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Paecilomyces japonica의 반복투여가 랫드에 미치는 영향
김용범,홍다해,조은상,임완중,김일환,손화영,Kim, Yong-Bum,Hong, Da-Hae,Cho, Eun-Sang,Im, Wanjung,Kim, Il-Hwan,Son, Hwa-Young 대한수의학회 2014 大韓獸醫學會誌 Vol.54 No.1
Cordyceps is a fungus used as a traditional medicine in China, Japan, and Korea. Paecilomyces (P.) japonica is a new cordyceps that was recently cultivated on silkworm pupae in Korea. The present study evaluated the toxicological effects of P. japonica in rats. Forty rats were treated with oral doses of P. japonica (0, 20, 100, or 500 mg/kg/day) for 4 weeks. Twenty additional rats were treated with 0 or 500 mg/kg/day of P. japonica for 4 weeks and then maintained for 2 weeks without treatment. Clinical signs, body weight, food and water consumption, and organ weight as well as hematology, serum biochemistry, and histopathology data were examined. Body weight gain of the group treated with 500 mg/kg/day was significantly reduced. Microscopically, karyomegaly, single cell necrosis, and mitosis were observed in the renal tubular epithelium of all treated groups. In conclusion, P. japonica caused a reduction of body weight and renal injury in rats. The no observed adverse effect level (NOAEL) of P. japonica was less than 20 mg/kg/day.
박현규,조재우,이병석,박희진,한지석,양미진,임완중,박도용,김우진,한수철,김용범 한국실험동물학회 2016 Laboratory Animal Research Vol.32 No.2
Nonhuman primates are increasingly used in biomedical research since they are highly homologous to humans compared to other rodent animals. However, there is limited reliable reference data of the clinical pathology parameters in cynomolgus monkeys, and in particular, only some coagulation and urinalysis parameters have been reported. Here, we reported the reference data of clinical chemical, hematological, blood coagulation, and urinalysis parameters in cynomolgus monkeys. The role of sex differences was analyzed and several parameters (including hematocrit, hemoglobin, red blood cell, blood urea nitrogen, total bilirubin, alkaline phosphatase, creatinine kinase, gamma-glutamyl tranferase, and lactate dehydrogenase) significantly differed between male and female subjects. In addition, compared to previous study results, lactate dehydrogenase, creatinine kinase, and aspartate aminotransferase showed significant variation. Interstudy differences could be affected by several factors, including age, sex, geographic origin, presence/ absence of anesthetics, fasting state, and the analytical methods used. Therefore, it is important to deliberate with the overall reference indices. In conclusion, the current study provides a comprehensive and updated reference data of the clinical pathology parameters in cynomolgus monkeys and provides improved assessment criteria for evaluating preclinical studies or biomedical research.
Specific Pathogen-Free BALB/c 마우스와 C57BL/6 마우스의 혈액학 및 혈액생화학 지표
김영희(Young-Hee Kim),이현숙(Hyun-Sook Lee),김용범(Yong-Beom Kim),임완중(Wan-Jung Im),임송(Song Lim),강부현(Boo-Hyon Kang) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.3
Establishment of the basic data line is very important in the evaluation of the result of clinical and/or nonclinical experiments, in the improvement the confidence of test results. A reference range data base containing serum chemistry and hematology values in 5 weeks old BALB/c and C57BL/6 mice which were purchased from the different companies is described. Hematological parameters are white blood cell count, red blood cell count, hemoglobin concentration, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, platelet count. In the BALB/c mice, there are significant differences observed between lots, sexes and strains. In the C57BL/6 mice, there are significant differences observed between lots and strains but no significant differences observed between sexes. Serum biochemistry parameters are aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, blood urea nitrogen, creatinine, glucose, total cholesterol, total bilirubin, total protein, albumin, triglyceride, calcium, inorganic phosphate, phospholipid, high density lipoprotein cholesterol, low density lipoprotein cholesterol, albumin globulin ratio, sodium, potassium, chloride. In both stains of mice, there are significant differences observed between lots, sexes and strains. Data from the present study will support in the proper interpretation and validation of these results.
Sprague-Dawley(SD) 랫드를 이용한 2주와 4주 반복투여 독성시험에 대한 혈액, 혈액생화학 및 장기중량 기초자료
강부현(Boo-Hyon Kang),김용범(Yong-Bom Kim),이현숙(Hyun-Sook Lee),김영희(Young-Hee Kim),임완중(Wan-Jung Im),하창수(Chang-Su Ha) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.2
We present background data of Sprague-Dawley (SD) rats from the control groups of 2 weeks and 4 weeks repeated-dose toxicity studies performed in our laboratory during 2002-2003. These include hematology, blood biochemistry and organ weights. These data can be used as background data for the interpretation of data from repeated-dose toxicity studies of drugs or chemicals in SD rats.