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김숙연 ( Suk Yeon Kim ),김주희 ( Joo Hee Kim ),황하원 ( Ha Won Hwang ),김광윤 ( Kwang Youn Kim ),박성훈 ( Sung Hoon Park ),황용일 ( Young Il Hwang ),장승훈 ( Seung Hun Jang ),정기석 ( Ki Suck Jung ) 대한천식알레르기학회(구 대한알레르기학회) 2015 Allergy Asthma & Respiratory Disease Vol.3 No.5
Good’s syndrome is an acquired immunodeficiency state associated with thymoma. It is characterized by recurrent infection, autoimmune disease, and immunologic abnormality. The insufficient immunity can be managed by intravenous immunoglobulin (IVIG) replacement therapy. We describe 2 patients who presented with Pneumocystis jiroveci pneumonia and Cytomegalovirus pneumonia after thymectomy for a thymoma. Immunologic study revealed hypogammaglobulinemia with very low B-cell count, consistent with Good’s syndrome. They were successfully treated with trimethoprim/sulfamethoxazole and gancyclovir respectively, and they are all well without additional infections, receiving regular IVIG replacement. (Allergy Asthma Respir Dis 2015;3:365-369)
ICR 마우스를 이용한 평위산과 발효평위산 급성독성 연구
장두례 ( Doo Rye Jang ),황윤환 ( Youn Hwan Hwang ),정기연 ( Ki Youn Jung ),하정호 ( Jeong Ho Ha ),박화용 ( Hwa Yong Park ),마진열 ( Jin Yeul Ma ) 대한한방부인과학회 2013 大韓韓方婦人科學會誌 Vol.26 No.1
Objectives: This study was conducted to investigate the acute toxicity of Pyungwi-san (Pingwei-san in Chinese) in ICR mice, according to KFDA and OECD guideline. Methods: In the present study, 15 male and female ICR mice administrated singly by gavage at dose levels of 0 and 2000 mg/kg of Pyungwi-san. During the experimental period, no treatment-related death was observed. There were no adverse effects on clinical signs, body weight, and gross findings at all treatment groups. Results: These results showed that the single oral adminstration of Pyungwi-san (Pingwei-san) did not cause any toxic effect at the dose levels of 2000 mg/kg in rats. Conclusions: Taken together, the median lethal dose (LD50) of Pyungwi-san (Pingwei-san) was considered to be over 2000 mg/kg body for both sexes.