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류마티스 관절염에서 염증 관여 유전자의 다형성 연구: 대식 세포 유주 억제 인자(MIF)
송주경 ( Ju Kyoung Song ),신현영 ( Hyun Young Shin ),이유선 ( You Sun Lee ),황재희 ( Jae Hee Hwang ),권양숙 ( Yang Sook Kwon ),정연주 ( Yeon Ju Jeong ),이윤종 ( Yun Jong Lee ),강성욱 ( Seong Wook Kang ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.2
Objective: Rheumatoid arthritis (RA) is characterized by the interaction of multiple mediators, especially cytokines. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine and has been shown to be involved in RA. This study explored the association of the MIF gene polymorphism with RA in Korean. Methods: 114 patients with RA, and 114 age and gender matched healthy controls were studied. Patients and controls were genotyped for a single nucleotide polymorphism (SNP) in the 5`-flanking region at position -173 of the MIF gene. Results: No significant differences in MIF gene polymorphism were observed in RA compared to healthy controls. No association with disease severity was detected for the MIF gene polymorphism. Conclusion: MIF -173 G/C polymorphism did not appear to be associated with genetic susceptibility and disease severity in Korean RA patients.
증례 : 류마티스 관절염 환자에서 infliximab 치료 후 발생한 간질성 폐렴 1예
유인설 ( In Seol Yoo ),송주경 ( Ju Kyoung Song ) 대한내과학회 2010 대한내과학회지 Vol.79 No.2
종양괴사인자 억제제는 류마티스 관절염에서 효과 및 안정성이 입증되어 현재 보편화된 치료이다. 부작용으로는 결핵 및 감염에 의한 폐렴, 급성 주사 반응, 루프스 유사 증후군, 악성 종양, 울혈성 심부전의 악화 등이 있으며 드물게 비감염성 간질성 폐렴이 외국에서 보고되었다. 비감염성 간질성 폐렴은 주로 methotrexate와 병용할 때 호발하며 국내에서는 아직 보고된 바가 없다. 저자들은 종양괴사인자 억제제인 infliximab을 사용한 류마티스 관절염 환자에서 발생한 비감염성 간질성 폐렴으로 고용량의 스테로이드를 사용한 후 호전된 증례를 경험하여 보고하는 바이다. Tumor necrosis factor (TNF)-α inhibitors are well-established biological agents for the treatment of a wide variety of chronic autoimmune diseases and inflammatory conditions, including rheumatoid arthritis (RA), ankylosing spondylitis, and psoriatic arthritis. Although these drugs have been noted to have good safety profiles, some important side effects, including infection, injection site reactions, lupus-like syndrome, congestive heart failure, and malignancies have been reported. Therefore, utilization of TNF-α inhibitors demands caution. Interstitial pneumonitis is a very rare complication of TNF-α inhibitors. We report here a 71-year-old man with RA who developed interstitial pneumonitis after the third infusion of infliximab. (Korean J Med 79:215-218, 2010)
신현영 ( Hyun Young Shin ),남효정 ( Hyo Jung Nam ),송주경 ( Ju Kyoung Song ),강성욱 ( Seong Wook Kang ),이상옥 ( Sang Ok Lee ),신동혁 ( Dong Hyuk Sheen ),임미경 ( Mi Kyoung Lim ),심승철 ( Seung Cheol Shim ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.2
In Behcet`s disease, thrombocytopenia has rarely been reported in association with the hemolytic uremic syndrome, thrombotic thrombocytopenic purpura or in association with cyclosporine or chlorambucil in the treatment of ocular inflammatory disease and meningoencephalitis. In this paper we report a case of thrombocytopenia in a 33-year-old female with Behcet`s disease who has taken no medications for three years. After history taking, physical examination, routine laboratory and bone marrow examination, we diagnosed her case as idiopathic thrombocytopenic purpura (ITP). She recovered with high dose steroid treatment. To our knowledge, this is the first report having ITP in a patient with Behcet`s disease.
김수민 ( Soo Min Kim ),박보형 ( Bo Hyung Park ),강유진 ( Yu Jin Kang ),박미희 ( Mi Hui Park ),송주경 ( Ju Kyoung Song ) 대한류마티스학회 2009 대한류마티스학회지 Vol.16 No.3
We describe a 28-year old man in otherwise apparently good health, in whom pain in his left knee joint caused by avascular necrosis led to a diagnosis of polyarteritis nodosa (PAN). The angiogram showed multiple microaneurysmal and thrombotic lesions, notably in the renal, mesenteric and tibial arteries. A skin biopsy of the upper dermis of the left thigh with an erythematous skin rash showed the infiltration of mononuclear leukocytes in the perivascular area. During hospitalization, he was diagnosed with chronic hepatitis B, and was treated with lamivudine, and corticosteroid, azathioprine to control the PAN. The knee joint pain improved progressively, and the patient could walk normally after several months. This case is an unusual presentation because the initial manifestation of PAN was avascular necrosis.
한국인 베체트병 환자에서 T-bet 유전자 다형성에 관한 연구
김진현 ( Jin Hyun Kim ),이윤종 ( Yun Jong Lee ),황재희 ( Jae Hee Hwang ),백한주 ( Han Joo Baek ),강성욱 ( Seong Wook Kang ),배영덕 ( Young Deok Bae ),송승택 ( Seung Taek Song ),최효진 ( Hyo Jin Choi ),송주경 ( Ju Kyoung Song ) 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.4
Objective: Behcet`s disease (BD) is a chronic systemic inflammatory disease with unknown etiology. A number of clinical and laboratory findings suggest a strongly polarized Th1 immune response in BD. T-bet is a newly identified Th1 specific T-box transcription factor selectively expressed in Th1 cells. However, it is not yet clear whether the T-bet protein is involved in the proposed Th1-mediated pathogenesis of BD at the transcriptional level. Therefore, this study investigated the potential associations of two single nucleotide polymorphisms (SNPs) at positions -99 (C/G) and -1993 (T/C) in the exon and promoter regions of the TBX21 gene with susceptibility to BD in the Korean population. Methods: 105 patients with BD and 105 healthy controls were studied. All subjects were genotyped using restriction fragment length polymorphism analysis. The genotypes of the two groups were compared with the chi-square or Fisher`s exact tests. Results: The genotypic and allelic distributions of the two SNPs did not differ significantly between the two groups. Furthermore, no associations between the polymorphisms and clinical manifestations were found, except a central nervous system manifestation and arthritis. Furthermore, no associations between the polymorphisms and severity were identified. Conclusion: TBX21 gene polymorphisms were not associated with susceptibility, clinical manifestations, or severity of BD in the Korean population.
정승현,송주경,정성수,강성욱 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1
저자들은 만성 기침이 있었으나 정확한 원인을 찾지 못한 채 보존적 치료만 받던 베체트병이 있는 37세 여자환자를 경험하였고 흉부 방사선사진과 흉부 전산화 단층 촬영으로 폐동맥류로 진단하고 고용량의 스테로이드로 치료하였고 이 과정에서 대량 객혈이 있었으나 보존적 치료로 호전된 베체트병 1 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Pulmonary Artery Aneurysm Manifesting as Chronic cough in Behcet's disease Behcet's disease is a relapsing chronic inflammation disorder of unknown etiology. Although Behcet's disease has originally been described as a triad of recurrent oral aphthous ulceration, genital ulceration and uveitis, it is now recognized as a multisystem disease with vasculitis as the main pathological finding. Clinical manifestations additional to this triad include involvement of the skin, joints, large vessels, lung, gastrointestinal and genitourinary tracts, brain. We report a case of pulmonary artery aneurysm manifesting as chronic cough in Behcet's disease. She was a 47 year-old woman with Bechet's disease treated with prednisolone and colchicine. She had suffered from chronic cough for several years, but been treated only with antitussive agents. Chest CT revealed multifocal patchy consolidation in lung parenchym and aneurysmal dialatation of pulmonary artery. We diagnosed pulmonary aneurysm with CT finding as the cause of chronic cough.