화상치료에 있어서 동종유래표피세포의 유용성

윤신혁,심정수,정재민,박대환,송철홍 대한성형외과학회 2008 Archives of Plastic Surgery Vol.35 No.4

Purpose: When choosing dressing method to treat skin defect by second degree or higher burn, we have to consider method of rapid epithelization and minimization of pain during the treatment. In this study, we used biologic dressing with cultured allogenic keratinocytes for skin defect due to burn. We followed up the degree of epithelization, the degree of pain, and patient satisfaction. Methods: From June 2003 to June 2006, among the patients with skin defect due to burn, 31 cases with second degree burn(moderate to severe) were selected and biological dressing with cultured allogenic keratinocytes were done. 21 cases did not use cultured allogenic keratinocytes. Most of the patients had second degree burn. We applied cultured allogenic keratinocyte by Kaloderm. For wounds that were not deep enough to effect the dermis, escharectomy was done before applying Kaloderm. After the operation, moist wound site was maintained by dressing with saline gauze for 5-7 days. We compared the condition of the wound site before and after applying Keloderm by grading epithelization by standardized percentage scoring scale(1-5), and degree of pain and patient satisfaction by visual analogue scale(0-10). Received March 31, 2008 Revised April 23, 2008 Accepted May 22, 2008 Address Correspondence: Jeong Su Shim, M.D., Department of Plastic and Reconstructive Surgery, College of Medicine, Catholic University of Daegu, 3056-6 Daemyung 4-dong Nam-gu, Daegu 705-718, Korea. Tel: 053)650-4578/Fax: 053)650-4584/E-mail: 21csue@hanmail.net Results: When cultured allogenic keratinocytes were applied for the same period of time, the mean score of epithelization were 3.29±0.529(mean±S.D.). Without the application, the mean score of epithelization were 2.86±0.655(mean±S.D.). The degree of pain was 7.71 ±1.419(mean±S.D.) and 2.35±0.950(mean±S.D.) before and after the application, respectively. The patients' satisfaction score was 6.45±0.850(mean± S.D.) and 8.45±0.961(mean±S.D.) before and after the application, respectively. Conclusion: Applying biological dressing with cultured allogenic keratinocyte to skin defect due to second degree burn showed satisfactory results in the degree of the epithelization, degree of pain and patients' satisfaction.

잠자는 생각에 말 걸기 - 고등학교 논리학 수업 운영 사례 -

윤신혁 한국철학교육학회 2007 철학ㆍ윤리 교육 연구 Vol.23 No.39

메조테라피의 부작용으로 발생한 피부괴사의 제거를 위한 복부성형술 증례보고

윤신혁,김찬우,박대환 대한미용성형외과학회 2009 Archives of Aesthetic Plastic Surgery Vol.15 No.1

Mesotherapy is one of skin rejuvenation methods and known to be effective for anti-aging, cosmetic treatment, and improvement of obesity. Furthermore, the side effect of mesotherapy has been known to be very little, therefore, it has been used widely. Because of these reasons, complication of mesotherapy has been disregarded. A 32-year-old woman visited a private clinic for improvement of obesity. The patient had placenta injection with aminophylline, lidocaine and epinephrine on abdomen for several times and she did not have any symptoms. However, placenta injection was carried out at the last time with aminophylline, lidocaine, epinephrine and dehydrated alcohol. Four days later, abdominal partial necrosis was developed. And she was refered to our department. Wound of the abdomen had eschar formation and reddish color change. So, debridement of necrotic skin, and immediate reconstruction using flap and cosmetic abdominoplasty were done immediately, and the patient was satisfied with results. Based on various circumstances, we concluded that one of the etiologies of necrosis might be dehydrated alcohol and epinephrine effect. The standard of materials that are mixed in mesotherapy has not yet been established. In fact, the safety of additives has not yet been verified. Therefore, more studies on the standard materials and safety are needed.

아젤라인산 및 비타민 B6의 육모효과 검증에 관한 연구

윤신혁,박대환,신정임 대한성형외과학회 2008 Archives of Plastic Surgery Vol.35 No.5

Purpose: Interest in the augmentation of hair growth for functional and aesthetic purpose has increased dramatically in recent years. Many hair growth products have been released, but most of these have not been proven scientifically. This study aims to measure the hair growth effect of azelaic acid and vitamin B6, which have been known as hair growth materials, in animal models. Methods: Six weeks old C57BL/6 mice were used in this study and hair of mice were removed by topical treatment. The mice were divided into five experimental groups according to the testing material such as saline (negative control), propylene glycol(vehicle control), azelaic acid, vitamin B6 and azelaic acid plus vitamin B6 in combination. Hair growth was documented photographically and histologically, and then analysed by the high quality hair analysis program system. The quantity of endocrine factors, IGF-I and TGF-β1 in the skin of mice was measured by PCR analysis. Received May 12, 2008 Revised June 16, 2008 Accepted July 14, 2008 Address Correspondence: Dae Hwan Park, M.D., Department of Plastic and Reconstructive Surgery, College of Medicine, Catholic University of Daegu, 3056-6 Daemyung 4-dong, Nam-gu, Daegu 705-718, Korea. Tel: 053) 650-4578/Fax: 053)650-4584/E-mail: dhpark@cu.ac.kr Results: The topical treatment of azelaic acid and vitamin B6 in combination for 2 weeks to dorsal skin accelerated hair regrowth more than other groups. The azelaic acid and vitamin B6-combined treatment also promoted hair follicle elongation and thickness compared to the others. Histologic studies showed increased number of basal cells in azelaic acid and vitamin B6-combined treatment. Furthermore, the azelaic acid and vitamin B6-combined group significantly increased the expression of IGF-I but decreased the expression of TGF-β1 in the skin of mice compared to other groups. Conclusion: These results suggest that azelaic acid and vitamin B6, when used together, have an additive effect and might be used as hair growth materials.

히트펌프 조건의 원형관에서의 착상에 관한 연구

윤신혁(Shin-Hyuk Yoon),조금남(Keumnam Cho),하야세 가쿠(Gaku Hayase) 대한설비공학회 2009 대한설비공학회 학술발표대회논문집 Vol.2009 No.-

The present study measured frost pattern on a cylinder to propose empirical correlation equations for the local and average frost thickness, frost density and frost mass. The key parameters were diameter of the cylinders (7㎜, 20㎜), cooling surface temperature of the circular tube, absolute humidity of air, air temperature and air velocity. A 50% ethylene glycol aqueous solution was applied as a coolant. The frost thicknesses at both front and rear were larger than those at the other parts, while they were increased as diameter of the cylinder was increased. The local frost thicknesses at high air velocity were more uniform than those at low air velocity. The values predicted by Kim et al. under the freezer condition showed larger by the maximum of 30~50% than the measured data under heat pump condition. The empirical correlations for the local and average frost thickness and frost mass were proposed. The correlation equations for the frost thickness and frost mass under the heat pump condition in the present study might predict more accurate than the other correlation equations. The proposed correlations might be applied for the freezer condition within the maximum 15% deviation from the previous correlations under freezer condition.

히트펌프 조건 시 냉각 평판에서의 착상 실험

윤신혁(Shin-Hyuk Yoon),조금남(Keumnam Cho),조홍기(Hong-Gi Cho),하야세 가쿠(Gaku Hayase) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.5

The present study measured the frost thickness and frost mass on a flat plate to propose the correlation equations for the local and average frost thickness, frost density, and frost mass. Key parameters were the cooling surface temperature of the flat plate from 258.2 to 268.2 K, absolute humidity of air from 2.98 to 4.16 g/㎏<SUB>DA</SUB>, air temperature from 273.5 to 280.2 K, and air velocity from 1.0 to 2.5 ㎧. Although the area of the plate is the same, local frost thickness was changed along the direction of the flat plate. Correlation equations for the local and average frost thickness and frost mass under the heat pump condition were proposed. The predicted values by the correlation equations under the freezer condition showed larger by the maximum of 30~50% than the predicted values by the present correlation equations under the heat pump condition. The proposed correlation equations might be partly applied to the freezer condition.

히트펌프 조건 시 휜-관 위의 착상에 관한 연구

윤신혁(Shin-Hyuk Yoon),조금남(Keumnam Cho),하야세 가쿠(Gaku Hayase) 대한설비공학회 2009 대한설비공학회 학술발표대회논문집 Vol.2009 No.-

The present study measured the frost thickness and frost mass on a flat plate and on a circular tube to propose the correlation equations for the local and average frost thickness, frost density, and frost mass. Key parameters were the cooling surface temperature, absolute humidity of air, air temperature, and air velocity. A 50% ethylene glycol aqueous solution was applied as a coolant. The correlation equations for the frost thickness and mass of the flat plate and circular tube were proposed. They utilized topredict the frost thickness and mass of the simple fin and tube. The predicted local and average frost thicknesses and masses were compared with the measured values for the simple fin and tube. The local frost thickness on the fin decreased along the air flow direction. The predicted frost thickness agreed with the measured data within 5% while the predicted frost mass agreed with the measured data within 10%. The methodology to predict the frost for the simple fin and tube was developed and proposed.

히트펌프 조건시 휜-관 열교환기의 휜 부분의 착상에 관한 연구

윤신혁(Shinhyuk Yoon),조금남(Keumnam Cho),하야세 가쿠(Gaku Hayase) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.11

The present study measured the frost thickness and frost mass on a flat plate to propose the correlation equations for the local and average frost thickness, frost density, and frost mass. Key parameters were the cooling surface temperature, absolute humidity of air, air temperature, and air velocity. A 50% ethylene glycol aqueous solution was applied as a coolant. The present study also measured the local frost thickness on a fin-tube model to compare the predicted values on the fin of the fin-tube model by the correlation equations from the experiments of the flat plate. The empirical correlations under the heat pump condition in the present study might predict more accurately than the other correlations. The proposed correlation for the frost thickness agreed with the measured data within 5%.

고등학교 교양 논리학, 무엇을 가르칠 것인가?

여영서,윤신혁 한국철학교육학회 2022 한국철학교육학회 학술대회 Vol.2022 No.02

이초식 교수와 초등교사들의 철학하기 - 대한민국 초등교육에서의 어린이 철학교육, 그 시작과 진행 -

김혜숙,윤신혁 한국철학교육학회 2023 한국철학교육학회 학술대회 Vol.2023 No.05