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이홍렬(Hong Lyeol Lee),곽승민(Seung Min Kwak),장중현(Jung Hyun Chang),김세규(Se Kyu Kim),김성규(Sung Kyu Kim),이원영(Won Young Lee),신동환(Won Young Lee) 대한내과학회 1992 대한내과학회지 Vol.43 No.6
N/A Backgrounds: Endobronchial metastasis of extrapulmonary malignancies was defined as those cases in which metastatic foci were grossly evident in the main or lobar bronchi and occurs in less than 5% of all cases. The common extrapulmonary tumors associated with metastatic involvement of a central airway are carcinomas of the breast, kidney, colorectum and malignant melanoma. In the majority of cases, the primary tumor site is clinically apparent before symptoms of endobronchial metastasis. The clinical and roentgenographic features of endobronchial metastasis and primary bronchogenic carcinoma were found to be indistinguishable. Mostly, the histologic appearance of the bronchoscopic biopsy suggests the correct diagnosis but in some instances it may be impossible to differentiate metastatic involvement of the bronchus by an asymptomatic extrathoracic adenocarcinoma from a primary central adenocarcinoma of the lung. In addition to the treatment aspect of neoplasm spread, palliative surgical removal of endohronchial metastatic malignancies are strongly recommended to improve the patients qualify of life and to prevent resultant obstructive complications. Methods: We experienced 5cases of endobronchial metastasis during the recent 1½ years and reviewed the medical records of 12cases previously confirmed as endobronchial metastasis by bronchoscopic bioposies since 1985 to 1990. We investigated the clinical manifestations, primary sites, time intervals and bronchoscopic findings. Results: Breast carcinoma was the most common primary malignancy leading to the endobronchial metastasis. We also found the metastatic cases of hepatocellular carcinoma, sebacious gland adenocarcinoma and mouth floor carcinoma. Mostly patients complained of dyspnea and productive cough and chest X-ray revealed atelectasis. Endobronchial metastasis developed within 3 years in more than half of the cases and the mean time interval was 40,6months. In one prostate cancer and one thyroid cancer, metastasis was diagnosed prior to primary site presentation. On bronchoscopic examination, the right upper lobar bronchus was most commonly involved and subtotal obstruction was the most frequent finding. More than half of the patients expired within 2 years after the diagnosis of endobronchial metastasis. Conclusion: Endobronchial metastasis has unique clinical significance in that it requires differential diagnosis with primary bronchogenic carcinoma and aggressive palliative surgical management. If atypical clinical features are present or atypical cell type is discovered by biopsy of the lesion in lung ca, appropriate diagnostic studies should be undertaken to exlude the possibility of an asymptomatic extrapulmonary tumor before definite therapy is undertaken.
양측성 폐종괴 양상을 보인 알레르기성 기관지 폐 아스페르길루스증
고원기 ( Won Ki Ko ),최승원 ( Seung Won Choi ),박재민 ( Jae Min Park ),안강현 ( Gang Hyun Ahn ),김세규 ( Se Kyu Kim ),장준 ( Joon Chang ),김성규 ( Sung Kyu Kim ),이원영 ( Won Young Lee ),최규옥 ( Kyu Ok Choe ),신동환 ( Dong Hwan 대한결핵 및 호흡기학회 1999 Tuberculosis and Respiratory Diseases Vol.46 No.2
이달의 X선 : Clomifen 호르몬제 복용후 호흡곤란이 악화된 환자에서의 미만성 망상형 간질성 폐침윤
박형천 ( Hyeong Cheon Park ),김영삼 ( Young Sam Kim ),김세규 ( Se Kyu Kim ),정경영 ( Kyung Young Chung ),신동환 ( Dong Hwan Shin ),이홍렬 ( Hong Lyeol Lee ),장준 ( Joon Chang ),김성규 ( Sung Kyu Kim ),이원영 ( Won Young Lee ) 대한결핵 및 호흡기학회 1995 Tuberculosis and Respiratory Diseases Vol.42 No.4
연령에 따른 C57BL/6계 마우스의 가슴샘, 지라, 림프절내 T세포 및 B세포의 분포변화에 관한 면역조직화학적 연구
조성배(Sung Bae Cho),이원규(Won Kyu Lee),신동환(Dong Hwan Shin),홍충만(Chung Man Hong),허영범(Young Buhm Hur),안희경(Hee Kyung Ahn) 대한체질인류학회 1998 대한체질인류학회지 Vol.11 No.2
C57BL/6계 마우스의 연령에 따른 면역기관의 변화를 관찰하기 위하여 생후1,4, 8, 12와 40주령의 C57BL/6계 마우스의 가슴생, 지라, 림프절을 대상으로 Ly1, L3T4와 Ly2단세포성항제 및 IgM 항제를 사용하여 연역조직염색을 시행하였다. Ly1 양성인 T세포는 가슴샘에서 생후 1주군에 이미 많이 분포하고 있었고 생후 8주군부터는 감소를 보였다. 지라에서는 생후 40주군에서 속동맥주위림프구집에서 감소하였다. 림프절에서는 40주군에서 감소를 보였다. L3T4양성인 조력T세포는 가슴샘에서는 큰 변화가 없었고 지라에서는 생후 40주군에서 감소를 보였으며 림프절에서는 변화를 관찰할 수 없었다. Ly2양성인 세포독성/억제T세포는 가슴샘에서 생후 4주군부터 감소하였으나 지라에서는 생후 40주군에서 감소하였으며, 림프절에서는 위치의 이동을 관찰할 수 있었다. IgM양성B세포는 유의한 차이를 발견할 수 없었다. 이상의 결과를 종합하면 마우스에서 연령이 증가함에 따라 가슴샘 지라, 림프절에서 T세포의 감소를 알 수 있었다.
소세포폐암에서 Neuron Specific Enolase의 면역조직 화학염색과 혈청농도에 관한 연구
곽승민 ( Seung Min Kwak ),김형중 ( Hyung Jung Kim ),신동환 ( Kong Hwan Shin ),장중현 ( Joong Hyun Jang ),이홍렬 ( Hong Lyeol Lee ),김세규 ( Se Kyu Kim ),안철민 ( Chul Min Ahn ),김성규 ( Sung Kyu Kim ),이원영 ( Won Young Lee ),이 대한결핵 및 호흡기학회 1992 Tuberculosis and Respiratory Diseases Vol.39 No.6