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      • KCI등재

        Perioperative Serum Carcinoembryonic Antigen Ratio Is a Prognostic Indicator in Patients With Stage II Colorectal Cancer

        우진선,김정빈,박인석,조현진,곽금희,양근호,배병노,김기환 대한대장항문학회 2018 Annals of Coloproctolgy Vol.34 No.1

        Purpose: The aim of this study was to evaluate whether the perioperative carcinoembryonic antigen (CEA) ratio could be used as a determinant for adjuvant therapy after curative surgery in stage II colorectal cancer. Methods: Data for 119 patients with stage II colorectal cancer who underwent radical surgery between 2010 and 2013 were collected. The perioperative CEA ratio was defined as the postoperative/preoperative serum CEA level, and the patients were grouped according to their perioperative CEA ratios: high ratio (≥0.5) and low ratio (<0.5). Overall survival rates were calculated, and their prognostic significances were analyzed. Results: The overall survival rates of the high and the low perioperative CEA groups were 68.2% and 86.8%, respectively (P = 0.033). In patients with normal preoperative CEA levels (<5 ng/mL), the high perioperative CEA ratio group showed a worse survival rate than the low perioperative CEA ratio group (71.7% vs. 100.0%, P = 0.007). In patients with high preoperative CEA levels (≥5 ng/mL), the high perioperative CEA ratio group showed a worse survival rate than the low perioperative CEA ratio group (33.3% vs. 75.0%, P = 0.036). In the multivariate analysis, perioperative CEA ratio (P = 0.046), age (P = 0.034), and venous invasion (P = 0.015) were independent prognostic factors for survival. Conclusion: The perioperative CEA ratio is a prognostic indicator for stage II colorectal cancer. Patients with normal preoperative serum CEA levels might also be considered for adjuvant therapy if their perioperative CEA ratios are higher than 0.5.

      • 한국의 對 남미공동시장 수출경쟁력에 관한 고찰

        우진선 성균관대학교 무역연구소 2020 Asian Trade Risk Management(ATRM) Vol.4 No.2

        MERCOSUR는 시장규모, 풍부한 자원, 중남미 지역 및 국제사회에서의 위상 등을 고려할 때, 한국이 전략적 협력대상으로 삼아야 할 중요한 지역으로 평가되고 있다. 이에 따라, 본 연구는 MERCOSUR 시장에서 다양한 지수를 활용한 수출경쟁력을 분석하였다. 또한, 수출경쟁력 분석을 통해 나타난 지수를 활용해 MERCOSUR 회원국 간 어떠한 관련성을 지니고 있는지 알아보고자 상관관계 분석을 진행하였다. 한국의 對 MERCOSUR 수출경쟁력 분석결과는 MERCOSUR의 회원국 간 차이가 존재했다. 하나의 예로, 시장점유율 부분에서 브라질은 전자집적회로에서 높은 시장점유율을, 아르헨티나는 액정 디바이스, 파라과이와 우루과이에서는 자동차산업과 관련한 시장점유율이 높게 나타났다. 또한, 상관관계 분석결과에서는 회원국 간 4가지 유사성이 나타났다. 첫째, 일부 품목에 대해 수입이 편중된 구조를 지니고 있다는 점, 둘째, 중산층의 확대로 소비품목이 증가할 것이라는 예상, 셋째, 가격경쟁력이 가장 중대한 영향을 끼치며, 마지막으로 파라과이와 우루과이 같은 작은 국가들은 MERCOSUR 회원국 상호 간의 교역 의존도가 높게 나타난다. 이를 통해 한국이 MERCOSUR와의 교역에서 상호 보완적인 무역구조로 경제적 효과를 가지고 있다는 점을 알 수 있었으며, MERCOSUR와의 무역협정(TA) 체결은 한국이 안정적으로 새로운 수출선을 확보하고, 주요국에 편중된 수출 구조의 한계를 극복하는데 기여할 수 있을 것이다. Korea is currently facing a variety of changes in its external environment, such as the return of protectionism, the U.S.-China trade war and Japan s export regulations. In this situation, the government is responding to the problem by signing various economic cooperation and free trade agreements to secure new export engines and diversify the market. The MERCOSUR is considered an important area for South Korea to be a strategic partner, considering its market size, abundant resources and its status in the Latin American region and the international community. This study analyzed export competitiveness using various indexes in MERCOSUR market. Further, the correlation analysis was conducted to find out the relevance of MERCOSUR member countries by using the index that was shown through the analysis of export competitiveness. According to the analysis of export competitiveness of Korea and the South American common market, there was a difference between member countries of the MERCOSUR. For example, in terms of market share, Brazil has a high market share in electronic integrated circuits, Argentina has liquid crystal devices, and Paraguay and Uruguay have a high market share in the automobile industry. In addition, the correlation analysis revealed four similarities among member states. First, imports have a biased structure for some items; second, the expectation that consumer goods will increase due to the expansion of the middle class; third, price competitiveness has the most significant impact; and finally, small countries like Paraguay and Uruguay are highly dependent on trade among their MERCOSUR members. This study showed that Korea has economic effects as a complementary trade structure in trade with MERCOSUR. A signing of trade agreement with the MERCOSUR would help South Korea secure new export lines in a stable manner and overcome the limitations of export structures that are biased toward major economies.

      • KCI등재

        Relation Between Tumor Size and Lymph Node Metastasis According to Subtypes of Breast Cancer

        민승기,이세경,우진선,정성미,유재민,유종한,이정언,김석원,채병주,남석진 한국유방암학회 2021 Journal of breast cancer Vol.24 No.1

        Purpose: Tumor size and lymph node metastasis are important factors that contribute to the progression of breast cancer. We aimed to analyze the relationship between tumor size and lymph node metastasis molecular subtype and examine the effects of nodal metastasis on overall survival (OS). Methods: We retrospectively reviewed the data of 16,552 patients who underwent breast surgery in Samsung Medical Center between 2000 and 2015. Information on tumor size (largest diameter of the invasive component), number of positive lymph nodes, and molecular subtype were obtained. We constructed a linear regression model to evaluate the relationship between tumor size and lymph node metastasis. To determine the effect of nodal metastasis on OS, we performed a Cox proportional regression analysis with Np/T (number of metastatic lymph nodes [n]/tumor size [cm]). Results: This study included 12,007 patients with a median follow-up of 62 months. The linear regression coefficients were 1.043 for luminal A, 1.024 for luminal B, 0.656 for HER2, and 0.435 for triple-negative breast cancer (TNBC) subtypes. No significant difference was observed in the coefficients between the luminal A and B subtypes (p = 0.797), while all other coefficients showed significant difference. After adjusting for other risk factors, the hazard ratio (HR) of Np/T for each subtype was significant for OS: luminal A (HR, 1.134; 95% confidence interval [CI], 1.097–1.171; p < 0.001), luminal B (HR, 1.049; 95% CI, 1.013–1.086; p = 0.007), HER2 (HR, 1.069; 95% CI, 1.014–1.126; p = 0.013), and TNBC (HR, 1.038; 95% CI, 1.01–1.067; p = 0.008). Conclusion: The incidence of lymph node metastasis differed according to molecular subtype. Luminal types have higher incidence of nodal metastasis than HER2 and TNBC. The HR of Np/T was highest in luminal A subtypes and lowest in TNBC subtypes.

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