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프로테오믹스 기술을 통한 쥐의 신장 피질에서 알도스테론(Aldosterone)에 의해 조절되는 단백질 동정
송미나(Mi-Na Song),전홍배(Hong-Bae Jeon),최효정(Hyo-Jung Choi),권태환(Tae-Hwan Kwon),백문창(Moon-Chang Baek) 대한약학회 2010 약학회지 Vol.54 No.3
Aldosterone, mineralocorticoid hormone, has important functions related to the regulation of blood pressure and balance of fluids and electrolytes in the distal region of the nephron. By genomic and non-genomic action of aldosterone, the physiological kidney functions are modulated. However, many of them except several kind of sodium channel have not been identified and analyzed yet. In this study, proteomic technologies with two-dimensional gel electrophoresis (2-DE) gel using aldosterone rat model were applied to analyze and identify the aldosterone dependently expressed proteins in rat kidney cortex. As a result, the established aldosterone rat model exhibited the normal physiological responses to aldosterone and modulated proteins were identified, which included 15 increased and 3 decreased proteins on 2-DE analysis. Among them, 11 proteins were identified as changed proteins by LC-MS/MS analysis. These proteins identified as aldosterone induced proteins were involved in several cellular pathways such as cytoskeleton remodeling, energy metabolism, amino acid metabolism, and chaperone process. In conclusion, our data could provide the insights into the new mechanism underlying regulation of kidney functions by aldosterone.
김홍태,천동욱,김형표,안혁수,전홍배 대한척추외과학회 1994 대한척추외과학회지 Vol.1 No.2
An instability is expected when the posterolateral bony components of a spine are excised for the treatment of a benign tumor in the region or for the decompression of a far lateral nerve root compression. In such a case there are to enough bony beds on the side of excision upon which to fuse, and also the spinal nerve is usually exposed on that side where the bone grafting is hesi- tated over the unprotected nerve. So the unilateral posterolateral spinal fusion can be applied in the other side. Four patients of unilateral posterolateral spinal fusions of the lumbosacral segment were reviewed. They were two men and two women having ages from 51 to 58 years. The follow-up time ranged from 8 months to 4 years and 3 months with an average of 28 months. All patients had far lateral herniation of the lumbosacral disc and the facet joint of that side were completely excised for discectomy. The fusions were performed on the other side using iliac bone graft without internal fixation/extension lateral views in all patients. Sumptoms were improved and there was no considerable low back pain in all patients except one who complained multiple pain of psychogenic origin. In conclusion, the unilateral posterolateral spinal fusion cas stabelize an unstable lumbosacral segment.
김홍태,박봉훈,천동욱,이형석,전홍배 대한척추외과학회 1994 대한척추외과학회지 Vol.1 No.1
Adequate pain drawings obtained from 119 patients who were surgically treated for a low back disordir during 1992 were analysed to evalutae the possibility of using the pain drawings in the initial diagnosis at first visit, in the assessment of psycho- logical status of patients, and in the prediction of the treatments results. An initial diagnostic impression was made at a glance over the pain drawing into five cate- gories and the results were compared with the final diagnosis after surgery. The penalty score of pain drawings evaluated by Ransford's scoring system were com- pared with the MMPI scores of 14 patients and with the treatment results of 79 patients who were followed more than one year after surgery. The initial impressions were five benign back pains, 53 disc herniations, 44 spinal stenosis, eight significant underlying disorders, and nine psychogenic back pain. The final diagnosis were 59 disc herniations, 42 spinal stenosis, and 18 significant under- lying disorders. Concerning the disc herniation, spinal stenosis, and significant underlying disorder there were statistically significant relationship between the intial impression and the final diagnosis. 84 pain drawings were evaluated as low penalty scores of two or less and 35 pain drawings as high penalty scores of three to 12. MMPI scores evaluated for 12 patients with high penalty score revealed more than 70 of hypochondriasis or hysteria scores in nine patients, but in all patients with low penalty scores revealed normal MMPI. A satisfactory clinical results of treatments without sinificant pain or disability was obtained in 53(96.4%) of 55 patients with low penalty scores and 18(75%) of 24 patients with high penalty scores. In conclusions a pain drawing was considered to be useful for the initial diagnostic screening, for the psychological assessment of patients, and for the prediction of treatment results.