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Development of an Optical Tissue Clearing Laser Probe System
여창민,강희성,배윤진,박지훈,이경중,J. Stuart Nelson,정병조 한국광학회 2013 Current Optics and Photonics Vol.17 No.4
Although low-level laser therapy (LLLT) has been a valuable therapeutic technology in the clinic, its efficacy may be reduced in deep tissue layers due to strong light scattering which limits the photon density. In order to enhance the photon density in deep tissue layers, this study developed an optical tissue clearing (OTC) laser probe (OTCLP) system which can utilize four different OTC methods: 1) tissue temperature control from 40 to 10℃; 2) laser pulse frequency from 5 to 30 Hz; 3) glycerol injection at a local region;and 4) a combination of the aforementioned three methods. The efficacy of the OTC methods was evaluated and compared by investigating laser beam profiles in ex-vivo porcine skin samples. Results demonstrated that total (peak) intensity at full width at half maximum of laser beam profile when compared to control data was increased: 1) 1.21(1.39)-fold at 10℃; 2) 1.22 (1.49)-fold at a laser pulse frequency of 5 Hz; 3)1.64 (2.41)-fold with 95% glycerol injection; 4) 1.86 (3.4)-fold with the combination method. In conclusion,the OTCLP system successfully improved the laser photon density in deep tissue layers and may be utilized as a useful tool in LLLT by increasing laser photon density
생체조직내 레이저 광 밀도 향상을 위한 압력 인가형 저출력 레이저 프로브
여창민,박정환,손태윤,이용흠,정병조,Yeo, Chang-Min,Park, Jung-Hwan,Son, Tae-Yoon,Lee, Yong-Heum,Jung, Byung-Jo 대한의용생체공학회 2009 의공학회지 Vol.30 No.1
Laser has been widely used in various fields of medicine. Recently, noninvasive low-level laser therapeutic medical devices have been introduced in market. However, low-level laser cannot deliver enough photon density to expect positive therapeutic results in deep tissue layer due to the light scattering property in tissue. In order to overcome the limitation, this study was aimed to develop a negative pressure applied low-level laser probe to optimize laser transmission pattern and therefore, to improve photon density in soft tissue. In order to evaluate the possibility of clinical application of the developed laser probe, ex-vivo experiments were performed with porcine skin samples and laser transmissions were quantitatively measured as a function of tissue compression. The laser probe has an air suction hole to apply negative pressure to skin, a transparent plastic body to observe variations of tissue, and a small metallic optical fiber guide to support the optical fiber when negative pressure was applied. By applying negative pressure to the laser probe, the porcine skin under the metallic optical fiber guide is compressed down and, at the same time, low-level laser is emitted into the skin. Finally, the diffusion images of laser in the sample were acquired by a CCD camera and analyzed. Compared to the peak intensity without the compression, the peak intensity of laser increased about $2{\sim}2.5$ times and FWHM decreased about $1.67{\sim}2.85$ times. In addition, the laser peak intensity was positively and linearly increased as a function of compression. In conclusion, we verified that the developed low-level laser probe can control the photon density in tissue by applying compression, and therefore, its potential for clinical applications.
여창민(Changmin Yeo),손태윤(Taeyoon Son),정병조(Byungjo Jung) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.10
Laser has been applied in various diagnostic and therapeutic medical fields. For last few decades, medical low level laser devices have been introduced in market, but they have limitations which cannot convey enough energy to deep layer of tissues for diagnostic or therapeutic purposes. To address the issue, there have been many studies of using physical and chemical methods; it is one of ways to apply negative or positive pressure to tissue. However, it is hard to apply desired pressure on tissues continuously when practical laser devices are used. In this study, we introduce a low-level laser probe which allows maintain pressure on skin tissue. Consequently, we arc confident that the pressure probe for low-level laser treatment should be a useful tool in order to deliver sufficient energy for practical uses.
Kiwoon Kwon,Taeyoon Son,여창민,정병조 한국광학회 2011 Current Optics and Photonics Vol.15 No.4
Various methods have been investigated to increase photon density in soft tissue, an important factor in low-level laser therapy. Previously we developed a compression-controlled low-level laser probe (CCLLP) utilizing mechanical negative compression, and experimentally verified its efficacy. In this study, we used Bezier curves to numerically simulate the skin deformation and photon density variation generated by the CCLLP. In addition, we numerically modeled changes in optical coefficients due to skin deformation using a linearization technique with appropriate parameterization. The simulated results were consistent with both human in vivo and porcine ex vivo experimental results, confirming the efficacy of the CCLLP.
의료용 표시기의 안전성 및 성능 평가를 위한 시험 항목 및 시험방법(안)연구
김영균,조승관,이태우,여창민,정병조,권영미,차지훈,허찬희,박기정,김동섭,김한성,Kim, Y.G.,Cho, S.K.,Lee, T.W.,Yeo, C.M.,Jung, B.J.,Kwon, Y.M.,Cha, J.H.,Hur, C.H.,Park, K.J.,Kim, D.S.,Kim, H.S. 대한의용생체공학회 2011 의공학회지 Vol.32 No.2
Tattooing is a performance for decorative and cosmetic marking by placing permanent ink into the skin. As the cultural meaning of tattoo in Korea is changing, the tattoo machines are widely spread n permanent cosmetic market. Though the use of the tattoo machine was increased, the evaluation standards of tattoo machine were not existed. Korea Food and Drug Association regulated the electrical and mechanical safety standards which were founded on the IEC 601-1 second edition. Also they regulated he biological safety standards which were derived from the ISO 10993 series, however, these general valuations of common medical device were insufficient for evaluating tattoo machine. We developed the standards of tattoo machine for safety and performance evaluation for tattoo machine by preliminary hazard analysis in ISO 14971. The evaluation criteria of tattoo machines are focused on the mechanical invasion. We suggested the additional evaluation items of the needle speed, length, vibration with general valuation criteria of common medical device. We anticipate that this research may be a primary stage to figure a standard regulation and evaluation for tattoo machine.