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내소승마탕(內消升麻湯)의 항암효과(抗癌效果) 연구(硏究)
심상희,박수연,김종한,최정화,Shim, Sang-Hee,Park, Su-Yeon,Kim, Jong-Han,Choi, Jung-Hwa 대한한방안이비인후피부과학회 2006 한방안이비인후피부과학회지 Vol.19 No.1
This study was carried out to evaluate antioxidative, cytotoxic and chemosensitizing effects for anti-tumor activities of Naesosungma-tang (NST). The results were as follows ; 1. The oxidative effects were measured by DPPH radical scavenging activity. NST water extract was showed more effective than ethanol extract and also various solvent fractions from NST showed effective in the following order : butanol fraction > ethyl acetate fraction > hexane fraction > aqueous fraction. 2. NST water extract was showed cytotoxic effects on the human cancer cells Calu-6 cell and SNU-601 cell, but not on MCF-7 cell. 3. The viability of cells was measured in 4 kinds of solvent fractions from water extract of NST by MTT assay. The results were as followings : 1) On the NIH3T3 cell, $IC_{50}$ value was $200{\sim}300\;{\mu}g/m{\ell}$ in three fractions except aqueous fraction. 2) On the Caco-2 cell, effective only in the butanol fraction. 3) On the Calu-6 cell, most effective in hexane fraction($IC_{50}:80\;{\mu}g/m{\ell}$) and effective in ethyl acetate and butanol fraction($IC_{50}:100{\sim}120\;{\mu}g/m{\ell}$). 4) On the MCF-7 cell, $IC_{50}$ value was similar in three fractions except aqueous fraction. 5) On the SNU-601 cell, $IC_{50}$ value was within $100\;{\mu}g/m{\ell}$ in three fractions except aqueous fraction. 6) On the HCT-1l6 cell, $IC_{50}$ value was $150{\sim}200\;{\mu}g/m{\ell}$ in three fractions except aqueous fraction. 7) On the AML-2/WT cell, not effective in four kinds of solvent fractions. 4. In combined effects of NST and vincristine on AML-2/D100 cell, water and ethanol extracts of NST and hexane fraction of water extracts of NST more effectively inhibited proliferation of AML-2/D100 cell. These results Suggest that NST has antioxidative and cytotoxic effects against Caco-2, Calu-6, MCF-7, SNU-601, HCT116 and NIH3T3 cell especially Calu-6 and SNU-601 cell, and also chemosensitizing effects against AML-2/D100 cell in combined vincristine.
심상희,김종한,최정화,정현우,Shim, Sang-Hee,Kim, Jong-Han,Choi, Jung-Hwa,Jeong, Hyun-Woo 대한한방안이비인후피부과학회 2002 한방안이비인후피부과학회지 Vol.15 No.2
Shibyukmiyouki-Eum was a drug that treated carbuncle and cellulitis. So, the purpose of this study was to investigate effect of Shibyukmiyouki-Eum on the anticancer and inhibitive effects of the secondary effects by anticarcinogen We used Shibyukmiyouki-Eum extract(SYE) with freeze-dried, 8wks-old male mice(balb/c, ICR) and cancer cell lines(L1210. S-180) for this Study, The proliferation of cells was tested using a colorimetric tetrazoliun assay(MTT assay). and measurement of WBC, RBC, hemoglobin and platelet was tested by a automated hematology analyzer. The results of this study were obtained as follow; SYE was showed significantly cytotoxicity on the L1210 and S-180 cell lines. increased proliferation of thymocytes decreased by anticarcinogen. In combined effects of SYE and vincristine(0.005㎎/kg), SYE was significantly inhibited proliferation of L1210 cells and significantly increased proliferation of thymocytes. Also SYE was significantly increased count of WBC. platelet and increased count of RBC, hemoglobin. These results suggest that SYE has not only anticancar action but inhibitive effects of on the secondary effects by anticarcinogen.
葛根解肌湯을 투여하여 치료한 단독 환자에 대한 임상보고 3례
심상희,정동환,유미경,박수연,최정화,김종한,위통순,Shim, Sang-hee,Jeong, Dong-hwan,Yu, Mi-kyung,Park, Su-yeon,Choi, Jung-hwa,Kim, Jong-han,Wee, Tong-sun 대한한방안이비인후피부과학회 2004 한방안이비인후피부과학회지 Vol.17 No.3
Erysipelas is a type of cellulitis in skin infection generally caused by group A ${\beta}$-hemolytic streptococci. An erysipelas skin lesion typically has a raised border that is sharply demarcated from normal skin. The underlying skin is painful, intensely red, hardened, swollen, and warm. Objectives: We reviewed three cases of erysipelas patients who hospitalized in Dongshin Univ. Suncheon Oriental medicine hospital from June 2001 to June 2002. Methods : We treated them with Galgunhaegitang(葛根解肌湯) for interior diease of Taeumin(太陰人) and also used acupuncture and cupping therapy. Results and Conclusions ; We had significant effects of Galgunhaegitang(葛根解肌湯) for three cases of erysipelas patients. So if the patient were a Taeumin(太陰人), we can consider using Galgunhaegitang(葛根解肌湯) for erysipelas. We can also use antibiotics properly in case there are high fever or open wounds.
심상희,Shim, Sang-Hee 한국생약학회 2008 생약학회지 Vol.39 No.1
Ubiquitin-proteasome proteolytic system plays an important role in selective protein degradation and regulates cellular events including apoptosis. Cancer cells have been shown to be more sensitive to the proapoptotic effects of proteasome inhibition than normal cells. Thus, proteasome inhibitor can be potential anticancer agent. Since the MeOH extracts of psoraleae semen and processed psoraleae semen showed potent proteasome inhibition activity, the fractions of the extracts were evaluated on the activity to screen the proteasome inhibitors. The $CHCl_3$ fr. of the processed psoraleae semen showed the most potent activity, of which chemical investigation led to two coumarins, psoralen and isopsoralen. Their structures were determined by spectroscopic methods such as $^1H-NMR$ and EIMS spectra.
當歸飮子加減을 응용한 乾癬 患者 1例에 대한 臨床的 考察
심상희,김종한,최정화,Shim, Sang-Hee,Kim, Jong-Han,Choi, Jung-Hwa 대한한방안이비인후피부과학회 2002 한방안이비인후피부과학회지 Vol.15 No.1
Psoriasis is a common genetically determined, chronic, inflammatory skin disease characterized by rounded crythematous, dry, scaling patches. It is caused to blood heat(血熱), shortage of blood(血燥) and blood stasis(血瘀) in oriental medicine. We treated a patient who suffered from chroinc and recurred psoriasis, and who was differenciated with endogenous wind due to shortage blood(血燥生風) with Danguiumjagagam(當歸飮子加減). After 10 days of treatment with Danguiumjagagam(當歸飮子加減) and acupunture, we observed an improvement. Based on this experience, it is considered that oriental medicine can be applied to the treatment of psoriasis.
심상희,정동환,김종한,최정화,박수연,Shim, Sang-hee,Jeong, Dong-hwan,Kim, Jong-han,Choi, Jung-hwa,Park, Soo-yeon 대한한방안이비인후피부과학회 2003 한방안이비인후피부과학회지 Vol.16 No.3
Dyshidrotic eczema is a eczema making vesicles at the hand and foot with pruritus, tend to chronically recurred. It is caused to retention of Damp-heat in interior(濕熱蘊積), interior heat due to Yin deficiency(陰虛內熱) in Oriental medicine. We treated a patient who suffered from recurred dyshidrotic eczema differentiated with retention of Damp-heat in interior(濕熱蘊積) with Chunggisangagam(淸肌散加減). After about 30 days of treatment with Chunggisangagam(淸肌散加減), acupunture and aroma therapy, we observed an improvement. Based on this experience, it is considered that the Oriental medicine can be applied to the treatment of dyshidrotic eczema.
7-O- 파라를루오로벤조일크라이신의 물성 및 혈당강하효과
심상희(Sang Hee Shim),신준수(Joon Su Shin),김명범(Myoung Bum KIm),김원기(Won Ki Kim),김성진(Sung Jin KIm),김박광(Bak Kwang Kim) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.3
7-o p-Fluorobenzoylchrysin was synthesized by condensing p-flouorbenzoic acid with chrysin in organic solvent, and its structure was identified by NMR, MS, UV, and IR. We also investigated the physicochemical properties, hypoglycemic effect, and the quantitative analysis method of this compound. The correlation coefficient of calibration curve on this compound was approximately 0.9945 by absorption spectrophotometry and 0.9989 by high perfornance liqid chromatography. 7-o-p-Fluorobenzoylchrysin was resolved in 6.014 min by reversed-phase HPLC column with solvents consisting of methanol (80%) and 10mM phosphoric acd. Its blood glucose inhibition rate is 20.7%.
헤어 미용인들의 보건위생 관심과 COVID-19에 대한 인식정도 연구
심상희 ( Sang Hee Shim ),이근광 ( Keun Kwang Lee ) 한국자연치유학회 2021 Journal of Naturopathy Vol.10 No.2
배경: 헤어 미용인들의 코로나감염증에 대한 위생과 인식에 대한 조사의 필요성이 대두되었다. 목적: 헤어 미용인들의 COVID-19에 대한 보건위생 관심 정도와 인식 정도를 조사하였다. 방법: 대전광역시 소재 헤어 미용인을 대상으로 설문 조사하였다. 회수한 설문지 총 260부를 SPSS 26.0 프로그램을 분석하였다. 결과: 미용인들의 보건위생 관심도는 연령, 학력, 직급, 미용실의 형태, 근속연수에 따라서 통계적으로 유의한 차이를 보였다. 코로나-19에 대한 인식 정도에서 코로나의 위험성에 대해서는 30대 이상, 원장, 중간크기 가게, 근속연수 10년 이상에서 높게 나타났다. 코로나에 대한 낙관적 측면에서는 20대, 보조 스텝, 대형가게 및 근속연수 5년 미만에서 높게 나타났다. 보건위생 관심, 위생 관심도, 손 위생 및 마스크 위생, 코로나 위험성 인식과 낙관적 인식은 정(+)의 상관관계가 있었다. 결론: 대전지역 헤어미용인들에 대한 보건위생 관심과 인식 정도는 연령, 학력, 직급, 헤어샵의 형태 및 근속연수에 따라서 유의하게 증가하였다. 본 결과는 이 분야의 연구에 기초자료가 되리라 평가한다. Background: The need for an investigation into the hygiene and awareness of hairdressers regarding Corona infection has emerged. Purpose: To investigate the level of interest in health and hygiene of hairdressers and their awareness of COVID-19. Methods: A questionnaire survey was conducted with hairdressers located in Daejeon Metropolitan City. The SPSS 26.0 program analyzed a total of 260 collected questionnaires. Results: The interest in the health and hygiene of hairdressers showed a statistically significant difference according to age, educational background, job title, type of hairdresser, and years of service. The hairdresser's risk and degree of awareness of COVID-19 were higher in those in their 30s or older, managers, medium-sized stores, and ten years of service. In terms of optimism about Corona, it was found to be high among those in their 20s, assistant staff, large stores, and less than five years of service. In addition, there was a positive (+) correlation between health care concerns, hand hygiene and mask hygiene, and awareness of corona risk and optimism. Conclusions: The level of health and hygiene interest and awareness of hairdressers significantly increased according to age, educational background, job title, type of hairdresser, and length of service. Therefore, it evaluated that this result would serve as primary data for research in this field.