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식이 Vitamin E 수준이 Cadmium 중독된 흰쥐 뇌조직의 지질과산화와 항산화효소활성에 미치는 영향
정선영(Sun-Young Jung),이순재(Soon-Jae Rhee),양정아(Jeong-Ah Yang) 한국식품영양과학회 1996 한국식품영양과학회지 Vol.25 No.4
식이 vitamin E수준이 Cd 중독된 흰쥐 뇌조직내의 지질과산화와 항산화계에 미치는 영향을 알아보기 위해 체중 60±5g되는 Spraue-Dawley종 흰쥐 숫컷을 식이내 vitamin E함량을 0, 40, 400㎎/㎏ of diet로 나누어 각각 2주 및 4주간 사육한 후 체중 ㎏당 2.5㎎/Cd을 하루에 한번씩 4회 투여하여, 실험 종료 후 쥐를 희생시켜 뇌조직내의 SOD, GSH-Px, GST의 항산화효소활성 및 지질과산화가를 측정하여 다음과 같은 결과를 얻었다. 전 실험기간 동안 체중변화를 관찰한 결과 대조군에 비해 실험군들이 모두 유의적으로 감소하였고, 식이 섭취량은 2주간 사육한 대조군과 각 실험군간에 차이가 없었으나, 4주간 사육한 대조군에 비해 Cd-0E군만이 유의적으로 낮았다. 식이 효율도 2주 및 4주 모두 대조군에 비해 실험군들이 모두 낮았다. 뇌, 간장 및 신장의 무게는 대조군과 실험군 간에 유의적인 차이가 없었다. SOD의 활성을 관찰한 결과 대조군에 비해 Cd-0E군이 유의적으로 낮았으나 Cd-40E와 Cd-400E군과는 차이가 없었다. GSH-Px 활성은 대조군에 비해 실험군이 Cd-400E, Cd-40E, Cd-0E순으로 낮았다. GST 활성을 측정한 결과는 대조군에 비해 Cd-0E, Cd-40E군에서는 유의적으로 낮았으며, Cd-400E와는 차이가 없었다. 뇌조직의 지질과산화가를 측정한 결과, 대조군에 비하여 Cd-0E, Cd-40E, Cd-400E군은 각각 2.5배, 1.8배, 1.4배 증가하였다. 그리고 Cd-40E, Cd-400E는 Cd-0E군에 비해 각각 28.8%, 44% 지질과산화가가 각각 낮았다. 2주 및 4주 동안 실험구간의 효소활성 및 과산화지질 함량은 유의적인 차이가 없었다. 결론적으로 Cd 중독된 흰쥐 뇌조직에서는 대조군에 비해 지질과산화 반응이 촉진되었으나 식이내 vitamin E의 적절한 첨가는 항산화계를 강화시킴으로써 뇌조직의 과산화적 손상을 완화시키는데 기여함을 알 수 있었다. The purpose of this study was to investigate the effect of dietary vitamin E levels on the enzymes such as superoxide dismutase(SOD), glutathione peroxidase(GSH-Px) and glutathione S-transferase (GST) involved in antioxidative defense system and lipid peroxidation in brain of cadmium administered rats. Sprague-Dawely male rats weighing 60±5g were divided into control and experimental groups. The experimental groups were divided into Cd-0E(vitamin E free diet), Cd-40E(40㎎ vitamin E/㎏ diet) and Cd-400E(400㎎ vitamin E/㎏ diet) according to the level of vitamin E supple After each group was fed diet ad libitum for 2 or 4 weeks, 2.5㎎ cadmium per kg body weight was injected intraperitoneally once a day for 4 days. The rats were sacrificed for examination on the next day after the last injection of cadmium. The results are as follows: SOD activities of rat brain were lower in Cd-0E, but had a similar tendency to Cd-40E, Cd-400E groups compared with control group. GSH-Px acivities of rat brain were decreased in Cd-400E, Cd-40E and Cd-0E groups. GST activities of rat brain were decreased in Cd-0E, Cd-40E groups and not significantly different in Cd-400E compared with control group. Thiobarbituric acid reactivesubstances(TBARS) of rat brain was increased in Cd-0E, Cd-40E, Cd-400E in that order, TBARS was lower in Cd-40E, and Cd-400E by 28.8% and 44%, respectively, than Cd-0E group. The present result suggests that high level of dietary vitamin E protects against lipid peroxidative damage in rat induced by cadmium.
원 저급성 심근경색증 환자에서 Everolimus-eluting Stent와 Biolimus-eluting Stent 시술 후 임상 경과
박인철 ( In Cheol Park ),정명호 ( Myung Ho Jeong ),김인수 ( In Soo Kim ),이정애 ( Jung Ae Rhee ),최진수 ( Jin Su Choi ),박인혜 ( In Hyae Park ),채임순 ( Leem Soon Chai ),정윤아 ( Yun Ah Jeong ),현대용 ( Dae Yong Hyun ),정해창 ( Ha 대한내과학회 2015 대한내과학회지 Vol.89 No.4
Background/Aims: We compared the efficacy and safety of the second-generation everolimus-eluting stent (EES) and the third generation biolimus-eluting stent (BES) in patients with acute myocardial infarction (AMI). Methods: We analyzed 629 consecutive patients (mean age 65.1 ± 11.2 years, 426 males) with AMI undergoing percutaneous coronary intervention from February 2008 to April 2012. They were divided into two groups according to stent type (EES group, n = 426; BES group, n = 203). The primary end-point was 2-year major adverse cardiac events (MACEs), defined as the composite of all-cause death, myocardial infarction, target vessel revascularization, non-target vessel revascularization and target lesion revascularization. The secondary end-point was 2-year target lesion failure (TLF). Results: There were no significant differences in baseline characteristics, except that the patients with EES had a significantly higher prevalence of diabetes mellitus (34.7 vs. 22.7%, p = 0.002) and were older (67.1 ± 11.3 vs. 64 ± 12.9 years, p = 0.039) com-pared with the patients with BES. After propensity score matching, 2-year clinical outcomes showed no differences in composite MACEs or TLF between the two groups. Multivariate Cox regression analysis showed that stent type was not a predictor of 2-year mortality or MACEs. However, older age (hazard ratio [HR] 1.037, 95% confidence interval [CI] 1.014-1.060, p = 0.001), diabetes mellitus (HR 2.247, 95% CI 1.426-3.539, p = 0.001) and a left ventricular ejection fraction ≤ 45% (HR 3.007, 95% CI 1.978-4.573, p = 0.001) were independent predictors for 2-year MACEs in patients undergoing EES or BES. Conclusions: Patients with BES had similar clinical 2-year outcomes compared with EES patients with AMI. (Korean J Med 2015;89:418-427)