굴곡부 망상 색소이상증

윤재일(Jai Il Youn),박흥배(Heung Bae Park),이유신(Yoo Shin Lee) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.4

Reticulate pigmented anomaly of the Flexures (Dowling-Degos disease) is the rare pigment anomaly characterized by spotted and reticulate pigrnentation of the flexures. We report a case of reticulate pigmented anomaly of flexures in a 37-year-old woman. She had reticulated network of brown-black macules on right infrarnammary region and arm. Histopathological findings showed branching melanized epidermal downward proliferations arising from the lower border of epidermis.

한국인의 건선

윤재일 ( Jai Il Youn ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.5

Psoriasis is a chronic cutaneous disease with papules and plaques with white scales on them. Psoriasis is a common skin disease throughout the world. When compared with Caucasian, prevalence rate is lower in Korean, however it has been increasing noticeably. We reported epidemiology, clinical features and HLA typing of psoriasis and psoriatic arthritis from patients who have been enrolled in Seoul National University Hospital psoriasis clinic during 30 years from 1982 to 2012. Peak age of onset in male was in their twenties, while it was in their teens in female patients. Age of onset in 4,526 patients was as follows: 20∼29 (31.3%), 10∼19 (25.9%), 30∼39 (16.6%), 40∼49 (10.6%), 0∼9 (6.3%), 50∼59 (5.7%), 60∼69 (2.8%) and over 70 (0.8%). We confirmed that Korean patients also have a bimodal onset of disease. The early onset type showed more extensive body surface area as well as increased family history as in Caucasians. Most common clinical type was the plaque form (84.6%). Fifty three (10.5%) of the 504 psoriasis patients were demonstrated to have psoriatic arthritis (PA). The mean age of onset of PA was 38.8±14.5. Spondylitis was found in 43.4%. Psoriasis preceded PA in 73.6% of total patients with the mean interval of 12.2 years. HLA-CW*0602 showed the strongest association (76.1%) with psoriasis in Korean patients. (Korean J Dermatol 2012;50(5):387∼402)

자외선 A 조사가 자외선 B에 의한 일광화상 세포 형성에 미치는 영향

윤재일(Jai Il Youn),조광열(Gwang Yeol Joh) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.1

This study was done to study the effect of UVA radiation upon sunburn cell formation by UVB. In this study a total of 67 ICR male albino haired mice were used. The results were as follows: 1. UVA radiation produce a little or no sunburn cell in doses 5 J/cm2, 10 J/cm2, and 15 J/cm2. 2. Preirradiation of UVA 5 J/cm, 10 J/cm2, 15 J/cm2 had no effect on the sunburn cell formation by UVB 20 mJ/cm2, 80 mj/cm2

건선에서의 Anthralin의 치료효과

윤재일(Jai Il Youn),신준우(Jun Woo Shin),이애영(Ai Young Lee),이유신(Yoo Shin Lee) 대한피부과학회 1988 大韓皮膚科學會誌 Vol.26 No.1

Our Study was performed to evaluate the effect of anthralin for the treatment of psoriasis. Thirty seven patients with mild form of psoriasis were trested with topical anthralin ointment. 1. Twenty patients(54%) showed clearing of lesion within 8 weeks. 2. Treatment with anthalin was failed in 15 patients(40.5%). 3. Side reaction such as staining, pruritus and erythems was noted in 18 patients (48.6%), among them, 8 patients(21.6%) terminated the therapy with anthralin due to marked side reaction.

만성지속성 광선과민증

윤재일(Jai Il Youn),정진호(Jin Ho Jung),이유신(Yoo Shin Lee) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.3

Persistent light reaction, actinic reticuloid, photosensitive eczema are three chronic photodermatoses with a feature of clinical, histological, and photobiologieal characteristics in common. These conditions were given the name of chronic persistent photosensitivity. Chronic persistent photosensitivity with the feature of photosensitive eczema developed in a 68-year-old male patient who had experienced persisited dermatitis. On phototesting the patient showed extremely severe photosensitivity to the short wave UVB. A skin biopsy showed microscopic finding of eczematous dermatitis.

건선에서의 저농도 Anthralin 효과의 비교 연구

윤재일(Jai Il Youn),이유신(Yoo Shin Lee),김규한(Kyu Han Kim) 대한피부과학회 1989 大韓皮膚科學會誌 Vol.27 No.3

We performed anthralin comparative study(0.01% vs 0.1%) to assess the effectiveness of low-strengh anthralin therapy in 34 psoriatic patients and the resu1ts can be summarized as follows. 1. In the case of 13 patients using Burdick UVB larnp, in 1 patient the effect of 0.1% anthralin was superior to that of 0.01% anthralin from the start to the end of treatment, in 5 patients(38.5%) initially the effect of 0.1% anthralin was superior but in time became equal to that of 0.01% anthralin, and in 7 patients (53.8%) the effect of either side was same throughout the courae of the treatment. In the case of 21 patients using Waldmann UVB cabinet, there were 2(9.5 %), 3(14.3%) and 16 patients(76.2%) in the order named above. 2. The side effect of 0.1% anthralin was more severe than or at least the same as that of 0.01% anthralin in every patient who complained about side effects. So low-strengh anthalin-UVB phototherapy was thought to be the effective and alternative method of treatment particularly for the purpose of lessening the side effects.

Tape stripping을 이용한 세포증식이 자외선 B에 의한 일광화상세포 형성에 미치는 영향

윤재일(Jai Il Youn),김방순(Bang Soon Kim),문상은(Sang Eun Moon) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.2

index (%) in unirradiated mouse skin was 11.0+4.3. LI was significantly increased by tape stripping to 22.1+4.6. 2. The number of SBC in 1cm epidermis after 50mJ/cm UVB exposure was 28.2+4.1. The number of SBC was increased by tape stripping to 57.4+Cell proliferation, by evaluating sunburn cell (SBC) formation, was studied in mouse skin following tape stripping and ultraviolet light B (UVB) exposun.. 1-radiation was achieved using high pressure mercury are UVB. The results are summarized as follows. 1. Labeling 19.2. These results suggest that proliferating cells are more sensitive to UVB exposure. (Kor J Dermstol 1992;30(2): 162-167)

Anthralin - UVB 광요법에 의한 건선의 치료

윤재일(Jai Il Youn),김규한(Kyu Han Kim),이유신(Yoo Shin Lee) 대한피부과학회 1984 大韓皮膚科學會誌 Vol.22 No.6

Our study was performed to evaluate the efficacy of anthralin-UVB therapy on patients with psoriasis. We studied twenty two patients suffering from plaque-type psoriasis of varying degrees of severity. The results can be summarized as follows. l. 2p patients(90.9%) out of the total 22 patients showed grade 4 improvement. The rernaining 2 patients failed to respond to treatment, 2. Arnong the improved 2Q patients, 2 patients who were treated more than 3p times for grade 4 improvement were excluded, so cleared patients were 18(81.8%). 3. Arnong the 18 cleared patients, the mean nurnber of therapy wasg. 6 for grade 3 and 12. 5 for grade 4 in the cases of trunk lesiona, and 13. 2 for grade 3 and 17. 8 for grade 4 in the cases of extrernities lesions. With above results, anth-ralin-UVB therapy was rnore effective in lesions of the trunk than in those of extremi.ties. 4. Notable side effects were pruritus in 6 patients(27.3pg), staining in 4 patients (18,2%), and 1ITltatioB in 2 patients(9.1%)

건선의 임상적 연구 - 1 . 침범범위에 따른 경중도의 분류 및 임상적 비교 관찰 -

윤재일(Jai Il Youn),이주홍(Joo Heung Ree),이유신(Yoo Shin Lee) 대한피부과학회 1988 大韓皮膚科學會誌 Vol.26 No.6

In study of 360 psoriatic patients between June 1982 and May 1987 in Seoul National University Hospital, psoriasis was classified according to the severity based on the extent of involvement. The guideline of the extent of involvement was as follows, 1) mi1d less than 5% involvement of whole surface area 2) moderate : 5% 30% involvement of whole surface area 3) severe: over 30% involvement of whole surface area This study was done to evaluate the distribution and clinical features of psoriasis according to the extent, of involvement. Among 360 psoriatics, 180(50.0%) patients had mild psoriasis, 140(38.9%) patients had moderate psoriasis and 40(11.1%) patients presented as severe psoriasis. The duration of psoriasis seemed longer in moderate and severe groups than in mild group but the difference was not signifcant. There was also a tendency that patients developing psoriasis before the age of 20 were more prevalent in severe group.

연화제 - 광요법에 의한 건선의 치료

윤재일(Jai Il Youn),이애영(Ai Young Lee),이유신(Yoo Shin Lee) 대한피부과학회 1983 大韓皮膚科學會誌 Vol.21 No.5

The present study was undertaken to evaluate the efficacy of white petrolatum-UVB therapy on patients with psoriasis. Nineteen patients with chronic plaque type psoriasis selected in the Department of Dermatology, Seoul National University Hospital were treated with white petrolatum followed by exposure to UVB. Clinical response to therapy was graded as follows: Grade 1: Minimal improvement, Grade 2: Definite improvement Grade 3 Considerable improvement, Grade 4: Clearing. We campared the clinical response according to involved site: trunk and extremity. A responsive case was defined as a case with G4 in trunk and/or extremities. The results can be summarized as follows: 1. Fourteen of the 19 patients(73. 7%) were classified as being responsive cases. 2. Among the responsive cases, the 11 cases of trunk lesion all showed G4 clea- ring. The extremities lesion cases showed G4 clearing in 9 out of 14 cases, the other 5 cases showing GR. This showed that the trunk lesions were more responsive to the treatment than the extremities lesions. 3. In the cases of trunk lesions, the mean number of therapy was 6. 3 for G2 response, 11. 2 for GR and 16. 7 for GR. In the cases of extremities lesions, the mean number of the therapy was 8. 6 for G2, 16. 1 for GR and 19. 2 for Gl. 4. Pruritus was a complaint in 13 patients (68. 4%) during therapy. Among them moderate to severe pruritus was noticed in 6 cases (51. 6%). From the above results the emollient phototherapy seems to be an effective therapy in the treatment of psoriasis.