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이상국 ( Sang Kook Lee ),이상훈 ( Sang Hoon Lee ),김송이 ( Song Yee Kim ),이우경 ( Woo Kyung Lee ),신동호 ( Dong Ho Shin ),방우대 ( Woo Dae Bang ),노송미 ( Song Mi Noh ),심효섭 ( Hyo Sup Shim ),박병훈 ( Byung Hoon Park ),이경종 ( 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.70 No.2
We report a case of Caplan`s Syndrome, which presented as multiple pulmonary nodules. A 58-year-old male was admitted to hospital due to multiple pulmonary nodules. In addition, the patient presented with multiple arthritis, and dyspnea on exertion. Rheumatoid arthritis had been diagnosed 35 years ago. The patient had worked as a stonemason for 20 years. Computed Tomography (CT) revealed numerous well-defined tiny nodules scattered in both lungs, which was suspicious of miliary tuberculosis or malignancy. The patient was started on antituberculous medications and referred to our hospital. First, a transbronchial lung biopsy was performed, which showed no evidence of granuloma. It was our opinion that the biopsy was insufficient, and a follow-up video-associated thoracoscopy was performed. The pathological report determined necrotizing granulomatous inflammation and silicosis on background. According to imaging studies, pathologic reports, and clinical symptoms, we concluded that the patient had Caplan`s syndrome. We controlled his rheumatic medications, and instructed him to avoid exposure to hazardous dust.
고도불포화지방산 함량이 높은 유지를 섭취시킨 흰쥐에서 양조간장과 멜라노이딘의 지질산화 억제효과
이상조(Sang-Jo Lee),류승희(Seung-Hee Ryu),이영순(Young-Soon Lee),송영선(Young-Sun Song),문갑순(Gap-Soon Moon) 한국식품영양과학회 2003 한국식품영양과학회지 Vol.32 No.6
In vitro와 in vivo에서 양조간장과 glucose-lysine 모델 멜라노이딘의 항산화효과를 조사하여 다음과 같은 결과를 얻었다. In vitro에서 양조간장과 멜라노이딘의 항산화효과를 linoleic acid emulsion계를 이용하여 비교하였을 때 양조간장과 멜라노이딘은 대조군에 비해 우수한 항산화활성을 나타내었고 특히 양조간장의 효과가 더 우수한 것으로 나타났다. DPPH 라디칼 소거활성 역시 멜라노이딘에 비해 양조간장의 효과가 큰 것으로 나타났다. 지방산 조성이 상이한 옥수수기름과 어유를 섭취시킨 흰쥐에 10% 양조간장 및 멜라노이딘을 5주간 섭취시켰을 때 간의 지방산 조성은 섭취지방산에 따라 차이가 뚜렷하였으나 양조간장과 멜라노이딘의 효과는 대조군과 유사하였다. 지질 과산화물 생성정도를 TBARS로 측정하였을 때 불포화지방산 함량이 높은 어유 섭취군에서 지질과산화가 증가하였으며 간장과 멜라노이딘은 지질과산화를 억제하는 효과를 나타내었다. CL(chemiluminescence)-HPLC 방법을 이용하여 간과 혈장의 막 인지질 PCOOH 함량을 측정한 결과, 어유의 섭취는 옥수수기름 섭취군에 비해 지질 과산화를 월등히 증가시켰고 양조간장과 멜라노이딘의 섭취는 유의적으로 지질 과산화를 억제한 것으로 나타났다. 특히 양조간장의 효과가 멜라노이딘 보다 우수하여 이는 콩유래 항산화물질인 수용성 펩티드나 저분자 단백질들이 효과적으로 항산화활성을 나타낸 것으로 여겨지며, 불포화지방산이 높은 식품의 섭취시 간장을 소스로 이용하는 것이 지질의 과산화를 억제할 것으로 기대되어진다. Soybean sauce, fermented with soybean and wheat, has been a major condiment of Korean diets from centuries ago. Melanoidin, a brown pigment generally found in various food systems, is a final product produced in amino-carbonyl reaction during soybean sauce processing. Antioxidative activities of soybean sauce and melanoidin were investigated in vitro system using linoleic acid emulsion. Soybean sauce and glucose-lysine model melanoidin showed the stronger antioxidative effect than control by ferric thiocyanate and conjugated diene assays. In addition, DPPH radical scavenging effect of soybean sauce was higher than melanoidin, which was ascribed to soluble peptide and low molecular protein existing in soybean sauce. To ascertain antioxidative effect of dietary soybean sauce and melanoidin in vivo, the male Wister rats were fed 10% soybean sauce or 10% glucose-lysine model melanoidin with corn oil or fish oil for 5 weeks. Fatty acid compositions in liver and plasma were influenced by oil source. Therefore, EPA and DHA contents of fish oil group were higher than those of corn oil group. When the inhibitory effect of soybean sauce and melanoidin on lipid peroxidation using TBARS methods was measured, fish oil group (FC) showed higher malondialdehyde (MDA) content than corn oil group (CC). However, supplementation of soybean sauce and melanoidin to fish oil group attenuated MDA formation. In the levels of phosphatidyl choline hydroperoxide (PCOOH) in liver and plasma by CL (chemiluminescence)-HPLC method, PCOOH in FC group was significantly higher than that of CC group both in liver and plasma. Supplementation of soybean sauce to fish oil groups significantly inhibited the formation of PCOOH in plasma and liver, while melanoidin suppressed hepatic PCOOH formation. Based on these results, it can be suggested that soybean sauce possesses stronger antioxidative potential than melanoidin.
巨濟地域住民(거제지역주민)의 B型(형) 肝炎(간염) 罹患率(리환률)과 HBsAg 陽性(양성) 兒童(아동) 家族(가족)원의 感染狀態(감염상태)
이상관 ( S K Lee ),송기용 ( G Y Song ),이호원 ( H W Lee ) 대한임상검사과학회 1993 대한임상검사과학회지(KJCLS) Vol.25 No.1
To know the incidence of HBV infection according to age, sex and economic status, 1,992 residents including both adults and children, who living at Koje island from June 1992 to May 1993, were examined for the HBV markers. And then 895 out of total 995 family members of 243 children who had been screened as HBsAg( +) and anti-HBs(-) in 43 and HBsAg(-) and anti-HBs(-) in 200, were also examined for the presence of HBV markers to compare the status of HBV infection between the two groups of family members of HBsAg ( + ) and HBsAg ( - ) children. Among total 1,992 residents, HBsAg( +) and anti-HBs( +) rates was 9.6% and 51.8% respectively. HBsAg( +) rate was 10.1% in male and 9.1% in female and was highest in the age group of 30~39 years and lowest in 0~9 years. The HBsAg( +) rate was higher in low economic class;10.4% than in middle class;9.7 % and high class;8.7%. The HBsAg( +) rate among 167 family members of children who were HBsAg( +) and anti -HBs(-); 50.1% (97 /167) was higher than that of 728 family members of children with HBsAg (-) and anti-HBs(-) children; 1.5% (11/728). The anti-HBs( +) rate was lower in family members of HBV infected children than those of not infected children. According to the family relationships, the HBsAg( +) rates of father, mother, brothers and sisters of HBV infected children were 41.0 %, 40.5%, 56.0% and 38.5% respectively, while those of not-infected control children were 1.5 %, 3.5% none and 1.2% respectively.
연구논문 : 화성호 유입하천의 강우시 비점오염물질 유출특성
이상은 ( Sang Eun Lee ),최이송 ( I Song Choi ),이인호 ( In Ho Lee ),홍대벽 ( Dae Byuk Hong ),오종민 ( Jong Min Oh ) 한국환경영향평가학회 2011 환경영향평가 Vol.20 No.5
The purpose of this study is to estimate the characteristics and pollutant loadings of nonpoint pollutants that flowed in the streams on precipitation for pollutant loading reduction of Hwa-sung lake inflow streams. Although it has been made an effort to improve the water quality of Hwa-sung basin through the strategies for the preservation of water quality, it is shown that the water quality is not greatly improved. Because it has been industrialized and urbanized near Hwa-sung basin so that it is difficult to reduce the water pollution due to the increase in pollutant loadings of point and non-point sources. In this study, it is investigated the outflow characteristics of non-point pollutants that discharged with storm runoff and estimated the effect of runoff on Hwa-sung basin. The final goal of this study is to utilize the basic information for proper management and strategies of non-point sources on Hwa-sung basin. At the result of inflow streams, Ja-an stream that has the greatest pollutant loadings on precipitation is strongly influenced on the water quantity of Hwa-sung basin. On the other hand, it is shown that Nam-yang stream is strongly influenced on the SS concentration of Hwasung basin among them. Also, all streams; Nam-yang, Ja-ahn, Ah-eun stream; has the degree of slope more than or near 1 in the correlation results so that they have strong pollutant loading impact and the concentration of SS is the highest among other pollutants. So, specific studies on initial rain phenomena are more necessary to manage the pollutants economically. Also, the proper control of SS concentration is required to manage the effluent pollutants effectively on precipitation. So, it is necessary to consider the strategies for non-point pollutants as well as point pollutants when the new management is imposed to reduce the pollutant load for improvement of Hwa-sung basin.