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마이크로웨이브법에 의해 제조된 HAp 및 BCP 분말이 뼈모세포 및 파골세포의 활성에 미치는 영향
송호연,민영기,양훈모,맹주양,Song, Ho-Yeon,Min, Young-Ki,Yang, Hun-Mo,Mang, Joo-Yang 한국재료학회 2007 한국재료학회지 Vol.17 No.12
Hydroxyapatite (HAp) and biphasic calcium phosphate (BCP) nano powders were synthesized using the microwave-assisted synthesis process dependent on pH and microwave irradiation time. The average size of a powder was less than 100 nm in diameter. Through in-vitro cytotoxicity tests by an extract dilution method, the HAp and BCP nano powders have shown to be cytocompatible for L-929 fibroblast cells, osteoblastlike MG-63 cells and osteoclast-like Raw 264.7 cells. The activation of osteoblast was estimated by alkaline phosphatase (ALP) activity. When the HAp and BCP were treated to MG-63 cells, alkaline phosphatase activities increased on day 3, compared with those of the untreated cells. Also, the collagen fibers increased when the HAp and BCP powders suspension were treated to MG-63 cells, compared to those of the untreated cells. Quantitative alizarin red S mineralization assays showed a trend toward increasing mineralization in osteoblast cultured with powder suspension. In conclusion, hydroxyapatite and biphasic calcium phosphate appeared to be a bone graft substitute material with optimal biocompatibility and could be further applied to clinical use as an artificial bone graft substitute.
방전플라즈마소결법에 의해 제조된 저탄성 타이타늄 다공질체의 생체적합성 평가
송호연,김영희,장세훈,오익현,Song, Ho-Yeon,Kim, Young-Hee,Chang, Se-Hun,Oh, Ik-Hyun 한국재료학회 2007 한국재료학회지 Vol.17 No.2
Porous Ti compacts were fabricated by spark plasma sintering (SPS) method and their in vitro and in vivo biocompatibilities were investigated. Alkaline phosphatase (ALP) activity representing the activity of osteoblast was increased when osteoblast-like MG-63 cells were cultured on the Ti powder surface. Some genes related to cell growth were over-expressed through microarray analysis. The porous Ti compact with 32.2% of porosity was implanted in the subcutaneous tissue of rats to confirm in vivo cytotoxicity. 12 weeks post-operation, outer surface and inside the porous body was fully filled with fibrous tissue and the formation of new blood vessels were observed. No inflammatory response was confirmed. To investigate the osteoinduction, porous Ti compact was implanted in the femur of NZW rabbits for 4 months. Active in-growth of new bone from the surrounded compact bone was observed around the porous body. From the results, The porous Ti compacts fabricated by spark plasma sintering might be available for the application of the stem part of artificial hip joint.
PMMA를 이용한 다공질 β-TCP 골충진제 제조 및 생체적합성 평가
송호연,윤민호,김영희,민영기,양훈모,이병택,Song, Ho-Yeon,Youn, Min-Ho,Kim, Young-Hee,Min, Young-Ki,Yang, Hun-Mo,Lee, Byong-Taek 한국재료학회 2007 한국재료학회지 Vol.17 No.6
Porous ${\beta}-tricalcium$ phosphate $({\beta}-TCP)$ bioceramic was fabricated by pressureless sintering using commercial HAp and different volume percentages of PMMA powders (30-60 vol.%). The range of spherical pore size was about $200-250\;{\mu}m$ in diameter. By increasing the PMMA content, the number of pores and their morphology were dramatically changed as well as decreased the material properties. In case of using 60 vol.% PMMA content, network-type pores were found, due to the necking of the PMMA powders. The values of relative density, elastic modulus, bending strength and hardness of the 60 vol.% PMMA content sample, sintered at $1500^{\circ}C$, were about 46%, 22.2 GPa, 5MPa and 182 Hv respectively. Human osteoblast-like MG-63 cells and osteoclast-like Raw 264.7 cells were well grown and fully covered all of the porous ${\beta}-TCP$ bodies sintered at $1500^{\circ}C$.
은 나노 입자의 항균기전과 항균제 응용을 위한 In vivo 실험
송호연 ( Ho Yeon Song ),김영희 ( Young Hee Kim ),고광균 ( Kwang Kjune Ko ),오익현 ( Ik Hyun Oh ),이병택 ( Byong Taek Lee ) 대한금속재료학회 ( 구 대한금속학회 ) 2006 대한금속·재료학회지 Vol.44 No.6
Silver is one of the most universal antimicrobial substances. Nano-technogy enables us to expand the surface area of silver particles markedly. Silver nano-particles were successfully produced less than 10 nm in size. Nanosilver showed excellent antibacterial activities against Salmonella typhi and Pseudomonas aeruginosa around 1 ppm and Mycobacterium tuberculosis around 10 ppm. Nanosilver induced the severe morphologic changes in cell wall and cytoplasm of bacteria. Antimicrobial mechanisms of nanosilver were different according to the species of bacteria; plasmolysis in Salmonella typhi and metabolic disturbance due to ingestion of nanosilver in M. tuberculosis. To confirm the toxicity of nanosilver, four groups of mice (60 mice in total) have been fed with nanosilver suspension (0, 10, 30, 100 ppm) for 6 months. Their behaviors, weight changes and hematologic findings of mice after feeding of nanosilver showed similar results with those of the control although the mice had been fed 100 ppm of nanosilver for 6 months. From the results, silver nanoparticles probably will be available as a good and safe antibiotic alternative.
자연어처리를 기반으로 한 코로나 정보 제공 챗봇 시스템
송호연 ( Ho-yeon Song ),곽찬우 ( Chan-woo Gwak ),이동원 ( Dong-won Lee ),이윤수 ( Yun-soo Lee ) 한국정보처리학회 2020 한국정보처리학회 학술대회논문집 Vol.27 No.2
본 논문에서는 코로나 바이러스로 인한 불편함을 겪는 사람들에게 코로나 관련 정보를 편리하게 제공하기 위해 인공지능 기반의 챗봇을 개발하였다. 인공지능 기술이 도입됨에 따라 챗봇이 여러 기관에서 고객 응대를 포함한 다양한 업무를 수행하고 있다는 점에 착안하여 IBM Watson Assistant 를 활용한다. Watson Assistant는 사용자가 입력한 말을 자연어 처리를 통해 분석하여 문장을 생성한 후 사용자에게 전달한다. Intent와 Entitiy를 통해 질의의 행위와 주체를 입력한 후 높은 빈도가 예상되는 질문을 작성하고, Dialog를 통해 대화 흐름을 파악한다. 사용자는 Axure로 설계된 사용자 인터페이스를 통해 대화 전송, 정보 수신 등 동작을 취할 수 있으며, 각 언어에 맞는 SDK 라이브러리를 제공한다는 이점을 활용하여 Node.js로 화면에서 발생하는 액션과 데이터 전달을 처리한다.
송호연(Ho-Yeon Song),하경란(Kyung-Ran Ha),고현철(Hyun-Chul Koh),신인철(In-Chul Shin),서대규(Tae-Kyu Suh) 대한약리학회 1994 대한약리학잡지 Vol.30 No.2
In an attempt to define the effects of Biphenyldimethyl dicarboxylate(DDB) on the lipid peroxidation, oxygen free radical scavenging enzymes activities and hepatic functions in ethanol-induced hepatotoxic rats, we studies malondialdehyde(MDA) level and the activities of catalse, superoxide dismutase(SOD), glutamic-oxaloacetic transaminase(GOT) and glutamic-pyruvic transaminase(GPT) in liver of the rats at 24, 48 and 72 hr after the injection of ethanol and DDB. Sprague-Dalwey albino rats weighing 250 to 280gm were injected intraperitoneally with ethanol(2.5 gm/kg ) only and ethanol plus DDB(300mg/kg ). The result obtained can be summarized as follows : 1) The group treated with ethanol showed significantly higher MDA level and lower catalase and SOD activities at 24, 48 and 72hr after the injection as compared with that of control group. 2) The group treated with ethanol showed significantly higher GOT and GPT activities at 24, 48 and 72hr after the injection as compared with that of control group. 3) The group treated with ethanol plus DDB showed significantly lower MDA level and higher catalase and SOD activities at 24, 48 and 72 hr after the injection as compared with that of ethanol group. 4) The group treated with ethanol plus DDB showed significantly lower GOT and GPT activities at 24, 48 and 72 hr after the injection as compared with that of ethanol group. These results suggest that the excessive oxygen free radicals resulting from the depression of the activities of catalase and superoxide dismutase is an important determinant in pathogenesis of ethanol-induced hepatotoxicity and DDB has antioxidant effects.
생체세라믹 알루미나 분말이 뼈모세포 및 파골세포의 증식에 미치는 영향
송호연 ( Ho Yeon Song ),김영희 ( Young Hee Kim ),고광균 ( Kwang Kjune Ko ),김양희 ( Yang Hee Kim ),오익현 ( Ik Hyun Oh ),이병택 ( Byong Taek Lee ) 대한금속재료학회 ( 구 대한금속학회 ) 2006 대한금속·재료학회지 Vol.44 No.6
The main cause of re-operation in patients who received total hip arthroplasty is wear debris-mediated osteolysis in bone-implant interface. Recently, alumina or zirconia ceramic hip joint have also become available. Therefore, Al2O3 particles induced cytotoxicity on osteoblast-like MG-63 cells and osteoclastlike Raw 264.7 cells was observed through in vitro and in vivo study. Low concentration of Al2O3 powders did not induce cytotoxicity, however the proliferation of osteoblast cultured with high concentration of Al2O3 powders were significantly inhibited. Al2O3 particles were also observed on the surface and inside the MG-63 and Raw 264.7 cells accompanied with the morphological changes of cytoplasmic organelles. Al2O3 particles injected in subcutaneous tissue of rats did not induce inflammatory response.