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쓴메밀 및 단메밀 에탄올 추출물의 항산화 및 지방세포 분화억제 효과
윤보라 ( Bo Ra Yoon ),조봉제 ( Bong Jae Cho ),이효구 ( Hyo Ku Lee ),김대중 ( Dae Jung Kim ),이성갑 ( Seong Kap Rhee ),홍희도 ( Hee Do Hong ),김경탁 ( Kyung Tack Kim ),조장원 ( Chang Won Cho ),최현선 ( Hyeon Son Choi ),이부용 ( Boo 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2012 한국식품저장유통학회지 Vol.19 No.1
In this study, 80% ethanolic extracts of tartary and common buckwheats were assessed for their total phenol content, total flavonoids content, antioxidant activity (DPPH, ABTS radical scavenging activity and reducing power), and anti-adipogenic effects. Our results show that total phenol contents of 80% ethanolic extract from tartary and common buckwheats were 17.35±0.41 and 8.20±0.28 μg GAE/g, respectively. Antioxidant activities of 80% ethanolic extract from tartary buckwheat were significantly higher than that of common buckwheat extract (p<0.05). During adipocyte differentiation, 80% ethanolic extracts of tartary and common buckwheat significantly inhibited lipid accumulation compared to control cells. We further evaluated the effect of buckwheat extracts on the changes of key gene expression associated with 3T3-L1 adipogenesis and ROS production. Tartary buckwheat extract was more suppressed the mRNA expressions (PPARγ and aP2) than that of common buckwheat extract. Moreover, tartary buckwheat inhibited the mRNA expression of both NOX4 (NADPH oxidase 4) and G6PDH (glucose-6-phosphate dehydrogenase). These results indicate that anti-adipogenesis effect of tartary buckwheat can be attributed to phenolic compound that may potentially inhibit ROS production.
尹寶羅(Yoon, Bo-ra),金大一(Kim, Dae-il),嚴翼相(Eom, Ik-sang) 중국어문학연구회 2021 중국어문학논집 Vol.- No.127
This article demonstrates the prosodic differences between reduplicated verbs and adjectives in Standard Chinese (hereafter SC). The second syllable of a reduplicated verb, e.g. zouzou ‘take a stroll’, or a reduplicated adjective, e.g. gaogao-xingxing ‘delighted’, is described in grammars of SC as often pronounced in the neutral tone. A phonetic experiment on four speakers of Beijing Mandarin using Praat indicates a distinction between the second syllable of reduplicated verbs and reduplicated adjectives. The second syllable of the reduplicated verb has a pitch height determined by the tone of the preceding syllable. In contrast, the second syllable of the reduplicated adjective is pronounced in a relatively high tone regardless of the tonal category of the preceding syllable. Accordingly, this article claims that the former is indeed the neutral tone, which has features [+tone, -stress], while the latter is an unstressed syllable, which has features [-tone, -stress]. This prosodic difference is closely related to the semantic difference. A reduplicated verb indicates a casual or brief action (zou ‘to walk’; zouzou ‘take a stroll’) while a reduplicated adjective indicates intensity or vividness (gaoxing ‘happy’, gaogao-xingxing ‘delighted’). This demonstrates the interface in SC of phonetics and phonology on the one hand with morphology, pragmatics, and semantics on the other.
연구논문 : C2C12 근육세포의 산화적 손상에 대한 홍경천-홍삼 추출물 혼합액 발효물의 보호효과
윤보라 ( Bo Ra Yoon ),김영현 ( Young Hyun Kim ),이종석 ( Jong Seok Lee ),홍희도 ( Hee Do Hong ),이영경 ( Young Kyoung Rhee ),조장원 ( Chang Won Cho ),김영찬 ( Young Chan Kim ),이옥환 ( Ok Hwang Lee ) 한국식품영양학회 2013 韓國食品營養學會誌 Vol.26 No.3
본 연구에서는 피로 회복 또는 원기 외복에 효능이 있는 것으로 알려진 홍경천과 홍삼을 이용하여 홍경천-홍삼 복합발효물의 산화적 손상 억제 효과를 평가하고자 H202로 산화적 스트레스를 유도시킨 C2C12 근육세포에 홍경천-홍삼 복합 발효물의 처리한후, 세포의 morphology, cell viability 및 항산화 효소들의 유전자 발현 양상을 비교, 분석하였다. 홍경천-홍삼 복합 발효물은 C2C12 근육세포의 cell viability를 유의적으로 증가시켰으며, Cu/Zn-SOD, Mn-SOD 및 GPx등과 같은 세포내 한산화 효소의 발현을 증가시킬 뿐만 아니라, 근육세포 분화의 주요 전사인자인 Myo D의 발현 또한 증가시키는 것으로 나타났다. 이상의 결과로, 홍경천-홍삼 복합 발효물은 세포내 항산화 효소 시스템을 증가시켜 외부로부터의 산화적 손상에 대한 방어효능을 갖는 것으로 나타났으며, 향후 in vivo 시스템 이용한 추가적인 연구가 수행된다면, 홍경천- 홍삼 복합 발효물을 이용한 항피로 건강기능식품의 소재개발이 가능할 것으로 판단된다. Rhodiola spp. and red ginseng have been used for food and medicinal applications in disease chemoprevention in many Asian countries. Increased oxidative stress by reactive oxygen species (ROS) has been proposed to be a major cause of muscle fatigue. The present study was designed to investigate the protective effects of a fermented hot-water extract mixture from Rhodiola sachalinensis and red ginseng (MFR) on cell damage and the antioxidant enzyme system in H2O2-induced oxidative stress in skeletal muscle cells. C2C12 myoblasts were treated with various concentrations of NFR (non-fermented Rhodiola sachalinensis extract), FR (fermented hot-water extract from Rhodiola sachalinensis) and MFR for up to 5 days after the standard induction of differentiation, followed by semi-quantitative RT-PCR. MFR treatment dose-dependently protected oxidative damage of C2C12 cells. The treatment with MFR also enhanced mRNA expressions of MyoD, Cu/Zn SOD, Mn-SOD and GPX up to 16%. These results indicate that MFR exerts an anti-oxidative effect through a mechanism (s) that may involve the up-regulation of antioxidant enzymes, which may be important for the cellular redox environment in muscle cells.
윤보라(Yoon Bo Ra),변지원(Byun, Jiwon) 한국중국어교육학회 2015 중국어교육과연구 Vol.0 No.22
This article presents current issues in erhua(儿化) education in Korea and suggests a new approach of it. Since 1992, certain changes have arisen in the Chinese language curriculum in Korea due to the diplomatic relationship: especially from Twainese to Putonghua. Putonghua erhua(儿化) does not correspond to Beijing accent erhua(儿化). Without telling this linguistic classification, erhua(儿化) began to be considered as one of the most characteristic phonetic features either in Beijing accent or in Putonghua, and it made Korean students as well as professors confused, stressed, and frustrated. We try to propose the reason why this misconception, the structure and the function of Beijing erhua(儿化) arose, in tandem with certain suggestions of methodologies for Chinese professors and students who need differentiated instruction.
KIDP ‘산업디자인통계조사’의 이해 : ’07, ’09 조사의 디자인산업 부분 비교를 중심으로
윤보라(Yoon Bo Ra),이주명(Rhi Joo-myung) 한국디자인학회 2010 한국디자인학회 학술발표대회 논문집 Vol.2010 No.10
In order to let our country, industry, and education fields realize the importance and necessity of design as well as promote the design to them, we need a tool to understand the current status of design industry through scientific and systematic methods, which is also be recognized by Industrial Design Prompotion Act. Since the 1997 survey, a total of five times has been done by the Ministry of Knowledge Economy and Korea Institute of Design Promotion (KIDP)through utilizing various basic materials of related policies. The study is comparing the survey in 2007 with that in 2009 through focus on the design industry, which examines the overall study subjects, duration, scope ,target and methods by analysing survey overview, examines the question of the overall configuration item, the number of items, detailed configuration by analysing survey questions, and examines if there is any change in the size of the design industry, the number of design-related companies, the internationalization status of design field, the distribution of design companies, customer awareness of the design, design-related resources and system by analysing the survey results.
연구노트 : 3T3-L1 지방세포내 ROS 생성에 대한 천년초 열수 및 에탄올 추출물의 항산화 효과
윤보라 ( Bo Ra Yoon ),이영준 ( Young Jun Lee ),김선구 ( Sun Gu Kim ),장중영 ( Jung Young Jang ),이효구 ( Hyo Ku Lee ),이성갑 ( Seong Kap Rhee ),홍희도 ( Hee Do Hong ),최현선 ( Hyeon Son Choi ),이부용 ( Bo Yong Lee ),이옥환 ( Ok Hw 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2012 한국식품저장유통학회지 Vol.19 No.3
Recently, NADPH oxidase 4 (NOX4)-mediated generation of intracellular reactive oxygen species (ROS) was proposed to accelerate adipogenesis of 3T3-L1 cell. We have previously shown that Cheonnyuncho (Opuntia humifusa) extract significantly inhibited adipocyte differentiation via downregulation of PPARγ (peroxisome proliferator-activated receptor gamma) gene expression. In this study, we focused on the molecular mechanism(s) of NOX4, G6PDH (glucose-6-phosphate dehydrogenase) and antioxidant enzymes in anti-oxidative activities of 3T3-L1 adipocytes. Our results indicate that Cheonnyuncho extracts markedly inhibits ROS production during adipogenesis in 3T3-L1 cells. Cheonnyuncho extracts suppressed the mRNA expression of the pro-oxidant enzyme such as NOX4 and the NADPH-producing G6PDH enzyme. In addition, treatment with Cheonnyuncho extract was found to upregulate mRNA levels of antioxidant enzymes such as Mn-SOD (manganese-superoxide dismutase), Cu/Zn-SOD (copper/zinc-SOD), glutathione peroxidase (GPx), glutathion reductase (GR), and catalase, all of which are important for endogenous antioxidant responses. These data suggest that Cheonnyuncho extract may be effective in preventing the rise of oxidative stress during adipocyte differentiation through mechanism(s) that involves direct down regulation of NOX4 and G6PDH gene expression or via upregulation of endogenous antioxidant responses.