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A Study on Cerebral Ischemia-Reperfusion Injury: Involvement of Platelet-Activating Factor
이원석,임병용,홍기환,Lee, Won-Suk,Rhim, Byung-Yong,Hong, Ki-Whan The Korean Society of Pharmacology 1993 대한약리학잡지 Vol.29 No.1
뇌의 허혈-재관류 손상에 있어서 혈소판 활성인자 (PAF, platelet activating factor)의 관련을 증명하기 위하여 흰쥐와 생쥐에서 양측 총경동맥을 10분간 결찰하고 그후 6시간동안 재관류시켜 허혈-재관류 손상을 야기시켰다. 생쥐에 PAF 길항제인 BN52021과 CV6209 (각각 1 mg/kg, i.p.)를 총경동맥결찰 10분전 또는 재관류 시작 1시간 후에 투여시 McGram stroke index는 심하게 억제되었다. 흰쥐와 생쥐에서 뇌허혈-재관류에 의한 뇌수분함량의 증가는 BN52021 또는 CV6209 전처치에 의하여 유의하게 억제되었다. BN52021 전처치는 허혈 후의 혈압변동을 개선시켰을 뿐만 아니라 뇌연막동맥의 확장지연에 대하여도 효과가 있었다. 이러한 실험결과로 보아 PAF가 뇌허혈-재관류 손상의 발생에 내인성 인자로서 중요한 역할을 하는 것으로 사료된다. 나아가 PAF 길항제가 뇌허혈후의 병리학적 후휴증의 개선 내지는 예방에 사용 될 수 있을 것으로 기대된다. To elucidate involvement of platelet-activating factor (PAF) in cerebral ischemia-reperfusion injury, male Sprague-Dawley rats and albino mice of either sex were subjected to a 10-min bilateral carotid artery occlusion and 6-hr recirculation. The McGraw stroke index in mice was markedly inhibited by PAF antagonists, BN 52021 and CV 6209 (1 mg/kg, i.p., each) When they were administered 10 min before bilateral carotid artery occlusion or 1 hr after reperfusion. The increases in brain water content were significantly attenuated by treatment with BN 52021 or CV 6209 in both animals. BN 52021 exhibited a significant improvement in the postischemic blood pressure change in association with a beneficial effect on the delayed dilatation of pial arterioles after 10 min of ischemia. Thus it is suggested that PAF plays an important role as an endogenous mediator in development of cerebral ischemia-reperfusion injury, and further, specific antagonists to PAF will be able to prevent or reverse the pathological sequelae of cerebral ischemia.
이원석,신동민,이규철,Lee, Won-Suk,Shin, Dong-Min,Lee, Kyu-Chul 한국정보통신학회 2007 한국정보통신학회논문지 Vol.11 No.8
유비쿼터스 환경으로 발전하면서 이종의 디바이스들을 자연스럽게 연동시킬 수 있는 기술에 대한 요구가 크게 증가하고 있으며, 이를 해결하기 위한 하나의 대안으로 웹서비스가 주목받고 있다. 최근 디바이스 연동을 선언적인 ECA(Event-Condition-Action) 룰로 정의하고 이를 이용하여 디바이스 연동을 수행할 수 있는 웹서비스 기반의 WS-ECA(Web Services-ECA) 프레임워크가 제안되었다. 본 논문에서는 WS-ECA 프레임워크에 대한 구체적인 모듈 단위의 설계 부분을 제안하고, 이를 기반으로 WS-ECA 프레임워크를 구현하였다. Requirement of coordination among heterogeneous devices is significantly increasing to meet the challenges presented by the evolvement of the ubiquitous computing environment. The web services technology is receiving much attention as a promising solution to support the inter-operability between such heterogeneous devices by means of well-defined protocol. Recenlty, ECA(Event-Condition-Action) rule-based framework for coordinating devices is proposed, which is called WS-ECA(Web Services-ECA) framework In this paper we propose a specific design and an implementation methodology for WS-ECA framework.
이원석,임병용,홍기환,Lee Won-Suk,Rhim Byung-Yong,Hong Ki-Whan The Korean Society of Pharmacology 1986 대한약리학잡지 Vol.22 No.1
후신경구절제(OB) 흰쥐에 있어서 muricide의 발생은 중추성 ${\alpha}$-adrenoceptors의 기능항진과 밀접한 관계가 있다는 가설하에 다음 실험을 행하였다. Muricide를 일으키는 OB 흰쥐의 전뇌내 noradrenaline(NA)의 전환율은 대조군에 비하여 현저히 낮았으나 $_{{\alpha}_2}$-adrenoceptor 길항약물인 yohimbine이나 idazoxan 투여시 NA 전환은 muricide의 억제와 함께 현저히 증가되었다. OB흰쥐의 전뇌 피질막의 $[^3H]$ yohimbine에 대한 최대결합능(Bmax)은 대조군에 비하여 현저히 높았다. ${\alpha}$-Adrenoceptor 효능약물 및 길항약물에 대한 친화도는 아무런 변동이 없었다. 이상의 결과로 보아 OB흰쥐에서 야기되는 muricide는 중추성 ${{\alpha}_2}$-adrenoceptor의 기능 항진과 밀접한 관련이 있다고 사료되는 바이다. The involvement of central $_{{\alpha}2}$-adrenoceptors in the development of muricide (mouse-killing behavior) in the olfactoly bulbectomized (OB) rats was strudied. The fractional turnover rate of noradrenaline (NA) in forebrain from OB muricidal rats was significantly lowered than that from sham rats. However, after yohimbine or idazoxan treatment, NA turnover was significantly increased in concert with inhibition of the development of muricide in OB rats. By radioligand binding studies with $[^3H]$ yohimbine, the maximum binding $(B_{max})$ of $[^3H]$ yohimbine to cerebral cortical membrane from OB rats was significantly higher than that from sham rats without change of affinity for agonists and antagonists$(K_i)$. With these results it was suggested that muricidal behavior of OB rats has a close relevance to the hyperactivity of central $_{{\alpha}2}$-adrenoceptor system.
이원석 ( Lee Won-suk ),윤현도 ( Yun Hyun-do ),최기선 ( Choi Ki-sun ),유영찬 ( You Young-chan ),김긍환 ( Kim Keung-hwan ) 한국구조물진단유지관리공학회 2006 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.10 No.2
Shear behavior of recycled aggregate coarse concrete (RACC) beams was investigated experimentally in order to contribute to the establishment of shear design methodology by comparing that of reinforced concrete beam made of natural aggregate. Tests have been performed on recycled aggregates and on four concrete mixes (conventional concrete and recycled concrete with 30, 60, 100% replacement of recycled coarse aggregates). For every test parameter, three reinforced beams without shear reinforcement were made and were tested to failure. The results showed that whereas the deflections and the ultimate loads were little affected by the different types of concretes. Experimental results were compared with analytical results by current codes. Codes predicted the shear strength of the recycled aggregate concrete in a reasonable error.
강섬유와 탄소섬유를 사용한 고인성 시멘트 복합체의 역학적 특성에 관한 실험적 연구
이원석 ( Lee Won-suk ),변장배 ( Byun Jang Bae ),윤현도 ( Yun Hyun-do ),김선우 ( Kim Sun Woo ),전에스더 ( Jeon Esther ) 한국구조물진단유지관리공학회 2006 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.10 No.1
The objective of this study is to examine mechanical properties of HPHFRCCs using steel cord and carbon fiber. This HPHFRCCs mixted with micro-fiber(Carbon fiber) and macro-fiber(Steel cord) improve on ductility, toughness, and deformation capacity under compressive and tensile stress. These properties of HPHFRCCs are affected by type of fiber, water cement ratio, type of admixture, rate of substitution and kind of sand. Furthermore these influence dispersion of fiber, mixing performance and fluidity of mixture. In this paper, HPHFRCCs made of steel cord and carbon fiber were tested with water cement ratio, type of admixture, rate of substitution and kind of sand to evaluate characteristics of mechanical properties of HPHFRCCs.