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각질형성세포에서 레티노인산(All-trans Retinoic Acid)에 의한 IL-8 발현의 기전
정예리 ( Yae Lee Chung ),강태원 ( Tae Won Kang ),오성민 ( Sung Min Oh ),정승용 ( Seung Yong Chung ),김수찬 ( Soo Chan Kim ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.6
Background: Retinoic acid (RA) has been reported to induce the up-regulation of inflammatory cytokines such as IL-1, TNF-α and IL-8 in dermal fibroblasts and keratinocytes. There is no evidence to support a direct interaction between the RA-mediated transcriptional machinery and IL-8 gene transcription. Objective: The aim of this study is to clarify the mechanism of the up-regulation of IL-8 in keratinocytes by RA. Methods: The IL-1, IL-8, TNF-α and MCP-1 mRNA expressions in HaCaT cells stimulated by RA were measured by quantitative RT-PCR. The effects of a NF-κB inhibitor and IL-1 receptor antagonist (ra) on the IL-8 mRNA expression were measured by quantitative RT-PCR. Electrophoretic motility shift assay (EMSA) was conducted on the RA-stimulated HaCaT cells that were or were not treated with NF-κB inhibitor to measure the NF-κB binding activity in each group. The phospho-IκB activity in the HaCaT cells after stimulation with RA was also measured by Western blotting. Results: An up-regulation of the IL-8 gene expression by RA was demonstrated in the HaCaT cells. The inhibition assay revealed the involvement of the NF-κB binding site of the IL-8 gene in the RA-enhanced promoter activity. EMSA demonstrated that RA enhanced the formation of the DNA-NF-κB complex. There was no evidence to support IL-1 as an intermediate stimulus between the RA-mediated transcriptional machinery and IL-8 gene transcription. Western blot analysis revealed increased phospho-IκB activity in the HaCaT cells after stimulation with RA. Conclusion: Our result suggested that the IL-8 gene expression of HaCaT cells after RA stimulation is caused by the activation of IKK and the dissociation of IκB from NF-κB and the transcription of NF-κB in the nucleus. (Korean J Dermatol 2009;47(6):674∼682)
소아에서 발생한 랑게르한스세포 조직구증 - 6예의 임상 및 병리조직학적 고찰 -
정한길(Han Gil Chung),김동건(Dong Kun Kim),정예리(Yae Lee Chung),양우익(Woo Ick Yang) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.2
N/A Background:Langerhans cell histiocytosis (LCH) is a broad spectrum of clinical diseases having proliferation of Langerhans cells in common. LCH may be manifested in a variety of ways, ranging from a spontaneously regressing skin lesion to a multisystemic life-threatening disorder. Congenital self-healing reticulohistiocytosis is widely regarded as a limited form of LCH. It is present at birth or shortly thereafter and involute spontaneously. Objective:Our purpose was to investigate the relationship between clinicopathologic characteristics and prognosis of LCH in children. Methods:Six children with LCH were investigated clinically and histopathologically. Immunostains were performed with CD1a and S100 antibodies in 5 cases using paraffin-embedded sections and an electron microscopic examination was done in 1 case. Results:Among the 6 cases of LCH, 4 cases were confined to the skin, and 2 cases showed internal organ involvement. All LCH confined to the skin showed resolution of the skin lesion in 1 year, and 2 cases involving internal organ showed bad prognosis. Histopathological findings showed large histiocytes with eosinophilic cytoplasm in common. Immunohistochemical stains (5 cases) showed positive reactions with CD1a and S-100, and electron- microscopical observation in one case demonstrated laminated dense bodies. There was no significant histopathological or immunohistochemical difference between LCH confined to the skin which showed resolution of lesions and LCH involving internal organs with grave prognosis. Conclusions:Clinical types of Langerhans cell histiocytosis could not be differentiated only from (Korean J Dermatol 2000;38(2):191~197)
진상현(Sang Hyun Jin),정예리(Yae Lee Chung),문태기(Tae Kee Moon),이민걸(Min Geol Lee) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.2
Transepidermal elimination is a mechanism whereby foreign or altered constituents can be removed from the dermis. The phenomenon of transepidermal elimination may occur as a primary process characterizing disorders such as elastosis perforans serpiginosa, reactive perforating collagenosis and chondrodermatitis nodularis chronica helicis; as well as a secondary process characterizing disorders such as granuloma annulare, necrobiosis lipoidica diabeticorum, calcinosis cutis, pseudoxanthoma elasticum, spitz nevi, pimented nevi, porokeratosis plantaris discreta and metastatic tumors. A 17-year-old man presented with a 2×2 cm sized well-circumscribed slightly erythematous plaque with some black colored papules on the left dorsum of his hand. The histopathology of the lesion indicated angiokeratoma circumscriptum with transepidermal elimination. (Korean J Dermatol 2000;38(2):258~261)
자연 치유된 원발성 피부 Alternariosis 2예
정예리,장성남,한승경,조흔정,서순봉,이광훈 대한의진균학회 1999 대한의진균학회지 Vol.4 No.2
The treatment of cutaneous altemariosis consists of surgical excision and systemic antifungal agent. However, only reduction or cessation of corticosteroids and immunosuppressive therapy, if it is possible, can be sufficient to treat the lesion in some cases. We present two cases of spontaneously healed primary cutaneous altemariosis. Case 1 was a 73-year-old female patient with diabetes mellitus, heart failure, chronic renal failure and chronic hepatitis. Case 2 was a 64-year-old male patient with iatrogenic Cushing's syndrome and diabetes mellitus. The correction of the underlying diseases resulted in improvement of the primary cutaneous altemariosis. [Kor J Med Mycol 4(2): 137-142]
Narrow Band UVB로 치료한 진행성 반상 저색소증 1예
김병대,정예리,이근수,한승경 대한피부과학회 2003 대한피부과학회지 Vol.41 No.12
Progressive macular hypomelanosis is an idiopathic acquired hypopigmentary disorder first descri-bad in 1988. The disorder is characterized by ill-defined, non-scaly, round to oval, hypopigmented patches symmetrically localized on the trunk. No clinical symptoms have been observed. Currently, diagnosis is made on clinical grounds and any histological, laboratory investigations are not diagenositc. This disorder does not respond to conventional treatment and its clinical course is variable. We experienced a case of progressive macular hypomelanosis that was successfully treated with narrow band UVB phototherapy. (Korean J Dermatol 2003;41(12):1664~1666)
수포성 유천포창 항원에 대한 항체를 가지고 있는 반흔성 유천포창 1예
김주영,김수찬,정예리 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.10
Cicatricial pemphigoid is a chronic autoimmune subepithelial blistering disease that predominantly involves mucous membrane with resultant scar formation. It may involve oral, ocular, nasal, pharyngeal, laryngeal, esophageal, and anogenital mucous membranes. Cicatricial pemphigoid is a heterogenous group of diseases with respect to the autoimmune target antigens including BP180(type XVII collagen), BP230, laminin 5(epiligrin), laminin 6, type VII collagen and other newly described antigen. We describe a patient with cicatricial pemphigoid in whom circulating IgA and IgG autoantobodies against BP180 and BP230 antigens were detected simunltaneously.