용하였다. 각 임프란트 시스템의 생존율을 측정하고, 술전 상악동저 높이와 식립된 임프란트 길이를 참고하여 이식골 높이의 방사선학적 변화를 평가하였다. 3. 결과 평균12개월의 추적기간 결과, $Br{\aa}nemark$ Ti-Unite 임프란트의 생존율은 100%(13/13 임프란트)이었으며, ITI SLA 임프란트의 생존율은 94.4%(17/18 임프란트)이었다. 초기 치유 기간인 6개월 동안 평균 이식골 높이의 감소는 $Br{\aa}nemark$ Ti-Unite 임프란트에서 0.67mm(10.73%), ITI SLA 임프란트에서는 0.55mm(8.18%)로 나타났다. 두 가지 임프란트 시스템 간의 유의성 있는 차이는 보이지 않았다. 4. 고찰 BAOSFE 술식과 동시식립한 $Br{\aa}nemark$ Ti-Unite 과 ITl SLA 임프란트는 위축된 상악 구치부를 갖는 환자에서 효과적인 치료방법이 될 수 있으며, 임프란트 표면에 따른 이식골의 치유 반응은 두 가지 임프란트 시스템에서 유사한 양상으로 일어남을 알 수 있었다.