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흰쥐 분만의 인위적 조절에 관한 연구 3 . Indomethacin 투여에 의한 분만지연 시험
윤창현(C . H . Yun),성환후(H . H . Seong),장규태(K . T . Chang) 한국축산학회 1987 한국축산학회지 Vol.29 No.11
This experiment was carried out to study the efficacy of the exogenous indomethacin for prolongation of parturition in white rats. Sixty of the pregnant white rats used were injected with indomethacin. The survival rate of newborn, the administration time and the amount of dosage affecting on the prolongation parturition were investigated. The results obtained were as follows: 1. The average survival rates of newborn in groups injected with indomethacin on day 15, 17 and 19 of gestation were 78.2, 82.0 and 85.5%, respectively. There were no differences by the amount of dosage of indomethacin. 2. Mean gestation lengths of rats injected indomethacin on day 15, 17 and 19 of gestation were 23.39±0.18, 23.28±0.22 and 23.19±0.09 days, respectively. There were no significant differences (P$lt;0.05) among experimental groups. 3. For the amounts of dosage of 0.2㎎ × 1time, 0.4㎎ × 1time and 0.6㎎ × 1time per ㎏ per day the average intervals from injection to parturition were 22.98±0.05, 23.48±0.15 and 23.40±0.04 days, respectively. There were no significant differences (P$lt;0.05) among experimental groups.
흰쥐 분만의 인위적 조절에 관한 연구 4 . Aspirin 투여에 의한 분만지연 시험
윤창현(C . H . Yun),성환후(H . H . Seong),장규태(K . T . Chang) 한국축산학회 1988 한국축산학회지 Vol.30 No.2
This experiment was carried out to study efficacy of the exogenous Aspirin for prolongation of parturition in white rats. Sixty of the pregnant White rats used were injected with Aspirin. The survival rate of newborn, the administration time and the amount of dosage affecting on the prolongation of parturition were investigated. The results obtained were as follows: 1. The average survival rate of newborns in groups injected with Aspirin on day 15, 17 and 19 of gestation were 77.1%, 76.0% and 79.7% respectively. There were no differences by the amount of dosage of Aspirin. 2. Mean gestation length of rats injected Aspirin on day 15, 17 and 19 of gestation were 23.08±.22, 22.65±0.12 and 23.18±0.30 days, respectively. There were no significant differences (P$lt;0.05) among experimental groups. 3. For the amount of dosage of 50㎎/㎏ × ltime, 100㎎/㎏ × Mime and 150㎎/㎏ × Mime per ㎏ per day the average intervals from injection to parturition were 22.67±0.17, 22.97±0.25 and 23.28±0.22 days, respectively. There were no significant differences (P$lt;0.05) among experimental groups.
Gossypol의 精巢實質內 投與가 생쥐의 血液性狀에 미치는 影響
黃權植,張奎泰,吳錫斗,成煥厚,李炳五,尹昌鉉 慶尙大學校 1992 論文集 Vol.31 No.2
We have previously shown that gossypol treatment was found to effectively inhibit the process of spermatogenesis. In this study, value of blood and blood chemistry were investigated weekly in ICR mouse of which testicular stroma was injected with gossypol. Red blood cell(RBC), hematocrit, white blood cell(WBC), basophils, eosinophils and monocytes, were not changecd significantly during each dose(5, 10 and 15mg/kg of body weight) and time(2,3 and 4weeks) after treatment of gossypol, but neutrophils and lymphocytes were increased and decreased significantly(P<0.05). On the other hand, value of blood chemistry, which included protein, albumin and globulin, were not changed significantly. But, high increased signigicaltly(P<0.05) were glucose volume followed dose and time after treatment of gossypol. In conclusion, it is suggested that gossypol treatment may be interfering with the process of spermatogenesis and directly acting on the sertoli cell itself within the seminiferous tubules or during its passage through the male vein tract in way that affect both of value of blood and chemistry.
Gossypol의 精巢實質內 投與가 생쥐의 造精機能에 미치는 影響
黃權植,張奎泰,吳錫斗,成煥厚,李炳五,尹昌鉉 慶尙大學校 1992 論文集 Vol.31 No.2
The effect of gossypol on spermatogenesis were investigated with the testis of ICR mouse which was injected gossypol in the stroma of testis(TS). The dossae of gossypol in polyethlene glycol injected in TS for were 5, 10 and 15 mg/kg of body weights, respectively. Counts of sperm from cauda epididymis and the balance weight of testis were examined at regular intervals after treatment, for periods extending up 2 to 6 weeks. All groups of gossypol treatment were markedly reduced(P<0.01) in the number of sperm and the weight of testis compared with the control group. But, the rates of malformation (loss of proacrosome, damage of midpiece and breaking of tail) of sperm were significantly, the weight of testis and the count of normal sperm were gradually increased and the malformation of sperm was decreased between 4 and 6 weeks after injection of 5mg of gossypol.