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심정연,변원철,홍정수,문희범,홍수종 ( Jung Yeon Shim,Won Chul Byun,Jeong Soo Hong,Hee Bom Moon,Soo Jong Hong ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Objective .' To evaluate the basophil histamine releasability in response to IgE- and non- IgE-mediated stimuli in children with atopic asthma. Met: Basophil histamine releasability was measured in Dermatophagoides farinae (D. farinae) -sensitive atopic asthmatics, D.farinae -sensitive healthy atopics, non-atopic asthmatics, and healthy non-atopics. Basophils were stimulated with D.farinae, goat antihuman IgE antibody, formyl-Met-Leu-Phe(fMLP), and Calcium ionophore A23187. Histamine was measured by automated fluorometric technique. Results '. Sponianeous histamine release was higher in atopic asthmatics compared to healthy non-atopics. Histamine release by D.farinae and by anti-IgE antibody was higher in atopic asthmatics compared to the other groups. There was no difference in histamine release by fMLP among all groups. Histamine release by Calcium ionophore was higher in healthy atopics and non-atopic asthmatics compared to healthy non-atopics. The atopics showed correlation between histamine release by D.farinae, by anti-IgE antibody and total serum IgE levels. Conclusions '. Spontaneous and IgE-mediated histamine release were related to the presence of both atopy and asthma, whereas non-IgE mediated histamine release was different depending on the stimuli.
흡연과 주거환경이 초등학생 천명 및 천식 발생에 미치는 영향
심정연 ( Jung Yeon Shim ),황수진 ( Soo Jin Hwang ),김정호 ( Jeong Ho Kim ),정선희 ( Sun Hee Chung ),박동혁 ( Dong Hyuk Park ),심재원 ( Jae Won Shim ),김덕수 ( Duk Soo Kim ),정혜림 ( Hae Lim Jung ),박문수 ( Moon Soo Park ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2010 소아알레르기 및 호흡기학회지 Vol.20 No.4
목적: 여러 환경적 요인이 천식 발생을 증가시킨다고 보고되고 있어 본 연구에서는 간접흡연과 주거 환경이 천명, 천식 발생에 미치는 영향과 천식의 위험 인자를 알아보고자 하였다. 방법: 서울의 한 초등학교 학생 969명을 대상으로 설문 조사를 하였다. 설문 조사에는 천식, 천명의 증상, 간접흡연 노출, 주거환경에 관한 내용이 있었고, 주거환경과 관련된 항목들 중에는 출생 후 1년 이내 새로 지은 집으로 이사한 적이 있는지, 부모님이 향수를 집안에서 사용하는지, 최근 1년 이내 새 가구를 들여놓았는지 등이 포함되어 있다. Logistic regression and Pearson chi statistics를 사용하여 분석하였다. 결과: 간접흡연에의 노출은 최근 1년 내 천명, 최근 1년 내 천명으로 잠에서 깨어난 것과 연관성이 있었다. 아버지의 하루 20개피 이상 흡연은 최근 12개월 이내 4회 이상의 천명과 연관이 있었다. 그러나 간접 흡연에 따른 폐기능, 총 IgE 농도, 알러젠 감작, 호산구수는 차이가 없었다. 출생 후 1년 이내 새집으로의 이사는 지금까지의 천식 진단과 연관이 있었고, 집안에서 향수를 사용하는 것과 최근 1년 이내 새가구를 사용하는 것은 최근 12개월 이내 천명 및 천식 치료, 야간 기침과 관련이 있었다. 결론: 간접흡연, 출생 후 1년 이내 새집으로 이사, 향수 사용과 새가구 사용은 초등학생에서 천명 및 천식의 위험 요인이다. Purpose: Environmental factors may increase risk for childhood asthma. The objective of this study was to investigate the association of environmental tobacco smoke (ETS) exposure and home environment with the development of wheeze and asthma. Methods: We conducted a cross-sectional survey of 969 elementary school students. Data included questions about asthma and wheeze symptoms, exposure to tobacco smoke, and home environment including history of moving into a new house within 1 year of age after birth, use of fragrance at home, recent purchase of new furniture. Logistic regression and Pearson chi statistics were used to estimate these associations. Results: ETS exposure was associated with current wheeze and nocturnal sleep disturbance. Paternal smoking over 20 cigarettes per day was associated with 4 or more episodes of wheeze during the past 1 year. However, there were no significant differences in pulmonary function, serum total IgE levels, blood eosinophil counts, and atopy between children with ETS exposure and non-exposure. Moving into a new house within 1 year of birth was associated with current asthma or wheeze. Use of fragrance at home and purchase of new furniture during the past 1 year were associated with current wheeze, current physician-diagnosed asthma, and nocturnal cough. Conclusion: Exposure to ETS, moving into a new house after birth, and indoor fragrance are risk factors for wheeze and asthma in schoolchildren. [Pediatr Allergy Respir Dis(Korea) 2010;20:238-246]
유체-구조 연성해석과 유체해석의 비교를 통한 연료레일에서의 맥동저감 특성 연구
심정연(Jeong-Yeon Shim),김동현(Dong-Hyun Kim),조윤태(Yun-Tae Cho) 한국유체기계학회 2006 유체기계 연구개발 발표회 논문집 Vol.- No.-
Complex pressure pulsation phenomenon in fuel rails is generated by rapid opening and closing of injectors and it commonly causes undesirable noise. In the previous study, fluid-structure interaction analyses based on FEM had been conducted to examine the pulsation damping characteristics for different shapes of fuel rails. The results showed that the fuel rail with a high aspect ratio rectangular cross section seems to be best in order to reduce the pressure pulsations as shown in the previous experimental test by Mizuno, K. et al. In this study, CFD analyses (the fuel rail is regarded as a rigid structure.) have been performed to compare with the fluid-structure interaction analyses. And also the modal analyses for the fuel rails are performed to examine the correlation between the structural behavior and pressure pulsation.
박서연 ( Seo Yeon Park ),송태종 ( Tae Jong Song ),김영주 ( Young Ju Kim ),이지은 ( Jee Eun Lee ),김미경 ( Mi Kyoung Kim ),김미라 ( Mi La Kim ),윤보성 ( Bo Sung Yoon ),성석주 ( Seok Ju Seong ),심정연 ( Jeong Yun Shim ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.11
Tuboovarian abscess occurred in pregnancy is a rare disease, especially which occurs after in vitro fertilization and embryo transfer (IVF-ET) is extremely rare. It is also difficult in diagnosis, because of its low incidence and nonspecific symptoms. Most of diagnosis is made in surgery. Although IVF currently is considered an effective treatment in women with endometriosis, there is the risk causing the infection of the endometrioma after oocyte retrieval. A case of tuboovarian abscess in IVF-ET pregnancy was presented and reviewed briefly.
CFD 해석을 이용한 Balloon형 인공심폐기 설계를 위한 구조적 해석
박영란 ( Young Ran Park ),심정연 ( Jeong Yeon Shim ),김기범 ( Gi Beum Kim ),김상진 ( Shang Jin Kim ),강형섭 ( Hyung Sub Kang ),김진상 ( Jin Shang Kim ),김민호 ( Min Ho Kim ),홍철운 ( Chul Un Hong ),김성종 ( Seong Jong Kim ) 한국화학공학회 2011 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.49 No.2
In this study, we attempted a structural analysis in order to design a balloon type extracorporeal membrane oxygenator that can induce blood flow without using blood pumps for the purpose of complementing the weakness in the existing extracorporeal membrane oxygenator. To analyze the flow characteristic of the blood flow within the virtual model of extracorporeal membrane oxygenator, computational fluid dynamics(CFD) modeling method was used. The operating principle of this system is to make the surface of the extracorporeal membrane oxygenator keep contracting and dilating regularly by applying pressure load using a balloon, and the ``Time Function Value`` that changes according to the time was applied by calculating a half cycle of sine waveform and a cycle of sine. waveform Under the assumption that the uni-directional blood flow could be induced if the balloon type extracorporeal membrane oxygenator was designed as per the method described above, we conducted a structural analysis accordingly. We measured and analyzed the velocity and pressure of blood flow at both inlet and outlet of the extracorporeal membrane oxygenator through CFD simulation. As a result of the modeling, it was confirmed that there was a flow in accord with the direction of the blood by the contraction/dilation. With CFD simulation, the characteristics of blood flow can be predicted in advance, so it is judged that this will be able to provide the most optimized design in producing an extracorporeal membrane oxygenator.
2 MW급 수상태양광 발전 설비의 전체 모듈 해석을 통한 구조 안전성 평가
이창열(Lee Chang-Ryeol),이권희(Lee Gwon-Hee),심정연(Shim Jeong-Yeon),최대한(Choi Dae-Han),이정호(Lee Jeong-Ho) 한국태양에너지학회 2021 한국태양에너지학회 논문집 Vol.41 No.6
Unlike land-based photovoltaic power generation systems, floating photovoltaic power generation systems are installed in a reservoir or marine environment and use a floating body and mooring device. Therefore, it is difficult to evaluate structural safety. To evaluate the structural safety of a floating solar power plant, it is necessary to calculate the wind load and wave load in consideration of the floating body, mooring device, and joint. In this study, analysis was performed on the entire model of a 2 MW class floating photovoltaic power plant. To calculate the applied load, a two-dimensional (2D) flow analysis was performed to calculate the wind load acting on the solar panel. Then, wave analysis, including currents, was performed to calculate the wave load acting on the floating body. Through the analysis, the tension and displacement acting on the mooring device generated by the current, wind load, and wave load were confirmed. Finally, structural analysis was performed on the unit where the wind load, current, wave load, and mooring force acted the most. Thus, the structural safety of the floating photovoltaic power generation facility was evaluated.
복강경보조질자궁절제술과 복강경전자궁절제술의 수술결과 비교
박현 ( Hyun Park ),최민철 ( Min Chul Choi ),윤보성 ( Bo Sung Yoon ),성석주 ( Seok Ju Seong ),조연경 ( Yeon Kyung Cho ),신중식 ( Joong Sik Shin ),전혜선 ( Hye Sun Jun ),심정연 ( Jeong Yun Shim ),김인현 ( In Hyun Kim ),박종택 ( Cho 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.7
목적: 복강경보조질자궁절제술 (LAVH)과 복강경전자궁절제술 (TLH)의 수술 결과를 비교하고자 하였다. 방법: 병원기록을 바탕으로 2006년 9월부터 2007년 8월까지 복강경자궁절제술을 받았고 병리소견이 자궁근종 혹은 샘근육증인 경우만을 대상으로 하여 LAVH를 받은 93명과 TLH를 받은 142명을 선정하였다. 수술방법에 따라서 환자의 인구학적 특징과 수술결과를 비교하였다. 여러 변수들 사이의 관계를 알아보고자 다중회귀분석을 실시하였다. 결과: 두 군 간에 나이 및 체질량지수, 수술력, 병리소견은 차이가 없었다. 단변량 분석에서 LAVH의 수술시간 (129.0±34.5분, 123.6±40.8분)과 실혈량 (385.5±296.1 mL, 294.7±285.4 mL)이 증가하였다 (P<0.050). 검체무게는 LAVH에서 무거운 경향이 있었으며 (378.7±211.7 g, 316.9±170.1 g, P=0.060), 입원기간 (5.63±1.61일, 5.71±1.61일)과 부작용 발생률 (10.8%, 14.0%)은 차이가 없었다 (LAVH, TLH, P>0.050). 다변량 분석에서 실혈량은 수술시간 및 검체무게과 관련이 있었으며 (P=0.000), 수술방법과는 관련이 적었다 (P=0.213). 결론: TLH에 비하여 LAVH가 시행된 경우에는 자궁이 무겁고 수술시간이 길며 실혈량이 많은 경향이 있었다. 다변량 분석을 통하여 복강경자궁절제술에서 실혈량은 수술방법과는 관련이 없으며 검체무게 및 수술시간과 비례함을 알 수 있었다. Objective: To compare the surgical outcomes between laparoscopy-assisted vaginal hysterectomy (LAVH) and total laparoscopic hysterectomy (TLH). Methods: The data were collected retrospectively from hospital records. Between September 2006 and August 2007, Patients undergone with LAVH (93 cases) and TLH (142 cases) with pathologic reports of leiomyoma or adenomyosis were enrolled. The characteristics and surgical results were compared according to the operation type. The correlations among the variables were analyzed with multiple linear regression. Results: Between two groups, the characteristics of patients were similar such as age, body mass index, surgical history, and pathologic findings. In the univariate analysis, the differences of operation duration and blood loss between LAVH (129.0±34.5 min, 385.5±296.1 mL) and TLH (123.6±40.8 min, 294.7±285.4 mL) were significant (P<0.050). Specimen weight was slightly heavier in LAVH (378.7±211.7 g vs. 316.9±170.1 g, P=0.060), Admission duration (5.63±1.61 day vs. 5.71±1.61 day) and the incidence of complications (10.8% vs. 14.0%) were indifferent to the groups (LAVH vs. TLH, P>0.050). In multivariate analysis, blood loss was correlated with operation duration and specimen weight (P=0.000) but not with operation type (P=0.213). Conclusions: LAVH tends to be selected in larger uteri and results in more blood loss and longer operation duration. Operation type (LAVH or TLH) does not affect blood loss which is related with operation duration and uterine weight.