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- 저자 : 김원회(Won Whe Kim) (검색결과 8 건)
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Isoflavone 이 골모세포의 Alkaline Phosphatase 의 활성도에 미치는 영향
김원회(Won Whe Kim),이규섭(Kyu Sup Lee),이상훈(Sang Hoon Lee) 대한폐경학회 2002 대한폐경학회지 Vol.8 No.1
N/A The real mechanism of bone loss leading to osteopenia or osteoporosis in postmenopausal women is yet to be studied further, but both increased bone destruction and/or decreased bone formation, in other words, either increased activity of osteoclasts or decreased activity of osteoblasts, or both must be responsible. Various kinds of substances administered in vitro have shown activation or suppression in differentiation of osteoblasts. Recently, phytoestrogen, especially isoflavone derived from soy, has been under attention by various authors. Human osteoblasts (RCB0454) supplied by Riken Cell Bank of Tsukuba, Japan were grown in DMEM media with 10% fetal bovine serum. The cells were treated with isoflavone 10㎕ and 50㎕, for 2 and 4 days respectively, and then, alkaline phosphotase activities were analyzed by means of Mouse Monoclonal Antibody Reagent (Zymed, U.S.A.). Followings are brief summary of this study. 1. The osteoblasts after treatment with isoflavone 10㎕ for 2 days had increased to 80×104/㎖ of cells, 46.5 percent of that were stained indicating alkaline phosphatase activities. Those after treatment for 4 days had increased to 220×104/㎖ of cells and 52.9% were alkaline phosphatase positive. 2. Osteoblastic cells treated with 10μ of isoflavone increased to 200×104/㎖ and 56.9 percent of activity after 2 days while those went up to 280×104/㎖ and 71.9 percent after 4 days. 3. Osteoblastic growth as well as its alkaline phosphatase activity were positively correlated with dosage and duration of its treatment with isoflavone. 4. Alkaline phosphatase mostly were found in the cytoplasm on 2nd day but on the 4th day, they were mainly present extracellularly and in their periphery of the osteoblast. In conclusion, this study showed that isoflavone, one of the phytoestrogens, may stimulates matrix development and induces the primary step of mineralization in human osteoblast (RCB0454) cell line to ultimately stimulate to form new bones as it provokes increased alkaline phosphotase activities of the cells.
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한국여성에 있어서 산과력이 폐경 후 골밀도에 미치는 영향
김원회(Won Whe Kim),장성규(Sung Kyoo Jang) 대한폐경학회 2002 대한폐경학회지 Vol.8 No.1
N/A The percentage of postmenopausal female population is in increase, and the importance of its medical and psychological implication has been highly appreciated. Menstrual irregularity, flushing and emotional problems can cause considerable distress during menopause. It is well known that hormone replacement therapy can relieve the menopausal symptoms, reduce risk of osteoporosis and coronary artery disease. In this point of view, author investigated the effect of HRT in postmenopausal women and to evaluate the relationship of parity and bone mineral density. The results were as follows: 1. The mean age of the studied patient was 54.3 years; treatment duration 4.9 years, gravity 5.9, parity 2.9 and mean number of living children were 2.8. 2. Naturally menopaused women were in 68.7%, while 1.7% were surgically menopaused and 29.6% were in perimenopause. 3. The symptoms complained by the patients were hot flush (25.8%), insomnia, urinary frequency (7.5%), back pain and arthralgia (7.5%) in its order and asymptomatic patient were in 24.1%. 4. The used HRT regimen in this study was livial (tibolon)(69.5%), combined premarin and provera (21.3%) and premarin only (1.7%). 5. After the HRT, the serum total cholesterol level decreased from 200 mg/dl to 197.2 mg/dl, triglyceride from 123.2 mg/dl to 94.2 mg/dl. Serum HDL cholesterol level increased form 47.9 mg/dl to 50.7 mg/dl. 6. After the HRT, the mean T-score increased from -1.42 to -1.07 and the mean Z-score, from -0.67 to -0.22. 7. There was tendency of decrease in bone mineral density with increase of gravity and parity. These results suggest that hormone replacement therapy can improve the symptoms of menopause and decrease the risk of osteoporosis and coronary artery disease in postmenopausal women considerably. Furthermore, we should liberally promote the use of the hormone replacement therapy and counsel women about the menopause and an individualized therapy and this will be possible by more studies on the quality of women's life.
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흰쥐에서 허혈성 뇌경색에 대한 에스트로겐의 신경보호 효과
김원회(Won Whe Kim),이규섭(Kyu Sup Lee),최영철(Yeong Cheul Choi),신병섭(Byung Sup Shin),김기형(Ki Hyung Kim) 대한폐경학회 2002 대한폐경학회지 Vol.8 No.1
N/A Objective: Overall incidence of stroke is uniformly higher in men than in women, and rare especially in women during the reproductive stage. A number of studies have demonstrated the reduced infarct size upon administration of estrogen to ovariectomized females in ischemic brain injury models. Design: We aimed to examine the potential neuroprotective effects of 17 beta-estradiol on the cerebral infarct size and then on the apoptotic mechanism after the completion of 2-hour occlusion of middle cerebral artery (MCA) and 24-hour reperfusion. Results: The ischemic zone with cerebral infarct was consistently observed in the cortex and striatum of the left hemisphere at 24 hours of reperfusion after the completion of 2-hour occlusion of left MCA. The infarct area and volume were significantly reduced, when rats received 4 and 10 mg/kg 17 β-estradiol intraperitoneally 24 hours before and 5 min after 2-hour ischemia. Samples from the regions corresponding to the penumbra showed markedly reduced Bcl-2 protein level and, in contrast, high levels of Bax protein and cytochrome c release. Both increased Bax and cytochrome c were significantly reduced, and decreased Bcl-2 protein was markedly restored by 17 β-estradiol. 17 β-estradiol(10-1-10-5M) potently scavenged hydroxyl radicals and inhibited intracellular hydrogen peroxide production. Conclusion: 17 β-estradiol treatments decrease ischemic brain infarction in association with inhibition of apoptotic cell death.
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卓惠政,朴仁士,朴正恨,金源會 최신의학사 1974 最新醫學 Vol.17 No.8
Nephrotic Syndrome in Pregnancy is known' to be an extremely rare condition. Differentiating it from either pre-eclampsia or other renal diseases is not easy since they are similar one another as far as clinical and laboratory findings are concerned. We have recently met such a case, which was proved by kidney, biopsy, to report it as well as a brief review of literatures. The kidney biopsy showed increased cellular infiltration and irregular thickening of the basement membrane in the glomerular tuft, diagnosing as membraneous glomerulonephritis.
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