우리나라 건강보험의 위험분담제도가 재정 및 환자접근성에 미친 영향

이종혁,방준석,Lee, Jong Hyuk,Bang, Joon Seok 한국임상약학회 2018 한국임상약학회지 Vol.28 No.2

Objective: This study examined the Risk Sharing Agreement (RSA) on pharmaceutical pricing system in Korean national health insurance. Through RSA, the insurer was able to maintain the principles in the price listing process while managing the budget effectively and improving patient access to new drugs. Despite these positive effects, there are still issues raised by some stakeholders, such as lack of transparency in the listing process and doubts about its effectiveness. Therefore, we investigated the impacts of RSA on national health insurance financing and patient access to analyze the effects of RSA. Methods: The impact of RSA was investigated by analyzing the health insurance claims data for 2014~2016. The degree of improvement in patient access was determined by the decreased amount of patients' payment. Results: Results showed that the financial impact of RSA was not significant and patients' access to the new drug greatly improved. Conclusion: These results show that RSA is a good system for improving patient access to new drugs without additional expense on insurance.

허니컴 구조 SiC 발열체 성능 평가 시뮬레이션

이종혁,조영재,김찬영,권용우,공영민,Lee, Jong-Hyuk,Cho, Youngjae,Kim, Chanyoung,Kwon, Yongwoo,Kong, Young-Min 한국재료학회 2015 한국재료학회지 Vol.25 No.9

A simulation method to estimate microstructure dependent material properties and their influence on performance for a honeycomb structured SiC heating element has been established. Electrical and thermal conductivities of a porous SiC sample were calculated by solving a current continuity equation. Then, the results were used as input parameters for a finite element analysis package to predict temperature distribution when the heating element was subjected to a DC bias. Based on the simulation results, a direction of material development for better heating efficiency was found. In addition, a modified metal electrode scheme to decelerate corrosion kinetics was proposed, by which the durability of the water heating system was greatly improved.

Streptozotocin을 이용한 제1형 당뇨 유발 흰쥐에서 KIOM-79의 효과

이종혁,윤상필,김진숙,장인엽,Lee, Jong Hyuk,Yoon, Sang-Pil,Kim, Jin-Sook,Chang, In-Youb 제주대학교 의과학연구소 2018 The Journal of Medicine and Life Science Vol.15 No.2

We investigated the effect of KIOM-79, 80% ethanolic extract of herbal prescription isolated from Magnolia officinalis, Pueraria lobate, Glycyrrhiza uralensis, and Euphorbia pekinensis, on streptozotocin-induced diabetes in Sprague-Dawley rats. The rats were treated orally with KIOM-79 (500 mg/kg/day) 1) for 3 days prior to streptozotocin (60 mg/kg, intraperitoneal) injection or 2) for 9 weeks after establishing diabetes model to examine acute and chronic effects on hyperglycemia and biochemical variables, respectively. As a result, KIOM-79 had little effects on hyperglycemic changes in acute model. Sexual comparison, however, showed reduced hyperglycemia in female rats, especially 24 hours after streptozotocin injection with or without KIOM-79 pretreatment. In chronic model, streptozotocin-induced hyperglycemia was well established, but KIOM-79 treatment showed no statistically significant effects on all variables. Thus, based on our findings KIOM-79 might have little effects on streptozotocin-induced insulin-dependent diabetes although it has been known to have hypoglycemic and antidiabetic effects on non-insulin-dependent diabetes models.

CUPID코드를 활용한 2×2 봉다발 부수로 내부 단상 및 2상 난류유동 해석

이종혁,박익규,이재룡,김정우,Lee, Jong Hyuk,Park, Ik Kyu,Lee, Jae Ryong,Kim, Jungwoo 한국전산유체공학회 2017 한국전산유체공학회지 Vol.22 No.4

It is important to understand the flow characteristic in a subchannel of nuclear rod bundle in the design process of a nuclear reactor considering the safety margin. In this study, the CUPID code was used to simulate the flow phenomena in the $2{\times}2$ rod bundle. The simulation of $2{\times}2$ rod bundle test under single- and two-phase flow conditions were conducted to validate the turbulence model. The liquid velocities at 0.45 m along the flow path with 0 and 45 degree of azimuthal angle were compared with experimental data. The CUPID results were a good agreement with experimental data, though the ones for 0 degree case has a little discrepancy. For the future work, the turbulent flow will be investigated by applying different turbulence models to improve the prediction of velocity near wall.

Split-Ring 공진기와 Spiral 공진기를 이용한 새로운 소형의 마이크로스트립 대역 저지 필터 설계

이종혁,오영철,명로훈,Lee, Jong-Hyuk,Oh, Young-Chul,Myung, Noh-Hoon 한국전자파학회 2007 한국전자파학회논문지 Vol.18 No.7

이 논문에서는 split-ring 공진기와 spiral 공진기를 complementary 형태로 구현한 새로운 형태의 두 가지 마이크로스트립 대역저지 필터를 제안하였다. 첫 번째는 마이크로스트립 전송 선로의 중앙 선로에 세 개의 split-ring 공진기를 일렬로 배열시켜 에칭 시킨 것이다. 중앙 선로에 구현된 세 개의 split-ring 공진기와 수직으로 시간에 따라 변하는 전계가 걸리면 특정 공진 주파수에서 유효 투자율이 음이 되는 현상이 벌어지며, 이에 따라 전파가 더 이상 진행하지 못하게 된다. 이는 특정 공진 주파수에서 대역저지 현상이 나타나는 것을 의미한다. 두 번째는 첫 번째 것과 비슷하게 마이크로스트립의 중앙 선로에 spiral 공진기를 세 개 나열하여 에칭하였다. Spiral 공진기는 그 축에 수직한 방향으로 전계가 걸렸을 때 특정 공진 주파수에서 self-resonance 현상이 일어나며, 이것이 대역저지 특성으로 나타난다. 제안된 두 필터는 쉽게 공진 주파수와 대역저지 폭을 결정할 수 있고, 매우 작은 크기를 갖으며, 통과대역 내에서 삽입손실이 거의 없으며, 매우 날카로운 스커트 특성을 갖는다. 또한 제작하기 쉽고, 향후 MMIC에 적용하기 쉬울 것으로 예상한다. In this paper, two novel compact microstrip bandstop filters using complimentary split ring resonators(CSRRs) and spiral resonators is proposed. The first one is the bandstop filter using an array of CSRRs etched on the center line of a microstrip. The bandstop is due to the presence of negative effective permittivity and positive permeability near resonant frequency which prevent the wave propagation. The second on is the bandstop filter using an array of spiral resonators etched on the center line of a microstrip. The bandstop is due to the self-resonance of spiral circuit. We have achieved controllable resonance frequency and bandwidth, super compact dimension, low insertion losses in the passband and high level of rejection in the stopband with sharp cutoff. The electrical sizes of two proposed filter are very small. Additionally, they can be easily fabricated and compatible with MMIC or PCB technology.

주변 골흡수 양상에 따른 임플란트와 골의 응력분산에 관한 유한요소 분석

이종혁,김성훈,이재봉,한중석,양재호,Lee, Jong-Hyuk,Kim, Sung-Hun,Lee, Jae-Bong,Han, Jung-Suk,Yang, Jae-Ho 대한치과보철학회 2010 대한치과보철학회지 Vol.48 No.2

연구목적: 본 연구에서는 임플란트 주변 골흡수 양상의 차이가 임플란트와 주변골의 응력 분산에 미치는 영향을 알아보기 위해 수평 골흡수와 임플란트 주변 수직 골흡수에 있어서 주변골의 응력분산, 생물학적 폭경의 형성과 응력분산의 변화 관계 및 병적인 골흡수시의 주변골 응력분포를 유한요소 분석법을 사용하여 비교하고자 하였다. 연구 재료 및 방법:우측 제1 소구치 전방에서 제2 대구치 후방까지의 하악골 모형에서 자연치를 제거하고 직경 4.0 mm, 길이 10.0 mm의 나사형 임플란트를 제1 대구치 부위에 식립하였다. 수평 수직 골흡수의 차이를 보기 위하여 골흡수가 나타나지 않은 형태를 대조군 (I)으로 하여, 1.5 mm 수평 골흡수 (H1.5), 3.0 mm 수평 골흡수 (H3.0) 모형과 이에 상응하는 수직 골흡수 모형 (VW1.5; 1.5 mm, VW3.0; 3.0 mm)을 설계하였고, 생물학적 폭경의 형성과 응력 변화를 관찰하기 위해 생물학적 폭경이 형성되는 과정을 가정한 모형(B0; 피질골에서 임플란트와의 골유착이 없이 밀접하게 접촉된 상태, B1; 피질골에 0.5 mm 폭의 수직 골흡수가 발생한 상태)과 생물학적 폭경이 형성된 상태 (B2)의 모형을 설계하였으며, 생물학적 폭경이 형성된 상태는 0.5 mm 폭을 가지며 임플란트 장축에 경사진 형태를 가지고 있는 1.5 mm 깊이의 수직 골흡수 상태로 형성하였다. 병적 골흡수 상태는 수직 골흡수를 가정한 기존 모형 (VW1.5, VW3.0)과 골흡수가 더 진행된 VW4.5, 기저부에 피질골화가 이루어지지 못한 VO3.0, VO4.5, VO6.0모형을 추가하였다. 하중조건은 수직, 수평하중 그리고 협측 $45^{\circ}$경사하중을 각각 100 N씩 임플란트 보철물 부위에 가하였다. 결과: 분석결과 수평 골흡수와 수직 골흡수에 있어서 전반적인 응력의 크기와 임플란트에 가해지는 응력의 크기는 서로 대응하는 모형에서 유사하였으며, 수직 골흡수에 서 수직력을 받을 때 C2에서 C4로 1.5 mm의 골흡수가 증가하였으나 골에서 발생한 최대응력은 오히려 감소하였다. 수직 골흡수에서 응력이 결손부의 수직 벽을 통해 상부로 분산되는 것을 볼 수 있었다. 생물학적 폭경 형성 단계에서 응력이 가해지는 경우 피질골에서의 결합이 없는 A2에서 피질골 전반에 높은 응력이 발생하였으며 생물학적 폭경의 완성을 가정한 B1에서는 임플란트와 피질골의 경계에서 발생한 응력이 경사진 피질골을 따라서 퍼져나가고 있음을 보였다. 병적 골흡수에서 골결손부 하방에 피질골이 없는 경우는 골흡수에 비례하여 응력이 증가 하였으나 피질골이 있는 경우에는 응력의 증가가 골흡수량의 증가와 비례하지 않음을 보였다. 결론: 임플란트 주변 골흡수의 양이 같아도 흡수된 형태에 따라 발생하는 응력의 크기와 응력분산이 다르게 나타났으며 초기 골흡수 현상은 피질골과의 결합이 약할 때 이 부위에 응력이 증가되어 나타나며, 이후 응력이 감소되어 평형을 이루는 것으로 보인다. 수직 골흡수가 증가할 경우 피질골의 존재 유무가 응력 분산에 큰 영향을 미치며 피질골이 있는 경우 일정 범위에서 응력의 감소가 나타나 응력분산에 유리한 형태에서 골흡수의 진행을 감소시킬 수 있을 것으로 보인다. Purpose: This 3D-FEA study was performed to investigate the influence of marginal bone loss pattern around the implant to the stress distribution. Material and methods: From the right second premolar to the right second molar of the mandible was modeled according to the CT data of a dentate patient. Teeth were removed and an implant ($\Phi\;4.0{\times}10.0mm$) was placed in the first molar area. Twelve bone models were created; Studied bone loss conditions were horizontal bone loss and vertical bone loss, assumed bone loss patterns during biologic width formation, and pathologic vertical bone loss with or without cortification. Axial, buccolingual, and oblique force was applied independently to the center of the implant crown. The Maximum von Mises stress value and stress contour was observed and von Mises stresses at the measuring points were recorded. Results: The stress distribution patterns were similar in the non-resorption and horizontal resorption models, but differed from those in the vertical resorption models. Models assuming biologic width formation showed altered stress distribution, and weak bone to implant at the implant neck area seams accelerates stress generation. In case of vertical bone resorption, contact of cortical bone to the implant may positively affect the stress distribution.

치과용 심미수복재료 세로모에서 수분흡수와 체적 변화에 관한 연구

이종혁,Lee, Jong-Hyuk 대한치과보철학회 2009 대한치과보철학회지 Vol.47 No.2

연구목적: 치과 영역에서 환자들의 심미적인 요구가 증가하면서 자연 치아의 색조를 재현할 수 있는 수복물의 개발이 이루어졌으며, 이러한 연구의 일환으로 도재와 복합레진의 특성을 겸비한 Ceromer(Ceramic Optimized Polymer)가 개발되었다. Ceromer는 기존의 복합레진에 무기질을 고밀도로 충전하여 물리적 성질을 향상시켰다. 연구 재료 및 방법:본 실험에서는 두 종류의 Ceromer[$Targis^{(R)}$(Ivoclar-vivadent AG., Schaan, Liechtenstein), $BelleGlass^{(R)}$(Kerr Co., Orange, CA, USA)]를 이용해 레진 전장관 형태의 시편을 제작하고 증류수에 침전한 후 발생하는 체적과 중량의 변화를 관찰하였다. 결과 및 결론:두 종류의 Ceromer 모두 수중 침적 시간이 증가할수록 높이와 폭이 증가되었으며, $Targis^{(R)}$보다 $BelleGlass^{(R)}$에서 더 큰 누적변화율을 보였다. 72시간까지 급격한 증가를 보이다 이후 누적변화율의 증가는 감소하였다. 통계적 분석결과 $Targis^{(R)}$의 높이와 무게의 누적 변화량이 24시간군과 나머지군 사이에 유의한 차이를 보였으며, $BelleGlass^{(R)}$에서는 폭과 무게에서 누적 변화량이 24시간군과 나머지군 사이에 유의한 차이를 보였다(<.05). $Targis^{(R)}$와 $BelleGlass^{(R)}$ 두 군간의 비교에서는 높이, 폭, 무게의 변화량은 통계적으로 유의한 차이를 보이지 않았으나 변화양상은 다르게 관찰되었다. Statement of problem: The increasing demand for esthetic restorations has been required developing new materials for tooth colored restoration. Ceromer(Ceramic Optimized Polymer) has some advantages over porcelain, and has gained increasing popularity in restorative dentistry. However, there is little information on the dimensional changes in a clinical restoration in moist conditions. Purpose: This study examined the dimensional changes in Ceromer restorations with a clinical crown shape that were fabricated in a clinical manner. Material and methods: The crowns for the maxillary central incisor were fabricated with two Ceromers($BelleGlass^{(R)}$ and $Targis^{(R)}$) using a similar clinical restoration manufacturing technique. A total of twenty specimens were prepared and immersed in distilled water at room temperature to allow for water absorption. The weight, height and width were measured at 24, 72 and 168 hours. The accumulated ratios of the changes were calculated and evaluated using a paired t-test and an independent independent t-test. Results: The dimensions and weight increased with increasing soaking time. $Targis^{(R)}$ showed significant differences in height and weight between 24 hours and the other times(P<.05). $BelleGlass^{(R)}$ showed significant differences in width and weight between 24 hours and the other times. The two materials showed different changing patterns of the dimensions but there were no statistically significant differences between them. Conclusion: The dimensions and weight of the Ceromer restorations were changed by water absorption. The clinical crown shaped specimen showed more complicated dimensional changes than the simplified specimens.

의치상의 종류에 따른 상악 의치상의 유지력에 관한 임상적 연구

이종혁,임주환,조인호,Lee Jong-Hyuk,Lim Ju-Hwan,Cho In-Ho 대한치과보철학회 2001 대한치과보철학회지 Vol.39 No.1

For the successful treatment of complete denture, obtaining a good retention is essential. There are lots of factors affecting denture retention. Denture material, one of those factors affecting denture retention, was the subject of this study, and internal surface treatment also considered for the method of enhancing denture retention. Two resin(Lucitone $199^{(R)}$(heat cured resin) Vertex $CP^{(R)}$(self cured resin)) and two metal($Biosil^{(R)}$(Co-Cr alloy), $Vitallium^{(R)}$(Co-Cr alloy)) denture base materials were used for making test denture base. Newly developed device was used for measuring denture retention. After the retention was measured. We treated internal surface of test denture base with $50{\mu}m\;Al_2O_3$ powder, under 90psi, for 1 minute. Then the retention was measured again. The result was analyzed with K-S test, one-way ANOVA test and independent t-test to deter mine the significant differences as the 95% level of confidence. The results are as follows : In cases of without internal surface treatment, the retention was increased in order of $Vitallium^{(R)},\;Biosil^{(R)},\;Vertex CP^{(R)}$ and Lucitone $199^{(R)}$. Except between Vertex $CP^{(R)}$ and $Biosil^{(R)}$, retention of the other materials was significantly different (p<0.05). After the treatment of internal surface, the retention was increased in order of $Vitallium^{(R)},\;Biosil^{(R)},\;Lucno\;199^{(R)},\;Vertex\;CP^{(R)}$. Except between Lucitone $199^{(R)}$ and Vertex $CP^{(R)}$, $Vitallium^{(R)}$ and $Biosil^{(R)}$ the retention of remaining groups was significantly different each other (p<0.05). In the matter of each material, after the internal surface treatment the retention was increased with Vertex $CP^{(R)},\;Biosil^{(R)}\;and\;Vitallium^{(R)}$ and the value of differences were statistically significant. When we compare the retention of resin and metal denture base, the retention of both denture bases increased significantly with internal surface treatment, and resin denture base showed better retention. As the results show, selecting denture base material could be an important choice of complete denture treatment. To increase denture retention, internal surface treatment can be considered as a possible method.

산업조직론 기본체계에 기초한 국내 PR산업 기초 분석 연구: 주요 PR기업의 경영성과를 중심으로

이종혁 ( Jong Hyuk Lee ),김주호 ( Joo Ho Kim ) 한국PR학회 2007 PR연구 Vol.11 No.3

In this study, we have performed an analysis on public relations industry based on the prime elements of industrial organization. A series of basic data set and its trends were analyzed in order to understand public relations industry. The analysis indicates that the average annual sales of public relations companies is between 4 and 6 billion won. Training expense that was chosen as an indicator of market activities comprised less than 0.3 percent of total sales throughout the companies regardless of their size. The portion of net profit showed 13.3 percent in average among companies with over 60 employees, but lower than that among smaller companies. Additional analysis` are needed to understand the fixed expenses, other than labor costs, that brings down the net profit. For the PR industry has been considered as high-value business relying on human intelligence, less than 5 percent of net income is contradictory to our traditional perception. The average sales per person was between 70 million and 100 million won as the labor costs took 50 percent of the total sales.

인터넷 정치 토론에서 양가성의 역동성과 영향 요인 검증

이종혁(Jong Hyuk Lee),양정애(JungAe Yang),정일권(Irkwon Jeong),최윤정(Yun Jung Choi) 한국방송학회 2015 한국방송학보 Vol.29 No.1