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대장 통과 지연성 만성 특발성 변비에 대한 섬유소의 효과
정문기(Moon Gi Chun),송치욱(Chi Wook song),문정섭(Jeong Seop Moon),진윤태(Yoon Tae Jeen),엄순호(Soon Ho Um),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu),현진해(Jin Hae Hyun) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.4
N/A Background/Aims: Chronic idiopathic constipation has been thought to be related to decreased intake of dietary ttber, and high fiber diet was recommended as an initial therapy for consitipated patients. So we estimated the effects of dietary fiber(psyllium husk) on symptoms and colonic transit time in patients with slow transit constipation. Methods: We measured colonic transit time using radioopaque markers in 74 controls and 68 patients with chronic idiopathic constipation. After 4 week treatment of psy]lium husk(3.25g/pack, t.I.d.), we re-evaluated symptoms and colonic transit time in 37 patients with slow transit constipation. Results: In controls, mean bowel frequency was 5.1/week, total colonic transit time was 16.9 hours, and segmental colonic transits were 4.0 hours for right, 5.1 hours for left, and 7.8 hours for rectosigmoid colon. Among 68 patients with chronic idiopathic constipation, 37 patients had delayed total colonic transit time (mean-t 2SD). In these patients with slow transit constipation, mean bowel frequency was 2.0/week, total colonic transit time was 56.6 hours, and segmental colonic transits were 16.2 hours for right, 22.4 hours for left and 18.0 hours for rectosigmoid colon. After treatment, bowel frequency increased from 2.0/week to 4.3/week, and total colonic transit time decreased from 55.6 hours to 37.7 hours. Right, left, and rectosigmoid segmental colonic transit time also decreased from 16.2 to 9.8 hours, 22.4 to 15.0 hours and 18.0 to 12.5 hours, respectively. We found 3 patients with abdominal bloating and I patient with abdominal pain, but no patients had any serious complications. Conclusions: In patients with slow transit constipation, psyllium husk improved symptoms and colonic transit without serious side effect. (Korean J Gastroenterol 1996; 28:513 - 519)
반복되는 담도성 산통을 호소하는 환자에서 담관내압검사와 담낭스캔의 의의
김재선(Jae Seon Kim),정문기(Moon Gi Chun),이성준(Seong Jun Lee),김경민(Kyoung Min Kim),변관수(Kwan Soo byun),박영태(Young Tae Bak),김진호(Jin Ho Kim),김종극(Jong Guk Kim),이창홍(Chang Hong Lee) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.5
N/A Background/Aims: Tbis study was aimed to evaluate the clinical significance of the sphincter of Oddi manometry (SOM), cholescintigraphy, endoscopic sphincterotomy(EST), and cholecystectomy in patients complaining of recurrent biliary-type abdominal pain. Methods: 20 patients with recurrent biliary-type abdominal pain not explained by conventional diagnostic studies were sampled. All the patients with manometrically verified sphincter of Oddi dystunction(SOD) and some patients with normal or failed manometry underwent EST. Among those with normal or failed manometry laparoscopic cholecystectomy was performed to patients with acalcu)ous cholecystopathy(ACP) diagnosed by cholescintigraphy. Results: Of 26 sessions of SOM tried in all the 20 cases, 2l sessions in 17 cases were technically successful. Among those 17 patients, SOM was abnormal in 9 cases(6:sphincter of Oddi dyskinesia; 3:sphincter of Oddi stenosis). Four of five patients undergoing cholescintigraphy in patients with normal or t'ailed manometry were verified as ACP. The procedure-related pancreatitis occurred in 7/26 sessions after SOM and in 3/12 sessions after EST. In 1 case, a micro-perforation followed EST. All these patients with complications recovered uneventfully. Mean duration of fo]low-up was 13.5(range 7 -24) months. EST was of benefit to 7 of 9 patients with manometrically verified SOD and also to all 3 patients with normal or failed manometry undergoing EST. Laparoscopic cholecystectomy was of henefit to all 3 patients with ACP undergoing cholecystectomy. Conclusions: Extensive diagnostic procedures such as SOM and cholescintigraphy and proper therapy according to their results should be considered with patients complaining of recurrent biliary-type abdominal pain not explained by other conventional diagnostic studies. (Korean J Gastroenterol 1995;27: 563 - 572)
감염과 관련된 위점막 조직의 Glutathione에 관한 연구
박동균 ( Dong Kyun Park ),김은수 ( Eun Soo Kim ),홍순홍 ( Soon Hong Hong ),정문기 ( Moon Gi Chun ),권오상 ( Oh Sang Kwon ),김선숙 ( Sun Suk Kim ),구양서 ( Yang Suh Kwon ),김유경 ( Yu Kyun Kim ),최덕주 ( Duck Joo Choi ),박현철 ( Hy 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> Helicobacter pylori(H. pylori)에 의한 위점막 손상은 H. pylori에 의해 활성화된 염증세포의 산소 유리기 생성 및 자극과 관련이 있다고 알려져 왔고 최근에는 H. pylori 자체에서도 산소 유리기가 발생한다는 연구가 있다. 본 연구에서는 updated Sydney system을 이용한 grading 과 산소 유리기를 간접적으로 측정할 수 있는 glutathione(GSH)의 농도를 분석하여 위점막의 산소유리기와 H
김창덕,현진해,정문기 대한소화기학회 1998 대한소화기학회지 Vol.30 No.2
Background/Aims: Chronic pancreatitis is a chronic inflammatory process leading to destruction of exocrine tissue, fibrosis, and in some patients, loss of endocrine tissue. A multiplicity of causes may lead to chronic pancreatitis; however, chronic alcohol abuse appears to be the etiologic basis in 70-80% of adult patients. As the problem of chronic alcoholism has grown in the our country, the prevalence of chronic pancreatitis is increasing. However, few reliable studies have been performed concerning the clinical features of chronic pancreatitis in Korea. So we investigate the clinical characteristics and diagnostic accuracy of imaging studies in chronic pancreatitis. Methods: We analyzed the 91 patients with chronic pancreatitis who were diagnosed and managed at Anam Hospital, Korea University in Seoul frorn January 1988 to December 199i. Results: The sex incidence showed male predominance with a male to female ratio of 4.7:1 and peak age groups were 5th and 6th decades. Most common cause of chronic pancreatitis was chronic alcohol consumption(54.9%), and the other causes were biliary disease, anomaly of the pancreas, hyperlipidemia, and hyperparathyroidism. Cause was not identified in 20.9% of patients. Most of patients complaints abdominal pain(91%), and other eomplaints were indigestion(73.6%), weight loss (39.6%), jaundice(13.2%) or diarrhea(8.8%). Elevated serum amylase and fasting sugar level were shown in 39.6% and 29.7% of patients respectively. Sensitivity of abdorninal sonogram, CT scan, and ERCP were 59%, 78% and 89% in diagnosis of chronic pancreatitis respectively. CT scan was supetior to other methods in detection of pancreatic calcification and smail cystic lesions, and ERCP was superior to others in detection of minor ductal change. Twenty-one cases were accompanied by complications such as pseudocysts, biliary stenosis, duodenal obstruction, splenic vein thrombosis & pseudoaneurysm. Endoscopic treatment was given in 12 cases and surgical operation was performed in 19 cases due to complicaiton. Conclusions: Chronic alcohol comsumption is a major cause of chronic pancreatitis. CT and ERCP are essential diagnostic tool in evaluating morphological changes of chronic pancreatitis.