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흰쥐에서 허혈성 뇌경색에 대한 에스트로겐의 신경보호 효과
김원회(Won Whe Kim),이규섭(Kyu Sup Lee),최영철(Yeong Cheul Choi),신병섭(Byung Sup Shin),김기형(Ki Hyung Kim) 대한폐경학회 2002 대한폐경학회지 Vol.8 No.1
N/A Objective: Overall incidence of stroke is uniformly higher in men than in women, and rare especially in women during the reproductive stage. A number of studies have demonstrated the reduced infarct size upon administration of estrogen to ovariectomized females in ischemic brain injury models. Design: We aimed to examine the potential neuroprotective effects of 17 beta-estradiol on the cerebral infarct size and then on the apoptotic mechanism after the completion of 2-hour occlusion of middle cerebral artery (MCA) and 24-hour reperfusion. Results: The ischemic zone with cerebral infarct was consistently observed in the cortex and striatum of the left hemisphere at 24 hours of reperfusion after the completion of 2-hour occlusion of left MCA. The infarct area and volume were significantly reduced, when rats received 4 and 10 mg/kg 17 β-estradiol intraperitoneally 24 hours before and 5 min after 2-hour ischemia. Samples from the regions corresponding to the penumbra showed markedly reduced Bcl-2 protein level and, in contrast, high levels of Bax protein and cytochrome c release. Both increased Bax and cytochrome c were significantly reduced, and decreased Bcl-2 protein was markedly restored by 17 β-estradiol. 17 β-estradiol(10-1-10-5M) potently scavenged hydroxyl radicals and inhibited intracellular hydrogen peroxide production. Conclusion: 17 β-estradiol treatments decrease ischemic brain infarction in association with inhibition of apoptotic cell death.
보조생식술후 태아에서 발생한 de novo 염색체 이상
안기헌 ( Ki Heon Ahn ),이국원 ( Kook One Lee ),주종길 ( Jong Kil Joo ),신병섭 ( Byung Sup Shin ),최욱환 ( Ook Hwan Choi ) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.9
We experienced two cases of de novo fetal chromosomal abnormalities after assisted reproductive technology (ART): One case was reciprocal translocation 46,XX,t(6;14)(p21.3;q12) after intracytoplasmic sperm injection & embryo transfer (ICSI-ET) and the other case was 46,X,iso(Xq) after in vitro fertilization & embryo transfer (IVF-ET), both were diagnosed prenatally by amniocentesis and postnatally cord blood culture. We report these cases with a brief review of literatures.
Ovarian Metastasis from Stage IB Cervical Adenocarcinoma : A Case Report 증례 보고
Kim, Ji Yeon,Lee, Dong Hyung,Shin, Byung Sup,Kim, Ki Hyung,Yoon, Man Soo 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.1
자궁경부암의 난소 전이는 드물다. 특히 조기암일 경우 그러하다. 최근 들어 삶의 질에 대한 관심이 높아지면서 초기 자궁경부암의 치료시 난소보존의 문제가 많이 거론되고 있다. 초기 자궁경부 편평상피암의 치료에서 난소보존은 비교적 잘 확립되어져 있으나, 자궁경부 선암의 경우 아직 논란의 여지가 있다. 본 증례는 우측 난소에 전이를 동반한 병기 Ib 자궁경부 선암의 예이다. 수술 소견상 양측 난소는 육안 및 촉진 소견상 별 특이 소견이 없었고 자궁경부 밖으로 병변이 진전된 육안 소견도 없었으며, 술 후 병리조직 검사에서 전이가 판명되었다. 자궁경부암의 난소 전이는 불량한 예후를 나타내는 인자중 하나로 본 저자들은 자궁경부 편평상피암에 비해 자궁경부선암의 경우 난소 보존이 그리 안전하지만은 않다고 생각하며 초기자궁경부암의 난소전이의 위험인자에 대한 더 많은 연구가 있어야 할 것으로 생각한다. Ovarian metastasis by cervical cancer is rare, especially in early stage cancer. Recently, concerning to quality of life, it is current issue that ovarian preservation in early stage cervical cancer. But it must be careful. In the case of squamous cell carcinoma of cervix, ovarian preservation in early stage cancer is well established, while this remains controversial in adenocarcinoma. The case presented here is a stage Ib cervical adenocarcinoma with right ovarian metastasis. In the operative findings, both ovaries were grossly unremarkable, and metastasis was detected on the postoperative histopathologic examination. We consider that it is not so secure that preservation ovaries in patient with cervical adenocarcinoma as compared to squamous cell carcinoma.