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대학시설계획(大學施設計劃)에 있어서 건축관련법(建築關聯法)의 적용(適用)에 관한 연구(硏究)
이근욱(Lee, Keun-Wook) 한국교육시설학회 1995 敎育施設 Vol.2 No.1
This study deals zoning and building codes that act on the physical planning and design of university campus in Korea. Campus facility related laws were analyzed in relation to various factor found out through the survey on the existing campuses in rural or urban area. The study shows that the gaps between the standards required by the law and the state of facilitation in many universities could be filled by applying varied norms in accordance with the locational characteristics of each university.
3배압 정류기를 적용한 비대칭 펄스폭 변조기법 LCC 컨버터의 해석
이근욱(Keun-Wook Lee),박기범(Ki-Bum Park),김영도(Young-Do Kim),문건우(Gun-Woo Moon) 전력전자학회 2009 전력전자학술대회 논문집 Vol.2009 No.1
정상상태해석을 통하여 3배압 정류기를 적용한 비대칭 펄스폭 변조기법의 LCC 컨버터를 해석하였다. 제안하는 해석을 통하여 입출력관계식을 계산하였고, 이 입출력 관계식을 통하여 레이저 프린트용 DC/DC 컨버터 스펙인 입력전압 24V이고 출력 전압 1500V, 출력 저항 45MΩ의 컨버터를 설계하여 실험을 통하여 제안하는 이론적 해석의 타당성을 증명하였다.
대장직장암 간전이 환자에서 수술전 FDG PET의 예후인자로서의 중요성
이효상 ( Hyo Sang Lee ),이원우 ( Won Woo Lee ),김덕우 ( Duck Woo Kim ),강성범 ( Sung Bum Kang ),이경호 ( Kyoung Ho Lee ),이근욱 ( Keun Wook Lee ),김지현 ( Jee Hyun Kim ),김상은 ( Sang Eun Kim ) 대한핵의학회 2009 핵의학 분자영상 Vol.43 No.5
목적: 본 연구의 목적은 대장직장암 간전이 환자에서 수술 전 FDG-PET의 예후인자로서의 중요성을 평가하는 것이다. 대상 및 방법: 진단시부터 간전이를 동반한 대장직장암 환자로서, 수술 전 FDG-PET을 실시하고, 원발병변과 간전이병변에 대한 근치적 수술이 가능했던 24명의 환자(남자: 여자=14:10; 나이 63±10세)가 연구에 포함되었다. 간전이병변은 13예는 간절제, 7예는 고주파절제술, 그리고 4예는 간절제와 고주파절제술을 함께 시행하였다. 잠재적 예후인자로 원발병변의 최대표준화섭취계수(이하 maxSUV), 간전이병변의 maxSUV, 원발병변/간전이병변의 maxSUV 비(M/P ratio), 조직학적인 분화도, 수술 전 CEA, 혈관/림프계/신경 침범여부, T-병기, N-병기, 간전이 병변의 개수, 림프절 전이 개수, 간전이 치료방법을 연구에 포함시켰다. 결과: 24명의 환자 중 14명의 환자가 추적관찰기간 중 재발을 일으켰으며, 이들의 중앙 추적관찰기간은 244일이었다. 추적관찰기간 중 재발을 일으키지 않은 10명 환자의 중앙 추적관찰기간은 504일이었다. 분석에 포함한 잠재적 예후인자 중 M/P ratio만이 재발군(0.72±0.14)과 비재발군(0.54±0.23)에서 통계적으로 유의한 차이를 보였다(p=0.038). Cox 비례위험 모형을 이용한 생존분석에서 M/P ratio만이 유일하게 통계적으로 유의하게 재발을 예측하는 예후인자였다(상대위험도 37.7, 95% 신뢰구간 2.01-706.1, p=0.016). M/P ratio 0.61을 기준으로 이분하였을 때, 낮은 군(<0.61) 11명의 무병생존률은 높은 군(≥0.61) 13명의 무병생존률에 비해 유의하게 높았다(p=0.026). 결론: 간전이병변/원발병변의 maxSUV 비(M/P ratio)는 간전이를 동반한 대장직장암 환자에서 술 후 재발을 예측하는 예후인자로서 유용하다. 간전이병변의 FDG섭취가 원발병변에 비해 상대적으로 높은 상태는 4병기의 대장직장암 중에서도 더욱 진행된 병기를 나타내는 것으로 보인다. Purpose: The purpose of this study was to assess the prognostic value of preoperative FDG-PET in colorectal cancer (CRC) patients with hepatic metastasis (HM). Materials and Methods: 24 CRC patients (M:F=14:10; age, 63±10 yrs) with HM who had undergone preoperative FDG PET were included. Cure-intent surgery was performed in all the patients and HMs were controlled using resection (n=13), radio-frequency ablation (RFA) (n=7), and resection plus RFA (n=4). Potential prognostic markers tested were maxSUV of primary tumor, maxSUV of HM, maxSUV ratio of HM over primary tumor (M/P ratio), histologic grade, CEA level, venous/lymphatic/nerve invasion, T stage, N stage, no. of HM, no. of lymph node metastasis, and treatment modality of HM. Results: 14 CRC patients developed a recurrence with a median follow-up duration of 244 days, whereas 10 patients did not develop recurrence with a median follow-up duration of 504 days. M/P ratios but other potential prognostic markers were significantly higher in the recurrent patients (0.72±0.14) than recurrence-free patients (0.54±0.23) (p=0.038). M/P ratio only was found to predict recurrence by Cox multivariate analysis (hazard ratio 37.7, 95% confidence interval 2.01-706.1, p=0.016). The 11 patients with lower M/P ratio of <0.61 had significantly better disease-free survival rate than the 13 patients with higher M/P ratio (≥0.61) (p=0.026). Conclusion: maxSUV ratio of HM over primary tumor (M/P ratio) may be useful for prognosis prediction of CRC patients with HM. Higher FDG uptake of HM than that of primary tumor may indicate a more advanced status in stage IV CRC. (Nucl Med Mol Imaging 2009;43(5):429-435)
조요한(Yo Han Joh),최인실(In Sil Choi),이근욱(Keun Wook Lee),오도연(Do Youn Oh),김병수(Byung Su Kim),이대호(Dae Ho Lee),김태유(Tae You Kim),방영주(Yung Jue Bang),우홍균(Hong Gyun Wu),성명훈(Myung Whun Sung),이철희(Chul Hee Lee),김광현(N 대한두경부종양학회 2001 대한두경부 종양학회지 Vol.17 No.2
Objective: The role of chemotherapy in locally advanced head and neck cancer has been established in nasopharynx and larynx as definitive therapy and organ preserving therapy, respectively. Oral cavity cancers are relatively uncommon and local recurrence is the main cause of treatment failure. We planned this retrospective study to evaluate the role of neoadjuvant chemotherapy in locally advanced oral cavity cancer patients. Materials and Methods: From 1988 March to 2001 February, locally advanced, previously untreated oral cavity cancer patients who received neoadjuvant chemotherapy were examined. Chemotherapy had been done in the following patients: Histologically proven squamous cell or poorly differentiated carcinoma, stage 3 or 4, and performance state 0-2 patients. Chemotherapy regimen consisted of cisplatin and infusional 5-fluorouracil. Response was evaluated after 2 cycles and in case of no response, definitive local therapy was done; otherwise 3 cycles was done before local treatment. Results: 48 patients were treated and 47 patients were evaluable for responses. Complete response rate was 6.4%(3/47) and partial response 80.0%(38/47), scoring overall response rate of 87.2%. Median time to progression was 27.0 months (95% CI : 0-58months) and overall 5 year survival was 54.8%. 5-year disease-free survival in the patients in remission after local treatment was 51.9%. In multivariate analysis, contributing factor to the survival were response to neoadjuvant chemotherapy and local treatment modalities. Extensive surgery was done in 10 patients and 25 patents (52.1%) was followed up with preserved function. With median follow-up of 57.0 months, 19 recurrences were detected, most of which were local or regional type. Conclusion: Neoadjuvant chemotherapy followed by local treatment in oral cavity cancer showed high response rate and was thought to be effective therapeutic approach especially in view of organ preservation.
김태용(Tae Yong Kim),조요한(Yo Han Joh),김진수(Jin Su Kim),홍용상(Yong Sang Hong),이근욱(Keun Wook Lee),윤탁(Tak Yun),송은기(Eun Ki Song),나임일(Im Il Na),신현춘(Hyun Chun Shin),김동완(Dong Wan Kim),이재서(Chae Seo RLee),성명훈(Myung W 대한두경부종양학회 2004 대한두경부 종양학회지 Vol.20 No.2
Background: About 3% of all cancer patients suffer from cancer of unknown primary origin. Generally, carcinoma of unknown primary (CUP) carries a grave prognosis, but primary tumor presented to the neck is exception to this. The aims of study are to determine the role of chemotherapy and to find the prognostic factors in unknown primary tumor presented to the neck. Method and Material: Eighty-four patients were diagnosed with unknown primary tumor presented to the neck between January 1996 and June 2002. Among 84 patients, 43 patients (52%) received chemotherapy, radiation or surgery were performed in 20 patients (23%), 21 patients (25%) had no treatment. Results: The response rates to chemotherapy were 87.5% in CUP only localized to the neck and 44.0% in CUP systemically involved (p=0.012). A median follow-up duration was 6.4 years and overall median survival time was 9 months. The median overall survival time of patients treated with chemotherapy were 17 months and that of patients who received surgery or radiation were 20 months (p=0.3548). The important prognostic factors were performance status and the number of involved organ. Conclusion: The prognosis of patients with CUP presented to the neck is more favorable than that of patients with CUP of other localization. The effectiveness of chemotherapy for CUP only localized to the neck was similar to that of surgery or radiation. The important prognostic factors were performance status and the number of involved organ.
Fentanyl 이 흰쥐 대동맥 평활근의 이완에 미치는 영향
이근욱,길혜금,김원옥,곽영란 대한마취과학회 1995 Korean Journal of Anesthesiology Vol.28 No.6
The mechanism of vasodilation induced by fentanyl was investigated using isolated rat thoracic aortic rings. Rings were contracted with norepinephrine(10^(-7) M, NE) and potassium chloride(40 mM, KCl) with and without endothelium Fentanyl (10^(-9)-10^(-5) M) produced dose-dependent relaxation and had no significant effect from endothelium(intact and denuded rings, test with 3×10^(-4) M LNAME, N-nitro-L-arginine methyl ester). Pretreatment of indomethacin(2.5×10^(-3) M, inhibitor of cyclooxygenase) failed to influence of cumulative dose-response curves. RD_(50)(50% relaxation dose) and KC1/NE ratio as potency difference of fentanyl, verapamil(10^(-8)-10^(-5) M, Ca^(2+) channel blocker), nitroglycerin(10^(-10)-10^(-5) M, activator of guanylate cyclase) were not similar. Fentanyl and control(distilled water) were not demonstrated any different contraction produced by incremental addition of Ca2+ to aortic rings exposed to Ca^(2+) free, K^+ -depolarized(100 mM KCl) solution(extracellular Ca^(2+) influx). But fentanyl had effectn intracellular Ca2+ release elicited by caffeine(20 mM) and NE(10^(-7) M) indicated by dose-dependent inhibition of contraction in Ca^(2+) free solution. We conclude that, in rat aorta, fentanyl-induced relaxation is endothelium-independent but mediated by inhibition of alpha-adrenoceptors operated intracellular Ca^(2+) release (inhibition of contraction by NE) and caffeine-induced Ca^(2+) release from store.
전신적인 피부병변으로 발현한 모세포성 NK세포 림프종 1예
이근욱,윤탁,김동완,김태유,허대석,박영주,김노경 대한내과학회 2004 대한내과학회지 Vol.66 No.4
저자들은 다른 장기의 침범 없이 전신적인 피부 병변만으로 발현한 모세포성 NK세포 림프종 1예를 국내에서 처음으로 경험하였기에 이를 문헌고찰과 함께 보고하는 바이다. Reports of blastic natural killer (NK)-cell lymphoma are rare. In previous reports, primary cutaneous blastic NK-cell lymphomas were even rarer. In asian patients, most CD56+ lymphomas are classified as nasal type extranodal NK/T-cell lymphoma and mostly associated with the presence of Epstein-Barr virus (EBV) and have an aggressive clinical course. Few cases of blastic NK-cell lymphoma were reported previously in Korea but there was report about blastic NK-cell lymphoma initially presented as disseminated skin lesions without any other organ involvement. We report such a young patient who was treated by systemic chemotherapy.