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이상승,정민섭,이창인,박상혁 국제문화기술진흥원 2023 The Journal of the Convergence on Culture Technolo Vol.9 No.3
In order for the military organization to be reborn as a high-tech science and technology strong force, science and technology that can be applied to the military is identified at the rapid development of science and technology, This should be quickly applied to military organizations, which is a growing consensus that Defense R&D planning system centered on rioters is needed to quickly acquire advanced weapons systems. In this respect, in order to successfully achieve the current government's defense policy, the high-tech weapons system necessary for national defense is required quicklyIt is necessary to closely examine defense planning, systems, organizations, and functions to develop into a high-tech science and technology military to link from raising to acquiring, and to reorganize the power enhancement and operation system. Therefore, this study proposes a high-efficiency defense operation system that combines advanced science and technology by Korean military organizations through "Defense Innovation 4.0", and we hope that follow-up research will be conducted following this study. 첨단 과학기술 강군으로 군(軍) 조직이 거듭나기 위해서는 과학기술의 빠른 발전속도에 맞춰 군에 접목이 가능한 과학기술을 식별하고, 이를 신속하게 군(軍) 조직에 적용할 수 있어야 하며 이는 첨단 무기체계의 신속한 획득을 위해 소요군이 중심이 되는 국방R&D 기획체계의 변화가 필요하다는 공감대가 확산되고 있는 실정이다. 이러한 측면에서 현 정부의 국방정책을 성공적으로 달성하기 위해서는 국방에 필요한 첨단 무기체계가 신속하게 소요제기부터 획득까지 연계되도록 첨단 과학기술 군으로 발전하기 위한 국방기획 및 제도·조직과 기능을 면밀히 살펴보고 전력증강 및 운영 체계에 대한 재정비를 실시해야 할 것이다. 따라서 본 연구는 ‘국방혁신 4.0’을 통해 우리나라 군 조직이 첨단과학기술을 접목한 고효율 국방운영 체계에 제언하는 바이며 더불어 본 연구에 이어 관련한 후속연구가 이루어지길 바란다.
이상승,이용복,오인준 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.7
In general, nanoparticles are internalized into cells by endocytosis. In the present study, we examine the cellular uptake of poly(lactic-co-glycolic) (PLGA) nanoparticles according to the hydrophilicity of the incorporated drug. Rhodamine B was used as a hydrophilic drug model and coumarin 6 as a hydrophobic drug model, both of which had fluorescent characteristics. The cellular uptake of the drug-loaded PLGA nanoparticles prepared by the solvent evaporation method was examined by flow cytometry and confocal microscopy. Rhodamine B could not pass through the membrane of HEK293 cells, however, rhodamine B-loaded PLGA nanoparticles could enter cells more easily. Conversely, both coumarin 6 and coumarin 6-loaded PLGA nanoparticles were observed inside cells, however, a higher fluorescence intensity was seen with coumarin 6-loaded PLGA nanoparticles in HEK293 cells than that of coumarin 6 alone. In order to investigate the nanoparticle uptake by cells, a fluorescent amine-PLGA (FA-PLGA), a PLGA polymer covalently bound directly to fluoresceinamine, was synthesized and observed inside cells by flow cytometry and confocal microscopy. The fluorescence of coumarin 6-loaded PLGA nanoparticles coated with chitosan was detected at the surface of cells, suggesting a charge interaction of the positive chitosan/ PLGA nanoparticles with the negative cell membrane. This study presents the uptake of hydrophilic and hydrophobic nanoparticles in HEK293 cells.
RTK-GPS를 이용한 구조물의 실시간 모니터링 적용가능성 연구
이상승,김정환,조두용,박선규 한국구조물진단유지관리학회 2011 한국구조물진단학회 학술발표회논문집 Vol.2011 No.9
The purpose of this study is to verify the applicability of RTK(Real Time Kinematic)-GPS(Global Positioning System) for the effective structural behavior monitoring. Also, this study shows feasibility and accuracy of sensor by comparing results of displacement measuring of LVDT(Linear Variable Differential Transformer) with those of RTK-GPS.