http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
소아 결핵 감염 진단에 있어서 결핵 특이항원 자극 Interferon-${\gamma}$ 분비능 측정의 진단적 유용성
순유진,임백근,김황민,남궁미경,차병호,어영,전진경,Soon, Eu-Gene,Lim, Baek-Keun,Kim, Hwang-Min,NamGoong, Mee-Kyung,Cha, Byung-Ho,Uh, Young,Chun, Jin-Kyong 대한결핵및호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.68 No.5
Background: $QuantiFERON^{(R)}$-TB Gold In Tube (QFT-G IT) has been used for diagnosing latent tuberculosis infection and active tuberculosis (TB) since 2007. However, there has not been enough data on QFT-G IT for universal use in children. In this study, we evaluated the clinical usefulness of the QFT-G IT in pediatric practice. Methods: We retrospectively reviewed the clinical records of 70 patients younger than 18 years of age who had taken QFT-G IT and had a tuberculin skin test (TST) between July 2007 and July 2009 at Wonju Christian Hospital. The subjects were divided into two groups, asymptomatic TB exposure group and disease group. Four patients who were taking immunosuppressants during the study period were excluded. Results: A total of 66 immunocompetent children were included in this study. Among 27 asymptomatic children who had contact histories of TB, 6 (22.2%) were found to be positive by QFT-G IT. Eleven (40.7%) and 5 (18.5%) children were found to be positive by TST with cutoff values of ${\geq}5mm$ and ${\geq}10mm$, respectively. Agreement was fair to good between QFT-G IT and TST (${\kappa}=0.59$: cutoff value ${\geq}5mm$, ${\kappa}=0.7$: cutoff value ${\geq}10mm$). In disease group, 14 patients (35.9%) were diagnosed with active tuberculosis, 8/14 (57.1%) were positive on TST and 9/14 (64.3%) on QFT-G IT. The positive rate of acid-fast bacilli smear, TB-polymerase chain reaction, and culture for tuberculosis was 11% (1/9), 27.3% (3/11) and 33.3% (3/9), respectively. Conclusion: Our data support that the QFT-G IT can be used as an additional diagnostic tool for latent and active tuberculosis infection in children.
Gradient-gel-SDS-PAGE를 이용한 사구체 질환에서의 저분자량의 요단백 분석
김종수,이해용,남궁미경,임백근 대한신장학회 1994 Kidney Research and Clinical Practice Vol.13 No.1
Urinary proteins have different patterns according to the deposit site of the CIC rather than to amounts of the urinary protein in immune-complex-glomerular diseases. Gradient-gel-SDS-PAGE is a good method for detecting of the low molecular weight (LMW) urinary proteins. We studied the LMW-urinary proteins of common renal diseases in childhood. The results were as follows: LMW urinary proteins were distributed from 66 kD to 29 kD in normal & HSP urine samples. Tubular proteinuria appeared in 1/4 of the cases of AGN, in 3/5 of the cases of IgA glomerulonephropathy and in 2/3 of the cases of minimal change nephrotic syndrome. However, there were no histological differences between tubular proteiriuria and non-tubuloproteinuria of IgA nephropathy. The bands which the researcher observed to be specific were as follows: 17 kD in AGN, 20 kD and ll kD in IgA nephropathy, and 14 kD and 12 kD in minimal change nephrotic syndrome. What the specific bands of LMW urinary protein in common renal diseases by gradient-gel-SDS-PAGE are should be definetly determined through further research.