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이은혜,백수연,김광연,이슬기,김상찬,이형식,김영우,Lee, Eun Hye,Baek, Su Youn,Kim, Kwang-Youn,Lee, Seul-Gi,Kim, Sang Chan,Lee, Hyeong Sik,Kim, Young Woo 대한한의학방제학회 2016 大韓韓醫學方劑學會誌 Vol.24 No.3
Objectives : Rheum undulatum Linne and Glycyrriza uralensis Fischer are widely used herbal medicine. In this study, anti-oxidant and liver protective effects of R. undunlatum extract (RUE) and G. uralensis extract (GUE) were investigated in HepG2 cells, respectively. Oxidative stress and liver fibrosis were induced by arachidonic acid (AA) and iron, and CCl<sub>4</sub>.Methods : MTT assay was assessed for cell viability, and immunoblotting analysis was performed to detect expression of apoptosis related proteins. In addition, reactive oxygen species (ROS) and mitochondrial dysfunction were measured. In vivo, BALB/c mouse were orally administrated with the aqueous extract of 10 mg/kg RUE and 100 mg/kg GUE for 3 days and then, injected with CCl<sub>4</sub> 0.5 ml/kg body weight to induce acute liver damage. Serum ALT level was measured, and histological change was observed in Harris's hematoxylin and eosin stainResults : RUE and GUE pre-treatment increased relative cell viability in concentration dependent manner and altered the expression levels of apoptosis-related proteins such as procaspase 3, PARP and Bcl-xL. RUE and GUE also inhibited the mitochondrial dysfunction and excessive reactive oxygen species (ROS) production induced by AA and iron. In addition, RUE and GUE activated liver kinase B1 (LKB1), by increasing phosphorylation. Moreover, RUE and GUE treatment decreased liver injuries induced by CCl<sub>4</sub>, as evidenced by decreases in histological liver damage as well as serum alanine amino transferase (ALT) level.Conclusions : These data suggest that RUE and GUE has anti-oxidant and liver protective effects against AA and iron-induced oxidative stress and CCl<sub>4</sub>-induced liver injury.
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국한성 두경부 혈관 중심위 림프종에서 화학방사선 병용치료법과 방사선치료 단독요법의 비교
장세경(Sei Kyung Chang),김귀언(Gwi Eon Kim),이상욱(Sang-wook Lee),박희철(Hee Chul Park),표홍렬(Hong Ryull Pyo),김주항(Joo Hang Kim),문성록(Sun rock Moon),이형식(Hyeong Sik Lee),최은창(Eun Chang Choi),김광문(Kwang Moon Kim) 대한방사선종양학회 2002 Radiation Oncology Journal Vol.20 No.1
목적: 국한성 두경부 혈관 중심위 림프종에서 화학방사선 병용치료법과 방사선치료 단독용법의 치료성적을 비교하여 화학방사선 병용치료법의 임상적 유용성 여부를 알아보고자 하였다. 대상 및 방법: 1976년부터 1995년까지 연세암센터에서 병기 Ⅰ,Ⅱ기의 두경부 혈관 중심위 림프종으로 치료받은 143예를 대상으로 하였다. 방사선치료단독(104예)의 경우 20~70 Gy(중앙갑 50.4 Gy)를 병소 부위에 국소적으로 조사하였고 화학방사선 병용치료(39예)의 경우에는 1~6회(중앙값 3회)의 화학요법을 시행한 후 병소 부위에 국소적으로 방사선치료를 시행하였다. 치료방법에 따른 반응율, 치료실패양상, 후유증, 생존율 등을 비교하여 보았다. 결과: 치료에 대한 높은 반응율에도 불구하고 국소치료실패가 치료실패양상의 가장 흔한 원인이었고 화학요법의 시행에 따른 치료실패양상의 변화는 없었다. 치료방법에 따른 환자들의 순응도에는 차이가 없었으나 혈구포식세포증후군(hemophagocytic syndrome), 폐혈증, 난치성 출혈(intractable bleeding), 2차 암(new primary cancer) 등의 발생빈도는 화학방사선 병용치료법을 시행한 경우에 방사선치료 단독용법을 시행한 경우보다 높은 경향을 나타냈다. 방사선 단독으로 치료한 경우의 5년 생존율과 무병 생존율은 각각 38%와 32%로 저조하였고 화학요법의 병용 여부는 생존율에 영향을 미치지 못했다. 결론: 국한성 두경부 혈관 중심위 림프종의 치료에서 화학방사선 병용치료법이 방사선치료 단독요법보다 유용하다는 사실이 입증되지 못하였다. Purpose: To Clarify the clinical benefit derived from the combined modality therapy (CMT) consisting of chemotherapy (CT) and involved field radiotherapy (RT) for stage Ⅰ and Ⅱ angiocentric lymphomas of the head and neck. Materials and Methods: Of 143 patients with angiocentric lymphoma of the head and neck treated at our hospital between 1976 and 1995, 104 patients (RT group) received involved field RT alone with a median dose of 50.4 Gy(range: 20~70 Gy), while 39 Patients (CMT group) received a median 3cycles(range: 1~6 cycles) of CT before involved field RT. The response rate, patterns of failure. complications, and survival data of the RT group were compared with those of the CMT group. Results: Despite a higher response rate, local failure was the most common pattern of failure in patients of both groups. The patterns of failure, including the systemic relapse rate were not influenced by the addition of combination CT. Although both modalities were well tolerated by the majority of patients, aberrant immunologic disorders or medical illnesses, such as a hemophagocytic syndrome, sepsis, intractable hemorrhage, or the evolution of second primary malignencies were more frequently observed in patients of the CMT group. The prognosis of patients in the RT group was relatively poor, with a 5-year overall actuarial survival rate of 38% and disease-free survival rate of 32%, respectively. However, their clinical outcome was not altered by the addition of systemic CT. Achieving complete remission was the most important prognostic factor by univariate and multivariate analyses, but treatment modality was not found to be a prognostic variable influencing survival. conclusions: Involved field RT alone for angiocentric lymphoma of the head and neck was insufficient to achieve an improved survival rate, but the addition of CT to involved field RT failed to demonstrate any therapeutic advantage over involved over involved field RT alone.
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이형식,정준기,박태형 연세대학교 산업기술연구소 1983 논문집 Vol.15 No.2
The chatter analysis has been studied by many authors using non-linear. In this study, the stability chart obtained from experimental work with a lathe was qualitatively compared with the result of chatter analysis by non-linear theory. Experimental results verify that the stability of the machining process is affected by the width of cut in the following manner. As the chip width is increased from zero with the rotational speed of the workpiece kept constant, three ranges are distinguished; (a) unconditionally stable range, (b) conditionally stable range, (c) unstable range. In the conditionally stable range the system is stable for small disturbances but unstable when these exceed a certain level. When the chatter occurs, the amplitude initially increases and stabilizes itself at a finite level. This phenomenon agrees well with the analysis of non-linear theory qualitatively.
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