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박경찬(Kyoung Chan Park),윤재일(Jai Il Youn),김원석(Won Suk Kim),이유신(Yoo Shin Lee) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.3
Solar urticaria is a rare skin disease characterized by urticarial reactions immediately following exposure to sunlight or artificial radiation. A 24-yr-old man had solar urticaria that was activated by visible light. Positive result of passive transfer of the reactivity with the patients serum to the skin of normal recipient suggested that his condition was attributable to an allergic response. Result of reverse passive transfer studies was negative. We report a case of solar urticaria which appeares to belong to type N in the classification of Harber.
Molecular Hybridization 을 이용한 첨규콘딜롬의 Human Papillomavirus DNA 검색에 대한 연구
박경찬(Kyoung Chan Park),이상학(Sang Hak Lee),이유신(Yoo Shin Lee),김영기(Young Kee Kim),박흥배(Heung Bae Park),서정선(Jeong Seon Seo) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.6
Condylomata acuminata are benign tumors which are mostly venereally transmitted. Common sites were coronal sulcus, perisnal area and prepuce. Among 28 patients, 21 acuminate lesions and 10 papular lesions were found. Twenty eight human genital warts in Korean were analysed by Southern blot hybridization. Sequences related to HPV6/11 are found in 89.3%(25/28) of the condylomata. HPV16 DNA was not found at sll. Subtype of HPV was determined by the restriction pattern of DNA cleaved with PstI restriction enzyme in 7 cases. Six cases of HPV6a and one case of HPV6c are found. The above results suggest that most of condylomata acuminata are caused by HPV6 and HPV11 in Korea.
김유찬(You Chan Kim),김선훈(Seon Hoon Kim),박경찬(Kyoung Chan Park),이유신(Yoo Shin Lee) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.5
Febrile ulceronecrotic PLEVA is an unusually severe from of PLEVA, characterized by the sudden onset of diffuse ulceronecrotic eruption aasociated with high fever. A mild eruption precede the acute fulminating course, We observed a 13-year-old boy presenting the form of febrile ulceronecrotic PLEVA. The histologic features were those of PLEVA. He received the systemic corticosteroids with aupportive care. To recognize this disorder is important because of a possibly fatal outcome, So close attention and vigorous therapy are necessary.
박경찬,윤재일,이유신 ( Kyoung Chan Park,Jai Il Youn,Yoo Shin Lee ) 대한피부과학회 1988 大韓皮膚科學會誌 Vol.26 No.2
We evaluated the clinical manifestations of 326 patients of vitiligo who had visited Seoul National University Hospital. The results were as follows : 1) There were 141 males (43.3%) and 185 females (56.7%). 2) The mean age of onset was 19.6 years (male : 18.3 years, female : 20.6 years). 3) The mean age at the first visit wss 23.9 years (male : 22.5 years, female : 24.9 years). 4) Duration of disease was less than 2 year in 156 patients (47.9%). 5) The most common site of initial involvement was face (36.2%). The common sites of involvement were face (55.2), abdomen (32.5%), neck (26.7%) and scalp (24.8%) in decreasing order of frequency. 6) There were 167 cases (51.2%) of generalized type, 118 cases (36.2%) of localized type, 31 cases (9.5%) of dermatomal type and 10 cases (3.1) of halo nevus. The most frequent site of dermatomal type was neck. Gray hair was noted in 91 cases (27.9%) and mucosal involvement was present in 43 cases (13.2%). 7) Family history was obtained in 24 cases (7.4%). Koebner phenomenon was present in 48 cases (14%). There were no precipitating factors in 309 cases (94.8%) prior to development of vitiligo. 8) The associated diseases were 1 csse of thyroiditis and 3 cases of alopecia areata.
소아에서의 백반증과 탈색모반 - 임상 및 DOPA 염색에 의한 비교연구 -
김유찬(You Chan Kim),김선훈(Seon Hoon Kim),박경찬(Kyoung Chan Park),이유신(Yoo Shin Lee) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.4
We performed analysis of 79 childhood patients diagnosed as vitiligo and nevus depigmentosus in Tediatric Dermatologie Department of Seoul National University Hospital from March 1987 to September 1987. The results were as follows : 1. Of the 79 patients, 31 patients(39.2%) were vitiligo 21 patients(26.6% )were nevus depigmentosus and 27 patients(34.2%)were uncertain by cliniral diagnostic ctriteri.. 2. Viiligo began rarely in infancy(6.4% )and most appeared evenly in all childhood over 1 year old. Nevus clepigmentosus was present at birth in 57.1% of patients and was discovered within the first 6 months after birth in 42.9% of patients. 3. In vitiligo, most lesions were multiple. The most common site of involvement was the face, and there was this tendency of periorficial predisposition. In nevus ciepigmentosus, most lesions were solitary. The most, common aites of involvement were the lowed limbs and trunk, but there was no tendency of periorfcial presposition. 4. We found focal type of vitiligo in,51,6% of patients, vulgaris type in 32. 3 % acrofacial type in 9.6% and segmerital type in 6.5%. We also found isolated pattern of nevus clepigrnento us in 76.2% of patients, ciermatomal p<:ttern in 19.0ki and whorlec1 pattern in 4.8% The contrast enhiancement between the hypopigmented skin and nomal surrounding skin by Wood's light, examinatior reflected the epiclermal melanin pig merit, i. e., the more marked loss of pigmentation, the more accentuatian of the contrast The before, Wood's light examination without I:3OPA staining could help to ciiagnose the atisculte type of vitiligo showing eidermal melanocytes and nevu c.Iepigmeritosus.
성기주위 사마귀양 병변의 Human Papillomaviruses DNA의 검색
최주현(Joo Hyun Choi),박경찬(Kyoung Chan Park),여운철(Un Cheol Yeo),김정애(Jeong Aee Kim),이유신(Yoo Shin Lee),송계용(Kye Yong Song) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.4
In situ hybridization using biotinylated HPV(Human papillomaviruses) probes was performed to detect HPV DNA in 24 patients with genital wart-like lesions. The lesions were divided into two groups, with or without dysplastic changes histologically. We could detect HPV6/11 in 13 of 17 lesions(76.5%) without dysplastic changes. HPU16/18 was detected in a case with dysplastic changes. HPV6/ll was also detected in a case considered to be misdiagnosed as bowenoid papulosis. Oncogenic HPV such as HPV16/18 was found in one of histologically splastic lesions(14.3%). (Kor J Dermatoi 28(4): 445 449, 1990)
최주현,김영기,서정욱,이유신,박경찬 대한감염학회 1991 감염 Vol.23 No.1
Clinical investigation of the patients with condylomata acuminata was made on 51 patients who were seen at C.A.F.G.H. from May. 1988 through October 1988. Histologic investigation was made on 21 patients who could be biopsied among the above 51 patients, and 26 cases diagnosed at Seoul National University Hospital. The results were as follows. 1) The mean age of the patients was 23.1 years. 2) The suspected sources of infection were prostitutes (60.8%), hostess (13.7%) and girl friends (15.7%). 3) The mean incubation period was 1.8 months. 4) The most common sites were coronal sulcus, glans, shaft and frenum and the shape of the lesion were cawliflower like (69.2%) and papular (30.2%). 5) Koilocytosis was observed in 66.0% of the patients. Although most cases showed marked acanthosis (74.5%), variable degree of hyperkeratosis, parakeratosis, papillomatosis and mitotic figure were observed.
중합효소 연쇄반응을 이용한 성기부사마귀와 후두유두종 Human Papillomavirus DNA의 검색 및 바이러스 전파경로에 대한 연구
정승용,김광현,최영민,이유신,박경찬 대한감염학회 1991 감염 Vol.23 No.1
Twenty genital warts and seventeen laryngeal papilloma were analysed by PCR to detect HPV DNA. Among 20 cases of condyloma, HPV6 was found in 15 cases, HPV11 in 13 cases. Both types were found in 8 cases. Among 16 cases of laryngeal papilloma, HPV6 was found in 11 cases, HPV11 in 6 cases. Both types were found in only one case. From these results, laryngeal papilloma in found to be a pure viral disease caused by HPV6 or HPV11 and also closely related to condyloma acuminatum which are caused by HPV6, 11. DNA extracted from ervical swabs of womens with treated cervical condyloma or without any remarkable past history, were examined for the presence of HPV DNA. Mothers of children with condyloma and laryngeal papilloma were also included to know the possible mode of transmission. HPV DNA was found in 7 out of 21 cases of normal female and female with previous cervical condyloma history. HPV DNA was also found in 2 out of 9 cases of mothers of children's condyloma and laryngeal papilloma patients. From these results, inapparent infection of HPV6, 11 in birth canal become evident but clinical significance of presence of these virus remained to be elucidated.