건선에서의 Anthralin의 치료효과

윤재일(Jai Il Youn),신준우(Jun Woo Shin),이애영(Ai Young Lee),이유신(Yoo Shin Lee) 대한피부과학회 1988 大韓皮膚科學會誌 Vol.26 No.1

Our Study was performed to evaluate the effect of anthralin for the treatment of psoriasis. Thirty seven patients with mild form of psoriasis were trested with topical anthralin ointment. 1. Twenty patients(54%) showed clearing of lesion within 8 weeks. 2. Treatment with anthalin was failed in 15 patients(40.5%). 3. Side reaction such as staining, pruritus and erythems was noted in 18 patients (48.6%), among them, 8 patients(21.6%) terminated the therapy with anthralin due to marked side reaction.

전신성 농포성 건선의 임상적 연구

윤재일 ( Jai Il Youn ),오준규 ( Jun Gyu Oh ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.2

Background: Generalized pustular psoriasis(GPP) is an uncommon from of psoriasis in which a widespread eruption of sterile oustules occurs. In Korea some cases of generalized pustular psoriasis have been reported, but clinical reviews on generalized pustular psoriasis are not available. Objective : We investegated the clinical and laboratory findings in some patients with generalized pustular psoriasis in Korea. Methods : We studied the clinical and laboratory findings in 27 patients with generalized pustular psoriasis who visited Seoul National University hospital during the past 10 years. All the data were analyzed in total of patients with generalized pustular psoriasis, and analyzed after the patients were separated into 4 clinical types. Results : 1. The male to female ratio was 1:2, and the average age of the first onset of GPP was 27.1 years. 2. The number of patients with previous history of psoriasis vulgaris were 19(70.4%). In these patients, the average age at the onset of psoriasis vulgaris was 23.4 years, and average age at the onset of GPP was 34.3 years. 3. The number of patients with a family history of psoriasis were 2(7.4%) 4. The number of patients with possible provocative factors were 16(59.3%). Systemic corticosteroid therapy was done before the onset of GPP in 7 patients, and was the most common provocative factor. 5. Fever(70.4%), chill(33.3%), and arthralgia(18.5%) were common systemic symptoms associated with GPP. 6. In laboratory tests, leukocytosis(63%), elevated ESR(62.5%), hypoalbuminemia(40.7%), and decreased cortisol(32.5%) were often found. 7. With the clinical types, the acute generalized type was 59.3%, juvenile and infantile type 25. 9%, annular and circinate type 7.4%, and GPP during pregnancy was 7.4%. In juvenile and in fantile type, patients with a previous history of psoriasis vulgaris and possible provocative factors of GPP were much less common than in the other types. Conclusion : In patients with GPP in Korea, a family history of psoriasis is much less frequent than in western countries. In the possible provocative factors of GPP, systemic corticosteroid therapy was the most common, so it is recommended that systemic steroid therapy should be avoided in the treatment of psoriasis vulgaris. In the comparison of the 4 clinical types, juvenile and infantile type showed a marked iifference in that GPP occurred spontaneously without any previous history of psoriasis and with no provocative factors. (Kor J Dermatol 1996;34(2): 233-239)

건선에서의 저농도 Anthralin 효과의 비교 연구

윤재일(Jai Il Youn),이유신(Yoo Shin Lee),김규한(Kyu Han Kim) 대한피부과학회 1989 大韓皮膚科學會誌 Vol.27 No.3

We performed anthralin comparative study(0.01% vs 0.1%) to assess the effectiveness of low-strengh anthralin therapy in 34 psoriatic patients and the resu1ts can be summarized as follows. 1. In the case of 13 patients using Burdick UVB larnp, in 1 patient the effect of 0.1% anthralin was superior to that of 0.01% anthralin from the start to the end of treatment, in 5 patients(38.5%) initially the effect of 0.1% anthralin was superior but in time became equal to that of 0.01% anthralin, and in 7 patients (53.8%) the effect of either side was same throughout the courae of the treatment. In the case of 21 patients using Waldmann UVB cabinet, there were 2(9.5 %), 3(14.3%) and 16 patients(76.2%) in the order named above. 2. The side effect of 0.1% anthralin was more severe than or at least the same as that of 0.01% anthralin in every patient who complained about side effects. So low-strengh anthalin-UVB phototherapy was thought to be the effective and alternative method of treatment particularly for the purpose of lessening the side effects.

Anthralin - UVB 광요법에 의한 건선의 치료

윤재일(Jai Il Youn),김규한(Kyu Han Kim),이유신(Yoo Shin Lee) 대한피부과학회 1984 大韓皮膚科學會誌 Vol.22 No.6

Our study was performed to evaluate the efficacy of anthralin-UVB therapy on patients with psoriasis. We studied twenty two patients suffering from plaque-type psoriasis of varying degrees of severity. The results can be summarized as follows. l. 2p patients(90.9%) out of the total 22 patients showed grade 4 improvement. The rernaining 2 patients failed to respond to treatment, 2. Arnong the improved 2Q patients, 2 patients who were treated more than 3p times for grade 4 improvement were excluded, so cleared patients were 18(81.8%). 3. Arnong the 18 cleared patients, the mean nurnber of therapy wasg. 6 for grade 3 and 12. 5 for grade 4 in the cases of trunk lesiona, and 13. 2 for grade 3 and 17. 8 for grade 4 in the cases of extrernities lesions. With above results, anth-ralin-UVB therapy was rnore effective in lesions of the trunk than in those of extremi.ties. 4. Notable side effects were pruritus in 6 patients(27.3pg), staining in 4 patients (18,2%), and 1ITltatioB in 2 patients(9.1%)

자외선 A 조사가 자외선 B에 의한 일광화상 세포 형성에 미치는 영향

윤재일(Jai Il Youn),조광열(Gwang Yeol Joh) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.1

This study was done to study the effect of UVA radiation upon sunburn cell formation by UVB. In this study a total of 67 ICR male albino haired mice were used. The results were as follows: 1. UVA radiation produce a little or no sunburn cell in doses 5 J/cm2, 10 J/cm2, and 15 J/cm2. 2. Preirradiation of UVA 5 J/cm, 10 J/cm2, 15 J/cm2 had no effect on the sunburn cell formation by UVB 20 mJ/cm2, 80 mj/cm2

건선환자에서의 Anthralin의 피부자극과 착색반응

윤재일(Jai Il Youn),이애영(Ai Young Lee) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.1

Both irritation and staining reaction of anthralin on the skin are the two most important problem of therapy. Irritation, such as erythema, edema and staining by p. lg anthralin ointment were studied with the chamber-testing technique in 21 psoriatic patients. We campared the skin reaction of short exposure time, such as 1 hour, 2 hours, and 3 hours with those of exposure of 24 hours through 3 days after application. The results were as follows: l. Incidence of erytherna reaction was 81.9% in exposure of 1 hour, 85.7%, in 2 hours, 90.5%, in 3 hours and 100% in exposure of 24 hours. Degree of erythema reaction was increased according to duration of application. 2. There were no edematous reactions in exposure of 1 hour or 2 hours, 9,5% in 3 hours and 28,6% of grade 1 reaction in 24 hours. 3. There was no staining reaction in exposure of 1 hour, 48% in 2 hours, 9.5%, in 3 hours and 71.4% in 24 hours. Degree of staining reaction elicited by short exposure time were all weaker than reaction caused by 24 hours exposure.

Facial Psoriasis as a Marker of Severe Psoriasis

윤재일 ( Jai Il Youn ) 대한피부과학회 2005 초록집 Vol.43 No.10

자외선에 의한 일광화상세포 형성에 미치는 세포분열 변화의 영향

윤재일(Jai Il Youn),김방순(Bang Soon Kim),김태흥(Tae Heung Kim),김정애(Jeong Aee Kim) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.3

The influence of ultraviolet light(UVL) upon sunburn cell(SBC) formation according to the change of mitosis was studied in mouse skin. Decrease of mitosis which suppress cell proliferation was done by methotrexate (MTX) intradermal injection. Increase of mitosis which stimulate cell proliferation was performecl by tape stripping(TS). A total of 75 ICR female albino mice was used in this study. UV light source was UVB using high pressure mercury arc. The arnount exposed was 100m J/cm. 1. The number of SBC in 1cm epidermis after UVI exposure was 42.4+20.9. The number of SBC was decreased by MTX injection(18.4+9.2), and increased by TS(78.5:+ 12.8). 2. Labelling index(LI, %) in normal mouse skin was 8.9+1.8. LI was decreased by MTX injection(4.4+1.7), and markedly increased by TS (24.2 l- 4.7). These results suggest that the change of mitosis which correlated with cell proliferation influence the SBC formation by UV exposure. (Kor J Dermatol 28(3): 269 277, 1990)

건선 환자 3,123명에 대한 임상적 연구 -서울대학교병원 피부과 건선 크리닉 20년간(1982-2002) 등록환자 3,123명에 대한 임상적 관찰-

윤재일 ( Jai Il Youn ),조성진 ( Seong Jin Jo ) 대한피부과학회 2004 대한피부과학회지 Vol.42 No.12

건선의 임상적 연구 - 1 . 침범범위에 따른 경중도의 분류 및 임상적 비교 관찰 -

윤재일(Jai Il Youn),이주홍(Joo Heung Ree),이유신(Yoo Shin Lee) 대한피부과학회 1988 大韓皮膚科學會誌 Vol.26 No.6

In study of 360 psoriatic patients between June 1982 and May 1987 in Seoul National University Hospital, psoriasis was classified according to the severity based on the extent of involvement. The guideline of the extent of involvement was as follows, 1) mi1d less than 5% involvement of whole surface area 2) moderate : 5% 30% involvement of whole surface area 3) severe: over 30% involvement of whole surface area This study was done to evaluate the distribution and clinical features of psoriasis according to the extent, of involvement. Among 360 psoriatics, 180(50.0%) patients had mild psoriasis, 140(38.9%) patients had moderate psoriasis and 40(11.1%) patients presented as severe psoriasis. The duration of psoriasis seemed longer in moderate and severe groups than in mild group but the difference was not signifcant. There was also a tendency that patients developing psoriasis before the age of 20 were more prevalent in severe group.