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한약재의 Cytochrome P450 결합관련 안전성에 관한 연구
유다영,우홍정,김영철,Yoo, Da-Young,Woo, Hong-Jung,Kim, Young-Chul 대한한방내과학회 2013 大韓韓方內科學會誌 Vol.34 No.4
Objectives : This study was performed to investigate the metabolic site of some medicinal herbs in the liver associated with CYP (Cytochrome P450). Methods : Cytochrome P450 is the major enzymes involved in drug metabolism and bioactivation. CYP3A4 and CYP2D6, the major CYP isoforms in humans, catalyse the major proportion of drugs available on the market. Scintillation proximity assay (SPA) is often used in studies to identify compounds that inhibit CYP3A4 and CYP2D6. 28 herbal extracts and radioisotopes were attached competitively to SPA beads, and followed by measuring the remaining radioisotopes in the medium. Erythromycin and dexamethasone, inhibitors of CYP3A4 and CYP2D6, were used as controls respectively. Results : Most of the 28 herbal extracts showed dose-dependent affinity to the CYP3A4 while some of the herbs showed affinity to the CYP2D6. Conclusions : These results suggest that most of the 28 herbal extracts are metabolized safely in the liver, combined with CYP3A4 and CYP2D6.
도시생태계 교육을 위한 시민 인식 설문조사 및 분석 -수원시를 중심으로-
유다영 ( Yoo Da-young ),이민지 ( Lee Min-gi ),김남춘 ( Kim Nam-choon ) 한국환경복원기술학회(구 한국환경복원녹화기술학회) 2020 한국환경복원기술학회지 Vol.23 No.6
The purpose of this study was to investigate the citizens' perception of urban ecosystem and urban ecosystem education to find out how to plan and create an effective urban ecosystem and how to utilize urban ecosystem education and educational media according to age groups. To this end, an online survey of 416 Suwon citizens was conducted, and based on the responses of the respondents, cross-analysis, multiple-response analysis, and correlation analysis were conducted using the IBM SPSS Statistics Statistical Program. The study found that fewer respondents showed a high understanding of urban ecosystem concepts compared to those who recognized the importance of environmental issues. Nevertheless, most of the respondents were aware of the importance of preserving and protecting the urban ecosystem and responded positively to the inconvenience. In addition, most of the respondents were aware of the need for urban ecosystem education and were found to have different preferred information media depending on age. It has been confirmed that the establishment of facilities such as ecological learning centers and seasonal environmental schools is the top priority among all age groups. Citizens are also aware of the importance of preserving and protecting the urban ecosystem and the need for education, but it is deemed necessary to supplement it because effective urban ecosystem conservation and protection plans and systematic education are not provided that citizens can sympathize with. In addition, it is deemed that various measures should be presented in selecting responsible organizations and educational media that host the education for effective education and promotion of urban ecosystem education according to conduct urban ecosystem education.
HSI와 MaxEnt를 통한 삵의 서식지 예측 모델 비교 연구
유다영 ( Yoo Da-young ),임태양 ( Lim Tai-yang ),김휘문 ( Kim Whee-moon ),송원경 ( Song Won-kyong ) 한국환경복원기술학회 2021 한국환경복원기술학회지 Vol.24 No.5
Excessive development and urbanization have destroyed animal, plant, habitats and reduced biodiversity. In order to preserve species diversity, habitat prediction studies are have been conducted at home and overseas using various modeling techniques. This study was conducted to suggest optimal habitat modeling research by comparing HSI and MaxEnt, which are widely used among habitat modeling techniques. The study was targeted on the endangered species of Prionailurus bengalensis in nearby areas (5460.35km2) including Cheonan City, and the same data were used for analysis to compare those models. According to the HSI analysis, Prionailurus bengalensis's habitat probability was 74.65% for less than 0.5 and 25.34% for more than 0.5 and the top 30% were forest (99.07%). MaxEnt's analysis showed that 56.22% of those below 0.5 and 43.79% of those above 0.5 were found to have a high explanatory power of 78.3% of AUC. The Paired Wilcoxn test, which evaluated the significance of thoes models, confirmed that the mean difference between the two models was statistically significant (p<0.05). Analysis of the differences in the results of those models using the matrix table shows that score 24.43% HSI and MaxEnt was accordance,12.44% of the 0.0 to 0.2 section, 7.22% of the 0.2 to 0.4 section, 2.73% of the 0.4 to 0.6 section, 1.96% of the 0.6 to 0.8, and 0.08% of the 0.9 to 1.0. To verify where the score difference appears, the result values of those models were reset to values from 1 to 5 and overlaid. Overlapping analysis resulted in 30.26% of the Strongly agree values, 56.77% of the agree values, and 11.92% of the Disagree values. The places where the difference in scores occurs were analyzed in the order of forest (45.23%), agricultural land (34.57%), and urbanization area (7.65%). This confirmed that the analysis of the same target species within the same target site also has differences in forecasts depending on the modelling method. Therefore, a novel analysis method combining the advantages of each modeling in habitat prediction studies should be developed, and future study may be used to select Prionailurus bengalensis and species-protected areas and species protection areas in the future. Further research is judged to require higher accuracy studies through the use of various modeling techniques and on-site verification.
근에너지기법(Muscle Energy Techniques)과 침치료를 이용한 특발성 요추부 척추측만증 치험 3례
엄태웅 ( Tae Woong Eom ),문태웅 ( Tae Woong Moon ),강명진 ( Myung Jin Kang ),공덕현 ( Duck Hyun Kong ),조태영 ( Tae Young Cho ),이기하 ( Ki Ha Lee ),유다영 ( Da Young Yoo ) 한방재활의학과학회 2008 한방재활의학과학회지 Vol.18 No.3
Methods : We have investigated 3 patients with idiopathic lumbar scoliosis, used muscle energy techniques and acupuncture therapy, measured Cobb`s angle before and after treatment. Results : After treatment, One case, the L-spine Cobb`s angle correctability was 62.74%, another case was 34.66%, the other case was 45.50%. Conclusions : These results suggest that muscle energy techniques and acupuncture therapy was effective treatment on patients with idiopathic lumbar scoliosis.