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간경변 환자에서 발생한 마크로아밀라아제혈증과 마크로리파아제혈증 1예
임평숙 ( Pyoung Suk Lim ),김소영 ( So Young Kim ),염동한 ( Dong Han Yeom ),조은영 ( Eun Young Jo ),최창수 ( Chang Soo Choi ),김학철 ( Haak Cheoul Kim ),조지현 ( Ji Hyun Cho ) 대한내과학회 2008 대한내과학회지 Vol.75 No.4
저자들은 알코올성 간경변 환자에서 지속적인 마크로아밀라아제혈증과 마크로리파아제혈증으로 ACR 및 PEG test 등 간단한 선별 검사 방법으로 진단된 1예를 경험하여 문헌고찰과 함께 보고하는 바이다. Macroenzymes are high molecular weight complexes formed in the serum by self-polymerization or by association with other proteins. Macroenzymes are filtered with difficulty by normal renal glomeruli. Clinically, it is important to detect macroenzymes, because they frequently interfere with the interpretation of serum enzyme results, and as a result they can cause diagnostic and therapeutic errors. Macroamylasemia and macrolipasemia have been found to occur in apparently healthy humans, as well as in a variety of disease states, including liver disease, diabetes, cancer, malabsorption, and autoimmune disorders. We report a patient with alcoholic liver cirrhosis and macroamylasemia and macrolipasemia, the latter two of which were discovered using a screening test. (Korean J Med 75:459-462, 2008)
임평숙 ( Pyoung Suk Lim ),김인희 ( In Hee Kim ),김성훈 ( Seong Hun Kim ),이승옥 ( Seung Ok Lee ),김상욱 ( Sang Wook Kim ) 대한소화기학회 2012 대한소화기학회지 Vol.60 No.3
Hepatitis A is typically a self-limited acute illness that does not progress to chronic hepatitis. In rare cases, acute hepatitis A can be associated with serious complications (such as fulminant hepatitis or acute kidney injury) and may result in death or liver transplantation. Pure red cell aplasia (PRCA) is a rare hematologic disorder characterized by anemia, reticulocytopenia in the blood, and isolated erythroblastopenia with normal granulopoiesis and megakaryopoiesis in the bone marrow. PRCA is a rare hematopoietic complication of acute viral hepatitis, and few cases associated with hepatitis A virus infection have been reported. Recently, we experienced a case of severe hepatitis A complicated by fulminant hepatitis and acute kidney injury followed by PRCA which showed a favorable response to oral corticosteroids. (Korean J Gastroenterol 2012;60:177-181)