치매(痴呆)에 관(關)한 동서의학적(東西醫學的) 비교(比較) 고찰(考察)

이동원,신길조,이원철,Lee, Dong-Weon,Shin, Gil-Jo,Lee, Won-Chul 대한한방내과학회 1995 大韓韓方內科學會誌 Vol.16 No.1

This study was done in order to investigate the etiology and pathology of dementia in the variety literature. Dementia in elderly persons(above the age of 60) mainly classfied Alzheimer disease and Cerebral vascular dementia. The results were as follows: 1. Dementia patients have abnormal mental function, who have no mental weakness but defects of memory, verbal disturbance, behavior disturbance and loss of intellectual function. 2. Dementia regard as 'me-beng(?病)', 'jeon-gwang(癲狂)', and 'heo-ro(虛勞)' in oriental medicine and the symptom is a silence with no response, mixing, a crying or a laugh, a stranger behavior and a amnesia; disturbances of speech, emotion, behavior. 3. Dementia caused by Alzheimer disease, Multi infarct dementia, Parkinson's disease, sequelae of acute CO poisoning, head injury and alcoholism(occidental medically) and the 'Dam(痰) and Damhwa(痰火), weakness of heart and spleen(心脾虛) caused by pent up anger of seven emotions(七情鬱結), the weakness of liver and kidney(肝腎不足)(oriental medically). 4. The causes of Alzheimer disease are various; a heredity factor, a morphological factor of brain tissues, a psychological factor and a biochemical factor (occidental medically) ; the 'Dam(痰) and Damhwa(痰火) caused by weakness of the internal organs and disturbance of the emotions(oriental medically). 5. Cerebral vascular dementia caused by loss of the certain cerebral neurons and oriental medically caused by obstruction of 'dam(痰)' or 'eo heul(瘀血)'. It is recommended that further study of many sided investigations, specially against a weakness of spiritual functions and a certain neurotoxin in the future.

레이저 열-압착 본딩 시스템의 Lateral Force 감소를 위한 유연 힌지의 설계

이동원,하석재,박정연,윤길상,Lee, Dong-Won,Ha, Seok-Jae,Park, Jeong-Yeon,Yoon, Gil-Sang 한국금형공학회 2020 한국금형공학회지 Vol.14 No.3

Laser Assisted Thermo-Compression Bonding (LATCB) has been proposed to improve the "chip tilt due to the difference in solder bump height" that occurs during the conventional semiconductor chip bonding process. The bonding module of the LATCB system has used a piezoelectric actuator to control the inclination of the compression jig on a micro scale, and the piezoelectric actuator has been directly coupled to the compression jig to minimize the assembly tolerance of the compression jig. However, this structure generates a lateral force in the piezoelectric actuator when the compression jig is tilted, and the stacked piezoelectric element vulnerable to the lateral force has a risk of failure. In this paper, the optimal design of the flexure hinge was performed to minimize the lateral force generated in the piezoelectric actuator when the compression jig is tilted by using the displacement difference of the piezoelectric actuator in the bonding module for LATCB. The design variables of the flexure hinge were defined as the hinge height, the minimum diameter, and the notch radius. And the effect of the change of each variable on the stress generated in the flexible hinge and the lateral force acting on the piezoelectric actuator was analyzed. Also, optimization was carried out using commercial structural analysis software. As a result, when the displacement difference between the piezoelectric actuators is the maximum (90um), the maximum stress generated in the flexible hinge is 11.5% of the elastic limit of the hinge material, and the lateral force acting on the piezoelectric actuator is less than 1N.

지주막하출혈에 의한 뇌기저동맥의 형태학적 변화에 미치는 양격산화탕(凉膈散火湯)의 효과

이동원,이원철,Lee, Dong-Won,Lee, Won-Chul 대한한의학회 1999 대한한의학회지 Vol.20 No.2

The present study was performed to investigate the effect of Yangkyuksanhoa-tang on the morphological changes of the basilar artery after experimentally induced subarachnoid hemonrrhages(SAH). Yangkyuksanhoa-tang has been used freguently for cerebrovascular accident Sprague Dawley rats weighing between 350-400 g were used. The 6 normal rats and 24 SAH elicited rats were used, The SAH induced by injection of the fresh autologus heart blood (0.3-0.4 ml) into the cisterna magna through the posterior atlanta-occipital membrane, Sample group was given 3.3 ml/kg/day of Yangkyuksanhoa-tang extracts for 2 days after SAH. The experimental animals were killed at 48hrs after SAH. The morphological changes of the arterial walls were examined by light and electron microscopy. Following are the obtained results: 1. In SAH elicited rats, the size of the lumen in basilar artery was diminished by about 45% and the thickness of arterial wall was increased by about 82%. In SAH elicited rats with Yangkyuksanhoa-tang treatment, the size of the lumen in basilar artery was merely diminished by about 18% and the thickness of arterial wall was merely increased by about 19%. 2. In light microscopic examination, the endothelium was swollen into a cuboid shape and the layer of smooth muscle was increased in the basilar artery of SAH elicited rats. In SAH elicited rats with Yangkyuksanhoa-tang treatment, the size of the lumen in basilar artery was enlarged and the thickness was decreased than in SAH elicited rats. The endothelium was flattened into a squamous shape and the layer of smooth muscle was decreased more than in SAH elicited rats. 3. In electron microscopic examination, the endothelial cells with fragmentation nuclei were changed into a cuboid shape and the internal elastic lamina were folded at the basilar artery of SAH elicited rat. The nuclei of smooth muscle cells were changed into a round or crumpled shape. The length of smooth muscle was shorten and thickness was increased. But all kinds of morphologic changes were diminished in SAH elicited rats with Yangkyuksanhoa-tang treatment. Conclusion : Yangkyuksanhoa-tang extracts were effective to treat cerebral vasospasm after experimentally induced subarachnoid hemorrhage in rats.

변화하는 교육과정과 그 속의 초등공학교육

이동원,Lee, Dong-Won 한국공학교육학회 2021 공학교육동향 Vol.28 No.4

신항만 개발방향 및 효율적 추징방안

이동원,Lee, Dong-Won 한국건설안전협회 1997 建設 安全技術 Vol.25 No.-

서양의 역사적인 지도제작법의 발달 과정과 수학적 지식의 상호 영향 관계를 통해 본 직교좌표계

이동원,Lee, Dong Won 한국수학사학회 2012 Journal for history of mathematics Vol.25 No.4

역사적인 지도제작법에 나타난 좌표계와 수학적 직교좌표계의 발전 과정을 비교하면서 위치를 표시하는 직교좌표계는 수학의 해석기하학과는 상관없이 인간 본연에 내재되어 있었던 공간지각능력의 일환으로 발전되어 왔음을 주장한다. 지도제작법의 발전이 해석기하학의 발명 전후 삼각함수, 로그, 기하학, 미적분학, 통계학 등 수학의 여러 분야와 상호 영향을 미치지만 원점의 표시나 음수 좌표의 사용과 같은 수학적 직교좌표계 자체에 대한 발전은 데카르트의 논문 발표 후 100여년 이상 지난 후에 이루어지는 점, 해석기하학을 발명하는데 공헌한 대부분의 수학자들이 당대의 문제 해결에 집중하면서 직교좌표계에 대한 수학적 설명없이 자연스럽게 사용하였던 점을 바탕으로 이런 결론을 얻는다. By comparing the development history of rectangular coordinate system in Cartography and Mathematics, we assert in this manuscript that the rectangular coordinate system is not so much related to analytic geometry but comes from the space perceiving ability inherent in human beings. We arrived at this conclusion by the followings: First, although the Cartography have much influenced to various area of Mathematics such as trigonometry, logarithm, Geometry, Calculus, Statistics, and so on, which were developed or progressed around the advent of analytic geometry, the mathematical coordinate system itself had not been completely developed in using the origin or negative axis until 100 years and more had passed since Descartes' publication. Second, almost mathematicians who contributed to the invention of rectangular coordinate system had not focused their studying on rectangular coordinate system instead they used it freely on solving mathematical problem.

러시아 티타늄계 고융점 화합물 분말합성 신기술

이동원,김병기,Lee, Dong-Won,Kim, Byeong-Gi 재료연구소 2004 機械와 材料 Vol.16 No.1

Spherodization of Granuled Cr₂O₃ Fine Ceramic Powder by Plasma Spray

이동원,이학성,유지훈,왕제필,Lee, Dong Won,Lee, Hak Sung,Yu, Ji-Hun,Wang, Jei-Pil The Korean Institute of Resources Recycling 2016 資源 리싸이클링 Vol.25 No.6

Spray dried $Cr_2O_3$ powder having an agglomerated structure of particles was twice treated into a plasma flame to increase its apparent density. The powder subjected to the first densification treatment did not show the entirely melted state keeping inner particle hollows, and it was fully melted after the second processing only. The powder size as a result of the second treatment decreased, and the apparent density as well as flowability were increased due to melting and surface smoothing effects. But a part of particles after the second densified treatment showed the hollow structure, especially those which were above $30{\mu}m$ in size. This densification behavior of the powder has been qualitatively discussed in terms of the thermal conductivity and inner gas pressure within aggregates exposed to the plasma flame. Spray dried $Cr_2O_3$ 분말은 겉보기밀도를 향상시키기 위해 plasma flame에 투입하여 실험을 진행 하였다. 첫번째 고밀도화 공정에서의 분말은 입자내부 공간까지 완전히 용해되어지지 않았으며, 두번째 공정 이후 완전히 용해가 되었다. 두번째 공정 결과 분말 입도는 작아졌으며, 용해 및 표면 연화에 의해 겉보기 밀도와 유동도는 향상이 되었다. 두번째 고밀도화 공정이 후 부분적으로 입자들이 $30{\mu}m$ 이상의 hollow structure을 보여주고 있다. 분말의 이러한 고밀도화는 plasma flame에 의해 응집되어진 응집체내의 열전도율 및 내부 가스압의 관점에서 정량적으로 논의 하였다.

불완전 가와사끼병에서 NT-proBNP의 진단적 역할

이동원,김여향,현명철,권태찬,이상범,Lee, Dong-Won,Kim, Yeo-Hyang,Hyun, Myung-Chul,Kwon, Tae-Chan,Lee, Sang-Bum 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.4

목 적: 지속적인 발열과 3개 이하의 가와사끼병 진단 기준을 만족하는 환자군에서 불완전 가와사끼병을 감별하는데 있어 NT-proBNP가 가지는 진단적 의미를 살펴보고자 하였다. 방 법: 2008년 1월부터 2009년 6월까지 가와사끼병으로 진단 및 치료 받은 환자 96명을 대상으로 하였다. 진단은 입원 당일 열을 포함한 가와사끼병의 고전적인 진단 기준에 따랐고, 진단 기준의 만족 정도에 따라서 완전 가와사끼병 환자군과 불완전 가와사끼병 환자군으로 구분하였으며, NT-proBNP를 포함한 혈액검사를 시행하였다. 지속되는 열과 함께 3개 미만의 진단 기준을 만족하였지만 임상 경과와 여러 검사들을 통해 환자 19명을 대조군으로 하여 분석하였다. 결 과: 96명의 가와사끼병 환자 중 고전적인 진단 기준을 3가지 이하로 만족한 불완전 가와사끼병 환자는 33명으로 전체 가와사끼병 환자의 34% 였다. 임상 양상으로 구강 점막의 변화와 안검 충혈이 가장 많았는데 완전 가와사끼병에 비해 발생 빈도는 적었다(76% vs 98%, 76% vs 90%). 불완전 가와사끼병 환자의 NT-proBNP는 대조군에 비해 유의하게 높았으며($1407.7{\pm}1633.5pg/mL$ vs $126.2{\pm}135.5pg/mL$, $P$<0.001), cutoff value를 158 pg/mL으로 하였을 때 민감도 81%, 특이도 74% 로 C 반응성 단백 ${\geq}3mg/dL$의 민감도 74%, 특이도 68% 보다 높았지만, 적혈구 침강 속도 ${\geq}40mm/hr$의 민감도 70%, 특이도 84%로 특이도에서 적혈구 침강 속도보다 낮았다. 결 론: 지속되는 열, 안검 충혈, 구강 점막의 변화가 있어 불완전 가와사끼병으로 의심해야 하는 환자에서 NT-proBNP 검사를 시행하고 진단에 이용하는 것이 가와사끼병의 빠른 진단과 치료에 도움이 될 것이다. Purpose : To determine the efficacy of the N-terminal fragment of B-type natriuretic peptide (NT-proBNP) as a useful diagnostic method in children with incomplete Kawasaki disease (KD). Methods : Ninety-six patients who were diagnosed as having KD between January 2008 and June 2009 were enrolled in the study. American Heart Association recommendations for diagnosis were used, and patients were divided into the complete KD and incomplete KD groups. Blood tests including NT-proBNP were performed on admission day. Nineteen patients who had other febrile diseases other than KD were enrolled as control. Results : Thirty-three patients (34%) had incomplete KD. Change in the lips and oral cavity and conjunctivitis were the most common clinical features, but their frequency was lower than complete KD (76% vs 98%, 76% vs 90%). Patients with incomplete KD exhibited significantly higher NT-proBNP level than that of control ($1,407.7{\pm}1633.5pg/mL$ vs $126.2{\pm}135.5pg/mL$, $P$<0.001). An NT-proBNP cutoff value of 158 pg/mL provided a sensitivity of 81% and a specificity of 74% for diagnosis of incomplete KD. Conclusion : NT-proBNP assay can be clinically useful for the diagnosis of incomplete KD, if the patient has persistent fever, change in the lips and oral cavity, and conjunctivitis, and if the patient with those symptoms is suspected to have incomplete KD.

기공실에서 발생되는 분진이 폐 조직에 미치는 악 영향

이동원,Lee, Dong-Won 대한치과기공학회 1985 대한치과기공학회지 Vol.7 No.1