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담관계 질환에서 세균 및 Helicobacter 감염과 담즙산 성분의 관계
이병석(Byoung Suk Lee),노임환(Im Hwan Roe),남승우(Seung Woo Nam),유권(Kwon Yoo),박현종(Hyun Jong Park),김정원(Jung Won Kim),신지현(Ji Hyun Shin),이종화(Jong Hwa Lee) 대한내과학회 2001 대한내과학회지 Vol.60 No.3
N/A Background : Bacterial and Helicobacter gene were commonly detected in diseased human bile, although the meaning of the presence of Helicobacter in biliary tract is still unclear. The aim of this study was to evaluate the changes of bile acid composition in bacterial and Helicobacter infected bile, and to determine whether Helicobacter pylori might grow in human bile or not. Methods : Thirty bile samples were obtained by percutaneous transhepatic biliary drainage or gallbladder puncture during cholecystectomy. According to the polymerase chain reaction analysis using bacterial 16S rRNA and Helicobacter genus specific 16S rRNA primers, 3 groups were divided; Group Ⅰ; no presence of any bacterial DNA, Group Ⅱ; positive bacterial DNA only, Group Ⅲ; positive bacterial and Helicobacter DNA. Bile acid analysis for deoxycholic acid (DCA), chenodeoxycholic acid (CDCA), lithocholic acid (LCA), and ursodeoxycholic acid (UDCA) was performed by high performance liquid chromatography. And then Helicobacter pylori was tried to culture in broth mixed with human bile at a final bile concentration of 50%. Results : The concentrations of DCA in group II and III were very low and significantly reduced compared to group I (p<0.01, respectively). The concentrations of LCA or UDCA were not shown any relationships between groups. Helicobacter pylori has grown actively in the broth mixed with human bile containing both of less than 0.1 gm/L of DCA and CDCA, compared to no growth in media mixed with human bile containing more than 3.0 gm/L of DCA and/or CDCA. Conclusion : DCA seems to have the strongest antibacterial effect. Helicobacter pylori is likely to grow in human bile containg very low concentrations of CDCA and DCA.(Korean J Med 60:215-221, 2001)
인체 담관 질환의 담즙에서 검출되는 Helicobacter 균주의 동정
김석배(Suk Bae Kim),이병석(Byoung Suk Lee),박태진(Tae Jin Park),고미혜(Mi Hye Ko),박현종(Hyun Jong Park),노임환(Im Hwan Roe),신지현(Ji Hyun Shin),이종화(Jong Hwa Lee) 대한내과학회 2000 대한내과학회지 Vol.58 No.5
N/A Background : Several studies have been reported that the presence of Helicobacter DNA in human bile sample, although its pathological role is not clear. The purpose of this study was to evaluate the presence and identification of Helicobacter species in human bile samples obtained from patients with biliary tract diseases. Methods : 58 bile samples (35 intrahepatic duct stones, 10 bile duct cancer, 13 pancreatic cancer) were obtained by percutaneous transhepatic biliary drainage (PTBD). DNA was isolated from bile sample. The primers were designed to amplify region of Helicobacter genus specific 16S rRNA. Polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) was developed to differenciate the presence of H. pylori, H. bilis, H. rappini and H. muridarum. Results : Forty-two of 58 (72.4%) bile samples obtained from patients with biliary tract disease showed positive PCR band for Helicobacter genus specific 16S rRNA. H. pylori was found in 83.3% of positive samples. Either H. bilis or H. rappini was in 16.7%. H. muridarum, however, was not detected. Conclusion : Helicobacter genus was detected in human bile samples obtained from patients with biliary tract diseases using PCR method, and the major species was H. pylori. In addition, RFLP technique was used successfully to identify Helicobacter species.(Korean J Med 58:526-531, 2000)
이수호(Lee su-ho),장대성(Chang dae-sung),이병석(Lee byoung-suk) 한국철도학회 2006 한국철도학회 학술발표대회논문집 Vol.- No.-
In order to ensure the optimized design in Korean High speed train, it is necessary to know the customer"s requirement obtained through the questionnaire performed in the Korean High speed train, performing the stabilization. This paper introduce the content and result of the questionnaire and explain the concept and characteristic of rendering for the Korean High speed train. Finally, it shows the concept of the Mock-up & design in the KTX-Ⅱ.
이수호(Lee su-ho),장대성(Chang dae-sung),이병석(Lee byoung-suk),김국진(Kim kuk-jin) 한국철도학회 2004 한국철도학회 학술발표대회논문집 Vol.- No.-
Opening commercial service of KTX at the time of demanding more flexible trainset for HONAM line and JEONLA line, it"s necessary for the Korean High speed train, performing the stabilization, to modify the design in aspect of passenger and maintenance. In order to ensure the optimized interior design in Korean High speed train, it is necessary to review the major items such as disabled passenger facility, toilet, seat arrangement, compartment partition and door, access door, electrical cabinet, color and paint through the European standard and compare with other high speed train.
한국 여성에서 중증 자궁내막증과 Human ${\alpha}2$-Heremans Schmidt Glycoprotein (AHSG) 유전자 다형성의 연관성
김진주,채수진,김종미,이경훈,최영민,김성훈,신정호,이택후,허준용,이병석,오성택,이규섭,임용택,Kim, Jin-Ju,Chae, Soo-Jin,Kim, Jong-Mee,Lee, Gyoung-Hoon,Choi, Young-Min,Kim, Sung-Hoon,Shin, Jung-Ho,Lee, Taek-Hoo,Hur, Jun-Young,Lee, Byoung-Suk,O 대한생식의학회 2008 Clinical and Experimental Reproductive Medicine Vol.35 No.4
목 적: 한국 여성에서 alpha2-Heremans Schmidt glycoprotein (AHSG) 유전자 다형성과 중증 자궁내막증의 연관성을 알아보고자 하였다. 연구방법: 자궁내막증이 없는 여성 224명과 중증 자궁내막증이 있는 여성 130명을 대상으로 하였다. 모든 여성은 복강경이나 개복수술을 시행하여 수술 소견 및 조직학적 진단으로 중증 자궁내막증의 존재 여부를 진단하였다. 환자군과 대조군의 혈액을 채취하였고 AHSG 유전자 다형성을 중합효소연쇄반응 (PCR) 및 제한효소 절편길이 다형성(restriction fragment length polymorphism; RFLP) 분석으로 조사하였다. 결 과: 자궁내막증 환자군에서 AHSG 1*1 유전자형의 빈도는 56.2% (73/130), AHSG 1*2 유전자형은 37.7% (49/130), AHSG 2*2 유전자형은 6.2% (8/130)로 정상 대조군의 55.8% (125/224), 39.3% (88/224), 4.9% (11/224)의 빈도와 차이가 없었다 (p=.864). 또한 AHSG 2 일배체형의 빈도 역시 환자군에서 25.0% (65/260), 대조군 24.6% (110/448)로 두 군간에 유의한 차이가 없었다 (p=.894). 결 론: 한국 여성에서 AHSG 유전자 다형성과 자궁내막증은 연관이 없었다. Objective: To evaluate the relationship between advanced stage endometriosis and polymorphisms in $\alpha$2-Heremans Schmidt glycoprotein (AHSG) gene in Korean women. Methods: One-hundred thirty women with endometriosis stage III and IV, and 224 women without endometriosis were enrolled. In these patients, we determined AHSG gene polymorphisms by PCR and RFLP (restriction fragment length polymorphism) analysis. Results: The genotype distribution of the AHSG gene polymorphism in the endometriosis group was not different from that of the control group (AHSG 1*1/AHSG 1*2/AHSG 2*2 frequencies were 56.2%/37.7%/6.2% and 55.8%/39.3%/4.9% for the endometriosis and control groups, respectively, p=.864). Also, the frequency of AHSG 2 haplotype was not different between endometriosis patients and controls (AHSG 1 haplotype /AHSG 2 haplotype rates were 75.0%/25.0% and 75.4%/24.6% for the endometriosis and control groups, respectively, p=0.894). Conclusion: AHSG gene polymorphism was not associated with the risk of advanced stage endometriosis in the Korean population.
정두영,이병석 全北大學校 1989 論文集 Vol.31 No.-
Recently, chemical soil stabilizations using the deep mixing method have been actively adopted for the improvement of soft ground in the offshore region. The objective of this study is to reveal the mechanism of strength development in the uncompacted stabiolized soils made by the deep mixing method. The mechanical properties of strength in the cement or lime stabilized soils were investigated. Furthermore, the reaction materials and process in them were elucidated by x-ray diffraction analysis and pH values. From the results, the relation between strength development and x-ray diffraction intensity in the uncompacted stabilized soils is discussed.