산후 심근증 1 례

송인철,남철,서호성,김창수,장병곤,박세준 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.5

최근 부산의료원 산부인과에서 제왕절개술 후에 발생한 확장성 산후 심근증으로 사료되는 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Postpartum cardiomyopathy is defined as a syndrome of cardiac failure occuring in the latter part of pregnancy or in the puerpirium, without obious cause and without prior evidence of heart disease. Despite its infrequency, this clinical problem may have devastating consequences upon maternal and fetal outcome. It is important to recognize the association of cardiac failure and pregnancy as a sepqrate syndrome so that, once identified, postpartum cardiomypathy can be treated promatly and aggressively. We have experienced one case of postpartum cardiomyopathy, which are presented with a brief review of the literature.

산전에 진단된 Thanatophoric Dwarfism 1 례

송인철,이재호,김창수,장병곤,노미숙 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.6

Thanatophoric dwarfism is the term applied to a distinctive, lethal form of bone dysplasia described by Maroteaux, Lamy and Robert in 1967. It is a severe neonatal short-limbs dwarfism with characteristic X-ray features, including vertebral and pelvic abnormalities, and a narrow thorax with short cupped ribs and irregular metaphyses. We experienced a case of fetal dwarfisms on antenatal ultrasound examination and then the baby was delivered by cesarean section. The diagnosis was confirmed to thanatophoric dwarfism by clinical features, radiological finding and autopsy. We reported a case of thanatophoric dwarfism with review of literature.

비기능성 후복막강 부신경절종 1 예

송인철,이재호,김철범,양희동,장병곤,구본상 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.8

저자들은 최근 지방공사 부산의료원 산부인과에서 하부 후복강내에 발생한 비기능성 부신경절종 1예를 치험하였기에 문헌 고찰과 함께 보고하는 바이다. Paraganglioma of the organ of Zuckerkandl is a rare retroperitoneal tumor that arises from the para-aortic paraganglioma around the origin of the inferior mesenteric artery. Because of relatively indolent growth characteristics and no reliable histopathologic features distinguishing malignant paraganglioma, complete surgical resection and prolonged follow up are indicated. Surgery should be aimed at complete removal, since adjunctive radiotherapy and chemotherapy can only be considered palliative measures. We present a case of paraganglioma arising from the organ of Zuckerkandl. The patient was 68-year-old woman with the complaint of palpable mass in the left lower abdomen for three years. The mass, measuring 19×16×12 cm and weighing 2500 gm, was completely resected by means of a transperitoneal approach and proved to be a paraganglioma pathologically. We experienced a case of nonfunctional paraganglioma arising in retroperitoneum and report the case with a brief review of the literature.

속도검출기없는 유도전동기의 벡터제어에 관한 연구

황락훈(Lak-Hoon Hwang),장병곤(Byung-Gon Jang),김종래(Jong-Lae Kim),장진혁(Jin-hyuk Jang) 대한전기학회 1999 대한전기학회 학술대회 논문집 Vol.1999 No.11

자궁근종에 대한 임상통계학적 연구

양희동,남철,서호성,김창수,장병곤,박세준 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.6

1989년 1월 1일부터 1994년 12월 31일까지 만 6년간 부산의료원 산부인과에 입원하여 수술을 받고 자궁근종으로 확진된 245예를 대상으로 임상 및 병리학적 연구를 하여 다음과 같은 결과를 얻었다. 1. 자궁근종의 빈도는 18.1%이었다. 2. 연령분포는 40~49세가 60%로 가장 많았고 평균연령은 43.9세이었다. 3. 임신경험이 한번도 없었던 경우가 6.9%이었고, 평균임신 횟수는 4.9회, 평균분만 횟수는 2.9회이었다. 불임인 경우는 8.2%에서 관찰되었으며 이중 원발성은 7.8%, 속발성은 0.4%이었다. 4. 발생부위는 체부가 96.3%, 경부가 3.7%이었고, 조직학적으로는 근내형이 58%, 혼재형이 18.7%, 장막하형 13%, 점막하형 10.2%의 순이었다. 5. 주소가 동통인 경우가 85.3%, 이상자궁출혈인 경우가 52.2%, 종류감이 19.2%순이었다. 6. 평균 혈식소치는 10.9g/dl이었으며, 혈식소치가 10g/dl이하인 경우가 33.5%이었다. 7. 자궁근종의 크기는 절제된 자궁 또는 자궁근종의 무게는 201~300g인 경우가 53.4%로 가장 많았고 평균 무게는 274.4 g이었다. 8. 자궁근종의 이차변성은 11.8%에서 보였으며, 초자양변성이 4.8%로 가장 많았다. 9. 자궁근종과 합병된 병변은 84.9%이었고, 이중 만성 경부염이 39.6%로 가장 많았다. 10. 월경과다증은 45.7%에서 나타났으며, 월경과 다증과 자궁근종의 조직학적 발생부위, 자궁선근증 사이에는 유의한 상관관계가 있었다(p$lt;0.05). 그러나 자궁무게와 월경과다증 사이에는 유의한 상관관계가 없었다(p$gt;0.5). 11. 월경곤란증은 39.2%에서 나타났으며, 월경곤란증은 자궁근종의 발생부위, 조직학적 발생부위, 자궁의 무게와 유의한 상관관계가 없었으나(p$gt;0.5), 자궁선근증이 병합된 경우에 유의한 상관관계를 보였다.(p$lt;0.05). 12. 수술방법은 78.4%가 복식전자궁적출술 및 자궁부속기적출술, 15.1%에서 복식전자궁적출술만을 시행하였으며, 복식부분자국적출술 2.9%, 자궁근핵적출술 1.6%, 질식자궁적출술이 2%에서 시행하였다. 13. 술후 합병증은 17.5%에서 나타났으며, 상처감염이 34.9%로 가장 많았으며 수술에 따른 심각한 합병증이나 사망은 1례도 없었다. From January, 1989 to December, 1994, 245 cases of uterine myoma were treated at the department of Obstetrics and Gynecology, Pusan Medical Center. A clinico-statical study on these 245 cases of uterine myoma was performed to understand the clinical characteristics of uterine myoma. The following results have been obtained: 1. The incidence of uterine myoma among 1,352 cases of major gynecologic surgery during this period was 18.1%. 2. Uterine myomas were observed most frequently in the age group 40 to 49 years, and the mean age was 43.9 years old. 3. The parity was 2.9 in average, the infertility was observed in 20 cases(8.2%) in while the primary infertility was 7.8%, the secondary 0.4%, respectively. 4. The corporeal myomas were observed in 236 cases(96.3%), whereas cervical myomas were 9 cases(3.7%). The intramural types were observed in 142 cases(58%), combined types in 46 cases(18.7%), subserous types in 32 cases(13.1%), submucous types in 25 cases(10.2%), respectively. 5. The most of frequent chief complaint was pain which was observed in 209 cases(85.3%), the next abnormal uterine bleeding in 137 cases(52.2%), palpable mass in 47 cases(19.2%), respectively. 6. The mean value of preoperative Hb was 10.9gm/dl, and transfusion was performed in 43 cases(17.5%). 7. The mean weight of the resected uterine myoma was 274.9 gm. 8. The secondary changes in uterine myomas were found in 29 cases(11.8%) and the most common change was hyaline degeneration(4.8%). 9. The most common associated conditions with myomas were chronic cervicitis(39.6%). 10. Hypermenorrhea was observed in 112 cases(45.7%) and there were significant correlations between the presence of hypermenorrhea and the type of myoma(p$lt;0.05), adenomyosis(p$lt;0.05) but no correlation with the weignt and location of myoma(p$gt;0.5). 11. There were no significant correlations between the dysmenorrhea and the weight of myoma, location of myoma, and types of myoma(p$lt;0.5). The incidience of dysmenorrhea was significantly higher in cases with adenomyosis than that in cases without adenomyosis(p$lt;0.05). 12. Total abdominal hysterectomy was performed in 37 cases(15.1%), total abdominal hysterectomy with unilateral adnectomy in 109 cases(44.5%), total abdominal hysterectomy with both adnexectomy in 83 cases(33.9%), vaginal hysterectomy in 5 cases(2%), and myonectomy in 4 cases(1.6%), respectively. 13. The postoperative com;lications were found in 43 cases and the most common complication of these was wound infection seen in 15 cases(34.9%).

전압형 Inverter에 의한 속도검출기 없는 유도전동기 속도제어

황락훈(LH Hwang),김종래(JI Kim),장병곤(BG Jang),이상용(SY Lee),나승권(SK Na),김주래(JL Kim),이춘상(CS Lee),조문택(MT Cho) 대한전기학회 2000 대한전기학회 학술대회 논문집 Vol.2000 No.7

3상 PWM 전압형 컨버어터의 전류제어기에 의한 고역율 제어에 관한 연구

황락훈(Lak-Hoon Hwang),김종래(Jong-Lae Kim),장병곤(Byong-Gon Jang) 전력전자학회 1999 전력전자학술대회 논문집 Vol.- No.-

This paper presents a current control strategy for a 3-phase PWM AC/DC converter. The input current is sinusoidal and an effective power factor is unity, Since the control variables of the 3-phase converter are sinusoidal, the conventional control strategy requires high control gains to achieve zero steady state error. However, the gains are limited because of sampling delay. To solve the problem, the authors propose a new current control scheme of a 3-phase PWM converter which has two special features: One is that a fast response of current is achieved by introducing a converter model In the controller. Another one is that the steady state AC current control error is canceled even if the parameter differences between the converter model and the actual converter exist. Moreover, the steady state current error can be eliminated under low gains by a feedback loop of the fundamental component of current error. The experimental data show the proposed control to be effective.

퍼지논리를 이용한 옵저버 시스템에 의한 유도전동기의 빠른 자속 및 속도 추정제어에 관한 연구

황락훈(Lak-Hoon Hwang),이춘상(chun-sang Lee),김종래(Jong-lae Kim),장병곤(Byong-Gon Jang),이상용(Sang-Yong Lee),나승권(Seng-Kwon Na),손영태,김현우(Hyun-Woo Kim),조문택(Moon-Tack Cho) 대한전기학회 1999 대한전기학회 학술대회 논문집 Vol.1999 No.7

세포주기 변화에 따른 방사선 유도 암세포 사망의 조절기전

정수진(Soo-Jin Jeong),정민호(Min-Ho Jeong),장지연(Ji-Yeon Jang),조월순(Wol-Soon Jo),남병혁(Byung-Hyouk Nam),정민자(Min-Za Jeong),임영진(Young-Jin Lim),장병곤(Byung Gon Jang),윤선민(Seon-Min Youn),이형식(Hyung Sik Lee),허원주(Won Joo 대한방사선종양학회 2003 Radiation Oncology Journal Vol.21 No.4

목 적 : K562 세포의 방사선에 의한 세포사망은 mitoticcatastrophe 현상이 위주로 나타나지만 herbimycinA(HMA)에 의하여 apoptosis 반응이 촉진되는 반면 genistein에 의하여 두 가지 형태의 세포사망이 모두 억제된다.본 연구에서는 HMA와 genistein에 의한 K562 세포의 방사선 유도 세포 주기 조절 변화와 세포 사망 양상의 연관성을 조사하였다. 대상 및 방법 : 지수증식기의 K562 세포에 6 MV 선형가속기(Clinac 1,800 C, Varian)를 이용하여 200˜ 300 cGy/min의 선량률로 10 Gy를 균일하게 조사하였다. HMA와 genistein은 각각 250 nM와 25μM 농도로 방사선 조사 후 즉시 투여하였다. 실험에서는 세포 주기,조절인자의 발현 및 활성,노화 및 분화정도 등에 있어서의 시간에 따른 변화를 조사하였다. 결 과: 방사선 단독조사에서 K562 세포는 G2기의 정체를 보였으나 정상적인 p53을 가지는 세포와는 달리 지속적인 세포 주기의 정체를 보이지 않았다. G2 정체가 유지되는 동안 cyclin B1의 점진적인 증가를 관찰할 수 있었으며, 이는 염색체의 복제가 완료되지 않은 상태에서 M기로 진행하여 미성숙한 염색체 응축과 mitotic catastrophe 현상이 나타나는 것 과 일치 한다. 방사선 조사와 함께 HMA를 투여한 경우에는 G2 정체가 빠르게 해소되었으며 동시에 G1기에서 세포가 정체되는 양상을 보였다. 세포 주기조절인자 cdc2 kinase 활성증가와 cyclinE와 A 발현 및 CDK2 활성의 감소 등의 현상으로 설명되며,이는 apoptosis의 증가와 연관성을 갖는다.반면 genistein의 경우에는 cyclin B1과 cdc25C 발현 및 cdc2 활성 이 모두 감소하는등 G2정체를 계속 유지하였다.이와 함께 방사선에 의한 노화와 megakaryocyte로의 분화도 지속되는 것을 관찰할 수 있었다. 결 론: HMA와 genistein에 의한 K562 세포의 방사선 유도 세포사망의 변화는 세포주기 조절과 밀접하게 연관되어 있음을 확인하였다.이는 다양한 방사선 유도 세포사망의 기전을 이해하는 데 독창적인 모델을 제공하며,방사선을 이용한 암 치료법의 개발에 새로운 표적을 제공할 수 있을 것이다. Purpose: In our previous study, we have shown the main cell death pattern induced by irradiation or protein tyrosine kinase (PTK) inhibitors in K562 human myelogenous leukemic cell line. Death o f t he cells treated with irradiation alone was characterized by mitotic catastrophe and typical radiation-induced apoptosis was accelerated by herbimycin A (HMA). Both types of cell death were inhibited by genistein. In this study, we investigated the effects o f H MA and genistein on cell cycle regulation and its correlation with the alterations of radiation-induced cell death. Materials and Methods: K562 cells in exponentialgrowth phase were used for this study. The cells were irradiated with 10 Gy using 6 MeV Linac (200-300 cGy/min). Immediately after irradiation, cells were treated with 250 nM of HMA or 25 M of genistein. The distributions of cell cycle, the expressions of cell cycle-related protein, the activities of cyclin-dependent kinase, and the yield of senescence and differentiation were analyzed. Results: X-irradiated cells were arrested in the G2 phase of the cell cycle but unlike the p53-positive cells, they were not able to sustain the cell cycle arrest. An accumulation of cells in G2 phase of first cell-cycle post-treatment and an increase of cyclin B1 were correlated with spontaneous, premature, chromosome condensation and mitotic catastrophe. HMA induced rapid G2 checkpoint abrogation and concomitant p53-independent G1 accumulation. HMA-induced cell cycle modifications correlated with the increase of cdc2 kinase activity, the decrease of the expressions of cyclins E and A and of CDK2 kinase activity, and the enhancement of radiation-induced apoptosis. Genistein maintained cells that were arrested in the G2-phase, decreased the expressions of cycl in B1 and cdc25C and cdc2 kinase activity, increased the expression of p16, and sustained senescence and megakaryocytic differentiation. Conclusion: The effects of HMA and genistein on the radiation-induced cell death of K562 cells were closely related to the cell cycle regulatory activities. In this study, we present aunique and reproducible model in which for investigating the mechanisms of various, radiation-induced, cancer cell death patterns. Further evaluation by using this model will provide a potent target for a new strategy of radiotherapy.

전력전자 회로해석을 위한 라이브러리 개발

서영수(oung-Soo Seo),송호빈(Ho-Bin Song),황락훈(Lak-Hoon Hwang),이상용(Sang-Yong Lee),김종래(Jong-Lae Kim),장병곤(Byung-Gon Jang),나승권(SeYung-Kwon Na),조문택(Moon-Taek Cho) 대한전기학회 1999 대한전기학회 학술대회 논문집 Vol.1999 No.7