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PBF와 DED 공정으로 제조된 17-4PH 스테인리스 강의 미세조직 및 기계적 특성 평가
윤종천,이민규,최창영,김동혁,정명식,최용진,김다혜 한국기계가공학회 2018 한국기계가공학회지 Vol.17 No.2
Additive manufacturing (AM) technologies have attracted wide attention as key technologies for the nextindustrial revolution. Among AM technologies using various materials, powder bed fusion (PBF) processesand direct energy deposition (DED) are representative of the metal 3-D printing process. Both of theseprocesses have a common feature that the laser is used as a heat source to fabricate the 3-D shape throughmelting of the metal powder and solidification. However, the material properties of the deposited metals differwhen produced by different process conditions and methods. 17-4 precipitation-hardening stainless steel(17-4PH SS) is widely used in the field of aircraft, chemical, and nuclear industries because of its goodmechanical properties and excellent corrosion resistance. In this study, we investigated the differences inmicrostructure and mechanical properties of deposited 17-4PH SS by PBF and DED processes, including theheat treatment effect.
還少丹이 microglia 염증반응 cytokine과 건망증 생쥐모델에 미치는 영향
윤종천,이상룡,정인철 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.1
Objectives : This experiment was designed to investigate the effect of the Hwanso-dan hot water extract & ultra-fine powder on microglia and memory deficit model Methods : The effects of the Hwanso-dan hot water extract on expression of IL-1β, IL-6, TNF-α mRNA and production of IL-1β, IL-6, TNF-α in BV2 microglial cell line treated by lipopolysacchaide were investigated. The effects of the Hwanso-dan hot water extract & ultra-fine powder on the behavior of the memory deficit mice induced by scopolamine and uric acid & AChE in serum of the memory deficit mice induced by scopolamine were investigated. Results : 1. The Hwanso-dan hot water extract suppressed the expression of IL-1β, IL-6, TNF-α mRNA in BV2 microglial cell line treated by lipopolysacchaide. 2. The Hwanso-dan hot water extract suppressed the production of IL-1β, IL-6, TNF-α in BV2 microglial cell line. 3. The Hwanso-dan hot water extract & ultra-fine powder decreased uric acid and AChE significantly in the serum of the memory deficit mice induced by scopolamine. 4. The Hwanso-dan hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze. Conclusions : This experiment shows that the Hwanso-dan hot water extract & ultra-fine powder might be effective for the prevention and treatment of Memory deficit disease. Investigation into the clinical use of the Hwanso-dan hot water extract & ultra-fine powder for Alzheimer's disease is suggested for future research.
윤종천 ( Jong Cheon Yoon ),정인철 ( In Chul Jung ),이상룡 ( Sang Ryong Lee ) 대전대학교 한의학연구소 2009 혜화의학회지 Vol.18 No.2
Abstract: Following thesis is about comprehensive treatment of insomnia through stability of the autonomic nervous system. It is widely accepted that most of the relevant symptoms of insomnia can be blamed on successive instability of the autonomic nervous system. In order to treat insomnia effectively, it is essential to maintain stability in the autonomic nervous system. When one is at stable stage of the autonomic nervous system, one maintains steady hormonal discharge. In Oriental Medicine, it is the stage when one has a sound qi-blood circulation. To treat insomnia effectively, one has to obtain both physical and mental relaxation through various ways.
환소단(還少丹)이 microglia 염증반응 cytokine과 건망증 생쥐모델에 미치는 영향
윤종천 ( Jong Cheon Yoon ),이상룡 ( Sang Ryong Lee ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2009 동의신경정신과학회지 Vol.20 No.1
Objectives: This experiment was designed to investigate the effect of the Hwanso-dan hot water extract & ultra-fine powder on microglia and memory deficit model Methods: The effects of the Hwanso-dan hot water extract on expression of IL-1β , IL-6, TNF-α mRNA and production of IL-1β , IL-6, TNF-α in BV2 microglial cell line treated by lipopolysacchaide were investigated. The effects of the Hwanso-dan hot water extract & ultra-fine powder on the behavior of the memory deficit mice induced by scopolamine and uric acid & AChE in serum of the memory deficit mice induced by scopolamine were investigated. Results: 1. The Hwanso-dan hot water extract suppressed the expression of IL-1β, IL-6, TNF-α mRNA in BV2 microglial cell line treated by lipopolysacchaide. 2. The Hwanso-dan hot water extract suppressed the production of IL-1β, IL-6, TNF-α in BV2 microglial cell line. 3. The Hwanso-dan hot water extract & ultra-fine powder decreased uric acid and AChE significantly in the serum of the memory deficit mice induced by scopolamine. 4. The Hwanso-dan hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze. Conclusions: This experiment shows that the Hwanso-dan hot water extract & ultra-fine powder might be effective for the prevention and treatment of Memory deficit disease. Investigation into the clinical use of the Hwanso-dan hot water extract & ultra-fine powder for Alzheimer`s disease is suggested for future research.
βA로 유도된 Alzheimer`s Disease 동물모델에 대한 형방사백산(荊防瀉白散)의 효과
윤종천 ( Jong Cheon Yoon ),이상룡 ( Sang Ryong Lee ),정인철 ( In Chul Jung ) 대한한방신경정신과학회 2010 동의신경정신과학회지 Vol.21 No.2
Objectives: This research investigates the effect of the HBSBS on Alzheimer`s disease. Specifically, the effects of the HBSBS extract on (1) the behavior (2) the infarction area of the hippocampus, and brain tissue injury in Alzheimer`s disease mice induced with βA were investigated. Methods: The effects of the HBSBS extract suppressed the expression of IL-1β, IL-6, TNF-α and NOS-II mRNA in BV2 microglial cell line treated with LPS plus βA were investigated. The effects of the HBSBS extract on the behavior of the memory deficit mice induced by scopolamine were investigated. Results: 1. The HBSBS extract suppressed the expression of IL-1β, IL-6, TNF-α and NOS-II mRNA in BV2 microglial cell line treated with LPS plus βA. 2. The HBSBS extract suppressed the expression of βA protein production in BV2 microglial cell line treated with LPS plus βA. 3. The HBSBS extract showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze. 4. The HBSBS group suppressed the over-expression of IL-1β protein, TNF-α protein significantly in the mice with Alzheimer`s disease induced by βA. 5. The HBSBS group reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer`s disease induced by βA. 6. The HBSBS group reduced tau protein, and GFAP in the brain tissue of the mice with AD induced by βA. Conclusions: These results suggest that the HBSBS group may be effective for the treatment of AD. Thus, HBSBS could be considered among the future therapeutic drugs indicated for the treatment of AD.
재활용 절삭칩으로 제조된 AC2B 합금의 용체화 열처리에 따른 미세조직 및 기계적특성 변화
김동혁,윤종천,최창영,최시근,홍명표,신상윤,예병준,Kim, Dong-Hyuk,Yoon, Jong-Cheon,Choi, Chang-Young,Choi, Si-Geun,Hong, Myoung-Pyo,Shin, Sang-Yoon,Ye, Byung-Joon 한국주조공학회 2018 한국주조공학회지 Vol.38 No.2
Changes in the microstructures and mechanical properties of an AC2B alloy through solution heat treatment were investigated using recycled AC2B cutting chips as raw material. The as-cast microstructure of the AC2B alloy comprised ${\alpha}$-Al, $Al_2Cu$, and coarse needle-shaped phases considered to be eutectic Si and an Al-Fe-Si based intermetallic compound. After solution heat treatments at $505^{\circ}C$ for 1 h and 6 h, the samples showed complete dissolution of $Al_2Cu$ and relatively fine distribution of intermetallic compounds. Hardness test results showed that the hardness rapidly increased after the solution heat treatment for 1 h by solid solution hardening, and the increase of hardness exhibited a plateau from 1 h to 6 h. The results of the hardness and tensile tests showed that there was no visible difference in the effect of 1 h and 6 h solid solution treatment.
Powder Bed Fusion(PBF) 공정의 Laser rotation 적용 여부에 따른 17-4PH 스테인리스강 소재의 미세조직 및 기계적 특성 변화
이승호,윤종천,어두림,연시모,최균석 대한금속·재료학회 2023 대한금속·재료학회지 Vol.61 No.6
17-4 precipitation hardened stainless steel (17-4PH SS) has been reported to have excellentmechanical properties and excellent corrosion resistance, and is one of the materials used and studied withthe powder bed fusion (PBF) method. Powder bed fusion (PBF) is a new manufacturing technology that hasrecently attracted attention in automotive, aerospace and other industries because of its ability to producecomplex geometries for high-strength and lightweight applications. In the PBF process, each layer has adifferent laser scan length resulting from the application of laser rotation. The laser rotation could affect thelaser scan length, which causes a difference in the peak temperature and cooling rate of the deposited layer,resulting in microstructure changes. This work aims to investigate how varying the laser scan pattern in thePBF process affects the microstructure and mechanical properties of 17-4PH SS. A decrease in cooling ratewas observed after applying laser scan rotation, resulting in a higher austenite phase fraction. It wasconfirmed that a transformation induced plasticity (TRIP) phenomenon affects mechanical characteristics. These results could be suggested for fabricating thin wall shaped such as tire blow mold parts in the powderbed fusion process using the 17-4PH SS.